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UACOOPERA University of AveirouacooperaUACOOPERA University of Aveiro posted this:
Production method of a new recombinant collagenase for collagens digestionMethod for obtaining collagenase with high collagenolytic activity, through a process based on recombinant DNA technology. This new process enables collagenase purification e isolation through a simple and economical procedure, obtaining an active enzyme with remarkable storage stability.
Technology Transfer Office at uacoopera
uacoopera posted this:
Production of a novel collagenase and applicationsThe described process for collagenase production and purification is rapid, cheap and reproducible. The obtained product is highly active and stable for long period storage (in solution or lyophilised). The features of this novel product are, certainly related to a novel domain organization and architecture not yet described for other collagenasesjaume mir posted this:
Production of chymosins from camel and bovine origin using recombinant yeast strainsThe use of chymosins for the production of cheese and cheese derivatives from milk has been known for years, and nowadays this technique has completely substituted the use of calf rennet. Biochemize SL has developed several recombinant yeast and bacteria strains able to express chymosins from bovine (chymosin A and chymosin B) and from camel origin, with very good expression levels (between 0,1 and 3 g/L) and activity.
CEO at Biochemize SL
jaume mir posted this:
Production of D-panose through an innovative microbial fermentation processD-panose (α-D-Glucopyranosyl-(1->6)-α-D-glucopyranosyl-(1->4)-D-glucose) is a high value tri-saccharide molecule that has been proposed as a low caloric content sugar (i), as a promoter for probiotics (ii) and having outstanding anti-oxidant. anti-tumoral properties (iii). Currently this rare sugar is obtained by chemical synthesis, and this is the reason for its extremely high cost/ price (1) and poor industrial uses (2). At Biochemize SL we have developed a (very simple) production process that leads the production of high pure (more than 99%) D-panose, through a microbial fermentation process using a recombinant bacteria strain engineered by us, at a significantly lower operational/production cost. We offer this process to be operated by/ be licensed to a manufacturing company operating in this area.
CEO at Biochemize SL
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
Production of high-affinity antibodies through the in vitro recreation of a germinal centerCSIC have developed a method for the in vitro generation of antigen-specific antibodies or cells producing thereof by means of the development of an in vitro germinal center useful to produce vaccines, immunomodulators or immunotherapies. Industrial partners from the biotechnology and/or pharmaceutical industry are being sought to collaborate through a patent licence agreement. An offer for Patent Licensing
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Production of isophorone derivatives by fungal peroxygenasesCSIC has developed a biocatalytic transformation of isophorone (3,5,5-trimethylcyclohex-2-en-1-one) and 4-hydroxyisophorone (4HIP) to selectively produce 4-hydroxyisophorone and 4-ketoisophorone (4KIP), valuable products for pharmaceutical, flavor and fragrance industry. The biocatalysts employed are unspecific peroxygenases from the fungi or recombinant proteins expressed in Aspergillus oryzae. Industrial partners from pharmaceutical, flavour or fragance industry are being sought to collaborate through a patent licence agreement. An offer for Patent Licensing IMDEA Energy posted this:
Production of Lactic Acid from 5C lignocellulosic sugarsA Lactobacillus pentosus strain called MAX2 highly efficient in the production of LA from xylose (C5) has been obtained, also significantly increasing the productivity with respect to the parental strain. The strain is capable of efficiently fermenting lignocellulosic sugars even at low pH (acidic environment found in LA production processes) without the need for neutralizing agents.
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Production of porous solids with embedded gases to be used as solid-gas nanocomposite materialsCSIC has developed a method for the production of nanoporous solids that contain gas inside their pores. The method is based on magnetron sputtering, but gas consumption is lower in comparison with conventional sputtering methods carried out in dynamic regime. Experimentally, layers of controlled thickness of these nanocomposite materials have been successfully obtained. Gas consumption during the production of these solids was only 0.5% of gas consumption in conventional magnetron sputtering in dynamic regime. Industrial partners from electronic or defence sectors or laboratory materials and chemicals products providers are being sought to collaborate through a patent license agreement. An offer for Patent Licensing
Fabian BelinLuxembourg Institute of Science and Technology (LIST)Fabian BelinPartnerships Development & IP Valorization at Luxembourg Institute of Science and Technology (LIST)
Fabian Belin posted this:
Production of triterpene-hydroxycinnamate form apple cell suspension cultureThe LIST technology is based on the culture of dedifferentiated plant cell in suspension. LIST has developed a process to use and culture dedifferentiated plant cells to produce conjugated pentacyclic triterpenes (LIST IP, WO2020161221A1). Cells are grown in a liquid medium, in a bioreactor optimized for optimal growth rate and triterpene production . LIST is developing through the Greentech Innovation Centre (GTIC), a platform aiming to reach “in house” a TRL7-8 (300L bioreactor), including the associated downstream process to recover and purify the triterpenes obtained. This corresponds to a pilot scale for mid-size cosmetic industry use of bioactive ingredient.
Partnerships Development & IP Valorization at Luxembourg Institute of Science and Technology (LIST)
María Mengual MesaIBIMA-Plataforma BionandMaría Mengual Mesa posted this:
Prognostic biomarker in COVID-19 patients.Non-invasive method to predict the clinical deterioration of patients with COVID-19, based on the study of the mRNA expression of a gene. The sample is taken from nasopharyngeal exudate, which offers two advantages: it is non-invasive, and it improves sensitivity (the primary impact of the virus occurs in the upper respiratory tract). The method allows results to be obtained quickly and affordably by RT-PCR, a technique widely used in the health sector.
Innovation Manager at IBIMA-Plataforma Bionand
Camille MILLIATKyoto UniversityCamille MILLIAT posted this:
Programmable Molecular Swarm Transporter for Light-Activated Cargo DeliveryOur technology is a swarm of kinesin-propelled microtransporters. DNA-conjugated microtubules collaborate to load a cargo under visible light , move and then unload the cargo at a desired area predefined with a UV photomask. Inspired from universal swarming behaviors observed in nature, this collaborative micro-robot has programmable interactions and controllable transportation functionalities in vivo, demonstrating remarkable parallelism, robustness and flexibility.
Commercialization Specialist at Kyoto University
Graft Polymer UK LtdGraft Polymer UK LtdGraft Polymer UK Ltd posted this:
Project: Innovative pilot production modified compounds by PE125 standard for multifunctional applications.Producing PE125 using GRAFTALEN™ MP-UHHD. Consumer properties, which should be taken into consideration: 1) The unique toughness of the material (the highest rate of all known polymers), namely, Over 160 kJ/m2 2) High abrasion resistance 3) Low friction coefficient (self-lubricating) 4) High resistance to chemically aggressive reagents (media) 5) High creep resistance (geometric stability) Ordinary way - This type of process is quite expensive. Production of PE125, in compounding with bimodal PE100, from 8 to 45% of supermolecular polyethylene is injected, reaching dispersion by multiple compounding (4 stages) in an extruder cascade (XXXXX technology). GRAFTALEN™ MP-UHHD (alloy) is a MELT-PROCESSABLE concentrate of UHMWPE on an HDPE matrix. As HDPE, you can choose the most affordable HDPE (pipe) grade. To obtain polyethylene according to the standards PE125 (with a minimum strength indicator MRS> 13.8-14 MPa, in comparison PE100 has MRS only 10 MPa), a significant improvement in the resistance against hydrostatic pressure is required. For a conventional bimodal HDPE, this indicator is difficult to achieve, since it directly correlates with the impact strength/density indicators and with simple extrapolation, it turns out that the required indicator for PE125 simply does not reach the bimodal HDPE matrix. Another problem - the difficulty in maintaining the geometric stability of the pipe (the thickness at the top of the pipe is often less than at the bottom) due to the sagging effect (the phenomenon of the gravitational flow of a polymer melt). This phenomenon is more pronounced for thick-walled pipes. The specific blend of HDPE with UHMWPE allows solving these problems above.
Maximilian Betz posted this:
Proof of Concept of GasVisor - The first platform-based service for the consumption-automated ordering of gasWe want to actively shape the change in how the restaurant, hotel and hospitality industry orders consumption-automated liquid goods and commodities to offer the customer a more sustainable and cost-efficient supply chain. We focus on making our products simple and easy to use on site (Plug & Play), maximising the digitisation and automation of our services, and engaging local suppliers to make our planet a better place. Currently we are in the Proof of Concept phase and are therefore looking for customer-, innovators- and investors feedback. Visit us and leave us a feedback. www.gasvisor.eu
CEO at GasVisor
Yeda posted this:
Prosody Based Speech AnalysisA major part of human communication is conveyed through intonation, or prosody – the music of speech. It is the least conscious, most instinctive activity of speech conveying all non-verbal linguistic information including sentiment, emphasis, conversation action and a large variety of signals: whether we are happy, irritated or even truthful can be detected through the way in which we utter the words. Remarkably, this aspect of communication has not yet been analyzed in a comprehensive, quantitative manner. A group of researchers from the Weizmann Institute of Science has created a model for analyzing prosodic patterns that enables access to non-verbal communication in speech, based on computational analysis of intonation-unit modulation. The model relies on a segmentation method that adds a compact layer of basic algorithmic analysis within a speech recognition engine, adding very little computational load. This provides the basis for universally describing prosody and grants access to non-verbal information in speech.
Benemérita Universidad Autónoma de PueblaBenemérita Universidad Autónoma de PueblaBenemérita Universidad Autónoma de Puebla posted this:
PROSTHESIS VESTIBULAR WITH TECHNOLOGY (MEMS)A vestibular prosthesis includes micro-electric-mechanical (MEMS) sensors, gyroscopes in each sensitivity axis (X, Y, Z), accelerometers in each sensitivity axis (X, Y, Z) to detect an angular and linear movement providing displacement measurements, gyroscopes in each one of the spatial axes (X, Y, Z), a microprocessor connected to the MEMS sensors and producing an electric pulse pattern or a continuous galvanic current pattern, a conditioning unit that amplifies and conditions the microprocessor output to apply current to the stimulation electrodes, the microcontroller being configured to determine the displacement of the cupula and the otolithic mass, determine a membrane potential as a result of a displacement detected by the MEMS sensors by means of determining a transduction current, and determine an action potential discharge pattern for the primary afferent neuron,; which synapses with the hair cell by means of a mathematical model of the informative process of the vestibular mechanoreceptor.
Georgetown UniversityGeorgetown UniversityGeorgetown University posted this:
PROTAC molecules targeting PAX3:FOXO1 fusion protein for rhabdomyosarcoma treatmentThis invention introduces novel PROTAC (proteolysis targeting chimera) molecules designed to induce degradation of the PAX3::FOXO1 fusion oncoprotein in rhabdomyosarcoma cells. The compounds consist of a PAX3::FOXO1 binding moiety, an E3 ubiquitin ligase binding moiety, and a bivalent linker. This targeted approach offers a potential breakthrough in treating fusion-positive rhabdomyosarcoma, addressing a significant unmet need in pediatric cancer therapy.
Yeda posted this:
Protein Based Treatment for Duchene Muscular Dystrophy and CancerDuchenne muscular dystrophy (DMD) is a disease that affects approximately 1 in 3,500 boys with a life expectancy of ~26 years. Newly approved FDA treatments are designed to treat specific mutations that account for only 25% of the patients, leaving an unmet need for an effective treatment for the clinical pathologies of the disease. Many of these pathologies are caused by dysregulation of the extracellular matrix (ECM). The lab of prof. Irit Sagi has developed an antibody-like inhibitor for a key ECM remodeling enzyme. This inhibitor is specific, stable and was proved beneficial in a DMD mouse model.
Yeda posted this:
Protein coupling using cystein-free inteinsTraceless covalent modification of proteins, including joining peptides or adding chemical groups, is extremely useful for numerous applications in chemical biology, protein chemistry, and biotechnology. A powerful tool currently used rely on Inteins, protein domains that auto-catalyze peptide bond formation. However, since inteins contain cysteine in their catalytic site, the reaction can only be made under reducing conditions, thus limiting the scope of proteins that can be modified. Prof. Pietrokovski and his collaborators at the University of Münster developed cysteine-less inteins that efficiently modify proteins under native and physiological conditions. They demonstrated their use with a full-length IgG antibody, an Fc fragment of an IgG, and nanobodies.
- Maciej LojewskiJagiellonian University
Maciej Lojewski posted this:
Protein disulphide isomerase inhibitorsProtein disulphide isomerase (PDI) family is a group of enzymes regulating endoplasmic reticulum protein. In addition to well-known role of PDI as molecular chaperones, their cell-surface disulfide exchange activity controls thrombosis, cancer cell adhesion, metastasis and vascular function. Thus, protein disulphide isomerase seems to be an interesting therapeutic target to be exploited to afford anti-thrombotic, anti-metastatic and vasoprotective action.
Technology Broker at Jagiellonian University Leading Biology posted this:
Protein Expression and Purification ServicesLeading Biology strives to provide advanced platforms for protein expression and purification service. As a leading biotechnology service supplier, we offer a variety of protein expression and purification systems for high-level expression and sample purification.
Leading BiologyLeading BiologyLeading Biology posted this:
Protein Expression in Bacillus SubtilisAdvantages of the Bacillus subtilis expression service in Leading Biology. 1. Having a variety of Bacillus subtilis expressing vectors, such as pHT101 and pHT254. 2. Having many different expressions hosts, such as intracellular expression host AS1, 1012, 168, secretory expression host WB800N, etc to fulfill different requirements of customers. 3. Could prepare high efficient competent Bacillus subtilis.
Business Development Manager at Leading Biology
- Leading BiologyLeading Biology
Leading Biology posted this:
Protein Expression in E coliLeading Biology has extensive experience and is very professional in E. coli protein expression and purification. We can solve various difficult problems during the protein expression and purification process.
Business Development Manager at Leading Biology
Unismart - University of Padua FoundationUnismart - University of Padua FoundationUnismart - University of Padua Foundation posted this:
Protein extraction method for diagnosticsThis patent defines a new method for the extraction and identification of proteins starting from a small quantity of biological material. The first diagnostic application that is currently at an advanced stage of development and validation is in the diagnosis of amyloidosis.
Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRIUniversidad de Alcalá-OTRI posted this:
Protein separation by using anionic carbosilane dendrimers.BIODEN research group (Biomedical applications of dendrimers) from the Department of Inorganic Chemistry of the University of Alcala along with the research group of Micro(sep) from the Department of Analytical Chemistry and Chemical Engineering have developed a technology based on the use of anionic dendrimers as nanoadditives in capillary electrophoresis (CE) for protein separation, more specifically for obtaining protein profiles useful in food characterization. The groups look for companies of chemical, pharmaceutical or biotechnological sector to sign research collaboration agreements or license agreements.
Vilnius UniversityVilnius UniversityVilnius University posted this:
ProteinGAN – deep learning framework for rapid generation of highly-functional synthetic enzyme librariesThe immense size of protein sequence space and poor understanding of sequence-function relationships renders current protein library design methods highly inefficient. Deep learning based technology developed by Biomatter Designs – ProteinGAN – provides a way to generate highly diverse and functional synthetic enzyme libraries. Due to high amounts of mutations in each synthetic enzyme sequence (up to 50% currently shown) and their retained catalytic activity, the designed libraries can be subjected to exceptionally potent screening for improved activity, thermostability and other characteristics.
Creative Proteomics posted this:
Proteomic ServiceCreative Proteomics specializes in a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies. We have one of the most advanced proteomics platforms in the world and our staff scientists are experienced proteomics professionals.
- UACOOPERA University of Aveirouacoopera
UACOOPERA University of Aveiro posted this:
PSA purification and concentration from urine samples for non-invasive early stage diagnosis of prostate cancerNew method for the pretreatment of human urine sam-ples, comprising the simultaneous extraction, concentration and purification of the prostate-specific antigen (PSA), a prostate cancer biomarker. In this technology, aqueous biphasic systems composed of ionic liquids and salts are used. These systems allow the selective extraction of PSA and to obtain high con-centration/enrichment factors, enabling the quantification of PSA using less sophisticated, cheaper and more affordable equipment.
Technology Transfer Office at uacoopera
