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 | Seeking injectable, highly flexible sealing system for personal care devices |
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We are looking for a material /process that allows to inject a flexible sealing / fluid barrier in particular areas of an already assembled device and that can fill gaps in the range of 1 mm – 3 mm between movable and fixed parts. |
| | Seeking Grooming Solutions |
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Grooming technology solutions that remove, trim, shape or style hair from the body and face, in safe, convenient ways that are achievable at home. |
| | Seeking Solutions for Repair and Protection of Enamel and Dentin |
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A product that delivers significant and long lasting repair to damaged tooth enamel and dentin |
 | Elimination of blade tip vortices of wind turbines |
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TECHNOLOGY/PRODUCT OVERVIEW Blade tip vortex is a powerful phenomenon that develops very quickly. However, ‘widening’ the blade tips increases the possibility of greater power and performance, at the same time, the vortex losses generated at the blade tips increase drastically. The solution currently used to reduce the vortices of the blade tips is reducing the angle of attack close to the blade tip. This is how it tries to avoid significant losses. At the same time, naturally, the drag force or the transmittable power decreases. In the case of horizontal axis wind turbines, the classic, pointed shape has to be used in order to ensure, among other things, the noise level. Eliminating or reducing blade tip losses (eliminating vortices around the blade tip) means significant energy savings and increased efficiency, especially when using wide blade tips. The elimination of blade tip loss reduces vibrations, thus reducing internal friction of the structure’s material, thereby increasing lifespan. This results in significant financial savings, e.g. in the case of a modern wind turbine’s blade. Due to centrifugal force, the “winglet” used on wings moving in a linear direction cannot be used in the case of a rotating system. |
 | New tannin-rich extract from vegetal sources for tanning hides and skins |
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The A3 Chair in Leather Innovation developed an innovative aqueous extraction procedure to obtain a tannin-rich extract from seed grapes. The new extract contains a mixture of tannins and non-tannins which confers an improved antioxidant and light fastness properties. The extract also contains a colouring agent similar to that obtained with the Chestnut Tree extract. The main characteristic is the capacity to precipitate proteins and make them resistant to decomposition, for which reason the extract is useful as tanning agent for hides and skins. |
 | NanoMEDIC gene editing delivery system |
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Background Gene therapy holds great potential for the treatment of genetic diseases. However, delivery to specific tissues is still a major bottleneck. Although AAV-delivered CRISPR-Cas9 editing is being developed for multiple diseases, its therapeutic translation is hindered by the limited packaging capacity of viral particles and possible immune response to them. Moreover, AAV transgenes tend to be expressed for an extended period of time, which increases off-target mutagenesis risk. Extracellular vesicles (EV) is another option and, when combined with ribonucleoprotein (RNP) delivery of CRISPR-Cas9, reduces off-target effects. The structural polyprotein Gag is typically used to package cargo into EVs, which nevertheless limits the EV packaging capacity. The present invention is an all-in-one EV delivery system termed NanoMEDIC (nanomembrane-derived extracellular vesicles for the delivery of macromolecular cargo). It is a transient EV-based CRISPR-Cas9 editing delivery system which ensures efficient genome editing in various cell types. |
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