TOP-seq: technology for high-resolution economical analysis of DNA epigenome

Summary of the technology

Dynamic patterns of DNA modification are part of epigenetic regulation in vertebrates, including humans, which contributes to normal phenotypic variation and disease risk and thus can be used as diagnostic and prognostic disease markers. We offer a robust and economical nucleotide-resolution technique (TOP-seq) for high-resolution mapping of epigenetic modifications in the genome using covalent tagging of the modification target sites.

Vilnius University

Details of the Technology Offer


Determination of genomic DNA modification profiles for research and diagnostics.


Epigenomic profiling, biomarkers, genomics, diagnostics, cell-free DNA.


Patents: EP2776575 (B1), US9347093 (B2), US9988673 (B2).

Applicant: Vilnius University.






Kriukienė et al. (2013)Nature Commun., 4: 2190.

Staševskij et al. (2017)Mol.Cell, 2017, 65: 554.

Daniūnaitė et al. (2019)Curr.Opin.Biotechnol., 2019, 55: 23

Current development status

Laboratory prototypes

Intellectual property status

Related Keywords

  • Biological Sciences
  • Biology / Biotechnology
  • Genome Research
  • Recombinant DNA
  • biomarkers
  • epigenomic

About Vilnius University

Vilnius University is the largest Lithuanian higher education and research institution. We are open for collaborative research, contract research or any cooperation activities with partners from business and public organizations. Multidisciplinary approach on R&D activities at Vilnius University provides unique opportunity to incorporate methodologies, perspectives, data and concepts from all scientific fields – biomedical, physical sciences, technologies, social sciences and humanities. We believe that the right mix of shared intentions with our partners and clients, outstanding teams of university researchers and open access to modern R&D infrastructure deliver remarkable solutions that can change organizations, markets and society in general.

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