Consejo Superior de Investigaciones Científicas

Transphagocytic T cells as anti cancer immunotherapy

Posted by Consejo Superior de Investigaciones CientíficasResponsive · Patents for licensing · Spain

Summary of the technology

Transphagocytic T cells as anti cancer immunotherapy
CSIC´s research group, in collaboration with scientists from the Centre of Molecular Biology “Severo
Ochoa” (CBMSO-CSIC), the Autónoma University of Madrid and the Health Research Institute of the
“La Princesa” University Hospital, developed a new method for anti-cancer immunotherapy based on
transphagocytic lymphocytes (tiCD4+ T cells)
Companies interested in a patent license or investors for creation of a start-up are being sought.
An offer for Patent Licensing

Consejo Superior de Investigaciones Científicas
Consejo Superior de Investigaciones Científicas

CD4


+ T cells are novel and potent tools in cancer immunotherapy Immunological synapse between a tiCD4+ T cell as antigen presenting cell and a CD8+ T cell, that is being activated. It is shown the actin ring typical of productive immunological synapses The results shows, for the first time, that CD4+ T cells, the paradigm of adaptive immune cells, and contrary to the current view, are bona fide antigen presenting cells.
It has recently shown that CD4+ T cells capture (and kill) bacteria from infected dendritic cells (DCs) in a process termed transinfection. Now, they have shown that CD4+ T cells process and cross-present bacterial antigens to naïve CD8+ T cells, which massively proliferate and become cytotoxic, triggering an immune response to cancer and infectious diseases.
The therapeutic potential of this potent activation of CD8+ T cells was tested using an aggressive melanoma tumor model (B-16OVA). They have showed that mice vaccinated with tiCD4+ T cells capturing bacteria (Listeria monocytogenes) expressing tumor antigens (OVA) are protected against tumor formation, which highlights the potential of tiCD4+ T cells as a potential tool for cancer immunotherapy.

Main innovations and advantages


· The invention can be used to prevent/treat tumours and/ or stimulation of an immune response against tumour antigens.
 tiCD4 · T cells (trained by bacteria) are newly defined antigen- presenting cells that can be useful as a cancer immunotherapy tool.
 tiCD4 · T cells mediated antigen presentation potently cross-prime naïve · CD8+ T cells.
 tiCD4 · T cells mediated antigen presentation generates central memory · C8+ T cells with very low levels of PD-1.
 The anti-tumour activity of tiCD4 · T cells has been tested in mouse melanoma models · The invention can be applied for melanoma and other highly immunogenic tumours.

Intellectual property status

Granted Patent
-
Patent filed in USA, Canada, Australia and EU

Granted Patent
-
Patent filed in USA, Canada, Australia and EU

Technology Owner

Consejo Superior de Investigaciones Científicas

Public Agency

Related keywords

  • Biological Sciences
  • Medicine, Human Health
  • Clinical Research, Trials
  • Cytology, Cancerology, Oncology
  • Gene - DNA Therapy
  • Medical Research
  • Medical Technology / Biomedical Engineering
  • Stem cell Technologies
  • Cellular and Molecular Biology Technology
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Medical Health related
  • Other Medical/Health Related
  • immunotherapy

About Consejo Superior de Investigaciones Científicas

Public Agency from Spain

The Spanish National Research Council (in Spanish 'Consejo Superior de Investigaciones Científicas (CSIC)') is a government agency for basic and applied scientific research.

It is the largest public research organization in Spain, with presence in all the Autonomous Communities through 126 centers and 145 associated units.

Send your request

By clicking "Send your request" you are signing up and accepting our Terms of Service and Privacy policy

Technology Offers on Innoget are directly posted and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.