innovations in Genetic Engineering / Molecular Biology | Innoget

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Universidad de Granada posted this:

Compounds for the treatment of Leishmaniasis and other diseases caused by trypanosomes.Several compounds have been synthesized that are useful for the treatment of Leishmaniasis and other diseases caused by parasites of the Trypanosomatidae family. These compounds show an improvement in the antiparasitic activity and reduced toxicity compared to the usual commercial treatments, causing damage to the key enzyme in the survival of the parasite without significantly affecting that of the human host. Therefore, they are a potential alternative to current treatments used to fight against Leishmaniasis or Chagas disease.

Compounds for the treatment of Leishmaniasis and other diseases caused by trypanosomes.

Universidad de Granada posted this:

Novel luminescent probes of lanthanide complexes for sensing of biomolecules.A research institution and a university from Spain have developed a new family of antenna chromophores able to sensitize effectively luminescence of lanthanides to be applied as labelling probes for biomolecules. Industrial partners specialized in fluorescent probes for biological research are being sought to collaborate through a patent license agreement.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

New method for the diagnosis of atherosclerosis Inflammation is an active driver of atherosclerotic plaque development and a risk factor for atherosclerotic events. It is therefore of utmost importance to understand the mechanisms behind these inflammatory processes and to be able to develop new diagnostics and treatment modalities for atherosclerotic disorders. CNIC, FJD (Fundación Jiménez Díaz) and UAM (Universidad Autónoma de Madrid) researchers conducted a study to identify new antibodies that show reactivity against the atherosclerotic plaque. They have found that one of these antibodies recognizes a mitochondrial dehydrogenase of the proline metabolism (PRODH). The levels of this protein are increased in the plasma of atherosclerotic mice and humans with carotid disease, supporting the potential use of this PRODH as a biomarker for atherosclerosis.

Subramani Naidu posted this:
Promoter at QuickGun LifeScience

Phytochemical based Therapy for Covid taste loss disorder and inflammation Our team of scientists have developed a pytochemical formulation for Covid which reduces viral load and inflammation. Its is useful in taste loss disorder. Its a combination of CBD-THC and a plant based alkaloid. They have safety profile of over 40 years. We have successfully formulated a rotocap based delivery system. We need strategic partners.

Fabiola Moreno posted this:
Technology Licensing Assistant at Binghamton University

Novel Therapeutic Agent to Target Microbial Biofilms A naturally produced signaling molecule combats chronic and resistant hard-to-treat infections and contaminations by inducing microbial biofilms to disperse.

Novel Therapeutic Agent to Target Microbial Biofilms

Subramani Naidu posted this:
Promoter at QuickGun LifeScience

Biomelanin synthesised from Fungi We have synthesised eumelanin from fungi at low cost. Currently cuttlefish, octopus is used for the same. Applications include UV protection and hair dye. Future potential includes fuel cell and electric car cathode

Yissum - Research Development Company of the Hebrew University posted this:

Novel Blood Test for Early Detection of Alzheimer’s Disease Non-Invasive Detection of Brain Cell Death Using Methylation Patterns of Circulating DNA: A Novel Blood Test for Early Detection of Alzheimer’s Disease Project ID : 47-2020-10832

Nadiia Kachaput posted this:
Project coordinator at Otava Research Institute

Catechol O‑Methyl Transferase Targeted Library OTAVAchemicals offers Catechol O‑Methyl Transferase (COMT) Targeted Library. It contains 504 compounds with predicted inhibitory activity against this enzyme. The library has been carefully designed with combination of ligand- and receptor-based pharmacophore modeling.

Catechol O‑Methyl Transferase Targeted Library

Leading Biology posted this:

Canine Monoclonal Antibody Service Canines are often used as animal models for vicious infection, inflammation and autoimmune diseases, especially some digestive system diseases. Based on rich experimental experience and technology accumulation of phage display, Leading Biology, with experience of large scale elutriation screening of high affinity dog mAb, has successfully established an immunization antibody library against several antigens. The antibodies prepared can be widely used in the biomedical field.

Covid-19 Innovation Challenges by Innoget posted this:

SARS-CoV-2 Helicase Targeted Library The offer SARS-CoV-2 Helicase (NSP13) Targeted Library, which contain 1170 compounds with predicted activity against this vital protein. The overall procedure included accurate flexible docking of Drug-like Green Collection into helicase active site.

SARS-CoV-2 Helicase Targeted Library

Nadiia Kachaput posted this:
Project coordinator at Otava Research Institute

SARS-CoV-2 Helicase Targeted Library The offer SARS-CoV-2 Helicase (NSP13) Targeted Library, which contain 1170 compounds with predicted activity against this vital protein. The overall procedure included accurate flexible docking of Drug-like Green Collection into helicase active site.

SARS-CoV-2 Helicase Targeted Library

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

SHIP-1 inhibitors for prophylactic treatment and/or prevention of infectious diseases Trained immunity can be defined as a defacto innate immune memory that induces enhanced inflammatory and antimicrobial properties in innate immune cells. Innate immune cells can be trained to exhibit an enhanced and lasting response to subsequent infections with microbial components. Importantly, this boosted response can be triggered against pathogens diverse from those that induce the training. However, improving the heterologous response of trained innate immune cells remains complicated. CNIC, Syracuse University and SUNY Upstate Medical University researchers have discovered that the use of SHIP-1 inhibitors, enhance the non-specific response of trained innate immune cells. This increased activity may offer an improved prophylactic treatment or prevention of subsequent infections.

SHIP-1 inhibitors for prophylactic treatment and/or prevention of infectious diseases

Leading Biology posted this:
Business Development Manager at Leading Biology

Protein Expression in E coli Leading Biology has extensive experience and is very professional in E. coli protein expression and purification. We can solve various difficult problems during the protein expression and purification process.

Protein Expression in E coli

Leading Biology posted this:

Protein Expression in E coli Leading Biology has extensive experience and is very professional in E. coli protein expression and purification. We can solve various difficult problems during the protein expression and purification process.

Protein Expression in E coli

Covid-19 Innovation Challenges by Innoget posted this:

A Novel Therapeutic Approach Targeting Coronavirus Replication-Essential RNAs by Oligonucleotides A Novel Therapeutic Approach Targeting Coronavirus Replication-Essential RNAs by Oligonucleotides. The research team plans to develop a drug to inhibit human SARS-CoV-2 replication. They will use comparative genomics to detect conserved regions within the coronavirus family, and within human CoV-19 population, in order to identify essential genes that can be targeted to inhibit the virus replication. Project ID : 47-2020-10912

A Novel Therapeutic Approach Targeting Coronavirus Replication-Essential RNAs by Oligonucleotides

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