Consejo Superior de Investigaciones Científicas posted this:In vitro method for designing a customized therapy for a subject with Parkinson´sDisease CSIC, Université de Lille, INSERM and Centre Hospitalier Regional Universitaire de Lille have developed an in vitro method for designing a customized therapy for a Parkinson ‘s Disease patient through the determination of the presence of a centrosomal deficit from that subject and therefore susceptible to receive a therapy based on a LRRK2 inhibitor. LRRK2 is a key player for the development of both genetic and sporadic forms of Parkinson’s Disease (PD). Industrial partners from pharmaceutical industry are being sought to collaborate through a patent licence agreement.
Yissum - Research Development Company of the Hebrew University posted this:Diagnosis & Rehabilitation of Language Disorders in Children, Using a Self-Operated Tablet Based AppDiagnosis & Rehabilitation of Language Disorders in Children, Using a Self-Operated Tablet Based App Project ID : 19-2019-8746
Yissum - Research Development Company of the Hebrew University posted this:Enhanced Secretion of Proteins by Tag-Cleaving Cellular SystemEnhanced Secretion of Proteins by Tag-Cleaving Cellular System Project ID : 6-2019-8747
Ivan Rodriguez Rosello posted this:
Licensing Manager at Universidad de Alicante
University of Vigo posted this:Valorization of whey and vinasses by producing antimicrobial extracts using biotechnological processesThis invention is based on the production of antimicrobial extracts with potential application against pathogenic microorganisms. The biotechnological production of antimicrobial metabolites was carried out using Lactobacillus plantarum strains. Two industrial wastes, whey, and wine distilled lees (or vinasses) were assayed in order to make the process economically competitive with regard to the chemical one. The extracts are mainly composed by lactic acid, 3-phenyllactic and bacteriocins. Whey was enzymatically hydrolyzed and the solutions were fermented sequentially or simultaneously. The bioprocesses were carried out continuously or discontinuously
University of Vigo posted this:Procedure for the extraction of biosurfactants contained in corn steep liquorsNowadays, most of the pharmaceutical and cosmetic products in the market contain chemically synthesized surfactants in its composition. In many cases, these surfactants are the same as those used in regular cleanup activities. In order to get more natural and biocompatible products, it would be interesting to include natural surfactants instead of chemical surfactants in the preparation of these pharmaceutical and cosmetic products. These biosurfactants are also present in the formulation of greener nanoparticles, replacing the chemical surfactants currently used in the preparation thereof. Most biosurfactants have antimicrobial activity, which would improve the properties of certain nanoparticles, as well as many pharmaceutical and cosmetic products. The main disadvantage of biosurfactants industrial production is related to the high cost compared to chemically synthesized surfactant production. The solution proposed by the Chemical Engineering research group at the University of Vigo, is the development of eco-friendly simple extraction of biosurfactant from a corn wet-milling industry byproduct, such as corn wash liquors, better known as "corn steep liquor (CSL)", which could compete in terms of cost production with its chemical counterparts.
National Cancer Institute CRO Aviano posted this:HPLC device for high-volume samples analysisFluidic device that allows high sample volume injection in HPLC systems and provides an automated purification step, reducing sensitivity problems and facilitating the analysis of extracted compounds from complex matrix.
National Cancer Institute CRO Aviano posted this:CHEMIOTHERAPY: IRINOTECAN DRUG MONITORINGThe effectiveness of many anticancer drugs varies greatly from patient to patient and personalized dosages are required to avoid adverse side effects. The invention provides for the first time an electrochemical method to measure the concentration of the drug Irinotecan in patient's plasma and then to establish the optimal dose, with an on site test readable in real time.
National Cancer Institute CRO Aviano posted this:CHEMIOTHERAPY: IMATINIB DRUG MONITORINGThe effectiveness of many anticancer drugs varies greatly from patient to patient, with risks of incorrect dosages and adverse side effects. The invention provides for the first time an electrochemical method to measure the concentration of the drug Imatinib in patient's plasma and then to establish the optimal dose, with an on site test readable in real time.
National Cancer Institute CRO Aviano posted this:Mechanisms of p53 inactivation in TP53 wild type tumors and factors affecting sensitivity to MDM2 inhibitorsThe research group led by Dr Roberta Maestro demonstrated that the overexpression of the protein Twist, detectable in a large fraction of sarcomas but also in a fraction of carcinomas, facilitates the MDM2-mediated degradation of p53 by making p53 more susceptible to MDM2 attack. The p53:MDM2 interplay is the target of a number of compounds currently under clinical trials. These compounds (MDM2i) are aimed at alleviating p53 from MDM2-mediated degradation and hence at restoring the p53 tumor suppressive activity. Maestro and coworkers gathered data indicating that the expression of Twist may significantly impact on the activity of these drugs.
Armand Henri posted this:
Business Development Manager at Palac Industries
LUCIA CORAL posted this:
Knowledge Tranfer Manager at National Cancer Institute CRO Aviano
University of Granada (OTRI) posted this:Method for diagnosing Hereditary Hemorrhagic Telangiectasia (HHT)Hereditary Hemorrhagic Telangiectasia (HHT) is a rare and genetic disease in which a disorder in angiogenesis exists. A new method for the molecular diagnosis of this disease has been developed. It is based on the quantification of a set of microRNAs (miRNAs) transported by plasma exosomes, and in addition, this set allows diagnosing different variants of the disease. This new method has the advantage of providing new biomarkers that allow a rapid and reliable diagnosis of HHT, since the current methods are not valid for all the patients affected with HHT.
UACOOPERA University of Aveiro posted this:
Technology Transfer Office at uacoopera