Consejo Superior de Investigaciones Científicas

Compounds for the treatment of optic neuritis

Posted by Consejo Superior de Investigaciones CientíficasResponsive · Patents for licensing · Spain

Summary of the technology

CSIC and the University of Athens have found that secoiridoids, such as oleacein and oleocanthal, are
useful to prevent or treat neuropathies that conduct to optic nerve injury, such as optic neuritis.

A company dealing with pharmaceutical or nutraceutical compositions for ophtalmic applications is
sought for licensing agreement.
An offer for Patent Licensing

Consejo Superior de Investigaciones Científicas

New pharmacological application

Oleocanthal Secoiridoids are monoterpenoids, derived from iridoids in plants, based on the 7,8-seco-cyclopenta[c]-pyranoid skeleton. Most of secoiridoids and iridoids have been isolated from plants and approximately 600 different structures are known. Almost all the secoiridoids are glycosides. This group of phytochemicals occur wide-spread in nature, and exhibit a wide range of biological and pharmacological activities, including antibacterial, anticancer, anticoagulant, antifungal, antioxidative, antiprotozoal and hepatoprotective activities.
The researchers have found that oleacein and oleocanthal, have protective effects on the integrity and function of the blood-brain barrier (BBB) as well as on the oxidative and immune-inflammatory events related to optic neuritis. Results were performed on a mouse model with intraperitoneal administration of the compounds obtained from an olive oil extract.

Main innovations and advantages

· This natural solution avoids serious side effects, in contrast with thecommon treatment with corticosteroids · The compounds provide in addition anti-inflammatory properties,immune regulation, and neuroprotective effects · Cheap and easy available from natural sources

Intellectual property status

Granted Patent
Spanish Patent application filed

Granted Patent
Spanish Patent application filed

Technology Owner

Consejo Superior de Investigaciones Científicas

Public Agency

Related keywords

  • Optics
  • Biological Sciences
  • Medicine, Human Health
  • Medical Research
  • Medical Technology / Biomedical Engineering
  • Pharmaceutical Products / Drugs
  • Virus, Virology / Antibiotics / Bacteriology
  • Medical Biomaterials
  • Biology / Biotechnology
  • Enzyme Technology
  • Protein Engineering
  • Medical Health related
  • Therapeutic
  • Other Medical/Health Related
  • Pharmaceuticals/fine chemicals
  • Clinical Medicine
  • Ophthalmology, Ear, nose and throat diseases
  • compounds
  • optic neuritis

About Consejo Superior de Investigaciones Científicas

Public Agency from Spain

The Spanish National Research Council (in Spanish 'Consejo Superior de Investigaciones Científicas (CSIC)') is a government agency for basic and applied scientific research.

It is the largest public research organization in Spain, with presence in all the Autonomous Communities through 126 centers and 145 associated units.

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