Fundació URV posted this:Gallic Acid for the treatment of pathologies produced by hyperactivation of renin-angiotensin-aldosterone systemGallic Acid is a naturally occurring phenolic compound that is widely distributed throughout the plant kingdom. Different studies have demonstrated the strong antioxidant, anti-inflammatory, anti-mutagenic and anticancer properties of GA, and daily intake may reduce the risk of diseases and bring health benefits. More recently, Gallic Acid has also been studied for its beneficial effects on cardiovascular diseases. It inhibits dyslipidemia, hepatosteatosis and oxidative stress in high-fat diet fed rats, protects the myocardium against isoproterenol-induced oxidative stress in rats, ameliorates the heart-function defects of myocardial dysfunction associated with streptozotocin-induced type-1 diabetic rats and exhibits anti-hyperglycemic and lipid-lowering properties in high-fat diet mice. Gallic Acid is commonly used as antioxidant by the food industry. However, until now, it is not known that the gallic acid could block the renin-angiotensin-aldosterone system (RAAS), which is the innovative aspect discover for the Nutrigenomic Group for the Gallic Acid. The inhibition of the RAAS by Gallic Acid is considered to be of special relevance because RAAS overactivity is currently associated with not only hypertension but also vascular inflammation, the development of atherosclerosis, left ventricular hypertrophy, nephrosclerosis and cardiovascular events. This discovery has a big importance because it opens a wide field of use for this compound in the food, nutraceutical or pharmaceutical industry.
Fundació URV posted this:ELECTRE-H software package: a tool for data analysis and decision aiding with hierarchical criteriaThe ELECTRE-H Software Package implements two new methods for ranking and ordered classification decision problems considering multiple criteria structured into a hierarchy. The hierarchy of criteria is a tool that allows the decision maker to better organize the problem based on its domain knowledge and needs, decomposing the general problem into smaller sub-problems. Both methods follow the well-known outranking model and belong to the family of ELECTRE methods. The ELECTRE approach is inspired on the voting-like procedure based on the opinion of the majority but also respecting the minorities (by allowing veto power). The software available to use ELECTRE methods does not allow a hierarchical decomposition of the problem, but on a flat organization of criteria. The novelties of these two methods are the following: -It fully applies the standard outranking procedure of ELECTRE at all the levels of the hierarchy of criteria (concordance and discordance indices are obtained from the results of the previous layer and exploited at each node to generate new results). -The user will get a result (a ranking or classification) at each intermediate node of the hierarchy as well as the root (or overall) node. -Preference uncertainty can be managed at each node of the hierarchy with its particular discrimination threshold values. -Veto power can be given to the appropriate nodes in the hierarchy, to avoid compensation with the rest of related criteria. -Different scales of measurement can be used both in the elementary criteria and in the intermediate criteria. -For the case of sorting, simple IF…THEN… decision rules are used to define the categories. The novelty of the software ELECTRE-H is that it is the implementation of these methods given by the authors. This guarantees that the program is fully following the methodology proposed. Its main features are: -Clear and easy-to-understand user interface. -Data can be easily provided using an Excel file. -All the parameters of the model can be easily changed in the user interface. -The results obtained can be graphically displayed (i.e. partial pre-orders, rankings) and exported into a PNG image or text files. Also, the calculations of the results are provided in log files. -Additional statistical tools to compute correlations for different ranking and classification results on the same set of alternatives and hierarchy are available. -A distance-based statistical tool to compare partial preorders is available. -The “Simos revised procedure” to calculate numerical values for criteria weights is available. -Analysis of the results can be done at different levels of the hierarchy. -The software supports large number of alternatives and criteria. Also the structure of the hierarchy is only limited to be a tree (each node has a single parent). The software is designed to be easy to use while providing the full functionality required in these two methods.
UATEC - Unidade de Transferência de Tecnologia posted this:Optical pressure sensor based on zirconia nanostructuresA group of researchers from a Portuguese university has developed the concept of a gas pressure gauge based on the control of the luminescence from zirconia nanostructures. The invention aims to measure the gas pressure based on the nanoparticles emission that is different depending on the amount of gas molecules surrounding the nanoparticles. Comparing with existing solutions, the advantage of this process, which operate in a pressure range of interest for various market sectors (ex. Food industry), is the absence of electrical contacts. The university is looking for companies that develop this type of solution on an industrial scale for the further joint development of specific applications or technology licensing.
UNIVERSIDAD DE BURGOS posted this:Detection Kit for drugs and toxic substancesTest kit for both qualitative and quantitative detection of different types of tertiary amines in situ. Detection of tertiary amines is very important as they are classified in several occasions as toxic analytes and/or contaminants. Among the tertiary amines capable of being detected by the developed method it is possible to include: pyrrolizidines, tropane alkaloids (scopolamine, atropine and cocaine), Opiates (Morphine, Codeine, Heroin).
Research & Technology Organization
UNIVERSIDAD DE ALICANTE posted this:Research and development into new fertilizers and biostimulantsThe research group Agricultural Chemistry of the University of Alicante has extensive knowledge and experience in the development of new fertilizers, biostimulants, iron chelates and inductors for plant defense system. It also has plant growth chambers, greenhouses and scientific-technological equipment to carry out different types of analysis. We offer our services to companies interested in developing R&D&i, specific training related to the research and any scientific and technical support.
UNIVERSIDAD DE BURGOS posted this:Food-grade collagen obtaining through natural degreasing using supercritical fluidsFood-use collagen obtaining through pigskin degreasing using compressed carbon dioxide (yields above 90%). The method does not alter the nature of the protein contained in the skin and uses a safe solvent (CO2) in order to obtain a suitable feedstock.
IMIM Institut Recerca Hospital del Mar posted this:New phenolic natural extract obtained from olive and herbal spices with proven cardioprotective effect.This product consists of a natural extract wich combines olive oil phenols and other bioactive compounds from herbal species. The bioactive compounds of the natural extract have been characterized and quantified. Its use allows a novel therapeutic approach by means of the combination of complementary antioxidants from different origins that provides additional health benefits. Consumer acceptance has previously been assessed by conducting a panel test. Data from a randomized, controlled, crossover, clinical trial showed an improvement of vivo endothelial function and HDL subclass distribution, in humans. These effects were obtained with a low daily intake of the extract.
Centre Technology Transfer CITTRU posted this:Nanocapsules for delivery of lipophilic compounds and method of their preparationThe present invention provides novel biocompatible “core-shell” systems and the surfactant-free method of their preparation using macromolecular compounds. Biocompatible nanocapsules with liquid cores which enable effective encapsulation of hydrophobic compounds are stabilized without low molecular weight surfactants. These beneficial features significantly increase the range of possible applications.
Centre Technology Transfer CITTRU posted this:Manganese-lactoferrin complex stimulating the growth of probiotic bacteriaThe subject of the offer is manganese-lactoferrin complex with properties stimulating the growth of probiotic bacteria in digestive system. Possible applications of the invention include prevention and treatment of bacterial infections (including sepsis in newborns), chronic inflammatory bowel diseases, dietary supplementation in prevention of bacterial infections and some other indications.
UNIVERSIDAD DE BURGOS posted this:Smart Tag to Determine the Quality of Packaged FishPolymeric material that responds colorimetrically to the presence of biogenic amines. The presence of biogenic amines is related to fish spoilage, becoming an indicator of freshness and quality for optimal consumption. The material developed is able to determine biogenic amines in solution and in gaseous phase.
Centre Technology Transfer CITTRU posted this:Staphylococcus pseudintermedius & bacteriocins – various applicationsThe subject of the present offer is new bacterial strain Staphylococcus pseudintermedius Sp222, isolated from dog pathologic dermal lesions. The offer includes also peptide and protein bacteriocins produced by S. pseudintermedius Sp222. These bacteriocins exhibit a broad spectrum of biological activities: - bacteriocin BacSp222 is able to kill a variety of Gram+ bacteria strains, including the methicillin resistant S. aureus (MRSA) strain. It is also cytotoxic towards selected eukaryotic cells and is resistant to action of proteolytic enzymes (either eukaryotic or prokaryotic) as well as to high temperature. The biological activity of BacSp222 is sustained even after limited fragmentation of its molecule by chemical reagents; - lysostaphin Sp222 has an ability to effectively lyse (and, in consequence, to kill) the cells of Gram+ bacteria.
DIT Hothouse posted this:BovAlert: Priority Animal Health TestingBovAlert is an electrochemical diagnostic device which tests the milk of animal herds for liver fluke, providing quick and easy information regarding disease status. The technology consists of a handheld electronic reader and an assay card for on-site field testing and validation.
Research & Technology Organization
Universidad de Alcalá-OTRI posted this:Procedure for obtaining peptides with antioxidant and antihypertensive properties from olive seeds.A research group from the Analytical Chemistry Department at Alcalá University has developed a procedure from which it is possible to obtain peptides with antihypertensive and antioxidant capacity of isolated proteins from olive seed by enzymatic digestion. The method consists of the protein extraction from the olive seeds using a previously developed process, and digest the extracted proteins with Thermolysin enzyme, allowing to obtain peptides with antihypertensive capacity in vitro, or with Alcalase enzyme leading to obtain a peptide extract with antioxidant properties. The group seeks to establish commercial , licensing or collaboration agreements with companies of the food and pharmaceutical sectors interested in both the use strategy of this waste material (olive pits), as in the use of the found bioactive peptides.