DIT Hothouse posted this:U-Learn: A Training Model for Breast Ultrasound imagingU-learn is a training and learning model for radiographers and registrars for training in breast ultrasound imaging. The model assesses the performance of a trainee registrar before, during, and after training using the ultrasound imaging phantom which is a realistic representation of the breast.
DIT Hothouse posted this:Cervassist: Cervical Cancer AnalyserCurrently, cytologists are needed to examine smear samples under a microscope to visually assess the shape, size and stain pattern and determine if abnormal cells are present which could indicate cervical cancer. Alternatively, automated image analysis is used to determine nuclear density but cytologists are still needed to determine the presence of abnormal cells. The current processes are prone to human error and misdiagnosis can be up to 60%. They are also time consuming and costly.Sample user interface for spectral acquisition and classification. Researchers at DIT have invented an easy to use, low cost, automated analyser that uses a pre-defined library of known cell signatures and a proprietary classification algorithm to detect abnormal cells with an accuracy of 99%. The analyser can be used with a regular microscope, an image analyser or as a point-of-care system with results displayed using an intuitive user interface. The image and the classification can be saved in digital format, stored in a national database, and sent to the medical team or experts worldwide
Universidad de Alcalá-OTRI posted this:Anticancer activity of Ru (II) Arene complexes with oxime ligands.Spanish research group from the department of Inorganic Chemistry the University of Alcala, together with a Moroccan research group from the University of Abdelmalek Essaadi, have developed a process to synthesize metal complexes with anticancer properties, which can be used for cancer treatment and prevention. The group is looking for companies working in the pharmaceutical and biomedical sector to achieve license, collaborative or commercial agreements with technical assistance.
IMIM Institut Recerca Hospital del Mar posted this:A prognostic and predictive serum biomarker in Small Cell Lung CancerPeripheral blood and its components (serum, plasma, and circulating cells) is an easily accessible fluid. An ELISA-based system that exploit circulating protein biomarkers found in this medium is more convenient to the patient compared to a more invasive lung biopsy. The researchers have found that high levels of serum hepatocyte growth factor (sHGF) protein in patients with SCLC shows clearly predicted for shortened survival and an incremental risk for death. HGF is a natural ligand for the oncogenic epithelial transition factor (c-Met) transmembrane tyrosine kinase receptor and serum HGF could be predictive of individual responses to new anti-cancer drugs: the Met inhibitors. The Met inhibitors are targeted therapies against c-Met receptor that are currently in development for the treatment of other neoplasms and are planned to be evaluated in SCLC. Therefore, a biomarker of prediction of response to these new Met inhibitors would be crucial for correct selection of patients for the clinical trials. Incorrect selection through other biomarkers in NSCLC has leaded to lack of benefit from these drugs in already performed phase 3 clinical trials, stressing the relevance of correct patient selection
Pragmatec posted this:Portable device for early detection of cervical cancer that provides immediate results using Biophotonics and Bioimpedance.This portable, non-invasive device scans different areas of cervical tissue, taking electrical measurements in different frequency ranges, optical measurements and wavelengths. The measurements are then processed by a configurable device or micro-controller in accordance with mathematical formulas obtained from multiple measurements taken from healthy and cancerous tissues.Three possible responses can be obtained immediately on the spot from the processing of the measurements: healthy tissue, cancerous tissue or the presence of human papilloma virus.
Universidad de Alcalá-OTRI posted this:Semipurified fraction of Ganoderma lucidum with antitumour activity (cytotoxic activity and apoptotic cells in murine lymphoma and human leukemia)A fraction of compounds obtained from Ganoderma lucidum has been described. This fraction is active on murine lymphoma DA-1 cells and human leukemia NB4 cells. This fraction induced DNA fragmentation, changes in cell membrane and cell death. The innovation lies on the antitumor activity, the source of such compounds (the mushroom Ganoderma lucidum grown in stablished conditions developed in our lab).
Small and Medium Enterprise
Creative Biogene posted this:Human SSTR2-FLAG Stable Cell Line-CHOSomatostatin receptors are activated by somatostatin secreted from nerve and endocrine cells. The Somatostatin Receptors (SSTRs) are expressed in a tissue-specific manner and involved in the regulation of secretion of insulin, glucagon and growth hormone as well as cell growth induced by neuronal excitation in both the central and peripheral nervous systems. Aberrent expression of somatostatin receptors is known in a large number of human tumours. SSTR2 is expressed in highest levels in the stomach, jejunum, cerebrum, thyroid and kidney.
Small and Medium Enterprise
Creative Animodel posted this:Animal Model Products & ServicesAs a world leader in custom transgenic animal model, Creative Animodel has years of experience serving hundreds of clients across six continents. Our full-service model has enabled medical and academic researchers to receive over 1,000 successful and unique gene targeted animal model lines. Creative Animodel's clients return regularly for the experience, service and results that push research forward.
RAMOT at Tel Aviv University Ltd. posted this:Macrolid Induced Correction of Premature Stop Codons: A novel Treatment for Colorectal CancerAn antibiotic of the Macrolid family was demonstrated as a new treatment for colorectal cancer and other genetic human diseases that arise from pre-mature stop codons in important coding sequences. Project ID : 10-2007-109
RAMOT at Tel Aviv University Ltd. posted this:A New Application for Vitamin DCalcitriol (1,25-dihydroxyvitamin D3), the main hormonally active metabolite of vitamin D was found, in vitro, together with some of its synthetic analogs to have the potential to reduce the damage inflicted to normal tissue by accepted anti-cancer therapy. Project ID : 10-2007-101
RAMOT at Tel Aviv University Ltd. posted this:A novel approach for a genome-wide detection of synthetically-lethal genes in cancer: Towards rational drug target identification and personalized treatmentsSynthetic lethality occurs when a perturbation of two nonessential genes is lethal. This phenomenon offers a unique opportunity to develop selective anticancer drugs that will target a gene whose Synthetic Lethal (SL)-partner is inactive only in the cancer cells. Towards the realization of this potential, screening technologies have been developed to detect SL-interactions in model organisms and in human cell lines. However, currently their scope falls short compared to the large spectrum of interactions that need to be surveyed in cancer. Here we present a data-driven computational pipeline for the genome-wide identification of SL-interactions in cancer, by analyzing large volumes of genomic profiles of cancer cell lines and clinical samples. Our approach is first shown to successfully capture the SL-partners of tumor suppressors and oncogenes, according to six published experimental SL-screens. Second, we construct the first genome-wide network of SL-interactions in cancer and demonstrate its utility in predicting gene essentiality in a cancer-specific manner. Third, we show that, as predicted, underexpression of SL-partners has a strong positive prognostic value for cancer survival. Fourth, we identify synthetic lethality arising from gene over-activation and show that it can be utilized to predict anticancer drug efficacy. Lastly, we develop a complementary computational approach that by harnessing the obtained SL-networks identifies the most suitable treatment per patient, and identifies novel anticancer drug-targets, providing drug repurposing leads. Our approach provides a solid basis guiding future experimental studies aimed at developing new, selective anticancer therapies. Project ID : 2-2013-713
Licensing Manager at uacoopera
uacoopera posted this:
Licensing Manager at uacoopera
Universidad de Alcalá-OTRI posted this:Nanoconjugates formed by dendritic molecules and peptides as antitumor agents against advanced prostate cancer.The Research Group in "Dendrimers for Biomedical Applications" of the University of Alcalá presents a new invention that refers to the formation of nanoconjugates with antitumor activity, mainly against advanced prostate cancer. Nanoconjugates are composed of dendritic systems (dendrimers and dendrons) and neuropeptides. The dendritic molecules are mainly of carbosilane structure and with ammonium functions in the periphery. And the peptides are preferably of the glucagon / secretin family (VIP, GHRH, PACAP…etc.) The research group seeks companies from the Biomedicine, Pharmaceutical and Health sector, to establish licensing agreements, cooperation agreements or commercial agreements with technical assistance.