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Seeking Solutions for Enhanced Delivery of Oral Care Actives and Flavors

• Posted by The Procter & Gamble Company
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• Project Size : 250,000 - 1,000,000 €

To improve the performance and consumer experience of oral care products using formulation excipients to improve deposition, retention and protection of actives, flavors, and sensates for extended periods

Seeking Respiratory Solutions and Technologies

• Posted by The Procter & Gamble Company
• ·
• Project Size : 250,000 - 1,000,000 €

Our preference is to find opportunities that are on-market, market-ready, or require limited development. Opportunities may consist of new product forms, packaging innovations, delivery technologies, or new products.

Seeking kerbside recyclable alternative to our flexible plastic bags used in frozen food cooking for microwave usage

• Posted by Nomad Foods
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• Project Size : 0 - 50,000 €

As a global market leader in frozen foods, Nomad Foods is seeking to future-proof our packaging portfolio by identifying sustainable, kerbside-recyclable alternatives to our current flexible plastic bags. The solution must withstand continuous storage at -18°C and meet RecyClass RAM Grade A or B criteria, specifically optimized for the UK recycling infrastructure. We prioritize materials that can be integrated into existing manufacturing lines and are supported by case studies of successful market implementation. The ideal solution should be scalable across our global brand footprint.

LIH383: novel modulator of the opioid system regulator ACKR3

• Posted by Luxembourg Institute of Health
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• Patents for licensing

LIH383 is a novel highly potent and specific negative modulator of ACKR3, developed by Dr Andy Chevigné, Head of Immunopharmacology and Interactomics, and Dr Martyna Szpakowska. It is an octapeptide (short chain of eight amino acids) with high selectivity and subnanomolar affinity for ACKR3. It was engineered by introducing a series of mutations to adrenorphin. Compared with other natural opioid ligands, its sequence (FGGFMRRK) confers it maximum specificity and affinity for ACKR3 and minimum selectivity and affinity for other opioid receptors. LIH383 therefore binds to and blocks ACKR3, thereby modulating the availability of opioid peptides that can bind to classical opioid receptors in the brain and potentiating their natural painkilling and antidepressant properties. LIH383 is therefore a positive regulator of the opioid system. In a nutshell, LIH383 presents the following advantages: > Subnanomolar potency > High selectivity for ACKR3 > Short chain (8 amino acids) > Easy to synthesise/customise

Elimination of blade tip vortices of wind turbines

• Posted by Peter Mogyorosi from Laser Consult Ltd.
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• Innovative Products and Technologies

TECHNOLOGY/PRODUCT OVERVIEW Blade tip vortex is a powerful phenomenon that develops very quickly. However, ‘widening’ the blade tips increases the possibility of greater power and performance, at the same time, the vortex losses generated at the blade tips increase drastically. The solution currently used to reduce the vortices of the blade tips is reducing the angle of attack close to the blade tip. This is how it tries to avoid significant losses. At the same time, naturally, the drag force or the transmittable power decreases. In the case of horizontal axis wind turbines, the classic, pointed shape has to be used in order to ensure, among other things, the noise level. Eliminating or reducing blade tip losses (eliminating vortices around the blade tip) means significant energy savings and increased efficiency, especially when using wide blade tips. The elimination of blade tip loss reduces vibrations, thus reducing internal friction of the structure’s material, thereby increasing lifespan. This results in significant financial savings, e.g. in the case of a modern wind turbine’s blade. Due to centrifugal force, the “winglet” used on wings moving in a linear direction cannot be used in the case of a rotating system.

Innovative Methods for Cell Transplantation

• Posted by Georgetown University
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• Innovative Products and Technologies

This invention provides a novel method for transplanting target cells into a subject by creating a sealed transplantation space using an acellular membrane attached to a visceral organ. This technique allows for the insertion of a mixture of support cells and target cells, enhancing cell survival and integration. For example, this method can be applied to improve the engraftment of insulin-producing beta islet cells for diabetes treatment, potentially increasing the success rate of cell transplantation.