Universidad de Alcalá-OTRI posted this:Carbosilane dendrons functionalized with fatty acids: Formation of micelles and uses in biomedicine as antiviral, antibacterial, antiprionic, antimicrobial and drug transporters.The research group of the University of Alcalá in «Dendrimers for biomedical applications» presents the following invention that refers to the formation of dendrons of carbosilane structure that have in their periphery preferably anionic or cationic groups and in the focal point fatty acids or derivatives of these. Its main field of application is in biomedicine, as non-viral transport agents, as drug transporters, to elaborate a drug, as antimicrobial, antiviral or antipyretic agents. In the environmental sector we also find its application as biocides for water treatment. The group seeks to reach license agreements, collaboration or commercial agreements with technical assistance with companies from the sector of Health, Pharma and Environment.
Universidad de Alcalá-OTRI posted this:Carbosilane dendrimers with a polyphenolic nucleus and their use as antiviralsThe research group in «Dendrimers for biomedical applications» of the University of Alcalá presents carbosilane dendrimers with a polyphenolic nucleus, its obtaining procedure and its uses as antiviral, antibacterial and antifungal agents. The group seeks to reach collaboration agreements, licensing or commercial agreements with technical assistance, with companies from the biotechnology, pharmaceutical and biomedicine sectors in general.
Universidad de Alcalá-OTRI posted this:Carbosilane dendrimers and their use as antiviralsThe research group in "Dendrimers for Biomedical Applications" of the University of Alcalá presents these highly branched macromolecules synthesized from a polyfunctional nucleus, of carbosilane structure and functionalized in its periphery with anionic groups that give the macromolecule a negative net charge. In addition, the invention relates to the use of the dendrimers as an antimicrobial and the process for obtaining them. The group seeks to reach collaboration agreements, licensing or commercial agreements with technical assistance, with companies in the biotechnology, pharmaceutical and biomedicine sectors in general.
Alphanosos posted this:Anti pyoderma solution in spray (veterinary)We are licensing our anti-staphylococci herbal mix extract (patent pending) with a great safety profile for veterinary use as anti-pyoderma spray (or other formulation). Successful animal model results are available. Available as API or finished product ( in preparation, Q2/2018 ).
Universidad de Alcalá-OTRI posted this:Metal nanoparticles stabilized with carbosilane dendrons for the treatment of infectious diseases and cancer.The research group in “Dendrimers for biomedical applications” of the University of Alcalá, in collaboration with researchers form the Foundation for Biomedical Research of Gregorio Marañón Hospital in Madrid, present the first example of dendronization of metallic nanoparticles with dendritic systems of ionic carbosilane nature. Also the present invention relates to the method of obtaining these nanoparticles and the use of the mentioned compounds for the treatment of infectious diseases or cancer. The researchers seek for collaboration agreements, licensing or commercial agreements with technical assistance, with companies or institutions from the biomedical sector.
Centre Technology Transfer CITTRU posted this:Novel antiviral agent based on modified chitosanThe subject of the new invention is new drug developed by researchers of the Jagiellonian University is intended for treatment and prevention of viral infections caused by coronaviruses in humans, including respiratory diseases manifested by impaired respiratory function – application in biotechnology & medicine.
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Research & Technology Organization
UNIVERSIDAD DE ALICANTE posted this:Procedure for the preparation of polysubstituted pyrrolidines as inhibitors of the hepatitis C virusThe research group has developed a highly enantioselective process catalysed by small amounts of a chiral complex formed by a silver(I) salt and a chiral phosphoramidite. This method allows the preparation of enantioenriched polysubstituted proline derivatives after a three-step sequence. These prolines are widely used for multiple purposes, but the most important activity is based on the high efficiency against the hepatitis C virus. The administration of these drugs in mammalians is beneficial because the risks of the multiple side effects are reduced and the required dose is very small, unlike the mixture of the pharmaceuticals employed in the current therapy. This research group asks for companies ready to acquire this methodology for a future exploitation. Innovation features: At this moment, this methodology is the unique dealing with the production of these antiviral agents in an highly enantioselective manner. This enantioselective synthesis is very reliable, reproducible and allows to react very bulky starting materials giving high chemical yields. This method is a clear example of the atom economy.
Universidad de Alcalá-OTRI posted this:Salts of pyridazino[2,3-a]pyrrolo[2,1-c]quinoxaline for the treatment of leishmania infections and diseases that involve the protein tyrosine phosphatise 1B (metabolic syndrome, diabetes and obesity)Research groups from the Department of Organic Chemistry and Inorganic Chemistry and the Department of Systems Biology of the University of Alcalá have developed pyridazino[2,3-a]pirrolo[2,1-c]-quinoxalinium salts as therapeutic agents in the treatment of leishmaniasis, metabolic syndrome, diabetes and obesity. The compounds exhibit high activity and selectivity for the Leishmania parasite, and they provide a new therapeutic tool for the treatment of type 2 diabetes. The group seeks pharmaceutical companies to reach licensing agreements or collaboration and commercial agreements with technical assistance.
Universidad de Alcalá-OTRI posted this:Protein separation by using anionic carbosilane dendrimers.BIODEN research group (Biomedical applications of dendrimers) from the Department of Inorganic Chemistry of the University of Alcala along with the research group of Micro(sep) from the Department of Analytical Chemistry and Chemical Engineering have developed a technology based on the use of anionic dendrimers as nanoadditives in capillary electrophoresis (CE) for protein separation, more specifically for obtaining protein profiles useful in food characterization. The groups look for companies of chemical, pharmaceutical or biotechnological sector to sign research collaboration agreements or license agreements.
Centre Technology Transfer CITTRU posted this:New compounds increasing the efficiency of antibiotics and anticancer drugsModern medicine is currently facing a serious problem of increasing antibiotic resistance of numerous strains of bacteria. It is one of the most serious threats which significantly reduce the effectiveness of treatment of many diseases caused by bacteria. A particular problem is related to infections evoked by gram-negative bacilli, including the most dangerous strains recognized by the Infectious Diseases Society of America as "alert pathogens." These include the enterococci, methicillin-resistant Staphylococcus aureus (MRSA), Klebisiella, Enterobacter, Pseudomonas aeruginosa and Acinetobacter baumannii. Therefore, intense research aimed at introducing new antibacterial compounds effective against "alert pathogens” is conducted. Another approach, which part is presented offer, is to increase the effectiveness of existing antibiotics.
Centre Technology Transfer CITTRU posted this:A new method for species identification and determination of phylogenetic relationships in the genus Staphylococcus.Staphylococci (Staphylococcus) are one of the most important human bacterial pathogens. Many methods have been developed for the identification and typing of bacterial isolates of the genus Staphylococcus (Staphylococcus aureus) in recent years. These methods can be divided into two groups: phenotypic and genotypic methods. The results obtained using commercial tests, which are based on biochemical and immunological reactions profiles, are affected by mistakes due to variable expression of phenotypic features and the ambiguity from the interpreting the test results. The overall accuracy of conventional tests is low and it is in the range 50-70%. Among genotypic methods, DNA-DNA hybridisation and 16S rRNA gene sequence analysis have defined the species in the genus Staphylococcus and they are recommended to confirm the results of the new methods that are introduced into general use. However, there is still no universal method for staphylococcal species identification and typing at the same time, which would be widely used in all laboratories and allow to obtain high reproducibility of the results. The proposed method may determine the species identification and phylogenetic relationships in the genus Staphylococcus. It shows a high sensitivity and specificity. The results of this method can be interpret very easy, even in the case of the intraspecific polymorphisms. There is the possibility to differentiate between even very closely related species such as S. delphini, S. intermedius and S. pseudintermedius.
Small and Medium Enterprise
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