Medical Research Technology Offers

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

A new therapy for the treatment of myeloproliferative diseases Myelodysplastic/myeloproliferative neoplasms (MPN) are a group of diseases that affect normal blood cell production in the bone marrow. In this case the bone marrow causes an overproduction of one or more blood cell types (red cells, white cells or platelets). Complications arise over time due to the abnormally high number of blood cells that accumulate in the bone marrow and in the circulating blood. In many cases, these diseases develop slowly and get worse gradually. In some cases, MPN can progress to leukemia. Compounds capable of preventing and treating these types of diseases are urgently needed. CNIC researchers have identified new therapeutic targets based on alterations in the regulation of mesenchymal stem cells (MSC) in the hematopoietic niche by sympathetic nerves. They have also defined an in vitro method for prognosis/diagnosis of MPNs and/or to define the disease´s stage, and a method to screen for therapeutic compounds useful to treat MPNs.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

Use of selective Beta-3 adrenergic receptor agonists to treat pulmonary hypertension Pulmonary hypertension (PH), defined as the increase of mean pulmonary blood pressure above normal values, encompasses a series of disorders characterized by the increase of pulmonary vascular resistance and progressive deterioration of the right ventricle. The incidence of pulmonary hypertension in the population is high and it is associated with high morbidity and mortality. Approximately two thirds of patients with left ventricular dysfunction (systolic or isolated diastolic) develop pulmonary hypertension. Currently, there is a lack of treatments for pulmonary hypertension. CNIC and CLINIC researchers have described a novel effective treatment for pulmonary hypertension of different etiology, both chronic and acute. They have found that selective stimulation of beta-3 adrenergic receptors has a beneficial effect in pulmonary hypertension.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

New microRNAs for the diagnosis of cardiomyopathies Inflammation in the myocardium or myocarditis is a disease with heterogeneous aetiology, frequently caused by an infectious pathogen, toxins, drugs or by an autoimmune disorder. Its clinical variability and its nonspecific symptoms make the diagnosis of myocarditis a process that is not always easy. There is an urgent need for accurate, fast point-of-care tests that simultaneously provide diagnostic and prognostic information about a patient entering the hospital with symptoms of acute heart failure. CNIC researchers have identified the role of an specific miRNA in cardiomyopathies processes and have studied the differential expression in blood plasma of patients compared with healthy subjects. These miRNAs can be used as biomarker to improve the diagnosis of acute myocarditis.

Jorian Bos posted this:
Other at EIT Digital

MECURIS - Platform for customisable and 3D-printed prosthetics and orthotics Individual, 3D printed orthoses and prostheses. This is not a thing of the future. This is happening right now. Do you want to know how you can actively use digital technologies for yourself and your work life? Then you have found exactly the right partner - Mecuris. We enrich wearers´ lives thanks to digitalisation and 3D printing We develop, together with the orthopaedic technician and the wearer, tailor-made orthoses and prostheses. Using the Mecuris Solution Platform, these can be easily and intuitively adapted to the patient's specific needs and design wishes prior to them being manufactured using 3D printing: The best thing is, you do not need any previous technical knowledge. We make our expertise available to you.

Centre Technology Transfer CITTRU posted this:

New active compound for the prevention and treatment of infections caused by Zika virus (ZIKV)The subject of the offer is new active compound - sodium polystyrene sulfonate (PSSNa which can be used to prevent and treat infections caused by Zika virus (ZIKV).

Centre Technology Transfer CITTRU posted this:

Mouse model of primary biliary cholangitis and Method for selection of active compounds for treatment and/or prevention of primary biliary cholangitis The subject of the offer is mouse model of primary biliary cholangitis and method for selection of active compounds for treatment and/or prevention of primary biliary cholangitis.

LUCIA CORAL posted this:
Knowledge Tranfer Manager at National Cancer Institute CRO Aviano

Cell models to evaluate activity of p53:MDM2 inhibitors Twist GAIN-of-function and LOSS-of-function cell models were developed and used for preclinical p53:MDM2 inhibitors evaluation, preliminary demonstrating that the expression of Twist hampers their efficacy. These findings support patient stratification on the basis of twist expression for treatment of a large fraction of sarcomas but also of a fraction of carcinomas. (Piccinin et al., Cancer Cell, 22, 404-415, Sept 11 2012).

Lidia Aguilera posted this:
Technology Transfer Officer at University of Luxembourg

Fluorescence Assisted Genome Editing Efficient method to derive genome edited populations by the use of fluorescent markers. The Fluorescence Assisted Genome Editing technique allows deriving correctly edited clones with precision genetic modifications. Produced cells are free from non-edited, random integrations and on-target allele NHEJ-containing populations.

Lidia Aguilera posted this:
Technology Transfer Officer at University of Luxembourg

Single cell OMICS technologies The Integrative Cell Signalling group at the LCSB investigates changes of cellular heterogeneity in health and disease at single cell resolution. In diverse projects including cell differentiation, cancer heterogeneity and brain chraracterization, we develop and apply single cell RNA sequencing (sc-RNAseq) methods such as Drop-seq, CITE-seq, ATAC-seq, Fluidigm C1, InDrop or SPLiT-seq.

OTRI-Universidad de Málaga posted this:
Technology Transfer Office (TTO) at Universidad de Málaga

NEUROPEPTIDE IN THE PREVENTION AND / OR TREATMENT OF DISORDERS AND ALCOHOL-RELATED EFFECTS The present invention relates to the use of galanin(1-15), or an analogue thereof, for use in the prevention and/or treatment of alcohol-related effects and disorders, especially the use thereof to reduce alcohol consumption.

OTRI-Universidad de Málaga posted this:
Technology Transfer Office (TTO) at Universidad de Málaga

NEW THERAPEUTIC TARGET IN THE TREATMENT OF ALZHEIMER A study carried out through the use of systems biology, with the analysis of complex data, starting with omics data and using integrative tools for the analysis of dynamic and modular responses, has identified a candidate target and the use of its inhibitor as new useful drug to combat Alzheimer's disease. The present invention refers to the total or partial inhibition of the expression of the localized gene, or of the activity of the enzyme encoded by said gene, to be used for the treatment of Alzheimer's disease.

Arkadiusz Rudawski, PhD posted this:
Technology Broker at Cracow University of Technology

A modern form of formulation on burn wound healing, containing bioactive lavender oil (Lavandula angustifolia)The subject of the invention will be a nanoformulation containing as a therapeutic ingredient bioactive lavender oil (Lavandula angustifolia).

Laser Consult Ltd. posted this:

Multifunctional Syringe (Protected Healthcare Workers)This is a medical device, is a syringe, which solves the problem of the danger of infecting patients and health care workers with diseases that can be transmitted by injecting with an already used needle. With this new syringe model, you can apply the drug enormously quickly while protecting yourself. It is intended for a single use with only one use practically possible. The dosage is much easier because it has two measuring scales. The volume is 15ml but can be changed as needed is it can be produced in different sizes. The disinfection mechanism is in the syringe, and one of the novelties is that the needle has no contact with the healthcare worker applying the therapy.

Covid-19 Innovation Challenges by Innoget posted this:

COVID-19 Rapid Diagnostic Kit Designing and developing vaccines, cures and diagnostic kits can be considered as the first priority for every country which is in the first line of fighting against coronavirus. Now there is only PCR test and IgG/IgM test for COVID-19 assessment. One of the most important problems of this diagnostic test is the time needed by the device to detect infected persons. This problem makes big companies in the field of pharmaceutical and medical devices manufacturing to design and develop rapid test kits. Our research team found that there are some specific proteins on the viral membrane which can make some reagents undergo a specific chemical reaction. Every reaction has a specific product related to substrates, so by detection of products with indicator reagents we are able to identify the virus in saliva. Indicator reagents usually change the reaction mixture color so by color change we can approve that the person is infected by COVID-19.

Alireza Daneshvar posted this:
Pharmacy Student and Researcher at Tehran University of Medical Sciences

COVID-19 Rapid Diagnostic Kit Designing and developing vaccines, cures and diagnostic kits can be considered as the first priority for every country which is in the first line of fighting against coronavirus. Now there is only PCR test and IgG/IgM test for COVID-19 assessment. One of the most important problems of this diagnostic test is the time needed by the device to detect infected persons. This problem makes big companies in the field of pharmaceutical and medical devices manufacturing to design and develop rapid test kits. Our research team found that there are some specific proteins on the viral membrane which can make some reagents undergo a specific chemical reaction. Every reaction has a specific product related to substrates, so by detection of products with indicator reagents we are able to identify the virus in saliva. Indicator reagents usually change the reaction mixture color so by color change we can approve that the person is infected by COVID-19. The advantages of using saliva include: specimen collection can be done without a healthcare professional no additional equipment such as swabs or transport media are needed as nasopharyngeal specimens can be 'uncomfortable' use of saliva-based testing may encourage recruits to clinical trials of vaccines. So far two prototypes have been designed: 1) For Home Testing: Disposable test kits where an individual adds a saliva sample into a vial containing the indicator reagent, the presence of the COVID-19 virus is indicated by a positive test as shown by a colour change. 2) Reusable Low Cost Test Kits for Healthcare Professionals: Where there is a low concentration of virus in saliva, for example in the first days after infection, viral proteins can be concentrated using a saliva condensation function. In this situation, multiple samples of saliva are placed into a device which can condensate the samples to increase concentration of any virus present. After the test has been completed, the vessel can be disinfected for ready for re-use. One of the most important properties of this approach is a much lower error rate than has been found in other devices. (errors found in other tests are in various submitted articles to different journals). The re-usable nature of this professional test could make it a practical solution for low-income countries where large scale expensive PCR testing is not an option.

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