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Yissum - Research Development Company of the Hebrew University posted this:

Rapid Computational Screening of Natural Products for COVID-19 Anti-Viral Agents Some edible compounds are potent antiviral agents and were tested successfully against SARS and MERS viruses. They hence provide an large source for rapid development and production of cure against COVID-19. These compounds are commercially available, and are generally recognized as safe (GRAS), with a vast chemical diversity. Despite the high-level genetic similarity to other coronaviruses, such as SARS-CoV and MERS-CoV, recent works demonstrate major structural differences in SARS-CoV2 (the causal agent of COVID-19 disease) proteins. The need for specific anti-SARS-COV2 treatments is acute. Rapid screening of the food derived compounds, using chemoinformatic modeling tools that are common in our lab, allow the identification of a small number of potent antiviral candidate inhibitors of recent published SARS-CoV2 target proteins. Project ID : 47-2020-10884

Yissum - Research Development Company of the Hebrew University posted this:

Using Peptide Nucleic Acids (PNAs) as a Tool to Diagnose COVID-19 Using Peptide Nucleic Acids (PNAs) as a Tool to Diagnose COVID-19 Project ID : 47-2020-10881

Using Peptide Nucleic Acids (PNAs) as a Tool to Diagnose COVID-19

Lidia Aguilera posted this:
Technology Transfer Officer at University of Luxembourg

CaSiAn – Tool for Calcium Signalling Analysis CaSiAn is an open source software implemented with java language that provides a graphical user interface allowing biologists to easily process a large amount of calcium signals, tune peak detection parameters for each signal, examine detected peaks/nadirs and access the quantified characteristics of calcium spikes in form of excel or text files for further analysis.

CaSiAn – Tool for Calcium Signalling Analysis

ICN2 posted this:

Multipurpose stamped conductive graphene nano films A new method for the fabrication and easy patterning of flexible exfoliated graphene nano films which can work as electrochemical electrodes for different applications.

Multipurpose stamped conductive graphene nano films

Laser Consult Ltd. posted this:

Multifunctional Syringe (Protected Healthcare Workers)This is a medical device, is a syringe, which solves the problem of the danger of infecting patients and health care workers with diseases that can be transmitted by injecting with an already used needle. With this new syringe model, you can apply the drug enormously quickly while protecting yourself. It is intended for a single use with only one use practically possible. The dosage is much easier because it has two measuring scales. The volume is 15ml but can be changed as needed is it can be produced in different sizes. The disinfection mechanism is in the syringe, and one of the novelties is that the needle has no contact with the healthcare worker applying the therapy.

Multifunctional Syringe (Protected Healthcare Workers)

Covid-19 Innovation Challenges by Innoget posted this:

COVID-19 Rapid Diagnostic Kit Designing and developing vaccines, cures and diagnostic kits can be considered as the first priority for every country which is in the first line of fighting against coronavirus. Now there is only PCR test and IgG/IgM test for COVID-19 assessment. One of the most important problems of this diagnostic test is the time needed by the device to detect infected persons. This problem makes big companies in the field of pharmaceutical and medical devices manufacturing to design and develop rapid test kits. Our research team found that there are some specific proteins on the viral membrane which can make some reagents undergo a specific chemical reaction. Every reaction has a specific product related to substrates, so by detection of products with indicator reagents we are able to identify the virus in saliva. Indicator reagents usually change the reaction mixture color so by color change we can approve that the person is infected by COVID-19.

COVID-19 Rapid Diagnostic Kit

Alireza Daneshvar posted this:
Pharmacy Student and Researcher at Tehran University of Medical Sciences

COVID-19 Rapid Diagnostic Kit Designing and developing vaccines, cures and diagnostic kits can be considered as the first priority for every country which is in the first line of fighting against coronavirus. Now there is only PCR test and IgG/IgM test for COVID-19 assessment. One of the most important problems of this diagnostic test is the time needed by the device to detect infected persons. This problem makes big companies in the field of pharmaceutical and medical devices manufacturing to design and develop rapid test kits. Our research team found that there are some specific proteins on the viral membrane which can make some reagents undergo a specific chemical reaction. Every reaction has a specific product related to substrates, so by detection of products with indicator reagents we are able to identify the virus in saliva. Indicator reagents usually change the reaction mixture color so by color change we can approve that the person is infected by COVID-19. The advantages of using saliva include: specimen collection can be done without a healthcare professional no additional equipment such as swabs or transport media are needed as nasopharyngeal specimens can be 'uncomfortable' use of saliva-based testing may encourage recruits to clinical trials of vaccines. So far two prototypes have been designed: 1) For Home Testing: Disposable test kits where an individual adds a saliva sample into a vial containing the indicator reagent, the presence of the COVID-19 virus is indicated by a positive test as shown by a colour change. 2) Reusable Low Cost Test Kits for Healthcare Professionals: Where there is a low concentration of virus in saliva, for example in the first days after infection, viral proteins can be concentrated using a saliva condensation function. In this situation, multiple samples of saliva are placed into a device which can condensate the samples to increase concentration of any virus present. After the test has been completed, the vessel can be disinfected for ready for re-use. One of the most important properties of this approach is a much lower error rate than has been found in other devices. (errors found in other tests are in various submitted articles to different journals). The re-usable nature of this professional test could make it a practical solution for low-income countries where large scale expensive PCR testing is not an option.

COVID-19 Rapid Diagnostic Kit

Covid-19 Innovation Challenges by Innoget posted this:

Expertise in molecular biology either experimentally or computationally The Institut de Biotecnologia i de Biomedicina (IBB) was created in 1970 as a research institute of the Universitat Autònoma de Barcelona (UAB) to promote fundamental biological research. In the year 2000, the focus of research evolved towards the Biotechnology and Biomedicine fields, with the aim of advancing scientific findings into translational results. At present, the Institute hosts 18 research groups organised into 3 programmes and working in 7 areas of expertise: • Bioinformatics • Cellular Biology • Structural Biology • Genomics • Immunology • Microbiology • Proteomics. This multidisciplinary character, one of the most relevant characteristics of the IBB, allows for a broad approach to biological problems, both basic and applied. The IBB is also highly engaged in academic training at the undergraduate and postgraduate levels.

Expertise in molecular biology either experimentally or computationally

IBB-UAB posted this:

Expertise in molecular biology either experimentally or computationally The Institut de Biotecnologia i de Biomedicina (IBB) was created in 1970 as a research institute of the Universitat Autònoma de Barcelona (UAB) to promote fundamental biological research. In the year 2000, the focus of research evolved towards the Biotechnology and Biomedicine fields, with the aim of advancing scientific findings into translational results. At present, the Institute hosts 18 research groups organised into 3 programmes and working in 7 areas of expertise: • Bioinformatics • Cellular Biology • Structural Biology • Genomics • Immunology • Microbiology • Proteomics. This multidisciplinary character, one of the most relevant characteristics of the IBB, allows for a broad approach to biological problems, both basic and applied. The IBB is also highly engaged in academic training at the undergraduate and postgraduate levels.

Expertise in molecular biology either experimentally or computationally

TEC Edmonton posted this:

Inhibitors of Viral Infectivity: Amphipathic Nucleoside Derivatives as Fusion Inhibitors A series of small pharmacological molecules have been discovered to be potent and non-cytotoxic inhibitors of viral fusion. The inhibitors act on the non-virally encoded lipids in the virion envelope. These molecules are rigid amphipathic compounds of inverted cone shape which locate to the outer leaflets of virion envelopes, creating a physical barrier to viral envelope and cell membrane fusion. These amphipathic nucleoside derivatives can serve as potential antiviral or therapeutic agents against herpes, HIV, influenza, hepatitis B & C, poxvirus and other DNA or RNA enveloped viruses. They can potentially be used as prophylactic ingredients in creams, lotions, gels and as antiviral disinfectants.

Inhibitors of Viral Infectivity: Amphipathic Nucleoside Derivatives as Fusion Inhibitors

Universitat Politècnica de Catalunya - UPC posted this:

Cardiovascular health assessment from a common electronic weighing scale An easy-to-use and affordable system able to quickly assess physiological parameters related to cardiac and vascular health of a subject from the force sensors of a common electronic weighing scale.

Cardiovascular health assessment from a common electronic weighing scale

Universitat Politècnica de Catalunya - UPC posted this:

SELF DRIVEN MICROFLUIDIC FILTER FOR SEPERATING LIQUID FROM A LIQUID INCLUDING DEFORMABLE PARTICLES (I.E. PLASMA FROM BLOOD)This Novel Microfluidic circuit has been developed in MicroTechLab of the Mechanical Engineering Department of UPC. Currently, partners to further develop the system and/or to establish commercial agreements along with technical cooperation are sought.

SELF DRIVEN MICROFLUIDIC FILTER FOR SEPERATING LIQUID FROM A LIQUID INCLUDING DEFORMABLE PARTICLES (I.E. PLASMA FROM BLOOD)

Lucas Montes posted this:
Technology Transfer Advisor at University of Granada (OTRI)

Multifunctionalized nanoparticles for cancer diagnosis and treatment A synthesis method of polymeric multifunctionalized nanoparticles has been developed. These nanoparticles have different agents that offer the ability to diagnose, treat and monitor different types of cancer specifically. Nowadays, functionalized nanoparticles are opening a wide range of opportunities to improve the diagnosis and treatment of different kind of pathologies. However, further studies are needed to optimize this nanosystem. In light of this, the present invention offers new efficient and versatile nanoparticles.

Alfonso del Rey Pérez posted this:
Technology Transfer Officer at ICMAB-CSIC

New dendrimer as a contrast agent in magnetic resonance imaging (MRI)ICMAB has developed a new dendrimer that can be used as a contrast agent (CA) in magnetic resonance imaging (MRI). This new CA is non-toxic and it is expelled from live tissues in hours, making it the best option when periodical MRI tests are needed.

New dendrimer as a contrast agent in magnetic resonance imaging (MRI)

LUCIA CORAL posted this:
Knowledge Tranfer Manager at National Cancer Institute CRO Aviano

Predictive Kit to identify patients non responding to platinum therapy Predictive Kit to identify patients non responding to platinum therapy. 10 gene signature as a predictive biomarker for platinum treatment against different cancer types. The invention consists in quantifying the expression of 10 genes from tumor cells to detect patients eligible for platinum treatment at higher risk of developing drug resistance and disease progression. Drugs such as cisplatin, oxaliplatin and carboplatin are used to treat various types of worldwide common cancer, but resistance is a frequent event. Patient stratification based on tumor gene expression profile allows to personalize treatment reducing side effects and costs.

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