Cellular and Molecular Biology Technology Technology Offers

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

New method for the diagnosis of atherosclerosis Inflammation is an active driver of atherosclerotic plaque development and a risk factor for atherosclerotic events. It is therefore of utmost importance to understand the mechanisms behind these inflammatory processes and to be able to develop new diagnostics and treatment modalities for atherosclerotic disorders. CNIC, FJD (Fundación Jiménez Díaz) and UAM (Universidad Autónoma de Madrid) researchers conducted a study to identify new antibodies that show reactivity against the atherosclerotic plaque. They have found that one of these antibodies recognizes a mitochondrial dehydrogenase of the proline metabolism (PRODH). The levels of this protein are increased in the plasma of atherosclerotic mice and humans with carotid disease, supporting the potential use of this PRODH as a biomarker for atherosclerosis.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

Antibodies for the diagnosis and/or treatment of atherosclerosis Novel atherosclerosis biomarkers are in need to improve the strategies for diagnosis and prognosis of cardiovascular disease. CNIC and DKFZ researchers have discovered 18 novel antibodies that show reactivity against the atherosclerotic plaque, which can thus be potentially used for the diagnosis of this disease. Moreover, the use of one such antibody, A12, delays the progression of atherosclerosis and reduces the level of free circulating cholesterol and LDL.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

iSuRe-Cre as a new genetic tool to modify and understand gene function Most analysis of gene function in biomedical research relies on the use of Cre-lox technology. Since its introduction in 1994, this technology has revolutionized biomedical science because it allows scientists to eliminate or activate the function of any gene in any cell type in the mouse. Because the Cre-loxP recombination event is invisible, genetic and fluorescent reporters have been developed to track Cre activity, so that cells reaching a certain threshold of Cre activity are labeled. However, the main problem is that often the Cre activity level is insufficient to fully recombine and eliminate expression of the target gene, generating uncertainty about whether the desired genetic modification has been achieved. CNIC researchers have developed a method that increases the efficiency and reliability of the analysis of Cre-dependent gene function. Moreover, the use of this genetic tool permits the induction of multiple genetic deletions in the same cell, to allow the study of functional genetic interactions.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

A new therapy for the treatment of myeloproliferative diseases Myelodysplastic/myeloproliferative neoplasms (MPN) are a group of diseases that affect normal blood cell production in the bone marrow. In this case the bone marrow causes an overproduction of one or more blood cell types (red cells, white cells or platelets). Complications arise over time due to the abnormally high number of blood cells that accumulate in the bone marrow and in the circulating blood. In many cases, these diseases develop slowly and get worse gradually. In some cases, MPN can progress to leukemia. Compounds capable of preventing and treating these types of diseases are urgently needed. CNIC researchers have identified new therapeutic targets based on alterations in the regulation of mesenchymal stem cells (MSC) in the hematopoietic niche by sympathetic nerves. They have also defined an in vitro method for prognosis/diagnosis of MPNs and/or to define the disease´s stage, and a method to screen for therapeutic compounds useful to treat MPNs.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

Use of selective Beta-3 adrenergic receptor agonists to treat pulmonary hypertension Pulmonary hypertension (PH), defined as the increase of mean pulmonary blood pressure above normal values, encompasses a series of disorders characterized by the increase of pulmonary vascular resistance and progressive deterioration of the right ventricle. The incidence of pulmonary hypertension in the population is high and it is associated with high morbidity and mortality. Approximately two thirds of patients with left ventricular dysfunction (systolic or isolated diastolic) develop pulmonary hypertension. Currently, there is a lack of treatments for pulmonary hypertension. CNIC and CLINIC researchers have described a novel effective treatment for pulmonary hypertension of different etiology, both chronic and acute. They have found that selective stimulation of beta-3 adrenergic receptors has a beneficial effect in pulmonary hypertension.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

New microRNAs for the diagnosis of cardiomyopathies Inflammation in the myocardium or myocarditis is a disease with heterogeneous aetiology, frequently caused by an infectious pathogen, toxins, drugs or by an autoimmune disorder. Its clinical variability and its nonspecific symptoms make the diagnosis of myocarditis a process that is not always easy. There is an urgent need for accurate, fast point-of-care tests that simultaneously provide diagnostic and prognostic information about a patient entering the hospital with symptoms of acute heart failure. CNIC researchers have identified the role of an specific miRNA in cardiomyopathies processes and have studied the differential expression in blood plasma of patients compared with healthy subjects. These miRNAs can be used as biomarker to improve the diagnosis of acute myocarditis.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

SHIP-1 inhibitors for prophylactic treatment and/or prevention of infectious diseases Trained immunity can be defined as a defacto innate immune memory that induces enhanced inflammatory and antimicrobial properties in innate immune cells. Innate immune cells can be trained to exhibit an enhanced and lasting response to subsequent infections with microbial components. Importantly, this boosted response can be triggered against pathogens diverse from those that induce the training. However, improving the heterologous response of trained innate immune cells remains complicated. CNIC, Syracuse University and SUNY Upstate Medical University researchers have discovered that the use of SHIP-1 inhibitors, enhance the non-specific response of trained innate immune cells. This increased activity may offer an improved prophylactic treatment or prevention of subsequent infections.

LUCIA CORAL posted this:
Knowledge Tranfer Manager at National Cancer Institute CRO Aviano

Cell models to evaluate activity of p53:MDM2 inhibitors Twist GAIN-of-function and LOSS-of-function cell models were developed and used for preclinical p53:MDM2 inhibitors evaluation, preliminary demonstrating that the expression of Twist hampers their efficacy. These findings support patient stratification on the basis of twist expression for treatment of a large fraction of sarcomas but also of a fraction of carcinomas. (Piccinin et al., Cancer Cell, 22, 404-415, Sept 11 2012).

Lidia Aguilera posted this:
Technology Transfer Officer at University of Luxembourg

Single cell OMICS technologies The Integrative Cell Signalling group at the LCSB investigates changes of cellular heterogeneity in health and disease at single cell resolution. In diverse projects including cell differentiation, cancer heterogeneity and brain chraracterization, we develop and apply single cell RNA sequencing (sc-RNAseq) methods such as Drop-seq, CITE-seq, ATAC-seq, Fluidigm C1, InDrop or SPLiT-seq.

Covid-19 Innovation Challenges by Innoget posted this:

Expertise in molecular biology either experimentally or computationally The Institut de Biotecnologia i de Biomedicina (IBB) was created in 1970 as a research institute of the Universitat Autònoma de Barcelona (UAB) to promote fundamental biological research. In the year 2000, the focus of research evolved towards the Biotechnology and Biomedicine fields, with the aim of advancing scientific findings into translational results. At present, the Institute hosts 18 research groups organised into 3 programmes and working in 7 areas of expertise: • Bioinformatics • Cellular Biology • Structural Biology • Genomics • Immunology • Microbiology • Proteomics. This multidisciplinary character, one of the most relevant characteristics of the IBB, allows for a broad approach to biological problems, both basic and applied. The IBB is also highly engaged in academic training at the undergraduate and postgraduate levels.

IBB-UAB posted this:

Expertise in molecular biology either experimentally or computationally The Institut de Biotecnologia i de Biomedicina (IBB) was created in 1970 as a research institute of the Universitat Autònoma de Barcelona (UAB) to promote fundamental biological research. In the year 2000, the focus of research evolved towards the Biotechnology and Biomedicine fields, with the aim of advancing scientific findings into translational results. At present, the Institute hosts 18 research groups organised into 3 programmes and working in 7 areas of expertise: • Bioinformatics • Cellular Biology • Structural Biology • Genomics • Immunology • Microbiology • Proteomics. This multidisciplinary character, one of the most relevant characteristics of the IBB, allows for a broad approach to biological problems, both basic and applied. The IBB is also highly engaged in academic training at the undergraduate and postgraduate levels.

Ivan Rodriguez Rosello posted this:
Licensing Manager at Universidad de Alicante

Antibacterial alternative to antibiotics, with high specificity against Escherichia coli The "Molecular Microbiology" research group at the University of Alicante has modified several phage proteins (Poll-N and UK-C) that have high specificity against Escherichia coli (E. coli), but not against other Gram-negative (G-) bacteria. For these reasons, their use as a specific antimicrobial against E. coli is potentially interesting, especially in the case of contaminated food, cosmetics or water. It would also be useful in the treatment of diseases (infections) caused by E. coli. The presence of a histidine tail attached to the phage proteins not only facilitates their purification but also improves lysis efficiency without the need of cell permeabilization treatments. Companies interested in the commercial exploitation of the technology through license agreements and/or technical cooperation are sought.

UACOOPERA University of Aveiro posted this:
Technology Transfer Office at uacoopera

MAGNETIC NANOPARTICLES FOR TEMPERATURE-CONTROLED MOLECULE AND CELL SEPARATION AND DETECTION Coated and functionalized magnetic nanoparticles for e.g. detection and separation of DNA and RNA, protein purification, cell separation and immunoassays, con-trolled by temperature. Contrary to state-of-art mag-netic nanoparticles presently used for separation, which always present a certain degree of aggregation, the present technology proposes nanoparticles with tem-perature-controlled magnetic response. The magnetic response of these new nanoparticles is suppressed at higher temperatures (tunable between 40°C and 100°C) avoiding aggregation and is enhanced at lower temperatures promoting separation.

Consejo Superior de Investigaciones Científicas posted this:

Identification of particles and/or cells in suspension using a mechano-optical system CSIC has developed a sample analyzing system that can identify particles and/or biological cells in aqueous suspension or in physiological medium. The system allows simultaneously measuring the mass and light scattering of the particles in suspension in real time. This technology has been used to distinguish different cell lines, making it useful for diagnosing diseases. Industrial partners manufacturers of lab equipment are sought to collaborate through a patent license agreement. An offer for Patent Licensing

Yissum - Research Development Company of the Hebrew University posted this:

Novel Naturally Occurring Compounds for Treating Respiratory Infections Cannabis project Preliminary data on CF Derivatives of cannabinoids have an antimicrobial and anti biofilm effect on pseudomonas and candida which are major ethological pathogenic factors in CF Project ID : 6-2019-6720

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