CSIC at the Instituto de Microelectrónica de Barcelona – Cento Nacional de Microelectrónica has developed a compact analytical device for rapid and multiplexed detection of multipurposed biomarkers present in biological fluids. The design of the analytical device simplifies scalability of an array of electrochemical cells, making it suitable for point-of-care analytical approaches.
Industrial partners from the biomedical industry are being sought to collaborate through a patent licence agreement.
Small multiplexed system that produces less material waste per analysis One of the most important limitations when designing compact electrochemical cells in a planar configuration is the space on the substrate occupied by electrical tracks and related contact pads.
The number of required connections greatly limits the size of the cell array and increases manufacturing complexity and overall cost of the resulting device. The developed approach overcomes the shortcomings of previous electrochemical cell array architectures by providing two-electrode electrochemical cell arrays sharing a common electrode connection. Its novel design allows easy coupling with a paper fluidic component for carrying out multi-parametric and/or multisample analysis.
The overall configuration combines in a single device a reusable array of electrochemical cells, a disposable microfluidic component and the use of magnetic nanoparticles for simple but sensitive and rapid biomarker analysis.
Fig 1. Scheme of device configuration and performance.
Main innovations and advantages
The main advantages of the prototype developed are the following:
The Spanish National Research Council (in Spanish 'Consejo Superior de Investigaciones Científicas (CSIC)') is a government agency for basic and applied scientific research.
It is the largest public research organization in Spain, with presence in all the Autonomous Communities through 126 centers and 145 associated units.
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