- New chemical process to produce C4'-modified nucleoside analogues.
- Potential application in developing antiviral and anticancer medications, as well as oligonucleotide-based therapeutic treatments.
- Provides new opportunities in drug design.
Nucleoside analogues are vital for modern medicine, serving as key treatments for cancer and viral infections, with C4’-modified nucleoside analogues being especially significant for antiviral and therapeutic research. Despite the significance of C4’-modified nucleoside analogues, the complexity of their synthesis presents an ongoing challenge for researchers. Currently, there is no general platform that provides direct access to libraries of naturally configured C4ʹ-modified nucleoside analogues.
University of Alberta researchers have developed a modular 5-step process to produce a diverse collection of C4ʹ-modified nucleoside analogues. This platform addresses many of the current shortcomings associated with the synthesis of C4ʹ-modified nucleoside analogues and provides a powerful tool for exploring new chemical space around this valuable chemotype to support efforts in drug design.
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