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Yeda posted this:
Covalent Inhibitors for Treatment of Inflammation and NeurodegenerationC-Jun NH2-terminal kinase (JNK) plays an integral role in many cellular processes and is associated with the pathophysiology of a number of neurological, inflammatory, and autoimmune diseases. Due to its ubiquity and its extensive activities, direct inhibition is likely and indeed was shown to have toxic effects. At the same time, inhibition of its upstream activators (MKK4/MKK7) is challenging due to their preserved ATP binding sites. The covalent inhibitor developed by the London group at WIS selectively targets a unique cysteine residue in the MKK7 protein. The inhibitor proved potent, specific to MKK7 and nontoxic in cultured cells, and is currently being optimized for in vivo testing.
CINBIO posted this:
Coverage of carbon nanotubes for use as an anchoring system for nano and micrometer devices with therapeutic activityCoverage of carbon nanotubes for use as an anchoring system for nano and micrometer devices with therapeutic activity. The present invention relates to a coating of carbon nanotubes for use as an anchoring system to the cell membrane and transport to the cytosol of micro-nanometric devices with therapeutic activity. A composition comprising a) a micro-nanometer device with therapeutic activity, and b) a carbon nanotube covering the micro-nanometer device is also contemplated.
Covid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by Innoget posted this:
COVID-19 Rapid Diagnostic KitDesigning and developing vaccines, cures and diagnostic kits can be considered as the first priority for every country which is in the first line of fighting against coronavirus. Now there is only PCR test and IgG/IgM test for COVID-19 assessment. One of the most important problems of this diagnostic test is the time needed by the device to detect infected persons. This problem makes big companies in the field of pharmaceutical and medical devices manufacturing to design and develop rapid test kits. Our research team found that there are some specific proteins on the viral membrane which can make some reagents undergo a specific chemical reaction. Every reaction has a specific product related to substrates, so by detection of products with indicator reagents we are able to identify the virus in saliva. Indicator reagents usually change the reaction mixture color so by color change we can approve that the person is infected by COVID-19.
Alireza DaneshvarTehran University of Medical SciencesAlireza DaneshvarPharmacy Student and Researcher at Tehran University of Medical Sciences
View ProfileAlireza Daneshvar posted this:
COVID-19 Rapid Diagnostic KitDesigning and developing vaccines, cures and diagnostic kits can be considered as the first priority for every country which is in the first line of fighting against coronavirus. Now there is only PCR test and IgG/IgM test for COVID-19 assessment. One of the most important problems of this diagnostic test is the time needed by the device to detect infected persons. This problem makes big companies in the field of pharmaceutical and medical devices manufacturing to design and develop rapid test kits. Our research team found that there are some specific proteins on the viral membrane which can make some reagents undergo a specific chemical reaction. Every reaction has a specific product related to substrates, so by detection of products with indicator reagents we are able to identify the virus in saliva. Indicator reagents usually change the reaction mixture color so by color change we can approve that the person is infected by COVID-19. The advantages of using saliva include: specimen collection can be done without a healthcare professional no additional equipment such as swabs or transport media are needed as nasopharyngeal specimens can be 'uncomfortable' use of saliva-based testing may encourage recruits to clinical trials of vaccines. So far two prototypes have been designed: 1) For Home Testing: Disposable test kits where an individual adds a saliva sample into a vial containing the indicator reagent, the presence of the COVID-19 virus is indicated by a positive test as shown by a colour change. 2) Reusable Low Cost Test Kits for Healthcare Professionals: Where there is a low concentration of virus in saliva, for example in the first days after infection, viral proteins can be concentrated using a saliva condensation function. In this situation, multiple samples of saliva are placed into a device which can condensate the samples to increase concentration of any virus present. After the test has been completed, the vessel can be disinfected for ready for re-use. One of the most important properties of this approach is a much lower error rate than has been found in other devices. (errors found in other tests are in various submitted articles to different journals). The re-usable nature of this professional test could make it a practical solution for low-income countries where large scale expensive PCR testing is not an option.
Pharmacy Student and Researcher at Tehran University of Medical Sciences
Jorian Bos posted this:
CREACTIVES - AI for Supply Chain ManagementCreactives’ AI technology combined with Knowledge Engineering cleanses, enriches and harmonises multi-lingual textual descriptions of materials managed in ERP records to improve supply chain processes. Listed by Gartner in the “Magic Quadrant for Master Data Management” in 2015 and as a “Cool Vendor in Italy” in 2012 and 2016.
Other at EIT Digital
UNIVERSIDAD DE BURGOS posted this:
Creation of guides and virtual and/or interactive visits for industry, commerce, etc...Design of virtual environments and visits for industry, tourism and culture. It is possible to recreate real elements as sceneries or interiors, adding historical information, product characteristics, room names or product prices. The access to these virtual visits through a worldwide available website. The visit also includes audio-visual media. This way, companies and other organisms can expose through the internet, allowing potential visitors to access virtually and attractively their facilities.
UNIVERSIDAD DE BURGOS posted this:
Creation of personalized tourist routes for android devicesThis application provides the user with a personalized tourist route over a defined town or city, devised according to certain preferences expressed by himself. The user will define the time of beginning and ending of the route along with which types of activities/sites he would enjoy the most (monuments, museums, restaurants, parks…). These are selected in an intuitive way, defining an overall degree of preferences. The application will present the user a personalized route that will comply with the user's time restrictions and visiting interests. To do this, it will use public information about the town to visit obtained from a constantly updated database, which will be completed with information obtained from the device from where the request is sent (with Andriod O.S.).
UNIVERSIDAD DE BURGOSUNIVERSIDAD DE BURGOSUNIVERSIDAD DE BURGOS posted this:
Crosslinking aromatic polyamides (aramids)The new cross-linked aramid polymers have shown improved properties, in particular, electrical insulation, thermal, stability, and/or mechanical properties while maintaining ease of processing. Further, the properties shown by the new cross-linked aramids of the invention render the product especially suitable for advanced technological applications. The crosslinking can be done without investment in nowadays aramid fiber industrial production facilities.
UNIVERSIDAD DE BURGOS posted this:
Crosslinking aromatic polyamides (aramids)The new cross-linked aramid polymers have shown improved properties, in particular, electrical insulation, thermal, stability, and/or mechanical properties while maintaining ease of processing. Further, the properties shown by the new cross-linked aramids of the invention render the product especially suitable for advanced technological applications. The crosslinking can be done without investment in nowadays aramid fiber industrial production facilities.
Institute of Chemical Research of CataloniaInstitute of Chemical Research of CataloniaInstitute of Chemical Research of Catalonia posted this:
Crysforma: services in pharmaceutical solid state developmentCrysforma provides complete scientific support for the discovery, analysis and scale-up of polymorphs, hydrates, amorphous phases, salts and co-crystals of active pharmaceutical ingredients or intermediates. Crysforma has developed its own crystallization screening methodology based on the combination of several crystallization procedures. We use high-throughput crystallization systems controlled by highly skilled scientists to maximize the information drawn from each experiment. Our projects are always carried out in close collaboration with the client, adapted to the customer's needs and under strict confidentiality conditions.
Universidad de Granada posted this:
CSC-based malignant melanoma model by 3D-bioprintingA new tri-layered malignant melanoma 3D model has been developed by 3D bioprinting, and based on cancer stem cells. This model reproduces the heterogeneity and complexity of the tumor microenvironment, and would comprise an alternative to animal testing and clinical trials for cancer diagnosis, prognosis and treatment studies.University of Porto posted this:
CUO/TIO2 polymeric nanocomposites with improved NIR reflectance for coloured external wall finishing coatings of buildingsThe use of darker colours for aesthetic purposes has been steadily growing in the construction field. This application has led buildings to have non-efficient thermal characteristics, due to the colour’s high absorption of solar radiation. Consequently, this increases the energy demand for cooling. To overcome the rise in energetic costs and ecologic footprint, these nanocomposites, which may be incorporated in conventional black colourants, ally the aesthetic side and the functional one by absorbing solar radiation in the visible spectrum, and at the same time increasing reflectance in the infrared spectrum in 40% when compared to conventional coatings.
Georgetown UniversityGeorgetown UniversityGeorgetown University posted this:
Curriculum for Non-Clinical Ophthalmic Medical Assisting- Comprehensive, structured curriculum for training non-clinical ophthalmic assistants, ensuring foundational knowledge and preparation for certification - Adaptable for both in-person and online-distance learning, allowing broader access to quality ophthalmic education - Supports the rapid development of new ophthalmic assistant programs, meeting industry demand for certified professionals
Meghan Meyer posted this:
Custom FLI I Monoclonal Antibody-The FLI I monoclonal antibody is superior to commercial polyclonal antibodies currently available due to its high binding specificity and affinity to detect the EWS::FLI I fusion protein - Production of renewable clonal hybridoma cells, immunopurified for enhanced specificity and binding affinity - This antibody can be used successfully in a variety of detection methods to localize EWS::FLI I and study protein-protein interactions and possibly nucleic acid-protein interactions
Other at Georgetown University
JPT Peptide TechnologiesJPT Peptide TechnologiesJPT Peptide Technologies posted this:
Custom Peptide SynthesisJPT Peptide Technologies has a substantial, long-standing expertise in custom peptide synthesis services, providing custom peptides with highest quality for even complex or unusual peptide sequences. If you would like to order a quality peptide synthesis service using regulated processes, choose JPT! Furthermore, our peptide synthesis service has a very high success rate (over 99%) as JPT has developed the know-how to choose and optimize the appropriate synthesis method for each peptide. We go the extra mile to get your peptides done!
Maxim KorshikovTechnoton EngineeringMaxim Korshikov posted this:
Custom smart meter and IoT meter development technologyTechnoton Engineering offers a new smart flow meter and IoT flow meter development services using its time-tested technology. Our ability in metering systems innovation, together with an organized approach to technologies, empowered us to create a Smart Meter Platform.
Innovation Manager at Technoton Engineering
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
Customized 3D porous carbon structures made from sustainable sourcesCustomized 3D porous carbon structures made from sustainable sources CSIC has developed 3D porous carbon structures from whey powder, a by-product from dairy industry. These structures can be obtained with a millimeter precision using casting or with a micrometric precision using additive manufacturing techniques. These parts are fully customizable in any shape and size. They find a wide range of applications: filters, catalysts support, carbon molecular sieves, scaffolds for tissue engineering, reactors, membranes, filtering or support of enzymes or biomolecules, 3D carbon electrodes. Industrial partners manufacturers of carbon materials or activated carbons are being sought to collaborate through a patent license agreement. An offer for Patent Licensing
Tech Transfer CIIMARCIIMAR - Interdisciplinary Centre of Marine and Environmental ResearchTech Transfer CIIMARBusiness Development Manager at CIIMAR - Interdisciplinary Centre of Marine and Environmental Research
View ProfileTech Transfer CIIMAR posted this:
Cyanobacterial bioactive compounds for Anticancer and Antifouling activityThe technology offer relates to bioactive compounds obtained from a cyanobacteria strain - hypoxanthine arabinoside, 2'-deoxyinosine, and phormidolide D. These compounds were found to have cytotoxic activity towards cancer cells. Additionally, the compounds also have antifouling activity against macro- and microfouling marine organisms.
Business Development Manager at CIIMAR - Interdisciplinary Centre of Marine and Environmental Research
CSIR posted this:
Cybersecurity Early Warning SystemThe CSIR has developed technology to provide small, medium, and large enterprises with software that detects network invasion at an early stage, to avoid disclosure of sensitive information and eventual loss of revenue. Global trends have shown that cybercriminals typically attack government and private institutions with the goal of acquiring data, primarily targeting personal data and intellectual property. Experts say preventing such leaks has become the priority for institutions locally and internationally. “The CSIR-developed Cybersecurity Early Warning System grants responsible managers a window period which allows them to take the necessary actions before the cyber-attacks reach a terminal stage. The software consists of subsystems, such as the port scan detector and the sweep scan detector that underpin the technology and enable it to function at an operational level. These subsystems give the technology a competitive advantage over similar technologies in the market,” says CSIR senior researcher Andre McDonald. The technology is inexpensive and reliable, which makes it stand out against its market competitors. The CSIR is offering the Cyber Early Warning System to smaller businesses and industry players at a reasonable cost. One of the ways to achieve this is through careful consideration of aspects such as the use of a total cost of ownership of technology approach, which is easy to manage and maintain. The total cost of ownership refers to the initial cost of technology, the installation manpower, and the maintenance and monitoring of the software. The technology enables the CSIR to address challenges that South African companies face and which international technologies cannot address. The system can be used in various sectors such as banking, information technology, communication, security and any organisation that handles large volumes of personal data.
Dr. Thomas Kallimopoulos posted this:
Cytisine - Smoking cessation agent- We provide supply of cGMP cytisine API in bulk, produced in FDA inspected installations in the USA, for use as smoking cessation agent. - We develop a small molecule (natural product) for treatment of opioids use disorder and for pain management.
CEO at Extranthis UG
D
Tiffany Wood posted this:
DAINtech - a platform technology for formulations without polymersDAINtech offers a new route to create stable formulations and composites without using polymers in solution thus offering an opportunity for manufacturing companies to avoid using unsustainable, synthetic polymers in solution. DAINtech stands for Dispersions Arrested in Nematic technology. Nematic lyotropic liquid crystalline phases occur when anisotropic (rod-shaped or disc-shaped) colloids or molecules are in solution, for example cellulose nanocrystals or anisotropic micelles (formed with surfactant mixtures). Correct design of the interaction between colloids and the nematic phase creates suspensions with excellent stability, shear-thinning characteristics and even coating performance.
Scientist at University of Edinburgh
Cracow University of TechnologyCracow University of TechnologyCracow University of Technology posted this:
Data Intensive Computing Lab at Cracow University of TechnologyOur Mission: • To conduct international quality research on exploring, development and study of data intensive scalable, reliable and intelligent complex systems and models, future generation technologies in artificial intelligence and bilogically inspired data intensive computing, large-scale, parallel and distributed computing, Big Data related areas, cognitive sciences and allied disciplines. • To support comprehensive evaluation, grassroots incubation, and seamless adoption of computational Intelligence technologies for educational, commercial, and research purposes. • To collect together the expertise and resources needed to help students experience the excitement of research. • To promote group visibility and dissemination of the research results of the group members and students in the relevant international forums.
Servei de Gestió de la InnovacióUniversitat Politècnica de Catalunya - UPCServei de Gestió de la InnovacióLicensing Manager at Universitat Politècnica de Catalunya - UPC
View ProfileServei de Gestió de la Innovació posted this:
Data modulation method for Wi-Fi off-the-shelf transmitters to communicate with non-Wi-Fi IoT devicesA technology that enables the communication from an off-the-shelf Wi-Fi device to non-Wi-Fi Internet of Things appliances, only through a software update. Partners to further develop the system and/or to establish commercial agreements along with technical cooperation are sought.
Licensing Manager at Universitat Politècnica de Catalunya - UPC
Jorian Bos posted this:
DC BRAIN - Optimise Your Networks in Real TimeDCbrain is the Artificial Intelligence specialist applied to Energy and Logistics networks allowing industrial companies to optimize, forecast and make reliable flows to obtain operational recommendations in real time. More Info & Videos: https://www.linkedin.com/smart-links/AQHI_DAp4Id5JA
Other at EIT Digital
University of Huelva posted this:
DC-DC CONVERTER WITH BIPOLAR OUTPUT AND ITS USE FOR CONNECTION OF A DISTRIBUTED GENERATION SYSTEM TO A BIPOLAR DC GRIDThe converter has an input for connecting a monopolar DC source and a bipolar DC output, with the same voltage but with opposite polarities. It is useful for the connection of a distributed generation system to a bipolar DC grid. For these applications, the proposed topology is a solution with sufficient guarantees of reliability, quality and performance. The converter circuit is very simple, it includes three inductors, four capacitors, two diodes and a power switch as a switching device.
Lukas Golka posted this:
Decarbonization TiO2 nanoparticles-based photocatalytic technology.FN NANO®️ technology film applied on exterior or interior building shells works as a sorbent (carbon capture) when activated by UVA light thanks to photocatalytic reaction (carbon utilization). NOx and bad Ozone 50% mitigation, moulds, viruses, bacteria and other harmful organic substance decomposition, Covid 19 100% in 30 minutes without pathogens left.
Manager at FN NANO CANADA
- Covid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by Innoget
Covid-19 Innovation Challenges by Innoget posted this:
Deciphering the Virus-Host Tango: Understanding network of interactions through evolution, structure, dynamics, and computational designDeciphering the Virus-Host Tango: Understanding network of interactions through evolution, structure, dynamics, and computational designProject ID : 47-2020-10875
