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LUCIA CORAL posted this:
Knowledge Tranfer Manager at National Cancer Institute CRO Aviano

Predictive Kit to identify patients non responding to platinum therapy Predictive Kit to identify patients non responding to platinum therapy. 10 gene signature as a predictive biomarker for platinum treatment against different cancer types. The invention consists in quantifying the expression of 10 genes from tumor cells to detect patients eligible for platinum treatment at higher risk of developing drug resistance and disease progression. Drugs such as cisplatin, oxaliplatin and carboplatin are used to treat various types of worldwide common cancer, but resistance is a frequent event. Patient stratification based on tumor gene expression profile allows to personalize treatment reducing side effects and costs.

University of Granada (OTRI) posted this:

Method for diagnosing Hereditary Hemorrhagic Telangiectasia (HHT)Hereditary Hemorrhagic Telangiectasia (HHT) is a rare and genetic disease in which a disorder in angiogenesis exists. A new method for the molecular diagnosis of this disease has been developed. It is based on the quantification of a set of microRNAs (miRNAs) transported by plasma exosomes, and in addition, this set allows diagnosing different variants of the disease. This new method has the advantage of providing new biomarkers that allow a rapid and reliable diagnosis of HHT, since the current methods are not valid for all the patients affected with HHT.

Method for diagnosing Hereditary Hemorrhagic Telangiectasia (HHT)

Consejo Superior de Investigaciones Científicas posted this:

Immunoassay for rapid diagnosis of infectious diseases caused by Pseudomonas aeruginosa CSIC, CIBER-BBN and UAB have developed an immunochemical method for diagnosis of infections produced by Pseudomonas aeruginosa. The immunoassay is fast and efficient, with low LOD and adaptable to point-of care devices.

Immunoassay for rapid diagnosis of infectious diseases caused by Pseudomonas

Yissum - Research Development Company of the Hebrew University posted this:

Novel Naturally Occurring Compounds for Treating Cystic Fibrosis Cannabis project Derivatives of cannabinoids have an antimicrobial and anti biofilm effect on pseudomonas and candida which are major ethological pathogenic factors in CF Project ID : 6-2019-6720

Irene Uceda posted this:
Employee at Consejo Superior de Investigaciones Científicas

An electrical stable electrochemical sensor device based on Electrolyte-gated field-effect transistor (EGFET)CSIC has developed an electrolyte-gated field-effect transistor (EGFET) with enhanced electrical stability. These new EGFETs operate in aqueous environment, and are stable for more than 12 hours under continuous operation, greatly surpassing current state-of-the-art EGFETs. The increased stability makes them suitable for real life applications. Industrial partners are being sought to collaborate through a patent licence agreement. An offer for Patent Licensing

An electrical stable electrochemical sensor device based on Electrolyte-gated field-effect transistor (EGFET)

IDIBELL posted this:

Drug repurposing for lupus nephritis therapy Drug repurposing for lupus nephritis therapy. Compound X, already approved for human use in other medical indications, administered orally, can be repurposed for lupus nephritis treatment. The principal goal of compound X therapy in lupus nephritis is to normalize renal function or, at least, to prevent the progressive loss of renal function. ✓ Less side effects than the standard of care ✓ Already approved for human in other medical indications (Reprofiling) ✓ Market with 1 approval in last 50 years

Drug repurposing for lupus nephritis therapy

IDIBELL posted this:

Exosomal miRNAs in seminal plasma as non-invasive markers of prostate cancer diagnosis Identified miRNAs, from the semen samples, could be used as non-invasive biomarkers that contribute in the diagnosis/prognosis of malignant prostate cancer.

Exosomal miRNAs in seminal plasma as non-invasive markers of prostate cancer diagnosis

Nadiia Kachaput posted this:
Innovation Manager at Ukrainian Laboratories

Synthesis of dual-targeted inhibitors of HDAC1 and mTOR for cancer therapy Our offer is a chemical optimization service - synthesis of two-target specific set of pyrazolo[3,4-d]pyrimidine derivatives as dual-targeted inhibitors of HDAC1 and mTOR. We will synthesize these novel analogs only upon your request.

Radoslaw Rudz posted this:
Licensing Manager at Centre Technology Transfer CITTRU

In vitro culture medium for cells, tissues, and organs of amphibians The subject of the offer is a specialized medium for the in vitro culture of cells, tissues, and organs of amphibians. Thanks to the unique composition of active substances and refined their concentrations to the requirements of amphibian cells, the use of medium enables long-term culture as well as a high level of cell proliferation and reduction of cell mortality.

In vitro culture medium for cells, tissues, and organs of amphibians

Cracow University of Technology posted this:

Comprehensive method to assess the technical condition of the pressure equipment of installation operated in the chemical and petrochemical industry A comprehensive method to assess the technical condition of the pressure equipment of installation operated in the chemical and petrochemical industry, with the use of acoustic emission signal analysis, structure stress field and the degradation st The algorithm for the assessment of the technical condition of pressure equipment of chemical and petrochemical installations, subjected to the long-term operation, allows to determine the damage degree of the material and allows to predict the further development of degradation processes in a function of time. The proposed approach to the problem of safe operation of devices is fundamentally different from the solutions which are currently used in industrial practice. Currently, the supervision of these objects is based mainly on standard non-destructive testing methods. The main limitation of used methods is the lack of the possibility of both examining the object in its entire volume and testing the device in working conditions. Developed algorithm allows to effectively solve current problems in the diagnosis of chemical installations related to the assessment of their technical condition and determination of the conditions for further operation in real time. The algorithm is particularly recommended for monitoring devices in which adverse damages occur due to the long-term operation.

Guillermo Rodríguez posted this:
R&D Manager at Biótica, Bioquímica Analítica,S.L.

Test for rapid quantifying Legionella in waters (1 hour) (Legipid) based on Immuno-Magnetic Separation (IMS)Advanced immunosensing for determination of Legionella in water scenarios. Friendly packaging. Validated and certified technique. Proven technology with available successful cases on both preventative and outbreak situations, supported by scientific and technical papers. Immuno-Magnetic Separation (IMS) requires the sample to be prepared according to the concentration step from ISO 11731:2017. There is an environmental test kit available for the detection of Legionella spp. which attaches microscopic magnets to live bacteria in order to enable detection. The result can be crudely measured by a colour change, or more accurately with the use of a photometer. This method can be advantageous in field laboratories which do not have the facilities to handle the growth and disposal of hazardous micro-organisms.

UACOOPERA University of Aveiro posted this:
Technology Transfer Office at uacoopera

LipidPro - Fluorescent dye for detection of lipid aggregates in living cells and other samples Family of dyes to be used in fluorescence microscopy imaging of cells in culture or entire organisms, including live cell imaging. The fluorophores are not toxic, and preferentially bind to lipid aggregates, such as intracellular lipid droplets. They also light up cells by binding weakly to several subcellular structures. Importantly, the fluorophores change color with the polarity of the environment and may be used to initially characterize alterations in organelle polarity. The most promising fluorophore, LipidPro, has been tested in fibroblast-based High Throughput Screens for the diagnosis of Faber’s disease.

LipidPro - Fluorescent dye for detection of lipid aggregates in living cells and other samples

Fundación para la Investigación Biosanitaria de Andalucía Oriental (FIBAO) posted this:

Predict method of Pregnant Gestational age Despite the great effort among all sectors of health, the rate of PD remains the "big problem" for obstetricians, neonatologists and other medical specialists, both the difficulties related to the care and complications of those born and their prognosis. long-term. Because PD, in addition to increasing perinatal morbidity and mortality, causes neurological damage and affects development in newborns, there is a great need to identify women at risk of preterm delivery and includes the mechanisms that culminate in PP. method that serves to predict, with clinical and analytical variables, the week of gestation in which delivery will occur.

Predict method of Pregnant Gestational age

Laijo Jose posted this:
Manager-Tech Transfer at Centre For Future (CFF)

Device for detecting early cervical and oral cancer This device is used for detection of most of the early cancerous and high-grade precancerous lesions of cervix and oral cavity. It gives a complete white light spectrum (equivalent to day light 5500-6000 K) and provides magnification with interchangeable lenses with optical power from 1 to 4 dioptre. The light of this instrument goes deeper inside the mucosal folds and provides a clear view with magnification for the differentiation of various categories of lesions. The aceto-white lesions of the cervix are screened by means of this device after the application of 5% freshly prepared acetic acid on cervix. The oral cavity is rinsed with 1% acetic acid solution for 20 seconds followed by water to remove the mucous and saliva and the examination is done. If any lesion suspicious for cancer is identified by this device, the observations regarding location, size, morphology and colour of the lesion are recorded and then confirmed cytologically and histologically. It is proved from the validation studies that this low cost portable device is with sufficient sensitivity and specificity in detecting high grade pre-cancerous and early cancerous lesions of uterine cervix and oral cavity. The technology provides a high sensitivity with a specificity of 94.3% for precancerous and early cancerous lesions of uterine cervix and reduces false positive results.

Unitat de Valorització de la URV posted this:
Licensing Manager at Fundació URV

New method for the diagnosis of diseases caused by helminths Cystic Echinococcosis, also known as hydatid disease (Hydatidosis), is a parasitic disease caused by the tapeworms of genus Echinococcus. Hydatidosis is globally distributed and found in every continent except Antarctica. Endemic areas are parts of Argentina, Peru, East Africa, Central Asia and China. The infection to humans occur through the ingestion of parasite eggs in contaminated water, food, soil or through direct contact with animal hosts such as dogs and sheep. Human infection with E. granulosus leads to the development of one or more hydatid cysts located most often in the liver and lungs, and less frequently in the bones, kidneys, spleen, muscles, central nervous system and eyes. The asymptomatic incubation period of the disease can last many years until hydatid cysts grow to an extent that triggers clinical signs. The diagnosis is done through ultrasonography imaging, which is usually complemented or validated by computed tomography and/or magnetic resonance imaging scans. Cysts can be incidentally discovered by radiography. Specific antibodies are detected by different serological tests and can support the diagnosis. Biopsies and ultrasound-guided punctures may also be performed for differential diagnosis of cysts from tumours and abscesses. In this invention, a new system for non-invasive, early, fast and easy to use diagnosis test for Hydatidosis from exhaled breath analysis has been developed.

New method for the diagnosis of diseases caused by helminths

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