Research & Technology Organization
Universidad de Alcalá-OTRI posted this:Development and method of construction of a new electrochemical sensor of Magnesium (Mg2 +), without the need to add organic salts, additives or organic solvents to the sampleThe research group in Bioelectrochemistry and Biosensors of the University of Alcalá in collaboration with the Textile Industry Research Association (AITEX) has developed an electrochemical sensor of magnesium (Mg2 +) and a construction method based on the formation of a polymeric three-dimensional network that allows the entrapment / immobilization of a selective indicator for Mg2 +, eriochrome black T, by the use of a crosslinking agent and a polymer. The combination of these three reagents allows the construction of the sensor on any conductive surface, avoiding the electro polymerization of the indicator. The resulting sensor allows to measure MG2 + in any type of samples, without the need to add organic salts, additives or organic solvents. The quantification of Mg2 + is done directly by incubating the sensor in the sample containing the analyte, resulting in a modification of the amperometric signal proportional to its concentration. This method has many applications especially in health and biomedical sector since Mg2 + participates in such important activities as neuronal, neuromuscular transmission, or regulation of blood pressure and plays a key role in various pathologies such as vascular and migraines headache. The group is looking for companies in the agro-food, bio-sanitary and environmental sectors, with the aim of reaching technical collaboration agreements, commercial agreements or patent licenses.
Merck KGaA posted this:Novel Pharmaceutical Salt Forming Counterions with Increased Dissolution Rates and SupersaturationOne of the major obstacles in developing promising New Chemical Entities (NCEs) as Active Pharmaceutical Ingredients (APIs) is their low solubility and therefore poor bioavailability. Merck has developed a novel class of salt forming anions as counter-ions for protonated free base APIs which result in an accelerated dissolution rate and increased solubility by supersaturation of the NCE. The invention is based on a systematic thermodynamic and molecular engineering approach to design the above mentioned anions resulting in crystal lattices of API salts with weak Coulomb interactions.
Creative Animodel posted this:CAR-T Preclinical in vivo StudyCreative Animodel provides customized preclinical testing services for your CAR-T cells. In cooperation with our CAR-T cells production division, Creative Biolabs, we are able to provide you with one-stop full service of both CAR-T production and preclinical testing. We also offer services for customized CAR-T cell toxicity management assessments.
Research InstituteView Profile
Germans Trias i Pujol Health Sciences Research Institute (IGTP) posted this:Apotransferrin to treat strokeOur group has demonstrated that intravenous administration of apotransferrin strongly reduces the brain damage (up to 75%) in 3 different rat models including both transient and permanent ischemic stroke and improves the neurological impairment (neuroscore 60%) induced by stroke. Thus, this new approach may benefit not only stroke patients who can be treated with current treatment to induce recanalization (transient stroke) but also the 80% of patients who could not benefit from current therapies directed to induce recanalization of the artery (permanent strokes). Results in the preclinical area and some results obtained in serum of stroke patients lead us to think that apotransferrin is a good neuroprotector in the early stages of the ischemic event.
University of Vigo posted this:Method for the sequential immunochemical evaluation on a same biological sample of NCAM (Neural Cell Adhesion Molecule) protein and its PolySialic Acid (PSA) tail, by western blot coupled to chemiluminiscence detection.The method optimizes the expression assays of PSA-NCAM isoforms in biological samples available in small quantities or restricted (as is the case of human specimens, for example). It improves quantitative and qualitative performance of PSA-NCAM analysis by western blot.
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DIT Hothouse posted this:Optimisation of Posterior Spinal Dynamic (PSD) Stabilisation SurgeryOptimising spinal surgery techniques through the use of a hip and spine simulator and a tension and torsion test machine to treat spinal patient such as those with crushed vertebra and spinal deformities, like scoliosis.
DIT Hothouse posted this:U-Learn: A Training Model for Breast Ultrasound imagingU-learn is a training and learning model for radiographers and registrars for training in breast ultrasound imaging. The model assesses the performance of a trainee registrar before, during, and after training using the ultrasound imaging phantom which is a realistic representation of the breast.
Fundació URV posted this:α-ketoglutarate as a predictor of morbid obesity-associated nonalcoholic fatty liver disease• Use of α-ketoglutarate as a novel biomarker of nonalcoholic fatty liver disease (NAFLD). • α-ketoglutarate analysis is a non-invasive quantitative measure of liver steatosis. • This method may reduce the need for liver biopsy, particularly in patients with metabolic risk factor. • The method could be used to design a kit to detect and quantify plasma α-ketoglutarate concentration. • Measurement of this biomarker may be useful in the assessment of NAFLD progression.
Small and Medium Enterprise
Creative Biogene posted this:Human SSTR1-FLAG Stable Cell Line-CHO-K1 Galpha16Somatostatin receptors are activated by somatostatin secreted from nerve and endocrine cells. The Somatostatin Receptors (SSTRs) are expressed in a tissue-specific manner and involved in the regulation of secretion of insulin, glucagon and growth hormone as well as cell growth induced by neuronal excitation in both the central and peripheral nervous systems. Aberrent expression of somatostatin receptors is known in a large number of human tumours.
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Creative Peptides posted this:APIs Antide cas 112568-12-4 Antide acetate (Ac-AA10-NH2)Antide acetate (Ac-AA10-NH2) is an LHRH antagonist and represses LH and FSH release from the pituitary gland. It shows a high antiovulatory activity and releases negligible histamine. We provide Antide. More information please visit the website:http://www.creative-peptides.com/product/antide-item-10-101-04-11.html
Creative Peptides posted this:APIs Lepirudin cas 138068-37-8Lepirudin is a recombinant hirudin derived from yeast cells. It is almost identical to hirudin extracted from Hirudo medicinalis. Lepirudin is a highly specific direct inhibitor of thrombin. More information please visit the website:http://www.creative-peptides.com/product/lepirudin-item-10-101-90-67.html
Creative Peptides posted this:DOTA-(Tyr3)-Octreotate cas 177943-89-4DOTA-(Tyr3)-Octreotate is a substance which, when bound to various radionuclides, has been tested for the treatment and diagnosis of certain types of cancer, mainly neuroendocrine tumours. More information please visit the website:http://www.creative-peptides.com/product/dota-tyr3-octreotate-item-o1002-6693.html
Creative Peptides posted this:APIs Antazoline cas 91-75-8 Antistine-Privine (Antazoline Sulfate)Antistine-Privine (Antazoline Sulfate) is a 1st generation antihistamine, with good anticholinergic properties. It is used to relieve nasal congestion and added in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis. More information please visit the website:http://www.creative-peptides.com/product/antazoline-item-10-101-110-10.html