Cellular and Molecular Biology Technology Technology Offers

Radoslaw Rudz posted this:
Licensing Manager at Centre Technology Transfer CITTRU

Hydrogel hybrid material for the reconstruction of bone defects The subject of the offer is an injectable, hydrogel hybrid material that can be used to construct a bioactive cell scaffold of a minimal invasivity. This scaffold may be located in place of a bone defect thus enabling reconstruction of bone tissue. Application: in tissue engineering for the reconstruction of orthopedic and dental bone defects.

Ukrainian Laboratories posted this:

Synthesis of Styryl-phenyl-ureas as Dual-targeted Inhibitors of PD-L1 and VEGFR-2 We offer the chemical optimization service - synthesis of targets-specific set of styryl-phenyl-urea derivatives as dual-targeted inhibitors of PD-L1 and VEGFR-2.

Ukrainian Laboratories posted this:

Synthesis of 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole Derivatives as Antiprotozoal Agents Our company offers the chemical optimization service - synthesis of a unique 1-(aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives for your biological projects, related to developing of antiprotozoal drugs.

Radoslaw Rudz posted this:
Licensing Manager at Centre Technology Transfer CITTRU

In vitro culture medium for cells, tissues, and organs of amphibians The subject of the offer is a specialized medium for the in vitro culture of cells, tissues, and organs of amphibians. Thanks to the unique composition of active substances and refined their concentrations to the requirements of amphibian cells, the use of medium enables long-term culture as well as a high level of cell proliferation and reduction of cell mortality.

Maria João Cardoso posted this:
Science and Technology Manager at UATEC - Unidade de Transferência de Tecnologia

Electrospinning system for large-scale manufacturing of aligned 3D fiber matrices Continuous electrospinning system and process for production of thick 3D matrices of aligned polymeric fibers. The matrices obtained with this technology can have aligned polymeric fibers with several patterns along the matrix’s thickness, which size depends solely on the number of layers of deposited fibers, on the fibers thickness and the compaction degree between layers. In this way, the present technology can be applied in varied areas, for the manufacture of products or structures, at the nanometric scale, that depend on high surface areas, such as biotechnology, pharmaceutics and tissue engineering.

Maria João Cardoso posted this:
Science and Technology Manager at UATEC - Unidade de Transferência de Tecnologia

LipidPro - Fluorescent dye for detection of lipid aggregates in living cells and other samples Family of dyes to be used in fluorescence microscopy imaging of cells in culture or entire organisms, including live cell imaging. The fluorophores are not toxic, and preferentially bind to lipid aggregates, such as intracellular lipid droplets. They also light up cells by binding weakly to several subcellular structures. Importantly, the fluorophores change color with the polarity of the environment and may be used to initially characterize alterations in organelle polarity. The most promising fluorophore, LipidPro, has been tested in fibroblast-based High Throughput Screens for the diagnosis of Faber’s disease.

Mansour Esmaeil Zaei posted this:
Technology Broker at Technology Transfer Centre, University of Warsaw (UOTT UW)

The Centre of New Technologies of the University of Warsaw (CeNT UW)The Centre of New Technologies of the University of Warsaw (CeNT UW) is an interdisciplinary research institute dedicated to the understanding of biological, chemical and physical phenomena. Our scientists tackle fundamental scientific problems, collaborate and apply the attained knowledge to the industry. CeNT UW provides a truly international outlook, establishes a perfect work environment for both young and established researchers, and promotes the education of PhD students. CeNT UW obtained the scientific rating of “A” (very-good level) in a heterogeneous group on the basis of a comprehensive assessment of scientific and R&D activities of scientific units made by the Ministry of Science and Higher Education for the period of 2013-2016. The institute was established by Resolution No. 362 of the Warsaw University Senate on April 20, 2011, as an organizational unit of the University of Warsaw.

Centre Technology Transfer CITTRU posted this:

In vivo delivery system of the DNA modifying enzymes The subject of the offer is a new method of in vivo genome editing with the use of hybrid nucleases, such as ZFN, TALEN and the CRISPR/Cas9 system, delivered to target cells by EVs derived from stem cells in serum-free conditions and defined as the RNA-containing vesicles expressing stem cells surface markers: CD90, CD105, CD147, CD309 (in more than 20% of RNA-positive events) and lack of expression CD45.

Maria João Cardoso posted this:
Science and Technology Manager at UATEC - Unidade de Transferência de Tecnologia

Separation of nucleic acids using chromatographic matrices functionalized with ionic liquids Novel multimodal chromatographic supports prepared by functionalizing matrices with ionic liquids, allowing the separation of RNA and DNA in a single chromatographic step with high selectivity, robustness and reproducibility. In comparison to other commercially available supports, a higher dynamic binding capacity for RNA was obtained.

Maria João Cardoso posted this:
Science and Technology Manager at UATEC - Unidade de Transferência de Tecnologia

Magnetic nanoparticles for selective enrichment of proteins in complex mixtures New method for preparing ion chelating magnetic nanoparticles, which allow selective protein enrichment, namely metalloproteases (MMPs) and His-tagged proteins, from complex mixtures.

Universidad de Alcalá-OTRI posted this:

Endothelial microvesicles with microbicidal effect for the preparation of a medicament or for a direct use The research group "Cell damage associated with senescence" of the University of Alcalá presents the microbicidal capacity of endothelial microvesicles. These vesicles destroy the main pathogens involved in sepsis and even strains derived from them resistant to multiple antibiotics. They have also been shown to be effective against the biofilms that form these microorganisms. The group seeks to reach licensing agreements, cooperation or commercial agreements with technical assistance, with pharmaceutical companies interested in the design of new medicines.

Eva Gabaldon posted this:
Licensing Manager at Spanish National Research Council

Extracellular matrix for increase the synthesis and/or deposit of collagen CSIC has developed an extracellular matrix with increased synthesis and/or deposit of collagen that is capable of regulating the differentiation of mesenchymal stem cells. Industrial partners from the biotechnological industry are being sought to collaborate through a patent licence agreement.

Universidad de Alcalá-OTRI posted this:

Derivatives of Indolin-2-one and its therapeutic use in inflammatory, autoimmune, metabolic, cardiovascular, neurological and cancer diseases.The research group of “Neuroendocrinology of the cannabinoid / vanilloid system” of the University of Alcalá, in collaboration with researchers from the Institute of Medical Chemistry of CSIC, have developed a series of compounds derived from indolin-2-one, emphasizing the pharmaceutical compositions containing in the compounds and their use for the treatment of diseases mediated by AMPK (AMP-activated kinase), particularly inflammatory, autoimmune, metabolic, cardiovascular, neurological and cancer. The group is looking for companies in the pharmaceutical and health sector with the objective of reaching technical cooperation agreements, commercial agreements with technical assistance or patent licensing.

Mª Eugenia Garcés Castellote posted this:
Commercialization Specialist at Universidad de Alcalá-OTRI

New inhibitor compounds of the tyrosine phosphatase 1B protein The research group in "Biological Chemistry" of the University of Alcalá has developed new compounds inhibitors of the Tyrosine Phosphatase 1B Protein, which are related to new Formulas I, II and III, with methods to prepare them, with the use of them as inhibitors of protein tyrosine phosphatase 1B (PTP1B) and with the use of the intermediates that lead to that compounds to prepare an inhibitor of PTP1B comprised by that formulas. These compounds have application in the treatment or prevention of diseases in which it is known that PTP1B is involved in the pathogenesis, so they can be used for the treatment of insulin resistance, glucose intolerance, obesity, diabetes mellitus, hypertension and ischemic diseases of large and small blood vessels, conditions that accompany type 2 diabetes and other disorders where insulin resistance is indicated. The group looks for companies in the health and pharmaceutical sector with the aim of reaching technical collaboration agreements, commercial agreements or patent licenses agreements.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendrons functionalized with fatty acids: Formation of micelles and uses in biomedicine as antiviral, antibacterial, antiprionic, antimicrobial and drug transporters.The research group of the University of Alcalá in «Dendrimers for biomedical applications» presents the following invention that refers to the formation of dendrons of carbosilane structure that have in their periphery preferably anionic or cationic groups and in the focal point fatty acids or derivatives of these. Its main field of application is in biomedicine, as non-viral transport agents, as drug transporters, to elaborate a drug, as antimicrobial, antiviral or antipyretic agents. In the environmental sector we also find its application as biocides for water treatment. The group seeks to reach license agreements, collaboration or commercial agreements with technical assistance with companies from the sector of Health, Pharma and Environment.

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