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Germans Trias i Pujol Health Sciences Research Institute (IGTP) posted this:Biosignatures for ulcerative colitisCurrently, the glucocorticoids are the first-line of treatment for of moderate-to-severe flare-ups. However, up to 40% of patients do not have an adequate response. Mechanisms of steroid-refractoriness in UC remains unknown. In addition, corticosteroid failure impair the effectiveness of rescue therapies.
Technology Transfer Office
TTPU posted this:Anti-adhesive Biopolymer CoatingResearchers have developed an anti-adhesive coating based on a polymer naturally and sustainable produced by a marine bacterium. This coating prevents the bacterial adhesion and the subsequent biofilm formation that usually leads to host bacterial infections difficult to eradicate and control with the antibiotics currently in use, namely in hospital environments. This coating can be applied in a cost effective way to a broad range of materials through the application of a universal glue.
University of Huelva posted this:New procedure for the genetic transformation of plant cells and kit for carrying out said methodThe strategy for transformation is extremely simple and does not involves subcloning the gene of interest in any vector. The kit is not based on specific promoters or regulatory DNA sequences, thus it can be applied to many different plant species, from unicellular microalgae to higher plant protoplasts. Since the strategy is not based on specific promoter or regulatory DNA sequences, only the marker and the gene of interest sequences are inserted in the microalgal genome, avoiding the introduction of undeserible DNA sequences in the transformant strain. This is very important given the concern that transfer of exogenous DNA through transgenesis causes in the public opinion
Universidad de Alcalá-OTRI posted this:Antimicrobial electrospun fiber membrane with retention and controlled release capacity of active substancesResearchers from the Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering of the University of Alcalá in collaboration with researchers from the Department of Chemistry and Physics of the University of Almería, presents a procedure for the manufacture of active membranes based on submicron fibers combining an antimicrobial action with the ability to retain apolar contaminants in aqueous solution. The membranes are produced by an electrospinning process in aqueous solution from mixtures of water soluble polyacids and polyols, which are subsequently stabilized by a thermal curing process and post-functionalized by the incorporation of amino-terminated dendrimers by a grafting process using a coupling agent. The material can be applied to the treatment of drinking water, to the regeneration of waste water, to the treatment of process waters and also to the controlled release of active substances, such as drugs, food preservatives, etc. The group seeks companies from the pharmaceutical, food, material technology and environmental sectors to sign technical cooperation agreements, commercial agreement with technical assistance and patent licensing agreements.
University of Vigo posted this:Valorization of whey and vinasses by producing antimicrobial extracts using biotechnological processesThis invention is based on the production of antimicrobial extracts with potential application against pathogenic microorganisms. The biotechnological production of antimicrobial metabolites was carried out using Lactobacillus plantarum strains. Two industrial wastes, whey, and wine distilled lees (or vinasses) were assayed in order to make the process economically competitive with regard to the chemical one. The extracts are mainly composed by lactic acid, 3-phenyllactic and bacteriocins. Whey was enzymatically hydrolyzed and the solutions were fermented sequentially or simultaneously. The bioprocesses were carried out continuously or discontinuously
Institute of Chemical Research of Catalonia posted this:Crysforma: services in pharmaceutical solid state developmentCrysforma provides complete scientific support for the discovery, analysis and scale-up of polymorphs, hydrates, amorphous phases, salts and co-crystals of active pharmaceutical ingredients or intermediates. Crysforma has developed its own crystallization screening methodology based on the combination of several crystallization procedures. We use high-throughput crystallization systems controlled by highly skilled scientists to maximize the information drawn from each experiment. Our projects are always carried out in close collaboration with the client, adapted to the customer's needs and under strict confidentiality conditions.
UATEC - Unidade de Transferência de Tecnologia posted this:Device for chromatic counting and quantification of organisms or particles in a suspensionThe execution of ecotoxicological tests with organisms in liquid medium, eg. Daphnia sp., requires its counting and characterization to evaluate several parameters. Currently the score is performed by technicians by direct observation (“naked eye”) of exposed organisms. This process is slow, tiring and subject to human error, and it can have adverse effects on visual acuity of the technical staff involved in the count. This patent, developed in a Portuguese university, solves the problem by counting and automating this process with gains in runtime and accuracy and enabling quick and efficient recount. It follows the optimization of the process of assessing the exposure to contaminants in tests that require the use of small-sized organizations. The university is looking for companies interested in the production and commercialization of this industrial equipment.
UATEC - Unidade de Transferência de Tecnologia posted this:Biopolymer based micro- and nanoparticlesA group of researchers from a Portuguese university developed a method for preparing new hybrid materials based on biopolymer and silica, in the form of spherical particles with uniform size and smaller than 1 micrometer for a number of applications in environmental and industrial areas. The method is also effective for coating nanoparticles of variable nature, with a thin shell (tens of nanometers) with composition identical to the hybrids. The materials have been successfully tested in the removal of chemical species in water at laboratory scale, in particular in the removal of organic pollutants dyes and pharmaceutical compounds. Other applications are being considered. The University looks for companies working in the environmental, pharmaceutical or biotechnology areas, or companies in the area of materials for licensing and / or future collaboration in developing new formulations and testing new applications.
UATEC - Unidade de Transferência de Tecnologia posted this:Electrochemical biosensor for the detection and quantification of alkylphenols.A group of researchers from Portuguese university developed a biosensor for the detection and quantification of alkylphenols (AP). This invention constitutes a fast, efficient and accurate method for the quantification of these contaminants, found in items ranging from detergents and pesticides to plastics, textiles and fuels. The apparatus has already been successfully tested in real samples and demonstrated to be faster and more efficient than the commonly used techniques for the quantification of AF, not requiring additional steps, namely, for sample preparation.
Universidad de Alcalá-OTRI posted this:Carbosilane dendritic compounds homo and heterofunctionalizedA Spanish research group from the Department of Organic and Inorganic Chemistry of Alcala University has developed a highly branched macromolecules called dendrimers or dendrons, with carbosilane structure and functionalized on its periphery with anionic or cationic groups, providing the macromolecule a net negative or positive charge respectively. The invention also concerns the dendrimers’ procurement process and their biomedical applications, particularly as carriers of drugs or nucleic acids (such ODN, siRNA, dsRNA or DNA), or as therapeutic agents with antiviral or antibacterial activity. The group is looking for companies in the biomedical sector to reach licensing agreements, collaboration and commercial agreements with technical assistance.
UNIVERSIDAD DE ALICANTE posted this:Sustainable production of biofuel (bioethanol) from shellfish wasteThe research group of Plant Pathology at the University of Alicante has developed a new process by using fungi to produce biofuel (bioethanol) and fungal biomass for agrobiotech use from shellfish waste. It is a sustainable alternative to agroforestry crops currently used. The current technology stands out because it uses chitosan as the sole source of nutrients, and produces bioethanol in profitable, sustainable and environmentally friendly manner. The research group is looking for companies or investors partners interested in acquiring this technology for commercial exploitation.
UNIVERSIDAD DE ALICANTE posted this:Research and development into new fertilizers and biostimulantsThe research group Agricultural Chemistry of the University of Alicante has extensive knowledge and experience in the development of new fertilizers, biostimulants, iron chelates and inductors for plant defense system. It also has plant growth chambers, greenhouses and scientific-technological equipment to carry out different types of analysis. We offer our services to companies interested in developing R&D&i, specific training related to the research and any scientific and technical support.
Universidad de Alcalá-OTRI posted this:New organo-metallic catalysts for the manufacture of polymersA research group from the Inorganic Chemistry Department of Alcalá University has developed a technology that presents a range of catalysts based on coordination complexes and organometallic, active in functionalization processes (expoditation, hydrosilylation) and polymerization of different organic substrates (olefins and cyclic esters). They are metal complexes belonging to the first transition groups (groups 4-6) and elements from the main groups (groups 1,2 and 13). Its application is aimed at the synthesis of materials with new properties (silicon polymers, biodegradable plastics, polyesters) and the production of small molecules with high added value, used as starting products in many industrial processes (epoxides, silanes). The group is looking for manufacturing agreements and joint venture agreements with companies from the agrofood industry, construction and petrochemicals.
Centre Technology Transfer CITTRU posted this:Nanocapsules for delivery of lipophilic compounds and method of their preparationThe present invention provides novel biocompatible “core-shell” systems and the surfactant-free method of their preparation using macromolecular compounds. Biocompatible nanocapsules with liquid cores which enable effective encapsulation of hydrophobic compounds are stabilized without low molecular weight surfactants. These beneficial features significantly increase the range of possible applications.