Biochemistry / Biophysics Technology Technology Offers

UACOOPERA University of Aveiro posted this:
Technology Transfer Office at uacoopera

MAGNETIC NANOPARTICLES FOR TEMPERATURE-CONTROLED MOLECULE AND CELL SEPARATION AND DETECTION Coated and functionalized magnetic nanoparticles for e.g. detection and separation of DNA and RNA, protein purification, cell separation and immunoassays, con-trolled by temperature. Contrary to state-of-art mag-netic nanoparticles presently used for separation, which always present a certain degree of aggregation, the present technology proposes nanoparticles with tem-perature-controlled magnetic response. The magnetic response of these new nanoparticles is suppressed at higher temperatures (tunable between 40°C and 100°C) avoiding aggregation and is enhanced at lower temperatures promoting separation.

Yissum - Research Development Company of the Hebrew University posted this:

Novel Naturally Occurring Compounds for Treating Cystic Fibrosis Cannabis project Derivatives of cannabinoids have an antimicrobial and anti biofilm effect on pseudomonas and candida which are major ethological pathogenic factors in CF Project ID : 6-2019-6720

Radoslaw Rudz posted this:
Licensing Manager at Centre Technology Transfer CITTRU

In vitro culture medium for cells, tissues, and organs of amphibians The subject of the offer is a specialized medium for the in vitro culture of cells, tissues, and organs of amphibians. Thanks to the unique composition of active substances and refined their concentrations to the requirements of amphibian cells, the use of medium enables long-term culture as well as a high level of cell proliferation and reduction of cell mortality.

UACOOPERA University of Aveiro posted this:
Technology Transfer Office at uacoopera

LipidPro - Fluorescent dye for detection of lipid aggregates in living cells and other samples Family of dyes to be used in fluorescence microscopy imaging of cells in culture or entire organisms, including live cell imaging. The fluorophores are not toxic, and preferentially bind to lipid aggregates, such as intracellular lipid droplets. They also light up cells by binding weakly to several subcellular structures. Importantly, the fluorophores change color with the polarity of the environment and may be used to initially characterize alterations in organelle polarity. The most promising fluorophore, LipidPro, has been tested in fibroblast-based High Throughput Screens for the diagnosis of Faber’s disease.

UACOOPERA University of Aveiro posted this:
Technology Transfer Office at uacoopera

BioMEMs - BioMicroElectroMechanical system device for bone regeneration BioMicroElectroMechanical System devices (BioMEMs) targeted to the promotion of bone regeneration by means of coating a biomedical metallic substrate with a functionalized ferroelectric/piezoelectric biocompatible oxide layer or with a functionalized piezoelectric biocompatible and biodegradable polymeric layer.

UACOOPERA University of Aveiro posted this:
Technology Transfer Office at uacoopera

Separation of nucleic acids using chromatographic matrices functionalized with ionic liquids Novel multimodal chromatographic supports prepared by functionalizing matrices with ionic liquids, allowing the separation of RNA and DNA in a single chromatographic step with high selectivity, robustness and reproducibility. In comparison to other commercially available supports, a higher dynamic binding capacity for RNA was obtained.

UACOOPERA University of Aveiro posted this:
Technology Transfer Office at uacoopera

Magnetic nanoparticles for selective enrichment of proteins in complex mixtures New method for preparing ion chelating magnetic nanoparticles, which allow selective protein enrichment, namely metalloproteases (MMPs) and His-tagged proteins, from complex mixtures.

Ukrainian Laboratories posted this:

New Original Squaraine Dye for protein detection Ukrainian Laboratories represents the original new squaraine dye for the protein detection. The dye is already synthesized and ready to use for biomedical application. The dye has a significant increase in the fluorescence intensity in the presence of protein (123 times) and does not change its intensity in the presence of nucleic acids.

Universidad de Alcalá-OTRI posted this:

Endothelial microvesicles with microbicidal effect for the preparation of a medicament or for a direct use The research group "Cell damage associated with senescence" of the University of Alcalá presents the microbicidal capacity of endothelial microvesicles. These vesicles destroy the main pathogens involved in sepsis and even strains derived from them resistant to multiple antibiotics. They have also been shown to be effective against the biofilms that form these microorganisms. The group seeks to reach licensing agreements, cooperation or commercial agreements with technical assistance, with pharmaceutical companies interested in the design of new medicines.

Universidad de Alcalá-OTRI posted this:

Derivatives of Indolin-2-one and its therapeutic use in inflammatory, autoimmune, metabolic, cardiovascular, neurological and cancer diseases.The research group of “Neuroendocrinology of the cannabinoid / vanilloid system” of the University of Alcalá, in collaboration with researchers from the Institute of Medical Chemistry of CSIC, have developed a series of compounds derived from indolin-2-one, emphasizing the pharmaceutical compositions containing in the compounds and their use for the treatment of diseases mediated by AMPK (AMP-activated kinase), particularly inflammatory, autoimmune, metabolic, cardiovascular, neurological and cancer. The group is looking for companies in the pharmaceutical and health sector with the objective of reaching technical cooperation agreements, commercial agreements with technical assistance or patent licensing.

Javier Martínez González posted this:
Commercialization Specialist at Universidad de Alcalá-OTRI

New inhibitor compounds of the tyrosine phosphatase 1B protein The research group in "Biological Chemistry" of the University of Alcalá has developed new compounds inhibitors of the Tyrosine Phosphatase 1B Protein, which are related to new Formulas I, II and III, with methods to prepare them, with the use of them as inhibitors of protein tyrosine phosphatase 1B (PTP1B) and with the use of the intermediates that lead to that compounds to prepare an inhibitor of PTP1B comprised by that formulas. These compounds have application in the treatment or prevention of diseases in which it is known that PTP1B is involved in the pathogenesis, so they can be used for the treatment of insulin resistance, glucose intolerance, obesity, diabetes mellitus, hypertension and ischemic diseases of large and small blood vessels, conditions that accompany type 2 diabetes and other disorders where insulin resistance is indicated. The group looks for companies in the health and pharmaceutical sector with the aim of reaching technical collaboration agreements, commercial agreements or patent licenses agreements.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendrons functionalized with fatty acids: Formation of micelles and uses in biomedicine as antiviral, antibacterial, antiprionic, antimicrobial and drug transporters.The research group of the University of Alcalá in «Dendrimers for biomedical applications» presents the following invention that refers to the formation of dendrons of carbosilane structure that have in their periphery preferably anionic or cationic groups and in the focal point fatty acids or derivatives of these. Its main field of application is in biomedicine, as non-viral transport agents, as drug transporters, to elaborate a drug, as antimicrobial, antiviral or antipyretic agents. In the environmental sector we also find its application as biocides for water treatment. The group seeks to reach license agreements, collaboration or commercial agreements with technical assistance with companies from the sector of Health, Pharma and Environment.

Universidad de Alcalá-OTRI posted this:

Development and method of construction of a new electrochemical sensor of Magnesium (Mg2 +), without the need to add organic salts, additives or organic solvents to the sample The research group in Bioelectrochemistry and Biosensors of the University of Alcalá in collaboration with the Textile Industry Research Association (AITEX) has developed an electrochemical sensor of magnesium (Mg2 +) and a construction method based on the formation of a polymeric three-dimensional network that allows the entrapment / immobilization of a selective indicator for Mg2 +, eriochrome black T, by the use of a crosslinking agent and a polymer. The combination of these three reagents allows the construction of the sensor on any conductive surface, avoiding the electro polymerization of the indicator. The resulting sensor allows to measure MG2 + in any type of samples, without the need to add organic salts, additives or organic solvents. The quantification of Mg2 + is done directly by incubating the sensor in the sample containing the analyte, resulting in a modification of the amperometric signal proportional to its concentration. This method has many applications especially in health and biomedical sector since Mg2 + participates in such important activities as neuronal, neuromuscular transmission, or regulation of blood pressure and plays a key role in various pathologies such as vascular and migraines headache. The group is looking for companies in the agro-food, bio-sanitary and environmental sectors, with the aim of reaching technical collaboration agreements, commercial agreements or patent licenses.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendrimers and their use as antivirals The research group in "Dendrimers for Biomedical Applications" of the University of Alcalá presents these highly branched macromolecules synthesized from a polyfunctional nucleus, of carbosilane structure and functionalized in its periphery with anionic groups that give the macromolecule a negative net charge. In addition, the invention relates to the use of the dendrimers as an antimicrobial and the process for obtaining them. The group seeks to reach collaboration agreements, licensing or commercial agreements with technical assistance, with companies in the biotechnology, pharmaceutical and biomedicine sectors in general.

Creative Biogene posted this:

Human HTR2B-FLAG Stable Cell Line-CHO 5-HT2B (5-hydroxytryptamine receptor 2B) is a receptor for serotonin. It is expressed in many peripheral and central nervous system tissues, including stomach fundus, liver kidney, muscle, intestine and brain. 5-HT2B receptors are responsible for many cardiovascular and central nervous system functions, such as blood vessel contraction, platelet shape changes, neuronal sensitization to tactile stimuli, and mediation of the hallucinogenic effects of phenylisopropylamin hallucinogens.

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