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CSIC - Consejo Superior de Investigaciones Científicas

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CSIC is a government agency for basic and applied scientific research. It is the largest public research organization in Spain, with presence in all the Autonomous Communities through 126 centers and 145 associated units.

Latest Open Innovation Opportunities

  • Technology Offers (100)

Biogenesis on-demand for the production of carotenoids and phytonutrients

CSIC and the Center for Research in Agricultural Genomics have developed a biotechnological method for the biofortification in carotenoids and other phytonutrients of green tissues. The method is based on the

Patents for licensing

Biogenesis on-demand for the production of carotenoids and phytonutrients
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Paper-based temperature sensor with high sensitivity

The CSIC has developed a thermo-resistive sensor comprising a semiconductor material onto a paper substrate. The use of this type of materials together with deposition technique of semiconductor element allow to design a t

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Paper-based temperature sensor with high sensitivity
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Polypeptides with antibacterial activity

CSIC has developed several polypeptides with bactericidal activity from a phage lysin of Pseudomonas aeruginosa. These compounds are particularly active against Gram-negative bacteria, such as P. aeruginosa, Acinetobacter ba

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Polypeptides with antibacterial activity
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Two in one: engineering recombinant biocatalysts for plastic recycling and towards bioplastic production

CSIC has developed recombinant genetic cassettes and bacterial host cells comprising them which are useful as biotechnological tools for the aerobic and anaerobic biodegradation of o-phthalate (PA) and its bioconversion int

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Two in one: engineering recombinant biocatalysts for plastic recycling and towards bioplastic production
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Rice husk as a filter for the removal of contaminants in water

The CSIC, in collaboration with the Technische Universität Berlin, has developed a manufacturing process for obtaining, from rice husk, activated carbon filters for the removal of emerging organic

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Rice husk as a filter for the removal of contaminants in water
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Carbon monoliths as suport for solid-base catalytic reactions

CSIC, in collaboration with the University Nacional de Colombia and University of Seville, has developed a procedure that, through the design and manufacture of extruder molds with 3D printing, en

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Carbon monoliths as suport for solid-base catalytic reactions
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High resolution paterning in organic semiconductors

CSIC has developed a new a method for high resolution structural and/or compositional modification in a molecular organic semiconductor film. This method has applications in the production of electronic, optoelectr

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High resolution paterning in organic semiconductors
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Intelligent device for the automatic parameterization through a digital twin of a

cyber-physical system CSIC and Universidad Politécnica de Madrid have developed an intelligent connectable device for the automatic parameterization of controllers of a physical and cybernetic system. This device has a new p

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Intelligent device for the automatic parameterization through a digital twin of a
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Direct sensor for electron microscopy with in-pixel energy measurement

CSIC has developed a pixelated direct sensor to capture high-resolution images using electron microscopes. Each pixel of the sensor uses more than one electrode to measure the charge generated, and the output of the sensor co

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Direct sensor for electron microscopy with in-pixel energy measurement
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Biohybrid catalyst with coper nanoparticles

CSIC has developed a novel hybrid material consisting on a protein matrix and nanoparticles of different copper species. The effect of the combination is an enhancement of the peroxidase activity of the material

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Biohybrid catalyst with coper nanoparticles
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Natural compound with antiviral properties against hepatitis C

CSIC, IISA, IACS, the University of Zaragoza and ARAID have discovered a natural compound with antiviral capacity against the virus that causes hepatitis C. The compound is extracted from a natural and edible source, non-toxi

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Natural compound with antiviral properties against hepatitis C
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Immunoassay for detection of Pseudomonas aeruginosa Quorum Sensing molecules

CSIC has developed an immunochemical method for diagnosis of infections produced by Pseudomonas aeruginosa targeting the main signaling molecules of the pqs Quorum Sensing system. The immunoassay is fast and efficient, with l

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Immunoassay for detection of Pseudomonas aeruginosa Quorum Sensing molecules
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Kit for the systematic generation of transgenic lines for transcriptomic analyses

The CSIC has developed a kit for performing dynamic and tissue-specific transcriptomic analysis through the TRAP (Translating Ribosome Affinity Purification) methodology. The system allows, through a

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Kit for the systematic generation of transgenic lines for transcriptomic analyses
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Therapeutic compositions of cortistatin for the treatment of chronic fibrosis

CSIC has developed a therapeutic tool that enables obtaining compositions of cortistatin highly effective, and without side effects, in the treatment of chronic fibrosis such as liver, lung and der

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Therapeutic compositions of cortistatin for the treatment of chronic fibrosis
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Novel luminescent probes of lanthanide complexes for sensing of biomolecules

CSIC and Universidad de Granada have developed a new family of antenna chromophores able to sensitize effectively luminescence of lanthanides to be applied as labelling probes for biomolecules. Industrial partners specialize

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Novel luminescent probes of lanthanide complexes for sensing of biomolecules
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Customized 3D porous carbon structures made from sustainable sources

Customized 3D porous carbon structures made from sustainable sources CSIC has developed 3D porous carbon structures from whey powder, a by-product from dairy industry. These structures can be obtained with a millimeter prec

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Customized 3D porous carbon structures made from sustainable sources
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Catalyst for nitrous oxide (N2O) decomposition

CSIC has developed a novel catalyst, with a simple preparation method, that achieves the removal of 98% of N2O emissions at temperatures below 350ºC, when applied in the so-called "tail gas" of nitric acid production plants

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Catalyst for nitrous oxide (N2O) decomposition
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Bacterial nanocellulose biomaterial production

The CSIC has developed the production of an emerging nano-cellulose biomaterial from autotrophic bacteria, with growth from a single inorganic carbon source (eg atmospheric CO2), for use in biomedicine, food, packaging, and p

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Bacterial nanocellulose biomaterial production
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Hybrid particles with thermal functionalized surface for molecule release

The CSIC and the University Complutense of Madrid have developed a controlled drug delivery system consisted on organic and inorganic hybrid material of silicone polymers. Industrial partners from the field of pharmacology,

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Hybrid particles with thermal functionalized surface for molecule release
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New formulation for drugs controlled release for ophthalmic use

CSIC and the University of Zaragoza have developed a new formulation to achieve a controlled and sustained release of different drugs inside the eyeball. Industrial partners from the ophthalmic or pharmaceutical industry are

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New formulation for drugs controlled release for ophthalmic use
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Tunable temperature and measuring angle holder for film and powder samples

Researchers from the Spanish National Research Council (CSIC) and the Catalan Institute of Nanoscience and Nanotechnology (ICN2-BIST) have recently developed a sample holder for measuring films or powder samples in a fluorime

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Tunable temperature and measuring angle holder for film and powder samples
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Metallic Catalysts for the Preferential Activation of Ammonia Over Other

Amines CSIC and the University of Zaragoza have developed a new, more economic, more sustainable and more effective methodology that allows obtaining nitrogen molecules using ammonia as raw material. Industrial partners are

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Metallic Catalysts for the Preferential Activation of Ammonia Over Other
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Imaging analysis of the zebrafish escape response

The CSIC has developed a procedure and system for kinematic analysis of the stimulus-evoked escape response in adult zebrafish. The procedure falls within the field of image analysis using algorithms. Research centres and In

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Imaging analysis of the zebrafish escape response
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Digital OR Pulse Combining Photomultiplier

Digital OR Pulse Combining Photomultiplier CSIC and the University of Seville have developed a digital OR pulse combining photomultiplier that reduces unnecessary energy expenditure that occurs in conventional architectures

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Digital OR Pulse Combining Photomultiplier
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Biocatalyst to transform fat into stabilizers, coatings, glues and polymers in a specific and environmentally friendly way

The CSIC has developed two mutated variants of an unspecific peroxygenase enzyme that improve the selectivity of the biocatalyst for two specific industrial applications. One is the epoxidation of unsaturated fatty acids fo

Patents for licensing

Biocatalyst to transform fat into stabilizers, coatings, glues and polymers in a specific and environmentally friendly way
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Catalyst for the upgrading of raw biogas

CSIC has developed a catalyst for the reaction of methanation of the carbon dioxide of biogas, which shows high levels of conversion per volume of catalyst, allowing the direct reaction, only in one step. The catalyst has be

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Catalyst for the upgrading of raw biogas
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Point-of-care analytical device for rapid and multiplexed detection of biomarkers

CSIC at the Instituto de Microelectrónica de Barcelona – Cento Nacional de Microelectrónica has developed a compact analytical device for rapid and multiplexed detection of multipurposed biomarkers present in biological f

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Point-of-care analytical device for rapid and multiplexed detection of biomarkers
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Peptide for the prevention and treatment of aneurysm

CSIC and the Research Institute of the Hospital de la Santa Creu i Sant Pau (IRHSCSP) have identified a compound that could be used in the treatment and prevention of aneurysm, increasing survival rate. Industrial partners f

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Peptide for the prevention and treatment of aneurysm
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Prevention of Lung Injury asociated with Acute Necrotizing Pancreatitis

CSIC has found the potential of polyethylene glycol on reducing the severity of acute necrotizing pancreatitis and associated lung injury, thus minimizing the systemic inflammatory response. Industrial partners f

Patents for licensing

Prevention of Lung Injury asociated with Acute Necrotizing Pancreatitis
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Application of ultrasound in clinical physiotherapy

The CSIC has developed a device to apply physiotherapeutic ultrasound. The device allows controlled and programmable focusing. Industrial partners from the field of physiotherapy are being sought to collaborate through a pate

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Application of ultrasound in clinical physiotherapy
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Dynamic Pupil for ophthalmological applications

Researchers from the Spanish National Research Council (CSIC) and the Catalan Institute of Nanoscience and Nanotechnology (ICN2-BIST) have recently developed a self‐‐regulating iris based on light‐‐actuated broadband

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Dynamic Pupil for ophthalmological applications
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Scalable aperture-combined optical telescope

CSIC and the Astrohita Foundation have developed a telescope, which comprises several optical assemblies that focus the light from a target on individual optical fibers, which are combined together in a final single optical

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Scalable aperture-combined optical telescope
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In vitro method for designing a customized therapy for a subject with Parkinson´s

Disease CSIC, Université de Lille, INSERM and Centre Hospitalier Regional Universitaire de Lille have developed an in vitro method for designing a customized therapy for a Parkinson ‘s Disease patient through the determina

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In vitro method for designing a customized therapy for a subject with Parkinson´s
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Isolation of the unsaponifiable fraction from oils and minor compounds

mmeeaassuurreemmeenntt The Spanish Research Council (CSIC) has developed a method to isolate the unsaponifiable fraction of fats and oils using a supported liquid extraction (SLE) column, its later purifica

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Isolation of the unsaponifiable fraction from oils and minor compounds
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A novel high-performance graphene fabrication method

Researchers from the Spanish National Research Council (CSIC) and the Catalan Institute of Nanoscience and Nanotechnology (ICN2-BIST) have recently developed a novel electrochemical reactor and procedure to fabricate gra

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A novel high-performance graphene fabrication method
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Microfluidics device for SERS

The CSIC has developed a microfluidic device for the performance of surface-enhanced Raman spectroscopy (SERS) using a solid SERS substrate. By coupling this device to a Raman microscope, it is possible to detect very low con

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Microfluidics device for SERS
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Photo-thermoelectric cell for the conversion of thermal energy into electricity

Photo-thermoelectric cell for the conversion of thermal energy into electricity The Instituto de Ciencias de Materiales de Madrid (ICMM-CSIC) has developed a photo-thermoelectric cell with spectral selectivity to visible and

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Photo-thermoelectric cell for the conversion of thermal energy into electricity
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Antibodies to measure residual levels of mycotoxin ochratoxin A in food

CSIC and the University of Valencia have developed antibodies capable of determining ochratoxin A in food and ensure compliance with legislation on food products regarding the presence of this mycotoxin. Antibodies have been

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Antibodies to measure residual levels of mycotoxin ochratoxin A in food
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Environmental indices through LandSAT images

The Spanish National Research Council (Consejo Superior de Investigaciones Científicas, CSIC) has developed the software GINASAT version 1.0 (Semi-Automatic Generation of Environmental Indices by Landsat), to automate the e

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Environmental indices through LandSAT images
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Immunoassay for rapid diagnosis of infectious diseases caused by Pseudomonas

aeruginosa CSIC, CIBER-BBN and UAB have developed an immunochemical method for diagnosis of infections produced by Pseudomonas aeruginosa. The immunoassay is fast and efficient, with low LOD and adaptable to point-of care de

Patents for licensing

Immunoassay for rapid diagnosis of infectious diseases caused by Pseudomonas
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Gold catalysts supported on mixed oxides highly efficient and stable in the Water Gas Shift reaction

CSIC, in collaboration with the University of Seville, has developed the synthesis of gold catalysts highly efficient in the Water Gas Shift Reaction (WGS). The catalysts, based on gold supported on CuO/ZnO/Al2O3 mixed oxides

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Gold catalysts supported on mixed oxides highly efficient and stable in the Water Gas Shift reaction
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Benzothiazole Derivatives as CK-1 Inhibitors for the Treatment of Amyotrophic

Lateral Sclerosis CSIC has synthesized a family of benzothiazoles which acts as casein kinase 1 (CK-1) inhibitors. Therefore, these compounds are useful for the treatment of diseases related to circadian rhythm and neurodege

Patents for licensing

Benzothiazole Derivatives as CK-1 Inhibitors for the Treatment of Amyotrophic
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Thermochromic mortar coating for a more sustainable construction

CSIC has developed a thermochromic mortar coating with optical properties in the solar radiation range that vary according to temperature in a reversible way. The mortar is especially interesting for energy efficiency in bui

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Thermochromic mortar coating for a more sustainable construction
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Graphene-based electroactive fluids for Energy Storage

Researchers from the Spanish National Research Council at the Institut Català de Nanociència i Nanotecnologia- CIN2 (CSIC) and the Catalan Institute of Nanoscience and Nanotechnology (ICN2) have recently developed a novel

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Graphene-based electroactive fluids for Energy Storage
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Biocatalysts for the food, pharmaceutical and cosmetic industry made from used batteries

The CSIC has developed a system that use the black mass of the used batteries to synthesize biocatalysts with a great capacity to synthesize products widely used in the food, pharmaceutical and cosmetic industry, such as arom

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Biocatalysts for the food, pharmaceutical and cosmetic industry made from used batteries
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Device to determine the food shelf-life

The Spanish National Research Council (CSIC) has designed a device to test the food oxidation, which applies real conditions of storage and transport combining light, temperature and dimensions of the device. This device all

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Device to determine the food shelf-life
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Stress and metabolic monitoring system to improve fish production

CSIC through the Instituto de Acuicultura “Torre de la Sa l” and the Instituto de Microelectrónica de Barcelona - Centro Nacional de Microelectrónica, and the Universidad de las Palmas de Gran Canaria have developed a

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Stress and metabolic monitoring system to improve fish production
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New antioxidant compounds: Polyphenols amide derivatives

CSIC has synthetized and studied unknown polyphenolic compounds possessing high antioxidant activity, comparable and in some cases even higher than those of known natural polyphenols, as resveratrol and hydroxytyrosol. We ar

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New antioxidant compounds: Polyphenols amide derivatives
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Low cost and reusable, non-invasive wireless chemical sensor for biological fluids

Low cost and reusable, non-invasive wireless chemical sensor for biological fluids Researchers from the Spanish National Research Council (CSIC) have developed a novel wearable sensor technology, which is suitable to detect a

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Low cost and reusable, non-invasive wireless chemical sensor for biological fluids
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Chimeric protein with high antimicrobial activity

Researchers from CSIC have developed a chimeric protein (ClyRODI-H5) with an improved lytic activity against Staphylococcus sp. and higher stability than the parental endolysins of the state of the art. Thus, the invention re

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Chimeric protein with high antimicrobial activity
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Microorganism and method to produce urolithins

Professor Francisco Tomas group at CEBAS-CSIC has isolated and characterized the first urolithins- producing microorganism from ellagic acid and ellagitannins present in the diet. A urolithin producing method based on the use

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Microorganism and method to produce urolithins
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Obtaining of food-grade natural prebiotic oligosaccharides by enzymatic synthesis from disaccharides

CSIC has developed an enzymatic synthesis procedure of lactosil-fructosilated derivatives obtained from natural disaccharides. Lactosil-fructosilated derivatives are prebiotics potentially usable in healthy food compositions

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Obtaining of food-grade natural prebiotic oligosaccharides by enzymatic synthesis from disaccharides
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Test for oral tolerance to triglycerides in humans

The Instituto de la Grasa of CSIC and University of Seville have developed a fast and simple procedure to evaluate the tolerance to dietary fats (triglycerides) in humans. A novel emulsified composition, easy to take and di

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Test for oral tolerance to triglycerides in humans
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Oleuropein obtaining procedure: high purity antioxidant

CSIC has developed a reliable and effective method for obtaining oleuropein from olive leaf: comprising a pretreatment that increases the concentration of oleuropein in the extracts over other known methods and achieving this

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Oleuropein obtaining procedure: high purity antioxidant
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Production of porous solids with embedded gases to be used as solid-gas nanocomposite materials

CSIC has developed a method for the production of nanoporous solids that contain gas inside their pores. The method is based on magnetron sputtering, but gas consumption is lower in comparison with conventional sputtering met

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Production of porous solids with embedded gases to be used as solid-gas nanocomposite materials
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Myt-healer: a new potent wound healing peptide

CSIC and the University Miguel Hernández have developed a minimal peptide core from the M yti lus galloprovidencialis Myticin C peptide with unique in vitro and in vivo wound healing and regenerating activities. Industria

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Myt-healer: a new potent wound healing peptide
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Modulating compounds of KChIP2 and its use for the treatment of cardiovascular

ppaatthhoollooggiieess CSIC and UAM have developed compounds that positively modulate protein-protein interactions that involve KChIP2 protein. Industrial partners from the pharmaceutical industry are being s

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Modulating compounds of KChIP2 and its use for the treatment of cardiovascular
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OPTOBIOTICS: Novel antibacterial proteins activated by blue light

CSIC has developed a chimeric protein that, when expressed in bacteria, changes its structure upon absorption of blue light, thus generating protein aggregates (amyloids) that inhibit bacterial growth Industrial partners fro

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OPTOBIOTICS: Novel antibacterial proteins activated by blue light
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Continuous indoor rearing of Philaenus spumarius, the main European vector of Xylella fastidiosa

CSIC has developed a methodology to rear the meadow spittlebug Philaenus spumarius (L.) (Hemiptera, Aphrophoridae) in control climatic conditions in the laboratory allowing the supply of nymphs and adults before they become a

Patents for licensing

Continuous indoor rearing of Philaenus spumarius, the main European vector of Xylella fastidiosa
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