Biology / Biotechnology Technology Offers

Centre Technology Transfer CITTRU posted this:

Method for conjugation of biomolecules and its new use The subject of the offer is a novel method for conjugation of free thiol group(s) containing biomolecules comprising a biomolecule reaction with a gold-donor agent in which a -S-Au-S- bond is formed. Specifically, the method leads to a complex formation that is a protein cage. The new method comprises following steps: (i) biomolecules preparation, (ii) conjugation of biomolecules by reaction of biomolecules with gold-donor and (iii) purification of conjugation product.

Method for conjugation of biomolecules and its new use

Centre Technology Transfer CITTRU posted this:

In vivo delivery system of the DNA modifying enzymes The subject of the offer is a new method of in vivo genome editing with the use of hybrid nucleases, such as ZFN, TALEN and the CRISPR/Cas9 system, delivered to target cells by EVs derived from stem cells in serum-free conditions and defined as the RNA-containing vesicles expressing stem cells surface markers: CD90, CD105, CD147, CD309 (in more than 20% of RNA-positive events) and lack of expression CD45.

In vivo delivery system of the DNA modifying enzymes

Yissum - Research Development Company of the Hebrew University posted this:

A Novel Synthetic Peptide to Inhibit Biofilm Creation of Bacillus cereus bacteria a novel synthetic peptide, for the inhibition of bacterial cell-cell communications (quorum sensing, QS), in order to inhibit virulent gene expression. Specifically, for Bacillus cereus bacteria Project ID : 23-2018-4670

Yissum - Research Development Company of the Hebrew University posted this:

Computational Tool for the Design of a Personalized Protocol for Cancer Therapy, Based on Protein Expression Cluster7 Cluster8 From big data analysis to personalized medicine in cancer: towards the development of a computational tool for the rational design of patient-specific combination therapy. Project ID : 10-2016-4322

Computational Tool for the Design of a Personalized Protocol for Cancer Therapy, Based on Protein Expression

Yissum - Research Development Company of the Hebrew University posted this:

Anti-Infectious Coating for Dental Implants Self-assembly of fluorine-capped moieties for prevention of biofilms Keywords: self-assembly, dental, dentistry, biolfilm, disruption Project ID : 9-2015-3142

Anti-Infectious Coating for Dental Implants

Yissum - Research Development Company of the Hebrew University posted this:

Algorithm to Identify Drug Candidates for Liposomal Reformulation Modeling structural drug descriptors for loading and leakage properties of liposomal drugs for the rational identification of new liposomal drug candidates. Project ID : 6-2016-4303

Yissum - Research Development Company of the Hebrew University posted this:

A New Tool to Diagnose and Monitor IBD Using Circadian Gene Expression A New Tool to Diagnose and Monitor IBD Using Circadian Gene Expression Project ID : 8-2018-4562

Yissum - Research Development Company of the Hebrew University posted this:

Pro-Nano Lipospheres as Oral Delivery Platform for Lipophilic Drugs Cluster9 oral dispersible concentrate preparation for improving the bioavailability and distribution of lipidic drugs that are substrates of first pass intestinal metabolism and/or are substrates of Pgp efflux. Thus, the formulation elevates the amount of drug that reach the systemic blood circulation and reduces the variability in the oral absorption properties. Project ID : 6-2008-2126

Pro-Nano Lipospheres as Oral Delivery Platform for Lipophilic Drugs

Yissum - Research Development Company of the Hebrew University posted this:

New CNS-Active Carbamate Derivatives for Epilepsy New CNS-active carbamate derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide with a broad potent antiepileptic activity Project ID : 6-2017-4419

New CNS-Active Carbamate Derivatives for Epilepsy

Yissum - Research Development Company of the Hebrew University posted this:

Nano-Particles for Intranasal Delivery of Biodegradable Neuropeptide Cluster9 Project ID : 6-2014-3054

Nano-Particles for Intranasal Delivery of Biodegradable Neuropeptide

Yissum - Research Development Company of the Hebrew University posted this:

Small Molecules Antagonists Of Toll Like Receptor 9 For Treatment Of Inflammatory Conditions Toll-like receptors, receptors of the innate immunity, play a critical role in the development of many pathological states, in acute and chronic inflammatory processes. Therefore, TLRs represent a new direction for immunotherapy. In order to discover novel ligands interacting with TLRs, Iterative Stochastic Elimination, an innovative beyond-state-of the-art in Silico method for predicting the chances of molecular bioactivity were employed (HUJI IDR). The most promising drug candidates were verified by a cell-based test-system (Fraunhofer IGB) that allows TLR antagonists/agonist to be identified in a reporter gene assay. The ISE process in addition with the assay lead to novel immune modulating therapeutics Project ID : 6-2015-3128

Small Molecules Antagonists Of Toll Like Receptor 9 For Treatment Of Inflammatory Conditions

Yissum - Research Development Company of the Hebrew University posted this:

Oral Delivery Platform for Lipophilic Drugs Based on Pro-Nano Lipospheres Cluster9 Dispersible Concentrate Lipospheres for the Delivery of Agents (PNL) Project ID : 6-2017-4492

Oral Delivery Platform for Lipophilic Drugs Based on Pro-Nano Lipospheres

Yissum - Research Development Company of the Hebrew University posted this:

Personalizing Risk Assessment and Treatment Decisions in Cancers Cluster8 A unified method for the diagnosis and treatment of cancer based on the Expression of the Cancer Tetis Antigen gene Family in Individuals. CTA genes are very active during cellular differentiation and growth and non-active otherwise. The biopsy is beeing tested. Big database. Project ID : 19-2016-4283

Yissum - Research Development Company of the Hebrew University posted this:

Small Molecules for Treatment of Diabetes by Induction of Cellular Senescence ENHANCEMENT OF GLUCOSE-STIMULATED INSULIN SECRETION BY CELLS THROUGH INDUCTION OF CELLULAR SENESCENCE Project ID : 6-2016-4284

Small Molecules for Treatment of Diabetes by Induction of Cellular Senescence

Yissum - Research Development Company of the Hebrew University posted this:

Repurposing of an Approved Drug to Increase NKp30 Ligands for Cancer Immunotherapy THE USE OF “INTEGRATED STRESS RESPONSE” ACTIVATORS FOR ENHANCING B7H6-TRAGETED TREATMENTS Project ID : 6-2018-4573

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