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Fundación Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS)Fundación Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS)Fundación Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS)Technology Transfer Office
View ProfileFundación Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS) posted this:
In vitro method for detecting tumor growth and diagnosing or prognosticating the risk of metastasis in a human subject that has been diagnosed with uveal melanomaProblem to solve: Uveal ocular melanoma is the most common primary ocular malignancy in adults, with an incidence of approximately 7 cases per million inhabitants per year. Its incidence is therefore not very high, but it is a disease for which there are has been no alternative for more than 50 years. In addition, the American Cancer Society has published an increase in the incidence, having been diagnosed only in the United States 2,730 new cases in 2014. By the year 2018 there are anticipated 3,540 new cases in the USA. According to www.cancer.gov, the database of the National Cancer Institute of the USA, the age-adjusted average incidence of uveal melanoma in the United States is about 4.3 new cases per million inhabitants, without a clear variation related to latitude. Men have a higher incidence than women (4.9 vs. 3.7 per million). The age-adjusted incidence of this cancer has remained stable since at least the first years of the 1970s. Incidence rates in the United States are low compared with the rates of other reporting countries, which range from 5.3 to 10.9 cases per million. Part of the variation may be the result of differences in the inclusion criteria and calculation methods. Innovation: The present invention provides an in vitro method for detecting tumor growth and diagnosing or prognosticating the risk of metastasis in a human subject that has been diagnosed with uveal melanoma, wherein the biological sample is treated with a lysis agent capable of disrupting the membrane of the exosomes prior to determining the expression of the melanocyte protein PMEL/ME20-S/gp 100. This method incorporates new techniques that differentiate it from the potential competitors in several aspects. Our method is non-invasive (as it does not require a tumor biopsy), it does not require specific training and sampling is included in the hospital routine (blood extraction). Besides, it can be used after the application of the treatment, allowing not only to monitor the tumor advance and the early development of metastasis but also to help monitoring the effect of the treatment. In addition, it would be a more economical method.
Universidad de Granada posted this:
In vitro method for the diagnosis and/or prognosis of malignant melanomaA group of single nucleotide polymorphisms (SNPs) related to the risk and aggressiveness of malignant melanoma has been identified. Thus, an in vitro method based on these biomarkers identification is proposed for diagnosis and/or prognosis of malignant melanoma and, additionally, to determine whether these patients respond adequately to treatment. In the same way, it has been proved with in vitro and in silico expression assays that the proposed SNPs for risk and aggressiveness of malignant melanoma are reinforced.
CINBIO posted this:
In vitro method for the diagnosis or prognosis of neurodegenerative disordersThe diverse etiopathogenesis and the absence of biomarkers that can be used in the diagnosis of neurodegenerative and neurological diseases make difficult a correct diagnosis and treatment. Achieving a biomarker that helps to make the correct diagnosis and select the appropriate treatment for each patient in the less possible time is crucial for the patient’s complete recovery. The present invention is focused on the provision of a panel of biomarkers elected among LRP proteins of fragments thereof. It is proposed an in vitro method for the diagnosis or prognosis of neurodegenerative disorders based on new fragments of LRP (LRP1 and LRP2) in a biological sample, wherein if the level of expression of the concentration of the LRP fragment is significantly lower or higher (depending on the neurodegenerative disorder) as compared with the level measured in healthy controls, this is indicative that the subject is suffering the disease or has a bad prognosis. The proposed biomarker and a new nanosensor for the detection of the fragments in biological samples through Surface-enhanced Raman Spectroscopy (SERS) technology for the diagnosis of Major Depression in a early stage have been validated in a cohort of patients.
Nerea AlonsoFundación Biomedica Galicia SurNerea Alonso posted this:
IN VITRO METHOD FOR THE DIAGNOSIS OR PROGNOSIS OF NEURODEGENERATIVE DISORDERSIt is proposed an in vitro method for the diagnosis or prognosis of neurodegenerative disorders based on a new 48 KDa fragment of LRP1 (48 KDa – LRP1), wherein if the ratio of 48 KDa – LRP1 / proLRP1 level is significantly higher as compared with the level measured in healthy controls, this is indicative that the subject is suffering from major depression or has a bad prognosis. The proposed biomarker and a new nanosensor for the detection of the fragment 48 KDa–LRP1 and proLRP1 in biological samples through Surface-enhanced Raman Spectroscopy (SERS) technology for the diagnosis of Major Depression in an early stage have been validated in a cohort of patients.
Innovation Manager at Fundación Biomedica Galicia Sur
Medical University of ŁódźMedical University of ŁódźMedical University of Łódź posted this:
In vivo and in vitro experimental laboratory complexKeeping animals to research projects as well as own cultures. Cytotoxicity of a medical device in the form of an extract using in vitro assays: NRU, MTT, XTT, colony formation. Research projects in the field of neurology, orthopedics, toxicology, experimental surgery, oncology, metabolic and behavioral research (AnyMAZE, Morris pool, the cage of fear, IntelliCage) Conducting studies using GMOs. Training in procedures on laboratory animals. Renting test equipment.
Jagiellonian UniversityJagiellonian UniversityJagiellonian University posted this:
In vivo delivery system of the DNA modifying enzymesThe subject of the offer is a new method of in vivo genome editing with the use of hybrid nucleases, such as ZFN, TALEN and the CRISPR/Cas9 system, delivered to target cells by EVs derived from stem cells in serum-free conditions and defined as the RNA-containing vesicles expressing stem cells surface markers: CD90, CD105, CD147, CD309 (in more than 20% of RNA-positive events) and lack of expression CD45.
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
In vivo estimation of the fatty acids profiles of fish muscleIn vivo estimation of the fatty acids profiles of fish muscle CSIC has developed a method to predict the fatty acid profile of fishes, that can be applied on the living organisms, avoiding the need of sacrifice. This allows for a periodic monitoring of profiles in individuals and populations, being therefore a method of great interest in aquaculture or research of wild populations. Industrial partners in the field of aquaculture are being sought to collaborate through a patent licence agreement for its use and exploitation. An offer for Patent Licensing
University of WaterlooUniversity of WaterlooUniversity of Waterloo posted this:
In-vehicle detection of distracted driving using mmwave radar technologyBackground Distracted driving is a serious problem that can lead to fatalities. Identification of distracted driving is commonly performed with machine learning methods using cameras. The use of cameras is invasive and requires significant amounts of processing power to be performed in real time. Additionally, current solutions lack the ability to rapidly calibrate to different operators. Mmwave devices require smaller data input sizes, potentially allowing for rapid calibration of devices before use, in addition to being non-invasive since no optical data is recorded. Mmwave devices also generate a 3D scattered image of the interior of the vehicle, which gives more spatial information than optical imaging, which generates a 2D image, potentially allowing for more precise classifications given more identifiable information.
Maria João CardosoInstituto de TelecomunicaçõesMaria João CardosoIntellectual Property and Technology Manager at Instituto de Telecomunicações
View ProfileMaria João Cardoso posted this:
Increasing the information capacity of optical communications through embedded data modulation over pilot symbolsMethod to perform modulation over pilot symbols in communications systems employing quadrature amplitude modulation (QAM). It allows to either increase the delivered bit-rate of the transmission system while keeping the same operating bandwidth and/or reduce the required signal-to-noise ratio (SNR) for error-free operation. It does not incur performance penalty or added computational complexity.
Intellectual Property and Technology Manager at Instituto de Telecomunicações
- University of WaterlooUniversity of Waterloo
University of Waterloo posted this:
Indoor 5G wireless transmission over powerlinesBackground To provide the best 5G service, wireless service providers deploy Centralized Radio Access Networks (C-RAN) in which digital baseband processor units (BBUs) and their associated remote radio units (RRUs) are detached from each other and are connected by a fronthaul transport fiber-optic link. 5G signal has limited indoor coverage due to its high frequency and therefore, multiple RRUs must be deployed in a building for indoor users. Providing indoor 5G access for apartments in a building where there are no fiber infrastructure in place is therefore a major challenge.
University of Porto posted this:
Indoor environmental quality (IEQ) system and DBT platformThe present invention consists in a complete Indoor Environmental Quality (IEQ) system designed to evaluate and summarize the quality of dynamic indoor environments. The system uses a variety of high-precision sensors to collect environmental data, which is subsequently processed by a set of proprietary algorithms. The information is presented on a specially designed online visualization platform, enabling different stakeholders—technicians, building management entities, and end users—to easily interpret the data. The invention as a whole is a comprehensive system that efficiently gathers, analyzes, and presents relevant indoor environmental data.
IMDEA Energy posted this:
Indoor testing of materials, solar concentrators, receivers, PV modules and daylighting devicesHigh-flux solar simulator (HFSS) to conduct research on synthesis and surface treatment of new materials is offered. High-flux solar simulators are specifically designed to recreate the high radiation intensity distribution usually met in concentrating solar systems.We are looking for commercial agreement with technical assistance and research cooperation agreement. Application in thermal electricity generation, solar thermochemistry to produce fuels and commodities, or synthesis and surface treatment of materials. High concentration photovoltaic systems usually operate above 100 kW/m2. High flux solar simulators are designed to recreate the high radiation intensity distribution usually met in concentrating solar systems.
Fabian BelinLuxembourg Institute of Science and Technology (LIST)Fabian BelinPartnerships Development & IP Valorization at Luxembourg Institute of Science and Technology (LIST)
Fabian Belin posted this:
Industrial production of humic and fulvic acid from biomethan digestateAnaerobic digestion is a process able to degrade organic waste to methane using a diverse microbial community. However, not all organics present in the feedstock can be biologically degraded and the undegraded fraction are disposed to fields or incinerated. This fraction, called the digestate, is underexploited and represents an interesting source of humic substances as they remain undegraded during the AD process. Our solution consists of a series of process to extract and concentrate those humic substances, specially fulvic acid. The first step is the mechanical separation of the liquid and solid phases. Then the liquid fraction undergoes a serie of filtration to remove inorganic precipitates, large particules and impurities. Then the concentration is done by reverse osmosis where the water is removed, and the humic substance solution retained. This technology allows a recovery of 60% of the humic substances in a solution containing at least 50% of fulvic acids. Further concentration steps can be done if necessary to obtain a solution with a minimum concentration of 12% w/w.
Partnerships Development & IP Valorization at Luxembourg Institute of Science and Technology (LIST)
Yeda posted this:
Inertial NEMS for Nanosensor Applications Based on Inorganic NanotubesInertial sensors for motion detection are being incorporated into an increasing number of portable devices, including diverse IoT applications, mobile phones, wearable electronics, automotive systems and medical diagnostic sensors. The current size reduction trend in electronics, requires incorporation of reliable nanoelectromechanical systems (NEMS) into nanosensors, yet market applications of NEMS are currently limited by high costs of fabrication and inconsistent quality. A new technology developed by a group of researchers from the Weizmann Institute, provides a unique, highly reproducible structure for inertial nanosensors, with high durability at the nanoscale and with a detection mechanism based on the piezoresistive effect. The invention further extends application opportunities of extremely small portable electronics, which, with the increasing use of spatial awareness in reduced size electronics and IoT, is expected to witness increasing market demand.
Jorian Bos posted this:
INFINITE FAUNDRY - Production Efficiency Digital-Twin Solutions for IndustryThe Problem Industrial production planning consistently fails • Production management tools are archaic, usually • Excel, with mistaken manufacturing capacity • Production optimization is done on a trial and error basis which is erroneous and time-consuming • Inaccurate production planning lead to quality defects that cost €200 billion per year to industry
Other at EIT Digital
Michael Burlakov posted this:
Information technology of automation of control of discrete technological and information processes (IT AC DTIP)Now, we have with you the all chances to create a unique company for implementing worldwide of a new science-intensive technology with many applications (see below). I invite you to participate in realization of this ambitious project in any capacity. Agree that far from often appears a new production company, when at the time of its creation becomes clear that it has all chances to become a world leader in its future activity. This is possible, obviously, only in the case that the basis for the activities of such a company will be the unique science-intensive know-how, the implementation package of which already exists. This is the case here for your consideration. The author of this letter (further - the author) recently completed his years-long work on the information-software package of materials (ISPM) on implementing a new science-intensive network technology with many applications called "Information technology of automation of control of discrete technological and information processes (IT AC DTIP)", the founder of which he is. With the presentation of both the technology itself and the ISPM for its implementation, you can familiarize here: https://www.slideshare.net/michael_burlakov/presentation-of-it-ac-dtip . More detailed information on this project you can learn from two English-Russian sites of the author:"Promotion Center of IT AC DTIP" (http://dtip-burlakov.com/en) and "Implementation Center of IT AC DTIP" (http://dtip-optim.com/en/main). I would like to draw your attention to the fact that this ISPM includes 11 multilingual optimizing software tools in the ordinary and network performances that allow to provide international network outsourcing services on optimal controlling the discrete processes for many purposes. So, for practical implementation of this technology, there are not required at all the financial investments for working out necessary for this means, since the latter ones already exist.
Scientist at Private person
Sayali WaradUniversity of Alberta, Technology Transfer ServicesSayali Warad posted this:
Inherently Matched Electrically Small Antennas-Inherently matched small antennas for use in body-worn RFID sensors -Suitable for use in space-constrained and complex dielectric environments
IP Market Analyst at University of Alberta, Technology Transfer Services
University of Huelva posted this:
INHIBITOR SYSTEM AGAINTS HARDWARE ATTACK ON THE I2C BUSThe effect of a clock glitching attack over the I2C communication process between master and slaves could have serious consequences in robot and control industrial system. This inhibitor is capable of detecting and defending attacks against to the clock signal in the I2C
University of Alberta, Technology Transfer ServicesUniversity of Alberta, Technology Transfer ServicesUniversity of Alberta, Technology Transfer Services posted this:
Inhibitors of Viral Infectivity: Amphipathic Nucleoside Derivatives as Fusion InhibitorsA series of small pharmacological molecules have been discovered to be potent and non-cytotoxic inhibitors of viral fusion. The inhibitors act on the non-virally encoded lipids in the virion envelope. These molecules are rigid amphipathic compounds of inverted cone shape which locate to the outer leaflets of virion envelopes, creating a physical barrier to viral envelope and cell membrane fusion. These amphipathic nucleoside derivatives can serve as potential antiviral or therapeutic agents against herpes, HIV, influenza, hepatitis B & C, poxvirus and other DNA or RNA enveloped viruses. They can potentially be used as prophylactic ingredients in creams, lotions, gels and as antiviral disinfectants.
Covid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by Innoget posted this:
Inhibitors of Viral Infectivity: Amphipathic Nucleoside Derivatives as Fusion InhibitorsA series of small pharmacological molecules have been discovered to be potent and non-cytotoxic inhibitors of viral fusion. The inhibitors act on the non-virally encoded lipids in the virion envelope. These molecules are rigid amphipathic compounds of inverted cone shape which locate to the outer leaflets of virion envelopes, creating a physical barrier to viral envelope and cell membrane fusion. These amphipathic nucleoside derivatives can serve as potential antiviral or therapeutic agents against herpes, HIV, influenza, hepatitis B & C, poxvirus and other DNA or RNA enveloped viruses. They can potentially be used as prophylactic ingredients in creams, lotions, gels and as antiviral disinfectants.
Yeda posted this:
Inhibitory Proteins for 20S Proteasome Regulation as Cancer TreatmentProteasomal protein degradation is crucial in maintaining cellular integrity and in regulating key cellular processes including cell cycle, proliferation and cell death. The 20S proteasome can function as an independent degradation machinery and tight regulation must exist to control its proteolytic capacity. Despite the major importance of 20S proteasome regulation only a small number of regulators have been identified to date. Here, we discovered a novel family of inhibitory protein - CCRs (Catalytic Core Regulators) that specifically regulate the 20S proteasome, and not the 26S counterpart, and increase its effectiveness in cancer treatment.
Mohammed VI Polytechnic UniversityMohammed VI Polytechnic UniversityMohammed VI Polytechnic University posted this:
Ink for Anti-Counterfeiting security applicationsA novel photoluminescent ink has been formulated by synthesizing Eu(FAC)3Phen as a red luminescent down-shifting emitter and employing SrAl2O4:Eu, Dy as a long persistent green phosphor. Both emitters are incorporated to design a photoluminescent ink with binary emission under a single UV excitation wavelength, where a red light is emitted when exposed under 325 nm, subsequently becoming green upon the UV light being switched off. The concept presented here is unequivocally distinct from the classical dual-mode emission, which requires a second extra near-infrared excitation around 980 nm to produce a binary luminescence.
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Ink for the production of superconducting flexible tapesInk for the production of superconducting flexible tapes CSIC, through the Institute of Materials Science of Barcelona ICMAB have developed a new YBCO precursor solution suitable for TLAG-CSD growth of superconducting films. Industrial partners are being sought to collaborate through a patent license agreement. An offer for Patent Licensing
Alfonso del Rey PérezICMAB-CSICWard Vleegen posted this:
Innovation Book on Vehicle Electrification (electric drivetrains, battery pack technologies, thermal management etc)We created an Innovation Book that contains the innovations from our member companies active in vehicle electrification. This Innovation Book is freely available as an E-Book to Automotive OEMs and Tier-1 Suppliers. Contact me if you want to get access to this E-book (only Automotive OEMs & Tier-1 Suppliers).
Business Development Manager at Agoria
PhD Isabel Gavilanes-Perez (RTTP)Spanish National Research CouncilPhD Isabel Gavilanes-Perez (RTTP)Open Innovation Manager at Spanish National Research Council
View ProfilePhD Isabel Gavilanes-Perez (RTTP) posted this:
Innovation in the Advanced Production of Semiconductor Qubits for quantum computingA semiconductor qubit fabrication with high precision, scalability, and complete alignment control, utilizing advanced lithography and manufacturing solutions to ensure maximum density and uniformity in industrial production.
Open Innovation Manager at Spanish National Research Council
Octavi Rodriguez posted this:
Innovative and customizable platform for mobile communication between users and professionals.This is the first platform available that permits safe and qualified communication between smartphone users a healthcare professionals. It can be easily customized and adapted the any company's needs, so they can have their own communication platform with a low investment. This can be offered as an extra service to their clients, either for free or with a pay-per-query system. Companies and users can reduce their costs and gain time as in many cases the use of this technology will make visit in person unnecessary. It will optimize resources, and also can be an alternative source of income.
CEO
Universidad de AlicanteUniversidad de AlicanteUniversidad de Alicante posted this:
Innovative and efficient antifungal composition for pharmacological (human &veterinary treatment), phytosanitary and cleaning (detergents) applicationsThis technology aims to help controlling resistant strains of important filamentous fungi and yeast fungi (e.g. Candida spp.) originated after prolonged treatment with currently used antifungals. The present invention provides for these purposes: a) The use of novel antifungals (COS and chitosan). b) The combined use (synergical) with existing antifungals (e.g. fluconazole) to reduce their doses. c) The use of COS and chitosan (alone or in combination with existing synergical antifungals) with an inhibitor of ARL1 gene to increase the sensitivity of fungi (including yeast) or their chitosan oligosaccharides (COS). Several experiments carried out have shown the significant synergistic effect of the combination object of the present invention (chitosan or COS, and an inhibitor of ARL1 gene or a currently used antifungal such as fluconazole) in inhibiting growth of filamentous fungi and yeast. Chitosan and COS are non-toxic for mammals, and therefore, they have a particular interest to use them as antifungal agents in some applications.
