Technology Offers Site map description
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María Mengual MesaIBIMA-Plataforma BionandMaría Mengual Mesa posted this:
Prognostic biomarker in COVID-19 patients.Non-invasive method to predict the clinical deterioration of patients with COVID-19, based on the study of the mRNA expression of a gene. The sample is taken from nasopharyngeal exudate, which offers two advantages: it is non-invasive, and it improves sensitivity (the primary impact of the virus occurs in the upper respiratory tract). The method allows results to be obtained quickly and affordably by RT-PCR, a technique widely used in the health sector.
Innovation Manager at IBIMA-Plataforma Bionand
Camille MILLIATKyoto UniversityCamille MILLIAT posted this:
Programmable Molecular Swarm Transporter for Light-Activated Cargo DeliveryOur technology is a swarm of kinesin-propelled microtransporters. DNA-conjugated microtubules collaborate to load a cargo under visible light , move and then unload the cargo at a desired area predefined with a UV photomask. Inspired from universal swarming behaviors observed in nature, this collaborative micro-robot has programmable interactions and controllable transportation functionalities in vivo, demonstrating remarkable parallelism, robustness and flexibility.
Commercialization Specialist at Kyoto University
Graft Polymer UK LtdGraft Polymer UK LtdGraft Polymer UK Ltd posted this:
Project: Innovative pilot production modified compounds by PE125 standard for multifunctional applications.Producing PE125 using GRAFTALEN™ MP-UHHD. Consumer properties, which should be taken into consideration: 1) The unique toughness of the material (the highest rate of all known polymers), namely, Over 160 kJ/m2 2) High abrasion resistance 3) Low friction coefficient (self-lubricating) 4) High resistance to chemically aggressive reagents (media) 5) High creep resistance (geometric stability) Ordinary way - This type of process is quite expensive. Production of PE125, in compounding with bimodal PE100, from 8 to 45% of supermolecular polyethylene is injected, reaching dispersion by multiple compounding (4 stages) in an extruder cascade (XXXXX technology). GRAFTALEN™ MP-UHHD (alloy) is a MELT-PROCESSABLE concentrate of UHMWPE on an HDPE matrix. As HDPE, you can choose the most affordable HDPE (pipe) grade. To obtain polyethylene according to the standards PE125 (with a minimum strength indicator MRS> 13.8-14 MPa, in comparison PE100 has MRS only 10 MPa), a significant improvement in the resistance against hydrostatic pressure is required. For a conventional bimodal HDPE, this indicator is difficult to achieve, since it directly correlates with the impact strength/density indicators and with simple extrapolation, it turns out that the required indicator for PE125 simply does not reach the bimodal HDPE matrix. Another problem - the difficulty in maintaining the geometric stability of the pipe (the thickness at the top of the pipe is often less than at the bottom) due to the sagging effect (the phenomenon of the gravitational flow of a polymer melt). This phenomenon is more pronounced for thick-walled pipes. The specific blend of HDPE with UHMWPE allows solving these problems above.
Maximilian Betz posted this:
Proof of Concept of GasVisor - The first platform-based service for the consumption-automated ordering of gasWe want to actively shape the change in how the restaurant, hotel and hospitality industry orders consumption-automated liquid goods and commodities to offer the customer a more sustainable and cost-efficient supply chain. We focus on making our products simple and easy to use on site (Plug & Play), maximising the digitisation and automation of our services, and engaging local suppliers to make our planet a better place. Currently we are in the Proof of Concept phase and are therefore looking for customer-, innovators- and investors feedback. Visit us and leave us a feedback. www.gasvisor.eu
CEO at GasVisor
Yeda posted this:
Prosody Based Speech AnalysisA major part of human communication is conveyed through intonation, or prosody – the music of speech. It is the least conscious, most instinctive activity of speech conveying all non-verbal linguistic information including sentiment, emphasis, conversation action and a large variety of signals: whether we are happy, irritated or even truthful can be detected through the way in which we utter the words. Remarkably, this aspect of communication has not yet been analyzed in a comprehensive, quantitative manner. A group of researchers from the Weizmann Institute of Science has created a model for analyzing prosodic patterns that enables access to non-verbal communication in speech, based on computational analysis of intonation-unit modulation. The model relies on a segmentation method that adds a compact layer of basic algorithmic analysis within a speech recognition engine, adding very little computational load. This provides the basis for universally describing prosody and grants access to non-verbal information in speech.
Benemérita Universidad Autónoma de PueblaBenemérita Universidad Autónoma de PueblaBenemérita Universidad Autónoma de Puebla posted this:
PROSTHESIS VESTIBULAR WITH TECHNOLOGY (MEMS)A vestibular prosthesis includes micro-electric-mechanical (MEMS) sensors, gyroscopes in each sensitivity axis (X, Y, Z), accelerometers in each sensitivity axis (X, Y, Z) to detect an angular and linear movement providing displacement measurements, gyroscopes in each one of the spatial axes (X, Y, Z), a microprocessor connected to the MEMS sensors and producing an electric pulse pattern or a continuous galvanic current pattern, a conditioning unit that amplifies and conditions the microprocessor output to apply current to the stimulation electrodes, the microcontroller being configured to determine the displacement of the cupula and the otolithic mass, determine a membrane potential as a result of a displacement detected by the MEMS sensors by means of determining a transduction current, and determine an action potential discharge pattern for the primary afferent neuron,; which synapses with the hair cell by means of a mathematical model of the informative process of the vestibular mechanoreceptor.
Georgetown UniversityGeorgetown UniversityGeorgetown University posted this:
PROTAC molecules targeting PAX3:FOXO1 fusion protein for rhabdomyosarcoma treatmentThis invention introduces novel PROTAC (proteolysis targeting chimera) molecules designed to induce degradation of the PAX3::FOXO1 fusion oncoprotein in rhabdomyosarcoma cells. The compounds consist of a PAX3::FOXO1 binding moiety, an E3 ubiquitin ligase binding moiety, and a bivalent linker. This targeted approach offers a potential breakthrough in treating fusion-positive rhabdomyosarcoma, addressing a significant unmet need in pediatric cancer therapy.
Yeda posted this:
Protein Based Treatment for Duchene Muscular Dystrophy and CancerDuchenne muscular dystrophy (DMD) is a disease that affects approximately 1 in 3,500 boys with a life expectancy of ~26 years. Newly approved FDA treatments are designed to treat specific mutations that account for only 25% of the patients, leaving an unmet need for an effective treatment for the clinical pathologies of the disease. Many of these pathologies are caused by dysregulation of the extracellular matrix (ECM). The lab of prof. Irit Sagi has developed an antibody-like inhibitor for a key ECM remodeling enzyme. This inhibitor is specific, stable and was proved beneficial in a DMD mouse model.
Yeda posted this:
Protein coupling using cystein-free inteinsTraceless covalent modification of proteins, including joining peptides or adding chemical groups, is extremely useful for numerous applications in chemical biology, protein chemistry, and biotechnology. A powerful tool currently used rely on Inteins, protein domains that auto-catalyze peptide bond formation. However, since inteins contain cysteine in their catalytic site, the reaction can only be made under reducing conditions, thus limiting the scope of proteins that can be modified. Prof. Pietrokovski and his collaborators at the University of Münster developed cysteine-less inteins that efficiently modify proteins under native and physiological conditions. They demonstrated their use with a full-length IgG antibody, an Fc fragment of an IgG, and nanobodies.
- Maciej LojewskiJagiellonian University
Maciej Lojewski posted this:
Protein disulphide isomerase inhibitorsProtein disulphide isomerase (PDI) family is a group of enzymes regulating endoplasmic reticulum protein. In addition to well-known role of PDI as molecular chaperones, their cell-surface disulfide exchange activity controls thrombosis, cancer cell adhesion, metastasis and vascular function. Thus, protein disulphide isomerase seems to be an interesting therapeutic target to be exploited to afford anti-thrombotic, anti-metastatic and vasoprotective action.
Technology Broker at Jagiellonian University Leading Biology posted this:
Protein Expression and Purification ServicesLeading Biology strives to provide advanced platforms for protein expression and purification service. As a leading biotechnology service supplier, we offer a variety of protein expression and purification systems for high-level expression and sample purification.
Leading BiologyLeading BiologyLeading Biology posted this:
Protein Expression in Bacillus SubtilisAdvantages of the Bacillus subtilis expression service in Leading Biology. 1. Having a variety of Bacillus subtilis expressing vectors, such as pHT101 and pHT254. 2. Having many different expressions hosts, such as intracellular expression host AS1, 1012, 168, secretory expression host WB800N, etc to fulfill different requirements of customers. 3. Could prepare high efficient competent Bacillus subtilis.
Business Development Manager at Leading Biology
- Leading BiologyLeading Biology
Leading Biology posted this:
Protein Expression in E coliLeading Biology has extensive experience and is very professional in E. coli protein expression and purification. We can solve various difficult problems during the protein expression and purification process.
Business Development Manager at Leading Biology
Unismart - University of Padua FoundationUnismart - University of Padua FoundationUnismart - University of Padua Foundation posted this:
Protein extraction method for diagnosticsThis patent defines a new method for the extraction and identification of proteins starting from a small quantity of biological material. The first diagnostic application that is currently at an advanced stage of development and validation is in the diagnosis of amyloidosis.
Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRIUniversidad de Alcalá-OTRI posted this:
Protein separation by using anionic carbosilane dendrimers.BIODEN research group (Biomedical applications of dendrimers) from the Department of Inorganic Chemistry of the University of Alcala along with the research group of Micro(sep) from the Department of Analytical Chemistry and Chemical Engineering have developed a technology based on the use of anionic dendrimers as nanoadditives in capillary electrophoresis (CE) for protein separation, more specifically for obtaining protein profiles useful in food characterization. The groups look for companies of chemical, pharmaceutical or biotechnological sector to sign research collaboration agreements or license agreements.
Vilnius UniversityVilnius UniversityVilnius University posted this:
ProteinGAN – deep learning framework for rapid generation of highly-functional synthetic enzyme librariesThe immense size of protein sequence space and poor understanding of sequence-function relationships renders current protein library design methods highly inefficient. Deep learning based technology developed by Biomatter Designs – ProteinGAN – provides a way to generate highly diverse and functional synthetic enzyme libraries. Due to high amounts of mutations in each synthetic enzyme sequence (up to 50% currently shown) and their retained catalytic activity, the designed libraries can be subjected to exceptionally potent screening for improved activity, thermostability and other characteristics.
Creative Proteomics posted this:
Proteomic ServiceCreative Proteomics specializes in a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies. We have one of the most advanced proteomics platforms in the world and our staff scientists are experienced proteomics professionals.
UACOOPERA University of AveirouacooperaUACOOPERA University of Aveiro posted this:
PSA purification and concentration from urine samples for non-invasive early stage diagnosis of prostate cancerNew method for the pretreatment of human urine sam-ples, comprising the simultaneous extraction, concentration and purification of the prostate-specific antigen (PSA), a prostate cancer biomarker. In this technology, aqueous biphasic systems composed of ionic liquids and salts are used. These systems allow the selective extraction of PSA and to obtain high con-centration/enrichment factors, enabling the quantification of PSA using less sophisticated, cheaper and more affordable equipment.
Technology Transfer Office at uacoopera
Fundació UdG Medicina posted this:
PSICODEM is a very simple software. It allows you to choose the most appropriate psychosocial intervention for people suffering from dementia, depending on their level of cognitive impairment and other signs and symptoms such as aphasia or anxietyIt is a very simple software. It does not needt to be installed, just needs internet access, together with a user name and password. It is very easy to use and very useful when professionals need to take quick decisions based on best existing evidence. They have to consider level of patient's dementia according to MMSE test and study their signs and symptoms in order to obtain the best psychosocial intervention that is recommended.
University of WaterlooUniversity of WaterlooUniversity of Waterloo posted this:
Pure white light emitting nanomaterial: NanoliteBackground Consumers and industry are seeking safe, durable, energy efficient alternatives to traditional incandescent light bulbs as this traditional form of lighting continues to be phased out (Europe started 2009, Canada in 2012). CFLs are energy efficient however they contain mercury, a toxic substance that requires special handling for disposal and in the case of bulb breakage. LEDs are a safer, longer lasting alternative to CFLs, however manufacturing White LEDs is a rather complicated and expensive procedure. Pure materials (molecules or semiconductors) generally emit light in a narrow range of the visible spectrum making the design of white light emitters very challenging and costly. Currently, “white” LEDs are created by first creating a blue LED and then applying an additional coating containing a mixture of different phosphors to create an approximate white appearance. These LED’s use costly substrate material (i.e. sapphire). Another method of creating a white LED is more complicated and involves combining red, green, and blue LEDs to approximate a white light.
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
Purine derivatives for the treatment of neurodegenerative diseasesCSIC has synthesized several substituted purine derivatives that are capable of inhibiting the activity of the CDC7 kinase. This inhibitory activity makes them useful for the treatment of neurological diseases. The compounds developed are, therefore, a new therapeutic alternative for Alzheimer's disease, amyotrophic lateral sclerosis or frontotemporal dementia. Industrial partners from pharmaceutical industry are being sought to develop and commercialized the compounds through a patent licence agreement. An offer for Patent Licensing
University of Vigo posted this:
Pyridazin-3(2H)-one Derivatives as Selective Inhibitors of Monoamine Oxidase-B Isoform (MAO-B)This invention is concerned essentially with pyridazinone derivatives substituted at C4, C5 or C6 with dithiocarbamate fragments that are selective MAO-B inhibitors, and their use for the preparation of medicaments for treating disorders resulting from MAO-B hyperactivity, including neurodegenerative diseases, such as Parkinson´s and Alzheimer’s diseases and other dementias. The pyridazine ring is a privileged fragment found in compounds with very different pharmacological properties, such as antihypertensive, antiplatelet, anti-inflammatory, antinociceptive, antidepressant, hypoglycemic, antiinfective or anticancer agents, many of them being pyridazin-3(2H)-one derivatives. The pyridazine ring is also included in polycyclic compounds acting as MAO-B inhibitors. However, simple pyridazin-3(2H)one derivatives have not been described so far as selective MAO-B inhibitors. The present invention provides novel pyridazin-3(2H)-one derivatives substituted at C4, C5 or C6 with several dithiocarbamate moieties that selectively inhibit the MAO-B activity and whose structure is unrelated to those currently available. Innovative aspects and advantages The novel pyridazin-3(2H)-one derivatives can be easily synthesized through a multicomponent reaction, in which the appropriate 6(5)(4)-bromoalkyl analogue, an amine and carbon disulfide react in the presence of anhydrous potassium phosphate at room temperature. The compounds of the present invention were inactive against MAO-A. However, these simple pyridazinone derivatives are inhibitors MAO-B with IC50 values in the micromolar range. Commercial applications and potential users The compounds of the present invention or their salts could be used by the pharmaceutical industry for the preparation of medicaments to treat disorders resulting from MAO-B hyperactivity, including neurodegenerative diseases, such as Parkinson´s and Alzheimer’s diseases and other dementias.
Peter Mogyorosi posted this:
Pyrolysis of carbonized Polyvinyl Chloride (PVC) waste to produce hydrochloric acidThis unique technology converts carbonized PVC waste into hydrochloric acid and uses mixed carbonized plastic waste as an energy source. This machine is suitable for processing PVC waste which comes from electric cables and construction waste or other sources, like the byproduct of Refuse-derived fuel (RDF) production.
CEO at Laser Consult Ltd.
Q
CSIR posted this:
Qfrency Text-to-Speech (TTS)The CSIR has developed a software product that converts digital text into synthetic speech, in all the 11 official South African languages. Up until the development and commercialisation of the CSIR’s Qfrency Text-to-Speech (TTS) product there had been no other text-to-speech product in the market that could deliver synthetic voices in all 11 official South African languages. Ten of South Africa’s official languages have been classified as resource-scarce, where resources in this context refers to digital language resources (text as well as speech) and research resources (research into linguistics). CSIR researchers have, in the past 18 years, developed capabilities to work with resource-scarce languages and adapt state-of-the-art techniques in text-to-speech, for the South African context. The CSIR’s Qfrency TTS technology overcomes the language barrier for users in government or business looking to reach a wider audience. The technology generates synthetic speech that is as close to human speech as possible, including articulation and accent. “We have progressed with our research and development of deep neural network (DNN) voices to the point that this technology presents a major leap in the naturalness of the synthetic voices that employ these DNN techniques. The next step in the Qfrency TTS development is to port this research and development into our commercial offering, thereby giving our customers access to the latest advances in this technology,” says CSIR senior engineer Aby Louw. The current focus of commercialisation efforts is the business-to-business sector, focusing on large-volume users such as call centres in telecommunications companies, adding speech channels to chat bots employed for self-service applications by large corporations and adding a speech modality to online learning platforms.Meghan Meyer posted this:
Quantitative Auxiliary-free Chirality Sensing with a Metal Probe- Simplified sensing assay with reduced cost and waste - Achievable with ligand-free, earth-abundant cobalt salts - Determination of the absolute configuration and the enantiomeric composition of the chiral analyte
Other at Georgetown University
- Georgetown UniversityGeorgetown University
Georgetown University posted this:
Quantitative Chirality and Concentration Sensing of Chiral Analytes Using a Relay Assay- The technology allows for the simultaneous determination of absolute configuration, enantiomeric composition, and concentration, surpassing conventional methods - With capabilities for multiwell plate technology, the assay streamlines processes, enabling rapid screening of numerous samples - From chiral amines to challenging mono-alcohols, our assay demonstrates versatility, offering a wide scope of compound analysis
Meghan Meyer posted this:
Quantitative Chirality and Concentration Sensing of Chiral Analytes Using Quinones, (Hetero)Aryl Isocyanates, and/or (Hetero)Aryl Isothiocyanates- A practical approach to simultaneously determine both the concentration and enantiomeric composition of a wide variety of chiral compounds. - The method employs simple measurements, is fast, uses inexpensive materials, and produces minimal wastage. - A notable solution for High-throughput screening, specifically in the pharmaceutical domain.
Other at Georgetown University
Niklas GuentherTransMIT GmbHNiklas Guenther posted this:
Quantum Imaging with Undetected PhotonsYou are working in the area of methods of imaging, spectroscopy or photometry? Then the new method of quantum imaging with undetected photons („QUIP“), developed at the university of vienna, is exciting for you. It allows to take images from objects without the need of detecting the light, being scattered from the object. This is achieved by first splitting up a primary beam of photons into two separate beams of entangled photons having different wavelengths. The two split-up beams are now themselves splitted up into two quantum-entangled split-up beams of different wave-length, whereat each one of these split-up beams of second generation has a wavelength of one of the split-up beams of the first splitting up. The split-up beams of first and second generation having the same wavelength are now merged and superposed so that their photons are now no longer distinguishable from each other. Due to the entanglement of the „combination-beams“ being acquired this way and having different wavelengths from each other, the behaviour of the photons of one of the beams can be determined by measuring the photons of the other beam – while both combination-beams, being entangled with each other and having different wavelengths. The object which is to be investigated will be illuminated with one of the combination-beams and the other combination-beam will be „analysed“. By doing so an object is being illuminated with one wavelength and the detection of the „result“ of the illumination will take place at another wavelength. Hence, the method is based upon the emission of photon pairs from two coherent SPDC processes and spatial correlation within the photon pairs. The image is developing as interference pattern in one of the two beams, whereat the object is illuminated by the other beam. It is not necessary to detect the „object-beam“, because its behaviour can be derived from the „detection-beam“ at a different wavelength, due to their entanglement with each other. On behalf of UniVie we (TransMIT Society for Technology Transfer) are looking for cooperation partners in areas of optics, measurement technology and medical imaging for further development or licensees in Germany, Europe, US, and Asia. I look forward to your message. Thank`s.
Senior Innovation & Alliances Manager at TransMIT GmbH
