Universidad de Alcalá-OTRI posted this:Carbosilane dendrimers with a polyphenolic nucleus and their use as antiviralsThe research group in «Dendrimers for biomedical applications» of the University of Alcalá presents carbosilane dendrimers with a polyphenolic nucleus, its obtaining procedure and its uses as antiviral, antibacterial and antifungal agents. The group seeks to reach collaboration agreements, licensing or commercial agreements with technical assistance, with companies from the biotechnology, pharmaceutical and biomedicine sectors in general.
Universidad de Alcalá-OTRI posted this:Carbosilane dendrimers and their use as antiviralsThe research group in "Dendrimers for Biomedical Applications" of the University of Alcalá presents these highly branched macromolecules synthesized from a polyfunctional nucleus, of carbosilane structure and functionalized in its periphery with anionic groups that give the macromolecule a negative net charge. In addition, the invention relates to the use of the dendrimers as an antimicrobial and the process for obtaining them. The group seeks to reach collaboration agreements, licensing or commercial agreements with technical assistance, with companies in the biotechnology, pharmaceutical and biomedicine sectors in general.
Merck KGaA posted this:Technology for Lysophosphatidic Acid (LPA) Receptor antagonistsMerck has developed and patented the results of its intense R&D activities for the identification of small organic molecules as antagonists to certain LPA receptors (LPAR1, -R2, -R3). Herein described are LPA-R2 receptor selective inhibitors. Based upon a rational screening cascade established, compounds have been identified and characterized with regard to their specific in vitro and cellular activities. The package includes access to the IP, experimental results, and materials. Merck offers the unique chance to acquire this promising program.
Merck KGaA posted this:Novel Pharmaceutical Salt Forming Counterions with Increased Dissolution Rates and SupersaturationOne of the major obstacles in developing promising New Chemical Entities (NCEs) as Active Pharmaceutical Ingredients (APIs) is their low solubility and therefore poor bioavailability. Merck has developed a novel class of salt forming anions as counter-ions for protonated free base APIs which result in an accelerated dissolution rate and increased solubility by supersaturation of the NCE. The invention is based on a systematic thermodynamic and molecular engineering approach to design the above mentioned anions resulting in crystal lattices of API salts with weak Coulomb interactions.
Small and Medium Enterprise
Hygea Salud y Nutrición posted this:Nutritional software which makes automatically personalized diets.Vitadieta is a system of Medical Nutrition Therapy, which makes automatically personalized diets for a wide range of goals (lose weight, healthy diet, sports nutrition, pathologies...). The system could be integrate inside a third-party software, or works online. Vitadieta offers functionalities of cross-selling oriented to franchises, recomending product and services of each franchise with the diets.
Cracow University of Technology posted this:The new lupeol derivative and the method of obtaining.This invention relates to a biologically active compound, the derivative of natural triterpene lupeol. This derivative is active for human skin cells, improving their proliferation process. In addition, the substance has the ability to neutralize free radicals. The described derivative can be used as an active ingredient in pharmaceutical and cosmetic preparations dedicated for damaged or burned skin, as well as in anti-aging cosmetics.
Universitat de Lleida posted this:Treatment and prevention of Amyotrophic Lateral SclerosisA group of researchers in the University of Lleida have preclinical evidence for the positive effects of a peptide administration in the mouse model for ALS (mSOD1G93A mice). When treated with a solution containing interleukin-4 polypeptide (IL4), the team is able to prolong survival, delay the manifestation of the most apparent symptoms of the disease and improve the clinical course of the disease attenuating body weight loss and improving the motor behavior. The University of Lleida seeks an industrial partner willing to further develop this technology under a license agreement.
Research InstituteView Profile
Germans Trias i Pujol Health Sciences Research Institute (IGTP) posted this:Diagnostic biomarkers for dementia with Lewy BodiesThe present data provide a solid basis for the development of genetic biomarkers for the early identification of patients suffering from dementia with Lewy bodies and to classify them into specific molecular subtypes. One of the biomarkers correlates with the development of Lewy pathology in the brain and may be useful to monitor the success of possible alpha-synuclein antiaggregatory therapies.
Technology Transfer Office
University of Granada (OTRI) posted this:New forms for controlled drug release composed by proteic hydrogel crystalsScientists from the University of Granada in collaboration with the Spanish National Reseach Cuncil (CSIC) have developed a procedure for fabricating a composition made with a hydrogel that contains crystalized proteins with pharmacological activity with a medium size of 12 microns, that can be even smaller up to 5 microns. The group has focused their work with insulin, though other proteins with therapeutic interest can be used. In any case, the crystalized proteins with pharmacological activity grow in situ inside de hydrogel.
Universidad de Alcalá-OTRI posted this:Metal nanoparticles stabilized with carbosilane dendrons for the treatment of infectious diseases and cancer.The research group in “Dendrimers for biomedical applications” of the University of Alcalá, in collaboration with researchers form the Foundation for Biomedical Research of Gregorio Marañón Hospital in Madrid, present the first example of dendronization of metallic nanoparticles with dendritic systems of ionic carbosilane nature. Also the present invention relates to the method of obtaining these nanoparticles and the use of the mentioned compounds for the treatment of infectious diseases or cancer. The researchers seek for collaboration agreements, licensing or commercial agreements with technical assistance, with companies or institutions from the biomedical sector.
Pragmatec posted this:Chitosan-based wound dressing for diabetic foot ulcer treatment and burn woundsChitosan-based wound dressing that stimulates the closure, neovascularization and permanent regeneration of dermis in diabetic feet’s ulcers. It reduces the risk of amputation in patients.This innovation can also be used to prevent or treat wound and burn infections, not only due to its intrinsic antimicrobial properties, but also due to its ability to deliver extrinsic antimicrobial agents to wounds and burns. Additionally, it can be used as a slow-release drug-delivery vehicle for growth factors to stimulate and improve wound healing. This technology offers a complete regeneration of the ulcer using a single copy of the material without the need for invasive treatment, ensuring no backsliding in the development of ulcers. The purification process triggered by the chitosan and the ensuing chemical modifications in the membranes reduce possible allergic reactions and maximize the benefits, such as its antibacterial effects.
Universidad de Alcalá-OTRI posted this:Service of plant in vitro culture and genetic characterization, focused on forest tree species.The research group on Agroforestry Biotechnology at Alcalá University and the INIA's Unit on Forest Tree Genomics offer a mixed service consisting of micropropagation and plant genotyping, focused on forest tree species, through in vitro culture and molecular markers of high discriminatory power. The in vitro culture is carried out at facilities of Alcalá University, being the INIA the institution in charge of the plant genotyping for their delivery once they have been molecularly characterized. Other plants obtained by other means can be also genotyped as well. Both institutions seek to reach commercial agreements with forestry, reforestation, horticultural companies, plant nurseries, companies specialized on cultivation of woody species to obtain biomass, agrarian transformation companies, ornamental companies and municipalities or local administrations interested in the maintenance of native species. Also, this service would be of special interest for pharmaceutical companies in obtaining bioproducts in general (i.e. willow-Acetyl Salicylic Acid, yew-Taxol, Maritime Pine-Pycnogenol and other active ingredients), and chemical companies interested in obtaining resins and other derivatives.
Cracow University of Technology posted this:Bioactive hydrogel wound dressings with nanosilver.The main aspect of innovation, which can be implemented in industrial practice, is application of degradable polymers, while maintaining the usable equivalence to current products. It is associated with a tendency to reduce environmental consumer waste. Specialized wound dressings are now one of the most profitable medical devices. Their variety of assortment and implementation of more niche application solutions demonstrate the ability of their wider application. It is assumed, that annual sales of specialized dressings on the markets in 2010-2015 will increase by about 4%.
Cracow University of Technology posted this:Hydrocolloid nanocomposite and production method thereof. Product is dedicated for superficial wounds in a shape of platesNanostructured silver is suspended in the gelling environment, which is a precursor of a colloidal system. A gelatin which is a natural protein polymer is a gelling environment. Nanosilver, due to its characteristics is widely used. The best-known advantage of silver nanoparticle is its antibacterial activity.