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Yeda posted this:
Treatment for Acute liver failure (ALF)Acute liver failure (ALF) is a rapid deterioration of liver function, resulting in a high mortality rate in the absence of liver transplantation. ALF treatment remains highly limited and mostly supportive due to a lack of a comprehensive understanding of the molecular base of ALF. The group of Profs. Eran Elinav and Ido Amit used high-resolution single-cell analysis methods to unravel the entire molecular mechanism that drives ALF progression. They show that ALF results from activation of the MYC signaling pathway in specific hepatic cells in response to gut microbiome signals. Based on their findings, inhibition of MYC, TLR, or MAPK pathways or microbiome modulation by antibiotics could attenuate ALF.
Yeda posted this:
Treatment for Drug-Resistant Non-Small Cell Lung CancerNon-Small Cell Lung Cancer (NSCLC) is a very common type of cancer, and despite currently available therapies, is one of the deadliest due to the emergence of drug resistance, which results in tumor recurrence. Thus, there is a clear need for novel therapeutic strategies to overcome resistance, especially in the EGFR+ cohort of patients. The group of Prof. Yosef Yarden has developed a new therapeutic antibody that blocks a common drug resistance mechanism. This antibody completely inhibited tumor progression and was proven especially efficient when administered in combination with known drugs by inhibiting drug resistance thus preventing relapses of NSCLC.
Yeda posted this:
Treatment for Ewing Sarcoma Using ETS ProteinsEwing sarcoma (ES) is a common bone malignancy in children and young adolescents which is usually treated by systemic chemotherapy. In about 25% of the cases, cancer has already spread to other parts of the body at the time of diagnosis. Here, we discover a novel family of ETS proteins that binds the glucocorticoid receptors and might retard cancer progression. This methodology can be used as an effective solution for Ewing Sarcoma's prognosis and treatment.
Yeda posted this:
Treatment for Inflammatory Diseases and CancerThe development of kinase inhibitors to treat inflammatory diseases was proved beneficial, however, designing specific inhibitors with minimal side effects and prolonged efficacy is challenging as drug resistance often develops. The current technology includes inhibitors that specifically target the nuclear translocation of p38 kinase, thus inhibiting only its pro? inflammatory activities without developing drug resistance. Two types of inhibitors were developed – a uniquely designed peptide and small molecules. The inhibitors were tested in mice models and proved to effectively treat inflammatory bowel disease and prevent chronic inflammation-driven tumor development.
Yeda posted this:
Treatment of Autoimmune Diseases by Modulating BregsChronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of leukemia each year. Presently, there is no cure for CLL, and the overall goal of leukemia treatment is to bring about a remission. Therefore, identifying new proteins that may serve as a target for inducing cell death in the malignant cells is highly desirable. The present technology identifies a new regulator protein that is essential for the survival of CLL cells.
Harshada WadkarBinghamton UniversityHarshada Wadkar posted this:
Treatment of L-DOPA-induced Dyskinesia in Parkinson’s DiseaseRepurposed antidepressant agents for treating levodopa-induced dyskinesia (LID) in Parkinson's disease dramatically reduced LID and maintained these effects for several weeks without altering L-DOPA’s positive anti-parkinsonian effects.
Graduate Assitant at Binghamton University
Georgetown UniversityGeorgetown UniversityGeorgetown University posted this:
Treatment of Metabolic Syndrome and Obesity- Potential to prevent or reduce weight gain, obesity, as well as the onset of metabolic syndrome and related diseases associated with dietary factors. - Promising drug treatment that targets a neutral amino acid transporter in fat cells. - A pharmaceutical composition that can be administered systemically with minimal to no adverse side effects.
Yeda posted this:
Treatment of Psychiatric Disorders by Inhibiting Importin Alpha 5Anxiety and stress-related conditions pose a significant health burden on modern healthcare systems. While currently, available anxiolytic drugs can be highly effective for some patients, their long-term use is limited by their potentially severe and debilitating side effects. The group of Prof. Mike Fainzilber discovered a new central regulator of anxiety and identified the nutraceutical ?-sitosterol as a potential treatment for anxiety disorders.
IMDEA Water Institute posted this:
Treatment of water from bentonite slurryWhy Does Water From Slurry Require Treatment? The problem arises once the slurry is used and subjected to the separation process by applying a filter press, in order to reuse the water to generate new slurry. The water, due to the loss of quality it suffers during the construction process, interferes with the proper functioning of bentonite, forming an unstable slurry, which tends to flocculate, and thus loses the necessary properties for application. Processing these waters entails a considerable environmental improvement, in addition to cutting operating costs by reducing water consumption and the dumping of effluent which, due to the physicochemical characteristics acquired, is not suitable for discharge under current legislation.
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
Tri-functional tanks for desalination processes CSIC has developed a water filtration installation. It contains tanks designed to perform various functions: water filtration by means of ultrafiltration, water filtration by reverse osmosis and recycling of reverse osmosis membranes. This installation is used, for example, in seawater desalination processes. Industrial partners from the hydraulic companies are being sought to collaborate through a patent licence agreement.
- Georgetown UniversityGeorgetown University
Georgetown University posted this:
TRPV1 Agonist Therapy for Stabilizing Blood Pressure in Septic Shock- TRPV1 agonists safely increase blood pressure without impairing blood flow to vital organs. - Offers an effective alternative to adrenergic and angiotensin II treatments. - Formulated for rapid, parenteral administration in critical care settings.
Danielle Whelan posted this:
TU Dublin have developed AI assisted hardware/software packageResearchers at TU Dublin have developed a machine learning (AI) assisted hardware/software package or ecosystem that is run locally, via wireless or physically tethered connection.
Marketing Manager at TU Dublin Hothouse
University of WaterlooUniversity of WaterlooUniversity of Waterloo posted this:
Tunable nanoscale corrugated metal patterning on metal nanoparticles and thin filmsThe present invention is an aqueous chemical patterning method for creating 1.5-2.3 nm grooves of tuneable depth (from sub-nm to tens of nm and above) in metal and metal alloy nanoparticles and thin films during their formation. The corrugated patterning results from performing a metal reduction with highly concentrated suspensions of the precursors in the presence of commercially available cationic surfactants causing the surfactants to self-assemble into worm-like micelles under the reaction conditions. This technology also enables the creation of mesoporous metal particles and films with a pore gap size corresponding to the minimal distance between two micelles.
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Tunable temperature and measuring angle holder for film and powder samplesResearchers from the Spanish National Research Council (CSIC) and the Catalan Institute of Nanoscience and Nanotechnology (ICN2-BIST) have recently developed a sample holder for measuring films or powder samples in a fluorimeter or UV-Vis-NIR spectrometer in transmission or reflection modes. The holder allows controlled temperature conditions, and an adaptable measuring angle for tuning the light incidence and/or light detection angle. The device is customizable to adapt to the instrumentation offered by different commercial brands. Company providing spectrophotometers and equipment for Raman and emission (e.g. fluorescence, phosphorescence, electroluminescence, etc.) are being sought to collaborate through a patent licence agreement.
uacoopera posted this:
Tungsten carbide based composite material, the appropriate method of production and applicationThe preferential production method of the composite material involves the sputtering for the modification of the particle surface by coating them with a nanocrystalline layer of iron-rich metallic binder with variable thickness. The rest of the processing follows the traditional powder metallurgy routes with pressing and sintering in a vacuum furnace. After processing, the composite contains tungsten carbide phase, eta-phase and iron rich binder.
Fabian BelinLuxembourg Institute of Science and Technology (LIST)Fabian BelinPartnerships Development & IP Valorization at Luxembourg Institute of Science and Technology (LIST)
Fabian Belin posted this:
TWISCO – Digital TWIn for Sustainable Supply Chain in ConstructionTwiSCo is a Digital Twin solution demonstrator whose purpose is to promote the sharing of data on construction products in order to finally have complete, accurate and reliable data on a built asset and thus be able to better manage its construction, maintenance and end of life, and to reduce the gap between designed and as-built performance of future constructions. To this aim, TwiSCo offers value-added services which, by enabling players of the construction supply chain to optimize their practices, lead them to formalize and structure their data, and to share them with a win-win perspective. Here are some examples of the gains that the construction supply chain can expect from the tool: Development of new BIM use cases dedicated to the construction phase of buildings, using IFC data coming from BIM models in order to optimize material deliveries on construction sites; Integration of product data from manufacturers (according to new ISO 23386 and 23387) using an ontology to ensure collaboration and efficient data exchanges; de facto, enrichment of as-built model; Implementation of Just-in-Time logistics through a web platform where construction companies and their subcontractors can customize kits and define where they will be delivered and installed, how it should be packaged and when it should be delivered; ·Better control of delivery conditions through the integration of sensors data on site; ·Customization of delivery means and constraints for each project based on user defined business rules ; ·Improved monitoring of the construction site thanks to parcel tracking that enables to locate the place where a material is stored or installed; ·Multi criteria evaluation of current delivery scenarios and alerts on unmanaged constraints; ·Proposition of optimized delivery scenarios calculated by a genetic algorithm.
Partnerships Development & IP Valorization at Luxembourg Institute of Science and Technology (LIST)
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Two in one: engineering recombinant biocatalysts for plastic recycling and towards bioplastic productionCSIC has developed recombinant genetic cassettes and bacterial host cells comprising them which are useful as biotechnological tools for the aerobic and anaerobic biodegradation of o-phthalate (PA) and its bioconversion into value-added biodegradable polymers. The present invention belongs to the fields of microbiology and biotechnology, in particular to support industrially-relevant microbial platforms for bioremediation of environments contaminated with phthalates, for plastic recycling and for bioplastic biosynthesis.
PhotonDelta posted this:
Two-dimensional optical beam steering moduleAn interference-free communication system having a central communication controller (CCC) with a wavelength-tunable light source that emits a tunable wavelength optical data signal, and controls the wavelength-tunable light source by conditioning, modulation and wavelength-tuning, the CCC includes a signal-transparent optical cross connect and fiber optic network, a pencil-radiating anten-na (PRA) that is a passive 2-dimensional diffractive module is coupled to the wavelength-tunable light source via the fiber optic network, the cross connect routes the optical data signal to the PRA, the optical data signal is transmitted through a confined optical pencil beam, the PRA deflects the pencil beam in 2 angular dimensions as a function of a wavelength of the pencil beam, the deflected pencil beam is disposed for communication with an opto-electronic communication device,; and a radio return channel that provides upstream communication from the communication device to the CCC includes a lack-of-connection communication between the communication device and the CCC.- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Tyrosine hydroxylase inhibitors for treatment of aortic aneurysmTyrosine hydroxylase inhibitors for treatment of aortic aneurysm CSIC and the Research Institute of the Hospital de la Santa Creu i Sant Pau (HSCSP-IR) have found the potential of tyrosine hydroxylase inhibitors for prevention and treatment of aortic aneurysm reducing aortic damage. Industrial partners from the pharmaceutical industry are being sought to collaborate through a patent licence agreement. An offer for Patent Licensing
U
UNIVERSIDAD DE BURGOS posted this:
UBUNurse. Home careIt is an application for mobile devices that allows health workers to evaluate home care.
Biótica, Bioquímica Analítica,S.L.Biótica, Bioquímica Analítica,S.L.Biótica, Bioquímica Analítica,S.L. posted this:
ULISENS Legionella Desktop AnalyzerFully automated equipment for 1 hour-determination of Legionella in concentrated water samples. The #ULISENS Desktop is a portable computer that makes it possible to analyze #Legionella in filtered water samples. With the "nespresso" philosophy, it uses a recyclable cartridge. "Push & Run" and the data is available in only 1 hour. It automates the rapid immunomagnetic method listed in the norm UNE100030:2017 for the control and prevention of #Legionella. (https://youtu.be/baiHP26xwCs)
Barani Design posted this:
Ultra low power MODBUS Temperature, Humidity, Pressure sensor• High accuracy meeting WMO standards • Fast response (short time constant) • Negligible self heating • Ultra-low power consumption • Digital RS485 MODBUS RTU & ASCII output • Highest lightning protection with Class A result for surge, EFT/burst, ESD per EN 61000-4-2, EN 61000-4-4, EN 61000-4-5 • Flexible 5 to 18VDC input
- Harshada WadkarBinghamton University
Harshada Wadkar posted this:
Ultra-high Solid State Capacitance CapacitorsFabricating the dielectric of capacitors with a thin & continuous coating, providing the best trade-off of capacitance and breakdown voltage
Graduate Assitant at Binghamton University
Yeda posted this:
Ultra-Rapid Structure Reconstruction Using an All-optical Digital TechnologyReconstruction of structures from their scattered intensity distributions is heavily exploited in a range of disciplines, with common methods limited when phase information is lost. Contemporary iterative algorithms depend on a priori knowledge of the object boundaries to solve such inverse scattering problems, but remain highly time-consuming and, at times, inaccurate. The proposed all-optical technology harnesses a digital degenerate cavity laser arrangement that registers the scattered intensity distribution only within the predefined boundaries of the object. The process is ultra-rapid (nanosecond-scale) and bears very high spatial resolution potential.
- University of WaterlooUniversity of Waterloo
University of Waterloo posted this:
Ultra-stable cryo-electron microscopy holderBackground One important technical problem in cryo-electron microscopy (cryo-EM), when trying to attain atomically resolved 3D structures of frozen hydrated specimens, is the negative effect on the resolution due to the vibration from liquid nitrogen cooling. Sample holders for cryo-EM have so far relied on the use of a Dewar with liquid nitrogen to cool down sample to temperatures below -170oC. The use of liquid nitrogen is often inconvenient and difficult to implement. Water crystallization inside the Dewar and relative hot spots may induce vibration through bubbling, limiting the attainable spatial resolution. Significant user expertise is required under such adverse conditions to perform single particle cryo-EM experiments and successfully achieve atomic spatial resolution (below 0.3 nm). There is thus a need for cryo-EM design that is stable (minimal to no vibration) and can provide prolonged cooling periods, hence longer viewing times. 
Tech Transfer CIIMARCIIMAR - Interdisciplinary Centre of Marine and Environmental ResearchTech Transfer CIIMARBusiness Development Manager at CIIMAR - Interdisciplinary Centre of Marine and Environmental Research
View ProfileTech Transfer CIIMAR posted this:
Ultra-violet absorbing compounds with antimicrobial propertiesThe patent relates to novel compounds able to absorb UV radiation and comprize antimicrobial properties as well. The compounds herein described are novel and undisclosed scytonemin analogs, able to absorb up to 90% of UV-A radiation and cover a broader UV to blue light absorption. The compounds described can be easily incorporated into formulations to be used in cosmetic products, sunscreens or lenses for sunglasses.
Business Development Manager at CIIMAR - Interdisciplinary Centre of Marine and Environmental Research
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Ultrafast and sensitive humidity sensor with subsecond response timesThe Spanish National Research Council (CSIC) have developed a humidity senso r. This sensor allows to detect and quantify the surrounding humidity by optical transduction. The device is based in the optical response of a photonic crystal. This humidity sensor has been successfully tested showing response times under one second. Industrial partners manufacturers of sensors are being sought to collaborate through a patent license agreement. An offer for Patent Licensing
University of Vigo posted this:
Ultrafast quantum random number generatorUVIGO and ICFO have jointly developed a novel system for the random generation of numbers exploiting an elementary quantum optics process. This physical random number generator is based on the quantum random phase noise of a single-mode laser, which is transformed in random amplitude pulses and subsequently detected using a fast photodiode. Innovative aspects and advantages
University of Vigo posted this:
Ultrafast quantum random number generator Authors: Marcos Curty, Valerio Pruneri, Morgan Mitchell and Marc JofreUVIGO and ICFO have jointly developed a novel system for the random generation of numbers exploiting an elementary quantum optics process. This physical random number generator is based on the quantum random phase noise of a single-mode laser, which is transformed in random amplitude pulses and subsequently detected using a fast photodiode.
