Production of Heterologous Extracellular Polypeptides in Yarrowia Lipolytica

  • CSIR
  • From South Africa
  • Responsive
  • Innovative Products and Technologies

Summary of the technology

Yarrowia lipolytica yeast based system for production of recombinant proteins and peptides.

CSIR

Applications

Yarrowia lipolytica yeast based system for production of recombinant proteins and peptides.

Technology Field

Biotechnology, pharmaceuticals

Business Opportunity

Investment for further technology development and conduct relevant trials

Technology Description

This invention relates to protein and/or polypeptide production, particularly improved production of extracellular heterologous polypeptides and proteins. In particular, the invention relates to compositions of cell populations capable of improved levels of extracellular secretion relative to control populations, kits containing such compositions, methods of producing heterologous proteins of interest and recombinant microorganisms capable of improved extracellular heterologous protein production.

Benefits & Advantages

High levels of recombinant protein and peptide production for various application

Inventors

Faranani Ramagoma Bethuel Bethuel Nthangeni Petrus Jakobus van Zyl

Related Keywords

  • Biotechnology
  • pharmaceuticals

About CSIR

The Council for Scientific and Industrial Research, commonly known as the CSIR, is a world-class African research and development organisation established through an Act of Parliament in 1945. The CSIR undertakes directed, multidisciplinary research and technological innovation that contributes to the improved quality of life of South Africans.
The CSIR’s shareholder is the South African Parliament, held in proxy by the Minister of Higher Education, Science and Innovation.

CSIR vision
We are accelerators of socio-economic prosperity in South Africa through leading innovation.

CSIR mission
Collaboratively innovating and localising technologies while providing knowledge solutions for the inclusive and sustainable advancement of industry and society.

CSIR values
CSIR values statement:
Our beliefs, principles and the impact we wish to make to improve the quality of life of South Africans are EPIC. Team CSIR pursues Excellence, celebrates People, personifies Integrity, and welcomes Collaboration.

Our mandate
“The objects of the CSIR are, through directed and particularly multi-disciplinary research and technological innovation, to foster, in the national interest and in fields which in its opinion should receive preference, industrial and scientific development, either by itself or in co-operation with principals from the private or public sectors, and thereby to contribute to the improvement of the quality of life of the people of the Republic, and to perform any other functions that may be assigned to the CSIR by or under this Act.”
(Scientific Research Council Act 46 of 1988, amended by Act 71 of 1990)

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