Potential to predict the development of HIV-associated neurocognitive disorder (HAND).
Potentially treat HIV patients with HAND or at high risk of HAND development.
Creates the possibility to monitor disease/treatment progress for HIV-HAND.
HIV-associated neurocognitive disorders (HAND) represent a spectrum neurological syndrome that affects up to 25% of patients with HIV/AIDS. Based on the relationship between HIV and a decrease in peroxisome activity, researchers at the University of Alberta have developed a method to measure biomarkers for HAND including (i) determining the levels of 4 microRNA (miRNA) sequences that downregulate expression of peroxins; (ii) measuring peroxisomal activity biomarkers; or (iii) measuring levels of peroxisomal enzyme substrates. In the case of HIV patients with HAND or at high risk for development of HAND, this creates potential to increase peroxisome activity and thus ameliorate the development of HAND symptoms. For example, approved peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonists such as fenofibrate may be useful.
Intellectual property status
Granted Patent
Patent number : US20200340056A1
Where : United States
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