Meghan Meyer

This toolkit developed by Georgetown researchers is designed for educators, students, and other changemakers — anyone taking creative action to address social problems. From undergraduate students to university leaders, the framework can help strengthen analytical skills, research, problem-solving a[…]

- Complete stereochemical analysis within minutes. - Stereodynamic chemosensors capable of determining absolute configuration, enantiomeric excess, and concentration of chiral compounds.[…]

- A practical approach to simultaneously determine both the concentration and enantiomeric composition of a wide variety of chiral compounds. - The method employs simple measurements, is fast, uses inexpensive materials, and produces minimal wastage. - A notable solution for High-throughput screenin[…]

- System with the ability to monitor the internet and other data continuously, discover hypotheses potentially explaining data, and notify users of identified and potential threats - Scalable, automated, theoretically sound method with wide-ranging national security and other applications. - Method […]

-The FLI I monoclonal antibody is superior to commercial polyclonal antibodies currently available due to its high binding specificity and affinity to detect the EWS::FLI I fusion protein - Production of renewable clonal hybridoma cells, immunopurified for enhanced specificity and binding affinity -[…]

- PARCI-MS revolutionizes elemental quantitation, achieving 100 times better sensitivity for fluorine quantitation than current methods, ensuring unparalleled precision in measurements. - The innovation requires only one standard per element, streamlining workflows by eliminating the need for compou[…]

- Potential non-surgical treatment for residual lesions of involuted infantile hemangiomas, involving the administration of a drug containing at least one bile acid or its salt - Avoids the dangers associated with common treatment methods involving surgery and anesthesia, including scarring, nerve d[…]

- Method for highly efficient query processing through search engine cache optimization. - Improves the main efficiency-performance metrics of search engines, such as latency and throughput, and reduces energy consumption. - Method adapts the cache-space utilization to the popularity of the various […]

- Modified immune cells overexpressing fibroblast activation protein (FAP) to enhance NK cell migration into tumors, potentially improving cancer patient outcomes. - Allows engineered NK cells to infiltrate solid tumors and lyse malignant cells, addressing limitations of current therapies. - Offers […]

- A novel method of obtaining patient telomere length data through the collection, processing, and analysis of genomic DNA derived from a biological sample - Method for the diagnosis of telomere-related conditions and diseases in patients, with the ability to monitor various aspects of patient healt[…]

- Identify likely infected individuals, including those exhibiting minimal symptoms. - Support automated, efficient contact tracing - Require minimal user cognizance of testing procedures[…]

- Innovative fluorescent sensors that rapidly assess the enantiopurity of diverse chiral compounds, aiding pharmaceuticals, agrochemicals, flavors, and more. - Replace slow chromatography, enable fast HTS enantioselectivity screening, and assess compound stability with in situ detection. - Revolutio[…]

- High-quality speech synthesis across multiple languages and accents with a single voice model - Personalized speech synthesis capabilities, which enable users to utilize their own voices - Requires less training data and allows for voice transformation[…]

- Development of an Eastern woodchuck animal model that produces a human HBV infection in the woodchuck animal through the administration of a new HBV-WHV chimeric virus - This new animal model may be used to study acute and chronic WHV and HBV infections in the same host for comparison of immunopat[…]

- Non-invasive methods for diagnosing and monitoring liver disease - Availability of a biomarker assay for the antifibrotic and anticancer effect of proglumide - Proglumide, with proven safety in human peptic ulcer trials, is orally bioavailable[…]

- Targets cancer cells with CCK-B receptors, significantly impacting pancreatic cancer treatment - Utilizes biodegradable, non-toxic nanoparticles for efficient siRNA delivery - Offers potential for broader application across various cancers expressing similar receptors[…]

- Histone deacetylase (HDAC) inhibitors, with applications for treating cancer, neurodegenerative disorders, neurological diseases, stroke, malaria, autoimmune diseases, autism, and other conditions - Compounds are highly selective inhibitors of the HDAC6 subtype - Method does not cause potential ge[…]

- A practical approach to determine the absolute configuration, concentration, and enantiomeric excess of chiral compounds. - The method employs simple, inexpensive materials and produces minimal wastage. - An inexpensive sensing method for High throughput application, more specifically employed in […]

- Potential to suppress tumor growth and cancer cell proliferation. - Treatment with a synergistic combination of YAP/SOX2 inhibitor(s) that effectively induce cancer cell death and tumor growth arrest in YAP-dependent cancer cells - Overcome SOX2-mediated resistance to YAP inhibitors in cancer cell[…]

- Topical mTOR-I may be effective in treating numerous cutaneous vascular and proliferative conditions - Potential to improve many rare and unmet dermatologic conditions for patients - Addresses unmet needs in dermatology, providing a novel approach to treating challenging skin conditions[…]

- A foldable, manually transportable solution with low power requirements, ideal for under-resourced settings and emergency situations. - Combining body temperature regulation and full resuscitation capabilities, the device significantly increases newborn survivability in resource-constrained enviro[…]

' Provides early detection of pancreatic cancer, significantly increasing the potential for successful treatment outcomes ' Utilizes targeted nanoparticles, enhancing specificity and reducing false positives in diagnostic imaging ' Supports the development of personalized medicine approaches by enab[…]

- Demonstrates over 96% efficiency in filtering submicron particles, including PM0.3, crucial for public health and environmental protection - Offers a robust and reusable solution, significantly reducing environmental waste compared to traditional filters - Possesses strong mechanical properties an[…]

- Innovative chiral bisoxazolidine ligand enables economical synthesis of chiral alcohols from aldehydes. - Ideal for pharmaceuticals and intermediates, with high yields and enantioselectivities in various reactions. - Utilizes low-cost alkyl-zinc reagents and offers ligand recycling, ensuring cost […]

- A group of novel small molecules that are phenyl-substituted nicotinic desensitizer ligands with a high affinity and selectivity for α4β2 nAChR subtypes. - The potential characterization of the compound VMY-2-95 and its analogs as a nicotinic acetylcholine receptor (nAChR) antagonist in animal mod[…]

- A group of novel small molecules that are 2,5-disubstituted-pyridyl nicotinic ligands with a high affinity and selectivity for α4β2 nAChR subtypes. - Potential characterization of nicotinic acetylcholine receptor (nAChR) antagonist in animal models for developing new therapeutics to treat addictio[…]

- A device to determine miRNAs' presence in interstitial fluid (ISF) through transdermal microfluidic technology. - Addresses the requirement for minimally invasive or noninvasive methods to detect circulating miRNA biomarkers. - By utilizing interstitial fluid (ISF) instead of blood, plasma, or ser[…]

- NMC cell lines from the pleural fluid and bone marrow aspirate of a pediatric patient diagnosed with thymic carcinoma. - Unique karyotypic abnormality, an original viable cell line from a pediatric patient (1997). - Potential use for drug screening and therapeutic research; allows exploration of i[…]

- Novel method to identify tumor-specific antigens for cancer immunotherapy. - Single-Molecule Real-Time (SMRT) Full-Length RNA-Sequencing to identify neoantigens or potential neoantigens as predictive biomarkers and synergistic treatment targets for cancer immunotherapy. - Method uncovers antigens […]

- Potential use in the treatment of respiratory distress syndrome (RDS), asthma, chronic obstructive pulmonary disease (COPD), HIV/AIDS-related lung diseases (PJP infection), tuberculosis, and severe acute respiratory distress syndrome. - Synthetic lung surfactant composed of Silk fibroin, easy to m[…]

- Potential minimally invasive method for monitoring the presence and progression of liver diseases and cancer. - Quantification of glycoprotein biomarkers using LC-MS-based glycoproteomic profiling of patient sera and informatics approaches.[…]

- Promising therapeutic agent for metastatic osteosarcoma. - The benefit of reduced toxicity compared to traditional chemotherapeutic methods. - Potential to advance the development of novel therapies for cancer.[…]

- Potential to suppress tumor growth and cancer cell proliferation in patients with neurofibromatosis 2 (NF2) mutations. - A treatment with YAP/TAZ inhibitor(s) that effectively hinders glycolysis in NF2-mutant cancer cells, halts tumor growth, and overcomes resistance to YAP/TAZ inhibitors. - Use o[…]

- A novel approach to pharmacologically upregulate PGC-1α, providing protection against neurodegeneration. - Proven efficacy in the prevention and treatment of various neurodegenerative conditions, such as Parkinson's Disease, Parkinson-plus syndrome, familial dementia, Alzheimer's Disease, Hunti[…]

- Non-invasive, affordable biomarkers can predict Alzheimer's disease (AD) progression, defining the asymptomatic period and enabling timely intervention. - Clinical indicators capable of differentiating Alzheimer's from Frontotemporal Dementia and aiding in identifying at-risk individuals for treat[…]

- Targets lung cancer stem cells and restores sensitivity to cisplatin and EGFR inhibitors. - Overcomes limitations of existing SLC25A1 inhibitors in crossing cell membranes effectively. - Offers the potential as a therapeutic option for hard-to-treat tumors and mutational landscapes.[…]

- A novel J-tube novel that provides a solution for situations requiring the bypassing of the stomach, allowing direct feeding into the intestinal tract for patients in need. - Overcomes the issue of leakage commonly encountered by a significant number of patients who require the use of feeding tube[…]

- Innovative High-Frequency Nasal Cannula (HIFI-NC) used for spontaneously breathing infants to avoid intubation or - postextubation respiratory support. - Portable, lunch box-sized, battery-operated, positive end-expiratory pressure (PEEP), and adjustable device. - Generates adjustable frequency vi[…]

- Minimally invasive transdermal device for delivering an antimicrobial to skin at access point of interstitial fluid sampling, medical monitoring, and/or transdermal drug delivery. - Mitigates risk of infection at surgical and other wound sites. - Can deliver multiple antimicrobials to the site at […]

- Rapid and simultaneous determination of the absolute configuration, enantiomeric composition, and overall concentration of free-form cysteine - Overcomes interference from biothiols and other amino acids - Compatible with aqueous solutions e.g., body fluids[…]

- Minimizes time and chemical waste - Facilitates asymmetric reaction screening - More economical than previous technologies -----------------------------------------------------------------------------------[…]

- Simplified sensing assay with reduced cost and waste - Achievable with ligand-free, earth-abundant cobalt salts - Determination of the absolute configuration and the enantiomeric composition of the chiral analyte[…]