Find Patents, Knowhow and Innovations in Biological Sciences, Genome Research, Gene Expression, Molecular Biology, Bioplastics, Ehealth and Biphysics
Cracow University of Technology posted this:Synthetic bone substitute with antimicrobial properties (antibacterial and antifungal).The offered product is a material used for reconstruction of skeletal system bone with long-term antimicrobial operation, in contrast to the pure hydroxyapatite most widely used in regenerative medicine. The resulting materials can be designed in many industries, but the emphasis is mainly focused on medical, dental and pharmaceutical applications.
Cracow University of Technology posted this:A composition for the preparation of dentifrices and other dental productsThe innovation is use of tin ions, polyphosphates and nanomaterials. The most important properties of tin ions are: reduction of plaque, anti-inflammatory and antimicrobial effect, combating odour and reduction of tooth sensitivity. Polyphosphates added to the composition prevent the formation of tartar and discoloration of teeth surface. These compounds are essential so that tin ions are stabilized. Silver, gold or copper nanoparticles are also the innovation. Theese metals present in the nanaocrystalline form are characterized by unique biocidal properties, which is especially desirable in the case of oral hygienization.
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USP Innovation Agency posted this:PROCESS TO OBTAIN SILVER NANOPARTICLES, SILVER NANOPARTICLES AND THEIR USESRecent data published by the World Health Organization (WHO) shows that every year 8, 8 million people died from cancer around the world. Therefore, the development of new technologies more efficient, chipper and environmentally-friendly for the treatment of this disease it is currently a very relevant goal. This invention is about a new methodology of synthesis of silver nanoparticles, in observance of the green chemistry and by using seaweed extracts as reducing agent of silver ions.
University of Vigo posted this:Pyridazin-3(2H)-one Derivatives as Selective Inhibitors of Monoamine Oxidase-B Isoform (MAO-B)The pyridazine ring is a privileged fragment found in compounds with very different pharmacological properties, such as antihypertensive, antiplatelet, anti-inflammatory, antinociceptive, antidepressant, hypoglycemic, antiinfective or anticancer agents, many of them being pyridazin-3(2H)-one derivatives. The pyridazine ring is also included in polycyclic compounds acting as MAO-B inhibitors. However, simple pyridazin-3(2H)-one derivatives have not been described so far as selective MAO-B inhibitors. The present invention provides novel pyridazin-3(2H)-one derivatives substituted at C4, C5 or C6 with several dithiocarbamate moieties that selectively inhibit the MAO-B activity and whose structure is unrelated to those currently available.
University of Vigo posted this:Method for the sequential immunochemical evaluation on a same biological sample of NCAM (Neural Cell Adhesion Molecule) protein and its PolySialic Acid (PSA) tail, by western blot coupled to chemiluminiscence detection.The method optimizes the expression assays of PSA-NCAM isoforms in biological samples available in small quantities or restricted (as is the case of human specimens, for example). It improves quantitative and qualitative performance of PSA-NCAM analysis by western blot.
University of Vigo posted this:Valorization of whey and vinasses by producing antimicrobial extracts using biotechnological processesThis invention is based on the production of antimicrobial extracts with potential application against pathogenic microorganisms. The biotechnological production of antimicrobial metabolites was carried out using Lactobacillus plantarum strains. Two industrial wastes, whey, and wine distilled lees (or vinasses) were assayed in order to make the process economically competitive with regard to the chemical one. The extracts are mainly composed by lactic acid, 3-phenyllactic and bacteriocins. Whey was enzymatically hydrolyzed and the solutions were fermented sequentially or simultaneously. The bioprocesses were carried out continuously or discontinuously
University of Vigo posted this:Procedure for the extraction of biosurfactants contained in corn steep liquorsNowadays, most of the pharmaceutical and cosmetic products in the market contain chemically synthesized surfactants in its composition. In many cases, these surfactants are the same as those used in regular cleanup activities. In order to get more natural and biocompatible products, it would be interesting to include natural surfactants instead of chemical surfactants in the preparation of these pharmaceutical and cosmetic products. These biosurfactants are also present in the formulation of greener nanoparticles, replacing the chemical surfactants currently used in the preparation thereof. Most biosurfactants have antimicrobial activity, which would improve the properties of certain nanoparticles, as well as many pharmaceutical and cosmetic products. The main disadvantage of biosurfactants industrial production is related to the high cost compared to chemically synthesized surfactant production. The solution proposed by the Chemical Engineering research group at the University of Vigo, is the development of eco-friendly simple extraction of biosurfactant from a corn wet-milling industry byproduct, such as corn wash liquors, better known as "corn steep liquor (CSL)", which could compete in terms of cost production with its chemical counterparts.
Barani Design posted this:Helical solar radiation shield for temperature sensorHelical shape provides natural aspiration of warmer air flow. Creates a vortex flow (similar to a mini tornado) which effectively ventilates the inside without a fan. Advanced aerodynamic design techniques from the aerospace industry enable this compact shield to achieve unprecedented levels of accuracy.
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Germans Trias i Pujol Health Sciences Research Institute (IGTP) posted this:Topical composition for the treatment of mucosal lesionsNew developed hydrogel dressing shield, biocompatible, biodegradable and bioactive, with an appropriate viscosity and adhesion capacity, easy to apply with the endoscope, to treat mucosal lesions in the gastrointestinal tract.
Universidad de Alcalá-OTRI posted this:Interactive plant cell : Educational robotics projectResearchers at the Alcalá University (UAH) have developed a didactic and interactive model in 3D that when it is completed constitutes a robotic plant cell. It comprises several pieces, that when pressed an audio is played and activate the corresponding led. This model can be applied in primary and secondary education. Researchers are looking for education-oriented technology development companies as well as textbook and school material publishers, in order to reach licensing, commercial or collaboration agreements.
Universidad de Alcalá-OTRI posted this:New therapeutic agents for the treatment of inflammatory disordersThe research group, « Heterobetaines », from Alcalá University in colaboration with the research group « Hipersensibility to medicines and inmmunitary innate response » form IDI La Paz, present a new generation of inhibitors of alfa tumoral necrosis factor (TNF-α) production, useful to prevent and / or treat inflamatory diseases. The group is looking for technical cooperation or license agreements with pharmaceutical companies, research centers or diagnostic and treatment against inflammatory diseases research institutions.
Universidad de Alcalá-OTRI posted this:Double port injector to corneal transplant DMEKThe Reseacrh group in Cell biology of solid tumors and tisular regeneration from Alcala University and the Research group in Cellular Engineering from University from Hospital La Paz, have developed a new injector designed to reduce endotellial damage during the corneal endothelial graft implantation in eye´s anterior chamber. The group is looking for cooperation or commercial agreement with companies manufacturers of sanitary products and medical devices, ophthalmological clinics and hospitals.
RAMOT at Tel Aviv University Ltd. posted this:A novel behavioral bioassay for preclinical testing and characterization of CNS agentsOur team, including zoologists, statisticians, and computer scientists have developed a new hi-res bioassay for preclinical testing and characterization of CNS agents, extracting key animal-centered parameters of behavior via computerized tracking and measurement of free exploration. The features that distinguish our system and method from other existing systems and methods are: elaborate data preparation for analysis and a methodology that secures replicability of results across laboratories, and exposes active management of kinematic variables. Our measured parameters are carefully designed, animal-centered building blocks of behavior. They are selected on the basis of an in-depth understanding of the mouse’s functional world. These quite unexpected and unusual parameters reflect the animal’s cognitive and emotional state and its information processing capacity; therefore they are most prone to be affected by drugs that act on respective CNS structures that mediate these states. Unlike all other existing systems we expose and quantify the rich and highly organized developmental dynamics of self regulated behavioral growth. The dynamics of this process before and after genetic manipulation and/or pharmacological treatment can now be readily measured by our system, articulating the effects of potential CNS drugs on behavioral growth and decay processes. Project ID : 2-2009-11
RAMOT at Tel Aviv University Ltd. posted this:Neurodevelopmental, Gestational, Lactational and Maternal Immune Stimulation Animal Model for SchizophreniaAnimal model, schizophrenia Project ID : 10-2011-141
RAMOT at Tel Aviv University Ltd. posted this:Oral Mucosa-derived Stem Cells: A Unique Population for the Prevention and Treatment of Ischemic Heart FailureStem cells (SC) are considered crucial building blocks for any regenerative strategy. Adult oral mucosa (OM) is a unique source for generating adult pluripotent stem cell (OPSC) populations. This uniqueness consists in the fact that 95% of the OM whole populations in culture (1st – 8th passages) express markers of embryonic and mesenchymal SC. Thus, in contradistinction to known sources which comprise very low numbers of SC, OPSC generation for clinical use is simple and cost effective and does not require cumbersome cost-consuming purification steps. The general objective is to lay the foundation for the development of a variety of products based on the pluripotency and simple and cost effective generation of billions of OPSC. The major aim of the proposed project is to develop a product for the treatment of ischemic heart failure (IHF). This product which will serve as a proof of concept was selected based on medicals needs, market cap and time to market. The specific aims of the proposal are: 1. To develop a cardiac product aimed at treating ischemic heart failure (IHF). The aim is to test the safety and therapeutic effect of OPSC on experimental IHF in a minipig model. 2. To strengthen the intellectual property by fully characterizing the profile of OPSC. The prevalence of IHF continuously increases (1 million new cases every year in the western world) and currently the market cap is estimated in the range of billions. Project ID : 10-2011-260