Pharmaceutical Products / Drugs Technology Offers

Universidad de Granada posted this:

Method for isolating circulating epithelial pulmonary cells and their use as markers for diagnosing Chronic Obstructive Pulmonary Disease (COPD)A procedure is described based on Liquid Biopsy techniques that allows both the diagnosis of COPD, as well as its evolution in patients. In order to do that, circulating pulmonary cells (CPCs) that could be present in blood of patients diagnosed with COPD are detected and characterized by combining two different techniques: - Immunogenetic positive selection for their isolation in peripheral blood. - Immunocytochemistry for detecting CPCs by using specific markers for pulmonary epithelial cells.

Russell Nicholls posted this:
Licensing Manager at Curtin University

Rhenium compounds as anticancer agents Metal-based anticancer agents, such as cisplatin, are used as gold standard cancer therapies. While these drugs are effective in eradicating malignant cells, their selectivity is poor, meaning that significant adverse effects are experienced during treatment through damage inflicted on healthy cells. Improved selectivity and targeted cancer therapies with minimal side effects are being sought. Many drugs have been developed which contain platinum, and other metals are now being developed as anticancer agents. Researchers at Curtin University developed a series of rhenium containing compounds that target cancerous cells and block their growth. These compounds are promising candidates for treatment of tumours with aggressive potential for metastasis (for example, pancreatic cancer). A library of molecular candidates have been synthesized, and structure-activity relationship to modulate selectivity and therapeutic potential has been explored.

Universidad de Alcalá-OTRI posted this:

Derivatives of Indolin-2-one and its therapeutic use in inflammatory, autoimmune, metabolic, cardiovascular, neurological and cancer diseases.The research group of “Neuroendocrinology of the cannabinoid / vanilloid system” of the University of Alcalá, in collaboration with researchers from the Institute of Medical Chemistry of CSIC, have developed a series of compounds derived from indolin-2-one, emphasizing the pharmaceutical compositions containing in the compounds and their use for the treatment of diseases mediated by AMPK (AMP-activated kinase), particularly inflammatory, autoimmune, metabolic, cardiovascular, neurological and cancer. The group is looking for companies in the pharmaceutical and health sector with the objective of reaching technical cooperation agreements, commercial agreements with technical assistance or patent licensing.

Mª Eugenia Garcés Castellote posted this:
Commercialization Specialist at Universidad de Alcalá-OTRI

New inhibitor compounds of the tyrosine phosphatase 1B protein The research group in "Biological Chemistry" of the University of Alcalá has developed new compounds inhibitors of the Tyrosine Phosphatase 1B Protein, which are related to new Formulas I, II and III, with methods to prepare them, with the use of them as inhibitors of protein tyrosine phosphatase 1B (PTP1B) and with the use of the intermediates that lead to that compounds to prepare an inhibitor of PTP1B comprised by that formulas. These compounds have application in the treatment or prevention of diseases in which it is known that PTP1B is involved in the pathogenesis, so they can be used for the treatment of insulin resistance, glucose intolerance, obesity, diabetes mellitus, hypertension and ischemic diseases of large and small blood vessels, conditions that accompany type 2 diabetes and other disorders where insulin resistance is indicated. The group looks for companies in the health and pharmaceutical sector with the aim of reaching technical collaboration agreements, commercial agreements or patent licenses agreements.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendrons functionalized with fatty acids: Formation of micelles and uses in biomedicine as antiviral, antibacterial, antiprionic, antimicrobial and drug transporters.The research group of the University of Alcalá in «Dendrimers for biomedical applications» presents the following invention that refers to the formation of dendrons of carbosilane structure that have in their periphery preferably anionic or cationic groups and in the focal point fatty acids or derivatives of these. Its main field of application is in biomedicine, as non-viral transport agents, as drug transporters, to elaborate a drug, as antimicrobial, antiviral or antipyretic agents. In the environmental sector we also find its application as biocides for water treatment. The group seeks to reach license agreements, collaboration or commercial agreements with technical assistance with companies from the sector of Health, Pharma and Environment.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendrimers with terminal thiol groups on their surface. Their preparation and their uses.The research group in «Dendrimers for biomedical applications» of the University of Alcalá presents the procedure for obtaining and using carbosilane dendrimers with terminal thiol groups on their surface, as antioxidants and radical scavengers for their application in the food industry, cosmetic and pharmaceutical. The group seeks to reach licensing agreements, collaboration agreements or commercial agreements with technical assistance, with enterprises from the food industry, cosmetic, biotechnology, Biomedicine or pharmaceutical sector.

UNIVERSIDAD DE ALICANTE posted this:

Holographic sensor for detection of adulterants in essential oils The research group of Holography and Optical Processing of the University of Alicante has developed a holographic technique for the detection of adulterants in essential oils. This technique is able to detect different types of adulterants qualitatively. In addition, a quantitative measurement of the degree of adulteration of an essential oil can also be performed by means of pre-calibration of the sensor for a particular adulterant. The sensor could be miniaturized and manufactured at a low cost compared to traditional methods of analysis such as gas chromatography and high performance liquid chromatography. The sensor can be used by unqualified personnel.

Zepponi Vanessa posted this:
Business Developer at CVT Valorisation Sud

Vaccine against bubonic and pneumonic plague Our offer is a vaccine against Bubonic and Pulmonary Plague. It was developed by researcher from the Pasteur Institute of Paris who is a WHO collaborating center on Plague.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendrimers with a polyphenolic nucleus and their use as antivirals The research group in «Dendrimers for biomedical applications» of the University of Alcalá presents carbosilane dendrimers with a polyphenolic nucleus, its obtaining procedure and its uses as antiviral, antibacterial and antifungal agents. The group seeks to reach collaboration agreements, licensing or commercial agreements with technical assistance, with companies from the biotechnology, pharmaceutical and biomedicine sectors in general.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendrimers and their use as antivirals The research group in "Dendrimers for Biomedical Applications" of the University of Alcalá presents these highly branched macromolecules synthesized from a polyfunctional nucleus, of carbosilane structure and functionalized in its periphery with anionic groups that give the macromolecule a negative net charge. In addition, the invention relates to the use of the dendrimers as an antimicrobial and the process for obtaining them. The group seeks to reach collaboration agreements, licensing or commercial agreements with technical assistance, with companies in the biotechnology, pharmaceutical and biomedicine sectors in general.

Merck KGaA posted this:

Technology for Lysophosphatidic Acid (LPA) Receptor antagonists Merck has developed and patented the results of its intense R&D activities for the identification of small organic molecules as antagonists to certain LPA receptors (LPAR1, -R2, -R3). Herein described are LPA-R2 receptor selective inhibitors. Based upon a rational screening cascade established, compounds have been identified and characterized with regard to their specific in vitro and cellular activities. The package includes access to the IP, experimental results, and materials. Merck offers the unique chance to acquire this promising program.

Merck KGaA posted this:

Novel Pharmaceutical Salt Forming Counterions with Increased Dissolution Rates and Supersaturation One of the major obstacles in developing promising New Chemical Entities (NCEs) as Active Pharmaceutical Ingredients (APIs) is their low solubility and therefore poor bioavailability. Merck has developed a novel class of salt forming anions as counter-ions for protonated free base APIs which result in an accelerated dissolution rate and increased solubility by supersaturation of the NCE. The invention is based on a systematic thermodynamic and molecular engineering approach to design the above mentioned anions resulting in crystal lattices of API salts with weak Coulomb interactions.

Hygea Salud y Nutrición posted this:

Nutritional software which makes automatically personalized diets.Vitadieta is a system of Medical Nutrition Therapy, which makes automatically personalized diets for a wide range of goals (lose weight, healthy diet, sports nutrition, pathologies...). The system could be integrate inside a third-party software, or works online. Vitadieta offers functionalities of cross-selling oriented to franchises, recomending product and services of each franchise with the diets.

Cracow University of Technology posted this:

The new lupeol derivative and the method of obtaining.This invention relates to a biologically active compound, the derivative of natural triterpene lupeol. This derivative is active for human skin cells, improving their proliferation process. In addition, the substance has the ability to neutralize free radicals. The described derivative can be used as an active ingredient in pharmaceutical and cosmetic preparations dedicated for damaged or burned skin, as well as in anti-aging cosmetics.

Universitat de Lleida posted this:

Treatment and prevention of Amyotrophic Lateral Sclerosis A group of researchers in the University of Lleida have preclinical evidence for the positive effects of a peptide administration in the mouse model for ALS (mSOD1G93A mice). When treated with a solution containing interleukin-4 polypeptide (IL4), the team is able to prolong survival, delay the manifestation of the most apparent symptoms of the disease and improve the clinical course of the disease attenuating body weight loss and improving the motor behavior. The University of Lleida seeks an industrial partner willing to further develop this technology under a license agreement.

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