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 | Seeking Fluid dynamic numerical simulation of a ballpoint pen writing system |
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BIC is looking for advanced computer simulations that can accurately model how ink flows in a ballpoint pen during writing. The writing performance of a ballpoint pen depends on the interaction between the ink, the ball and ball socket, and the paper. Fluid dynamic numerical simulations could help determine quantitatively on the one hand the magnitude of certain key parameters such as the ink viscosity, surface roughness, shear rate, stress & strain distribution etc and on the other their influence on ink flow and consumption. The group has extensive empirical knowledge of the parameters affecting writing but has never used numerical simulations to further enhance it. A quantitative analysis of the influence of a system parameter on writing would help us pinpoint those that have to be adjusted to meet the expected product performance. |
 | Seeking Analytical Platform to Characterize Biofilm |
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The study of microbial biofilm formation is of paramount importance in a wide range of industries, including those associated with health products, food, water, paper mills, medical health, and pharmaceuticals. Research on the impact of various parameters on biofilm formation has been conducted within the framework of these industries, with varying results depending on the specific methods used in the industry. |
 | Seeking Recycling technologies for biodegradable films |
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We are looking for solutions to convert bio-based packaging back to starting materials or other high-value added chemicals (no fuels). |
 | Inhibitors of Viral Infectivity: Amphipathic Nucleoside Derivatives as Fusion Inhibitors |
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A series of small pharmacological molecules have been discovered to be potent and non-cytotoxic inhibitors of viral fusion. The inhibitors act on the non-virally encoded lipids in the virion envelope. These molecules are rigid amphipathic compounds of inverted cone shape which locate to the outer leaflets of virion envelopes, creating a physical barrier to viral envelope and cell membrane fusion. These amphipathic nucleoside derivatives can serve as potential antiviral or therapeutic agents against herpes, HIV, influenza, hepatitis B & C, poxvirus and other DNA or RNA enveloped viruses. They can potentially be used as prophylactic ingredients in creams, lotions, gels and as antiviral disinfectants. |
 | Nitroxoline for prevention and treatment of coronavirus disease |
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University of Ljubljana has repurposed Nitroxolin for the prevention and treatment of diseases caused by coronaviruses, in particular SARS-CoV-2. A significant advantage of nitroxoline over other candidate drugs for the treatment of covid-19 (repurposing drugs – amantadine, teicoplanin) is that the mechanism of action on the target has been extensively investigated. Our process can additionally generate a variety of compounds with improved antiviral activity. |
 | GEL-AID: Gelified isotonic water for hydration in dysphagia |
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GEL-AID is a new formulation for hydration adapted to different needs of dysphagia. A new formulation based on different types of thickeners that allows the commercialization of an isotonic gelled water ready for its consumption; that shows a uniform consistency, with three different viscosities adapted to different needs of dysphagia; a greater stability of the gel over time (without refrigeration); at a lower price and with a proven hydration capacity. |
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