CSIC and the University of Athens have found that secoiridoids, such as oleacein and oleocanthal, are
useful to prevent or treat neuropathies that conduct to optic nerve injury, such as optic neuritis.
A company dealing with pharmaceutical or nutraceutical compositions for ophtalmic applications is
sought for licensing agreement.
An offer for Patent Licensing
New pharmacological application
Oleocanthal Secoiridoids are monoterpenoids, derived from iridoids in plants, based on the 7,8-seco-cyclopenta[c]-pyranoid skeleton. Most of secoiridoids and iridoids have been isolated from plants and approximately 600 different structures are known. Almost all the secoiridoids are glycosides. This group of phytochemicals occur wide-spread in nature, and exhibit a wide range of biological and pharmacological activities, including antibacterial, anticancer, anticoagulant, antifungal, antioxidative, antiprotozoal and hepatoprotective activities.
The researchers have found that oleacein and oleocanthal, have protective effects on the integrity and function of the blood-brain barrier (BBB) as well as on the oxidative and immune-inflammatory events related to optic neuritis. Results were performed on a mouse model with intraperitoneal administration of the compounds obtained from an olive oil extract.
Main innovations and advantages
· This natural solution avoids serious side effects, in contrast with thecommon treatment with corticosteroids · The compounds provide in addition anti-inflammatory properties,immune regulation, and neuroprotective effects · Cheap and easy available from natural sources
The Spanish National Research Council (in Spanish 'Consejo Superior de Investigaciones Científicas (CSIC)') is a government agency for basic and applied scientific research.
It is the largest public research organization in Spain, with presence in all the Autonomous Communities through 126 centers and 145 associated units.
Create your free account to connect with CSIC - Consejo Superior de Investigaciones Científicas and thousands of other innovative organizations and professionals worldwide
Send a request for information
to CSIC - Consejo Superior de Investigaciones Científicas
Technology Offers on Innoget are directly posted
and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.
Need help requesting additional information or have questions regarding this Technology Offer?
Contact Innoget support
