The research group has developed a highly enantioselective process catalysed by small amounts of a chiral complex formed by a silver(I) salt and a chiral phosphoramidite. This method allows the preparation of enantioenriched polysubstituted proline derivatives after a three-step sequence. These prolines are widely used for multiple purposes, but the most important activity is based on the high efficiency against the hepatitis C virus. The administration of these drugs in mammalians is beneficial because the risks of the multiple side effects are reduced and the required dose is very small, unlike the mixture of the pharmaceuticals employed in the current therapy. This research group asks for companies ready to acquire this methodology for a future exploitation.
Innovation features:
At this moment, this methodology is the unique dealing with the production of these antiviral agents in an highly enantioselective manner. This enantioselective synthesis is very reliable, reproducible and allows to react very bulky starting materials giving high chemical yields. This method is a clear example of the atom economy.
Description of the technology
Highly enantioselective process catalysed by small amounts of a chiral complex formed by a silver(I) salt and a chiral phosphoramidite. This method allows the preparation of enantioenriched Polysubstituted proline derivatives after a three-step sequence. These prolines are widely used for multiple purposes, but the most important activity is based on the high efficiency against the hepatitis C virus. The administration of these drugs in mammalians is beneficial because the risks of the multiple side effects are reduced and the required dose is very small, unlike the mixture of the pharmaceuticals employed in the current therapy. This research group asks for companies ready to acquire this methodology for a future exploitation.
Specifications
Main advantages of its use
Applications
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