innovations in Genetic Engineering / Molecular Biology

Centre Technology Transfer CITTRU posted this:

Method for conjugation of biomolecules and its new use The subject of the offer is a novel method for conjugation of free thiol group(s) containing biomolecules comprising a biomolecule reaction with a gold-donor agent in which a -S-Au-S- bond is formed. Specifically, the method leads to a complex formation that is a protein cage. The new method comprises following steps: (i) biomolecules preparation, (ii) conjugation of biomolecules by reaction of biomolecules with gold-donor and (iii) purification of conjugation product.

Centre Technology Transfer CITTRU posted this:

In vivo delivery system of the DNA modifying enzymes The subject of the offer is a new method of in vivo genome editing with the use of hybrid nucleases, such as ZFN, TALEN and the CRISPR/Cas9 system, delivered to target cells by EVs derived from stem cells in serum-free conditions and defined as the RNA-containing vesicles expressing stem cells surface markers: CD90, CD105, CD147, CD309 (in more than 20% of RNA-positive events) and lack of expression CD45.

Yissum - Research Development Company of the Hebrew University posted this:

A Novel Synthetic Peptide to Inhibit Biofilm Creation of Bacillus cereus bacteria a novel synthetic peptide, for the inhibition of bacterial cell-cell communications (quorum sensing, QS), in order to inhibit virulent gene expression. Specifically, for Bacillus cereus bacteria Project ID : 23-2018-4670

Laijo Jose posted this:
Manager-Tech Transfer at Centre For Future (CFF)

Bioresorbable polymer composite for bone-soft tissue fixation.An advanced and cost effective bioresorbable, biocompatible polymer composite for bone soft tissue fixation has been developed, and their use in preparing different orthopedic devices that serves the purpose of fixation of soft tissue injuries and low-load bearing bone fractures. The use of the given bioresorbable polymer composite in orthopedic devices is an attempt to replace the traditional metallic implants and making it accessible to masses at affordable prices, and therefore overcome the limitations of currently available bioresorbable orthopedic devices in the market. The technology produces a novel bioresorbable, biocompatible polymer composite for bone soft tissue fixation. The polymer composite biomaterial is composed of bioresorbable polymer such as poly-ε-caprolactone (PCL), natural fiber silk fibroin and an osteoconductive component like Magnesium oxide (MgO) in nanoparticle form and it can be used to prepare different orthopedic devices. The silk fiber of 20% and MgO nanoparticles in concentration of 10% were mixed together with PCL as base polymer in twin-screw extruder to produce composite orthopedic biomaterial. The newly developed bone screw is having a design with screw head shape, thread-tip design, thread profile and volume. It is found that millions of screws are being used for bone or soft-tissue fixations per year and the need of such fixations devices in world orthopedic market is ever-growing. The cost effective bioresorbable composite device thus made is also having wider clinical applications with its higher bioactivity (biomineralization), biocompatibility, infection resistivity and proper bone remodeling properties.

Zymvol Biomodeling S.L posted this:

In silico enzyme engineering Zymvol is a service providing firm that assists companies in the discovery and development of new industrial enzymes through computer simulations.

Yissum - Research Development Company of the Hebrew University posted this:

Computational Tool for the Design of a Personalized Protocol for Cancer Therapy, Based on Protein Expression Cluster7 Cluster8 From big data analysis to personalized medicine in cancer: towards the development of a computational tool for the rational design of patient-specific combination therapy. Project ID : 10-2016-4322

Yissum - Research Development Company of the Hebrew University posted this:

Anti-Infectious Coating for Dental Implants Self-assembly of fluorine-capped moieties for prevention of biofilms Keywords: self-assembly, dental, dentistry, biolfilm, disruption Project ID : 9-2015-3142

Yissum - Research Development Company of the Hebrew University posted this:

Algorithm to Identify Drug Candidates for Liposomal Reformulation Modeling structural drug descriptors for loading and leakage properties of liposomal drugs for the rational identification of new liposomal drug candidates. Project ID : 6-2016-4303

Yissum - Research Development Company of the Hebrew University posted this:

Engineering Known Enzymes for the Development of Herbicide-Resistant Plants Cluster11 Project ID : 8-2018-4605

Yissum - Research Development Company of the Hebrew University posted this:

A New Tool to Diagnose and Monitor IBD Using Circadian Gene Expression A New Tool to Diagnose and Monitor IBD Using Circadian Gene Expression Project ID : 8-2018-4562

Yissum - Research Development Company of the Hebrew University posted this:

Differential Production of Cannabinoids CBD and THC Cluster11 Project ID : 8-2017-4417

Yissum - Research Development Company of the Hebrew University posted this:

Pro-Nano Lipospheres as Oral Delivery Platform for Lipophilic Drugs Cluster9 oral dispersible concentrate preparation for improving the bioavailability and distribution of lipidic drugs that are substrates of first pass intestinal metabolism and/or are substrates of Pgp efflux. Thus, the formulation elevates the amount of drug that reach the systemic blood circulation and reduces the variability in the oral absorption properties. Project ID : 6-2008-2126

Yissum - Research Development Company of the Hebrew University posted this:

New CNS-Active Carbamate Derivatives for Epilepsy New CNS-active carbamate derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide with a broad potent antiepileptic activity Project ID : 6-2017-4419

Yissum - Research Development Company of the Hebrew University posted this:

Nano-Particles for Intranasal Delivery of Biodegradable Neuropeptide Cluster9 Project ID : 6-2014-3054

Yissum - Research Development Company of the Hebrew University posted this:

Small Molecules Antagonists Of Toll Like Receptor 9 For Treatment Of Inflammatory Conditions Toll-like receptors, receptors of the innate immunity, play a critical role in the development of many pathological states, in acute and chronic inflammatory processes. Therefore, TLRs represent a new direction for immunotherapy. In order to discover novel ligands interacting with TLRs, Iterative Stochastic Elimination, an innovative beyond-state-of the-art in Silico method for predicting the chances of molecular bioactivity were employed (HUJI IDR). The most promising drug candidates were verified by a cell-based test-system (Fraunhofer IGB) that allows TLR antagonists/agonist to be identified in a reporter gene assay. The ISE process in addition with the assay lead to novel immune modulating therapeutics Project ID : 6-2015-3128

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