Consejo Superior de Investigaciones Científicas

Biotechnological production of 11α hydroxylated steroids using recombinant bacteria.

Posted by Consejo Superior de Investigaciones CientíficasResponsive · Patents for licensing · Spain

Summary of the technology

CSIC has developed a procedure for the biotechnological production of 11α hydroxylated
steroids by generating and subsequent use of recombinant bacteria. These recombinant
bacteria allow to perform microbial biotransformation processes that result in 11αhydroxylated steroid compounds from raw materials such as phytosterols and intermediate
products efficiently and economically. These compounds have numerous applications in
pharmacology.
Companies are sought for implementing and commercializing the new technology under
patent license agreement.
An offer for Patent Licensing

Consejo Superior de Investigaciones Científicas

Biotransformation of Steroids


Bioreactor for steroids production Steroids are widely distributed in nature. Besides, for many years steroidal pharmaceuticals have been used to maintain quality of life when used as anti-tumor, antiinflammatory, antimicrobial, antiviral, anti-estrogenic and anti-allergic. Therefore, they have preventive and therapeutic activity in various pathologies Many of these compounds are chemically synthesized, however, in recent years, it is known that microbial transformation of steroids is highly effective in generating new steroidal drugs. It is important to remark that the hydroxylation of these compounds increases their biological activity when compared with non hydroxylated The Researchers have developed recombinant bacteria that can be used for direct production of steroid 11α-hydroxylated from natural steroids or synthons (intermediates in the industrial synthesis of steroid drugs) in a single fermentation process. Furthermore, these bacteria, unlike other microorganisms, do not produce side products in the process.

Main innovations and advantages


· Recombinat bacteria were generated from unusual strains in the biotechnological production of steroids · Obtaining steroids takes place in a single fermentation process without side products.
· The process can be applied to natural and non-hydroxylated steroids synthons.

Intellectual property status

Granted Patent
-
Priority patent application filed

Granted Patent
-
Priority patent application filed

Technology Owner

Consejo Superior de Investigaciones Científicas

Public Agency

Related keywords

  • Applications for Health
  • Pharmaceutics
  • Biological Sciences
  • Medicine, Human Health
  • Medical Research
  • Pharmaceutical Products / Drugs
  • Virus, Virology / Antibiotics / Bacteriology
  • Biology / Biotechnology
  • Industrial Biotechnology
  • Biobased Materials related to Industrial Biotechnology
  • Medical/health
  • Medical Health related
  • Therapeutic
  • Therapeutic services
  • Other therapeutic (including defibrillators)
  • Pharmaceuticals/fine chemicals
  • pharmacology
  • recombinant bacteria
  • steroids

About Consejo Superior de Investigaciones Científicas

Public Agency from Spain

The Spanish National Research Council (in Spanish 'Consejo Superior de Investigaciones Científicas (CSIC)') is a government agency for basic and applied scientific research.

It is the largest public research organization in Spain, with presence in all the Autonomous Communities through 126 centers and 145 associated units.

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