UATEC - Unidade de Transferência de Tecnologia posted this:Electrochemical biosensor for the detection and quantification of alkylphenols.A group of researchers from Portuguese university developed a biosensor for the detection and quantification of alkylphenols (AP). This invention constitutes a fast, efficient and accurate method for the quantification of these contaminants, found in items ranging from detergents and pesticides to plastics, textiles and fuels. The apparatus has already been successfully tested in real samples and demonstrated to be faster and more efficient than the commonly used techniques for the quantification of AF, not requiring additional steps, namely, for sample preparation.
Universidad de Alcalá-OTRI posted this:Double mesh prosthesis that corrects defects in the abdominal wall and prevents adhesion formation at the peritoneal interfaceA research group from the Surgery Department of Alcala University has designed an implantable prosthesis made of two meshes joined together, for abdominal surgery uses. This prosthesis prevents the erosion of the viscera by promoting mesothelial deposition. Both meshes induce fibroblast proliferation and collagen deposition achieving the definitive repair of the defect at the expense of connective tissue. This research group is looking for manufacturing and license agreements.
Universidad de Alcalá-OTRI posted this:Disposable electrodes based on filtered nanomaterials.A Spanish research Group from Analytical Chemistry, Physical Chemistry and Chemical Departments at University of Alcalá (Spain) has designed and developed different disposable electrodes constituted exclusively by conducted nanomaterials for analytical measurement of electroactive molecules for (bio-) sensoric in relevant areas such as health, agri-food and environmental. The group is looking for companies in the chemistry, clinical, agri-food and environmental sectors to reach licensing agreements or collaboration and commercial agreements for technical assistance.
Creative Biogene posted this:Human RXFP1-FLAG Stable Cell Line-HEK293TThe relaxin family peptide receptor RXFP1, also known as LGR7 or RX1, is a 757-amino acid 7 transmembrane protein. RT-PCR detected RXFP1 expression in various organs of the reproductive system along with the brain, heart, and lungs. RXFP1 is known to be important to the connective tissue cells of the breast and play a central role in endometrial deciduation. https://www.creative-biogene.com/Human-RXFP1-FLAG-Stable-Cell-Line-HEK293T-195279-11.html
RAMOT at Tel Aviv University Ltd. posted this:Zymoxins, HCV NS3 protease-activated chimeric toxins:a novel antiviral therapy for the treatment of HCV infectionsRationally designed viral-protease activated chimeric toxins were developed (“Zymoxins”). The chimeric toxins were constructed by fusing diphtheria toxin A (DTA) or Ricin A chain (RTA), to an inhibitor peptide/domain (defensin for DTA; ribosome stalk peptide for RTS) via an HCV NS3 protease-cleavable linker, thus converting a constitutively active toxin to an HCV NS3 protease-activatable form. The HCV NS3 protease is a virally encoded protease which expression and activity in infected cells is essential for viral replication/maturation. Thus these zymoxins are activated in HCV infected cells which specifically express HCV NS3 protease. In addition, the Zymoxins were fused to the binding and translocation domain of Pseudomonas exotoxin A (PE) for efficient delivery to the cell cytosol, where the toxins inactivate elongation factor 2 (DTA) or inactivate ribosomes (RTA) and cause cell death. For increased specificity, the non-specific cell binding domain I of PE can be replaced with target-specific antibodies. Project ID : 2-2011-177
RAMOT at Tel Aviv University Ltd. posted this:Macrolid Induced Correction of Premature Stop Codons: A novel Treatment for Colorectal CancerAn antibiotic of the Macrolid family was demonstrated as a new treatment for colorectal cancer and other genetic human diseases that arise from pre-mature stop codons in important coding sequences. Project ID : 10-2007-109
RAMOT at Tel Aviv University Ltd. posted this:System for Automatic Pathology Detection & Categorization in Chest Radiographsmethods to provide automated segmentation of lesions and tumors, with minimal user interaction; the computerized algorithms will enable a reproducible measure, which is one of the most critical criteria for measurement; in addition, automated tracking over time will be developed. Given a new case, automated tools will enable the extraction of a previous case of the patient, based on which the current case can be analyzed more in context, and the abnormalities can be more accurately detected, segmented and measured. Project ID : 8-2012-310
RAMOT at Tel Aviv University Ltd. posted this:Iron oxide nanoparticles (IOP) for the treatment of acute myocardial infarction (AMI) and other inflammatory conditionsA novel approach for the treatment of AMI has been developed using IOPs. IOPs, when injected into the infarcted myocardium, lead to improved heart function after MI. IOPs activate anti-inflammatory macrophages and thus promote tissue healing and repair and prevent myocardial remodeling and dysfunction. Potential Applications IOPs can be used to treat AMI and other inflammatory conditions associated with pro-inflammatory activated macrophages and to promote tissue healing and repair. Advantages ? IOPs are nontoxic ? IOPs are FDA approved for use in humans for MRI imaging Stage In vivo studies in mouse and rat models of MI and heart failure Project ID : 10-2011-247