Molecular design Technology Technology Offers

Centre Technology Transfer CITTRU posted this:

Method for conjugation of biomolecules and its new use The subject of the offer is a novel method for conjugation of free thiol group(s) containing biomolecules comprising a biomolecule reaction with a gold-donor agent in which a -S-Au-S- bond is formed. Specifically, the method leads to a complex formation that is a protein cage. The new method comprises following steps: (i) biomolecules preparation, (ii) conjugation of biomolecules by reaction of biomolecules with gold-donor and (iii) purification of conjugation product.

Maria João Cardoso posted this:
Science and Technology Manager at UATEC - Unidade de Transferência de Tecnologia

Magnetic nanoparticles for selective enrichment of proteins in complex mixtures New method for preparing ion chelating magnetic nanoparticles, which allow selective protein enrichment, namely metalloproteases (MMPs) and His-tagged proteins, from complex mixtures.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendrons functionalized with fatty acids: Formation of micelles and uses in biomedicine as antiviral, antibacterial, antiprionic, antimicrobial and drug transporters.The research group of the University of Alcalá in «Dendrimers for biomedical applications» presents the following invention that refers to the formation of dendrons of carbosilane structure that have in their periphery preferably anionic or cationic groups and in the focal point fatty acids or derivatives of these. Its main field of application is in biomedicine, as non-viral transport agents, as drug transporters, to elaborate a drug, as antimicrobial, antiviral or antipyretic agents. In the environmental sector we also find its application as biocides for water treatment. The group seeks to reach license agreements, collaboration or commercial agreements with technical assistance with companies from the sector of Health, Pharma and Environment.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendrimers and their use as antivirals The research group in "Dendrimers for Biomedical Applications" of the University of Alcalá presents these highly branched macromolecules synthesized from a polyfunctional nucleus, of carbosilane structure and functionalized in its periphery with anionic groups that give the macromolecule a negative net charge. In addition, the invention relates to the use of the dendrimers as an antimicrobial and the process for obtaining them. The group seeks to reach collaboration agreements, licensing or commercial agreements with technical assistance, with companies in the biotechnology, pharmaceutical and biomedicine sectors in general.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendrimers with polyphenolic groups. Uses as antioxidants and anticancer.The "Dendrimer for biomedical applications Research Group" at Alcalá University presents dendritic macromolecules with skeleton of carbosilane nature that contain in their structure polyphenolic groups (GPF). These compounds are powerful antioxidants and free radical scavengers, as well as anticancer agents, with application in sectors such as food, cosmetics and pharmaceutical industry. The invention provides a process for its procurance and uses.

Universidad de Alcalá-OTRI posted this:

New therapeutic agents for the treatment of inflammatory disorders The research group, « Heterobetaines », from Alcalá University in colaboration with the research group « Hipersensibility to medicines and inmmunitary innate response » form IDI La Paz, present a new generation of inhibitors of alfa tumoral necrosis factor (TNF-α) production, useful to prevent and / or treat inflamatory diseases. The group is looking for technical cooperation or license agreements with pharmaceutical companies, research centers or diagnostic and treatment against inflammatory diseases research institutions.

DIT Hothouse posted this:

Raman Spectroscopy for Molecule Detection and Analysis Raman is an advanced spectroscopic technique with applications in disease diagnosis, identification of biochemical markers, and drug discovery.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendritic compounds homo and heterofunctionalized A Spanish research group from the Department of Organic and Inorganic Chemistry of Alcala University has developed a highly branched macromolecules called dendrimers or dendrons, with carbosilane structure and functionalized on its periphery with anionic or cationic groups, providing the macromolecule a net negative or positive charge respectively. The invention also concerns the dendrimers’ procurement process and their biomedical applications, particularly as carriers of drugs or nucleic acids (such ODN, siRNA, dsRNA or DNA), or as therapeutic agents with antiviral or antibacterial activity. The group is looking for companies in the biomedical sector to reach licensing agreements, collaboration and commercial agreements with technical assistance.

Centre Technology Transfer CITTRU posted this:

Monoclonal antibody Miraculum for serological diagnostic in vitro New IgG antibody suitable for specific agglutination of erythrocytes, particulary for blood typing. The unique IgG3 antibody Miraculum may be a valuable, high-quality, next generation blood typing reagent with extended shelf life. It does not lose its property after freezing. Its production is very efficient and can be more profitable compared to currently used IgM-class antibody. The invention consists in conversion of any non-agglutinating monoclonal antibody that recognizes an antigen on the surface of human erythrocytes into agglutinating molecule. The antibodies obtained in this way can be much more useful than IgM antibodies, which are currently used in agglutination assays.

Universidad de Alcalá-OTRI posted this:

Estimated binding energy model based in Quantitative Structure-Activity Relationships (3D QSAR), for the pharmaceutical industry A research group from the Pharmacology Department of Alcalá University has develop a technology that consists in a model to estimate the interaction energy with the receptor of a pharmaceutical compound that permits the prediction a priori of the activity of new compounds before their synthesis. The model, based on the 3D QSAR method uses application techniques for the study of the behavior of macromolecules and drug design. The group is looking for technical cooperation or commercial agreements with technical assistance.

Universidad de Alcalá-OTRI posted this:

Protein separation by using anionic carbosilane dendrimers.BIODEN research group (Biomedical applications of dendrimers) from the Department of Inorganic Chemistry of the University of Alcala along with the research group of Micro(sep) from the Department of Analytical Chemistry and Chemical Engineering have developed a technology based on the use of anionic dendrimers as nanoadditives in capillary electrophoresis (CE) for protein separation, more specifically for obtaining protein profiles useful in food characterization. The groups look for companies of chemical, pharmaceutical or biotechnological sector to sign research collaboration agreements or license agreements.

xrqtc posted this:

Modeling of silica supported catalyst as an additional tool for catalyst characterization and optimization The technology is able to perform enough accurate solid state IR and NMR modelling resulting in more reliable structures than M-L distances obtained by Extended X-ray absorption fine structure. the group has developed small scaled but still reliable models suitable for the exploration of the full reaction mechanism including, if necessary, the most relevant deactivation pathways.

Ventura Medical Technologies posted this:

A new surgery kit for Pectus Excavatum From the cooperation between Ventura Medical Technologies and Hospital Parc TaulÃ, a new method, Taulinoplastia, and a new surgery kit, Pectus Up, are born to correct the Pectus Excavatum. This new technique presents suitable advantages over current used methods. Pectus Up is a set of tools and implants manufactured with the aim of treating Pectus Excavatum with the Taulinoplastia, being less painful and with a reduced post-operative time than other methods.

Maria João Cardoso posted this:
Science and Technology Manager at UATEC - Unidade de Transferência de Tecnologia

Production method of a new recombinant collagenase for collagens digestion Method for obtaining collagenase with high collagenolytic activity, through a process based on recombinant DNA technology. This new process enables collagenase purification e isolation through a simple and economical procedure, obtaining an active enzyme with remarkable storage stability.

Universidad de Alcalá-OTRI posted this:

Nanoconjugates formed by dendritic molecules and peptides as antitumor agents against advanced prostate cancer.The Research Group in "Dendrimers for Biomedical Applications" of the University of Alcalá presents a new invention that refers to the formation of nanoconjugates with antitumor activity, mainly against advanced prostate cancer. Nanoconjugates are composed of dendritic systems (dendrimers and dendrons) and neuropeptides. The dendritic molecules are mainly of carbosilane structure and with ammonium functions in the periphery. And the peptides are preferably of the glucagon / secretin family (VIP, GHRH, PACAP…etc.) The research group seeks companies from the Biomedicine, Pharmaceutical and Health sector, to establish licensing agreements, cooperation agreements or commercial agreements with technical assistance.

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