Consejo Superior de Investigaciones Científicas

Obtaining of food-grade natural prebiotic oligosaccharides by enzymatic synthesis from disaccharides

Posted by Consejo Superior de Investigaciones CientíficasResponsive · Patents for licensing · Spain

Summary of the technology

CSIC has developed an enzymatic synthesis procedure of lactosil-fructosilated derivatives obtained
from natural disaccharides. Lactosil-fructosilated derivatives are prebiotics potentially usable in healthy
food compositions to prevent diseases of the gastrointestinal system.

Looking for food or pharmaceutical companies to develop and produce the compound under patent

An offer for Patent Licensing

Consejo Superior de Investigaciones Científicas
Consejo Superior de Investigaciones Científicas
Consejo Superior de Investigaciones Científicas

New method of obtaining from natural disaccharides or

disaccharide-rich food by-products Lactosacarose (A) and main lactofructosilated derivatives The present invention obtains lactosil-fructosilated with a degree of polymerization between 4-10 by a combined and sequential process of transfructosylation using two enzymes.
The bi-enzimatic reaction substrates are lactose and sucrose or by-products food rich in disaccharides, e.g.. Cheese Whey permeate or those resulting from the exploitation of the sugar cane.
The synthesis process is simple and cost-effective to use substrates, reagents and equipment for low cost, and is therefore also easily scalable.
The obtained lactosil-fructosilated derivatives are potentially prebiotics powerful prebiotics due to their structural characteristics and of link, and its high structural affinity with fructooligosaccharides (FOS).
The lactosil-fructosilated derivatives can be a food composition with potential positive effects on the health of the gastrointestinal system (prevention of constipation, development of hyperlipidemia, or inflammatory bowel disease).

Main innovations and advantages

· The synthesis of lactosil-fructosilated derivatives from disaccharidesprocedure offers higher performance, higher purity and lower costthan current procedures for the synthesis of lactosil-fructosilatedderivatives.
· The procedure of synthesis originates a variety of lactosil-fructosilatedderivatives, including some not previously described.
· The final product is free of undesirable substances, the use of food-grade reagents.
· The process is environmentally clean without generation of toxic by-products.
· The product is also a sweetener, and low in calories.

Intellectual property status

Granted Patent
Spanish patent granted

Technology Owner

Consejo Superior de Investigaciones Científicas

Public Agency

Related keywords

  • Biological Sciences
  • Agrofood Industry
  • Technologies for the food industry
  • Food Additives/Ingredients/Functional Food
  • Medical Health related
  • Agro and Marine biotech

About Consejo Superior de Investigaciones Científicas

Public Agency from Spain

The Spanish National Research Council (in Spanish 'Consejo Superior de Investigaciones Científicas (CSIC)') is a government agency for basic and applied scientific research.

It is the largest public research organization in Spain, with presence in all the Autonomous Communities through 126 centers and 145 associated units.

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