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Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRIUniversidad de Alcalá-OTRI posted this:
Analysis and heuristic optimization software system for wind farm design.The utilization of technologies of soft computing has been vaguely applied to the optimization of the design of wind farms, and only with a limited set of parameters. Gheode group has developed a series of algorithms that consider in a much more realistic way the designing of parks, having in addition a great versatility to incorporate improvements or made-to-measure expansions for every client in particular.
University of WaterlooUniversity of WaterlooUniversity of Waterloo posted this:
Anchor system for FRP platesFiber reinforced material and, in particular, fiber-reinforced-polymers (FRP), have been introduced for the structural rehabilitation and retrofitting of aging infrastructure as they are stronger than steel and not susceptible to corrosion. However, FRP plate can be more difficult to anchor to the base material (the underside of a bridge for example) because of low transverse compressive strength (i.e. it’s easily crushed), which can lead to breakage at or near the anchor point. Finding a suitable anchor system for FRP plates is a challenge as FRP plate is generally sensitive to lateral stress. It is, therefore, desirable to provide an improved anchoring system for fiber reinforced materials. Further, typical anchors for FRP plates tend to be very large, expensive, and difficult to manufacture.
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
Andrographolide derivatives for its use as treatment for inflammatory diseasesAndrographolide derivatives for its use as treatment for inflammatory diseases related to cytokine storm. CSIC, the Polytechnic University of Valencia, the University of Navarra and the Medical Applied Research Foundation have developed semi-synthetic derivatives of andrographolide, a plant-derived product, very useful for the treatment of inflammatory diseases related to a massive cytokine release. These new compounds show a secure and specific way to control the inflammation, that can be caused by a viral infection, as COVID-19, a bacterial infection or by immunotherapy. Industrial partners are being sought to collaborate through a patent licence agreement or codevelopment. An offer for Patent Licensing or Collaboration for development
TTPU posted this:
Anti-adhesive Biopolymer CoatingResearchers have developed an anti-adhesive coating based on a polymer naturally and sustainable produced by a marine bacterium. This coating prevents the bacterial adhesion and the subsequent biofilm formation that usually leads to host bacterial infections difficult to eradicate and control with the antibiotics currently in use, namely in hospital environments. This coating can be applied in a cost effective way to a broad range of materials through the application of a universal glue.
Leading BiologyLeading BiologyLeading Biology posted this:
Anti-GPCR Antibody ProductionWith rich experience in antibody discovery and membrane protein studies, experts from Leading Biology have launched a membrane protein antibody development platform. We provide a one-stop service of anti-GPCR membrane protein antibody discovery service against a variety of GPCR targets now.
Business Development Manager at Leading Biology
Yeda posted this:
Anti-QSOX1 Antibody for Treating Cancer and MetastasisCancer, and especially cancer metastasis, is a leading cause of death worldwide. Research in recent years highlighted the importance of the extracellular matrix (ECM) surrounding the tumor in cancer progression metastasis formation. Therefore, many attempts currently address the unmet need to target enzymes that remodel the ECM to treat cancer. The current technology is a monoclonal antibody that specifically inhibits QSOX1, an enzyme that remodels the ECM and is up-regulated in several cancers. The antibody effectively inhibited tumor progression and metastasis formation in several mouse models, especially when combined with chemotherapies. The antibody potentially offers a generalized treatment for several cancer types as a single agent or in combination with standard of care chemotherapies.
Javier Montiel BonmatíUniversidad de AlicanteJavier Montiel Bonmatí posted this:
Antibacterial alternative to antibiotics, with high specificity against Escherichia coliThe "Molecular Microbiology" research group at the University of Alicante has modified several phage proteins (Poll-N and UK-C) that have high specificity against Escherichia coli (E. coli), but not against other Gram-negative (G-) bacteria. For these reasons, their use as a specific antimicrobial against E. coli is potentially interesting, especially in the case of contaminated food, cosmetics or water. It would also be useful in the treatment of diseases (infections) caused by E. coli. The presence of a histidine tail attached to the phage proteins not only facilitates their purification but also improves lysis efficiency without the need of cell permeabilization treatments. Companies interested in the commercial exploitation of the technology through license agreements and/or technical cooperation are sought.
Universidad de Alicante
Dirección de Transferencia Tecnológica (DIT) Universidad Adolfo IbáñezUniversidad Adolfo IbáñezDirección de Transferencia Tecnológica (DIT) Universidad Adolfo IbáñezAgente de Innovación at Universidad Adolfo Ibáñez
View ProfileDirección de Transferencia Tecnológica (DIT) Universidad Adolfo Ibáñez posted this:
Antibacterial Nano-Spheres, wide range of applicationsThis innovative method synthesizes hollow titanium dioxide nano-spheres with high antimicrobial capacity and a broad spectrum of application, ranging from food to the disinfection of surgical instruments and hospital rooms. In contrast with other known methods such a electro-deposition, in-situ synthesis or freeze-unfreeze cycles, it is better at handling the residues from the synthesizes process, less complex and economic. It is a most effective method than antibiotics due to the rose of resistance in bacterias.
Agente de Innovación at Universidad Adolfo Ibáñez
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Antibiotics to treat diseases caused by HelicobacterCSIC, the University of Zaragoza, Institute Pasteur, IISA and ARAID have developed chemical derivatives that act selectively against the bacterium Helicobacter pylori, managing to reduce the bacterial load and even eradicate gastric infections caused by it. Industrial partners from the pharmaceutical industry are being sought to collaborate through a patent licence agreement. An offer for Patent Licensing
CNIC (TTO)Spanish National Center for Cardiovascular Research (CNIC)CNIC (TTO)Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)
View ProfileCNIC (TTO) posted this:
Antibodies for the diagnosis and/or treatment of atherosclerosisNovel atherosclerosis biomarkers are in need to improve the strategies for diagnosis and prognosis of cardiovascular disease. CNIC and DKFZ researchers have discovered 18 novel antibodies that show reactivity against the atherosclerotic plaque, which can thus be potentially used for the diagnosis of this disease. Moreover, the use of one such antibody, A12, delays the progression of atherosclerosis and reduces the level of free circulating cholesterol and LDL.
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Antibodies to measure residual levels of mycotoxin ochratoxin A in foodCSIC and the University of Valencia have developed antibodies capable of determining ochratoxin A in food and ensure compliance with legislation on food products regarding the presence of this mycotoxin. Antibodies have been generated using novel functionalized derivatives of ochratoxin A. These immunoreagents have shown their efficacy in both direct and indirect competitive ELISA to detect concentrations close to parts per trillion. We are looking for companies interested in patent licensing for the development of fast, sensitive and portable kits for the analysis of ochratoxin A in foods and beverages based on these antibodies. The license of the patent is offered Effective, fast and accurate detection Ochratoxin A has a higher incidence in cereals, wine, juices and coffee One of the most harmful and frequent mycotoxins in food is ochratoxin A. Its presence is a real problem for human health due to its toxicity, and it causes significant economic losses to various productive sectors. The main fungi producing ochratoxin A belongs to the genera Penicillium and Aspergillus, and the products with the highest incidence are cereals, wine, juices and coffee. The small concentrations at which this potent toxin is usually found commonly require the use of sophisticated chromatographic methods. An alternative is the generation of antibodies against ochratoxin A with superior performance to the existing ones that allow this toxin being recognized with high affinity and specificity. These immunoreagents can be easily implemented in various analytical platforms, from the simplest, such as competitive ELISAs and immunochromatographic strips, to more complex, like chips or biosensors of different types, which allows us to simultaneously analyze a large number of samples in low-resource settings such as warehouses, cellars and even farmlands. Main applications and advantages Ochratoxin A derivatives functionalized at new positions have been synthesized that faithfully preserve the structure and characteristics of this potent mycotoxin. These new compounds have proven to be extremely efficient as haptens to generate antibodies capable of recognizing ochratoxin A with an affinity and selectivity not previously described. Immunoassays developed using these immunoreagents have been shown to be very sensitive, allowing analysis of ochratoxin A at levels close to 10 parts per trillion. These new methods are faster than instrumental procedures, especially when analyzing complex samples such as wine and coffee. The generated immunoreagents are easily adaptable to portable methods, such as ELISA kits or immunochromatographic strips. Patent status Prioriy patent application filed suitable for international extension For more information contact with: Mª Jesus Añón Marín Instituto de Agroquímica y Tecnología de Alimentos Consejo Superior de Investigaciones Científicas (CSIC) Tel.: +34 963900022 E-mail: mjanon@iata.csic.es
Yeda posted this:
Antibody Based Therapy to Treat Cancer and GI Related DiseasesA novel therapeutic antibody against MMP-7, with exceptional specificity, for the treatment of aggressive cancers. Although early programs targeting MMPs (matrix metalloproteins) were largely unsuccessful due to adverse side effects, they remain a viable and highly desirable therapeutic target. The main obstacle in the attempts to target MMPs is the ability to selectively target individual MMPs. The present invention provides highly selective targeted therapy against MMP-7, which is strongly associated with aspects of cancer development such as angiogenesis and metastasis. In a further development of their previous groundbreaking synthetic metal-protein mimicry molecules, researchers from Prof. Irit Sagi’s lab generated an antibody which exhibits exceptional degree of specificity towards MMP-7 over other MMPs. The present technology offers an opportunity to re-introduce improved MMP-targeting agents to the cancer therapeutics market, in particular aggressive cancers that face a major unmet medical need.
ALL Chemistry Inc. posted this:
Antibody Drug Conjugates (ADCs)At ALL Chemistry Inc. we are dedicated to providing our customers with the highest quality Antibody-drug Conjugates technology. From our passionate customer service staff to our cutting edge technology, we guarantee that no project is too great or too small. So if you're looking for an experienced and reliable provider of Antibody-drug Conjugates technology, we at ALL Chemistry Inc. are here to help!
- Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRI
Universidad de Alcalá-OTRI posted this:
Anticancer activity of Ru (II) Arene complexes with oxime ligands.Spanish research group from the department of Inorganic Chemistry the University of Alcala, together with a Moroccan research group from the University of Abdelmalek Essaadi, have developed a process to synthesize metal complexes with anticancer properties, which can be used for cancer treatment and prevention. The group is looking for companies working in the pharmaceutical and biomedical sector to achieve license, collaborative or commercial agreements with technical assistance.
Universidad Andres BelloUniversidad Andres BelloUniversidad Andres Bello posted this:
Antidepressant targeting AstrocytesA fast-acting antidepressant candidate whose pharmacological target is not a neuron receptor but an astrocyte channel. The technology is based on small molecules that modulate specific astrocyte channels showing antidepressive effects.
Rui Manuel SilvaNOVA University LisbonRui Manuel Silva posted this:
Antimalarial Agent, Methods and Uses ThereofThe present disclosure relates to compounds and compositions for the treatment of malarian diseases. The compounds comprise a class of halogenated alkyl-aromatic secondary metabolites, including hierridic C, or pharmaceutically acceptable salts, esters, solvates or prodrugs thereof. The compounds comprise a halogen; C1-C6 alkyl, H, COCH3, COH, CO-alkyl, or CO-aryl; and a C3-C30 alkyl. In at least one embodiment, the compound is 3-chloro-4,6-dimethoxy-2-pentadecylphenol. The present disclosure also relates to methods of obtain the compounds from a solution comprising a cyanobacterium.
Innovation Manager at NOVA University Lisbon
University of Alberta, Technology Transfer ServicesUniversity of Alberta, Technology Transfer ServicesUniversity of Alberta, Technology Transfer Services posted this:
Antimicrobial Coating for Face Masks and Self-Sanitizing SurfacesUniversal virus/bacteria negation coating efficiently inactivates transmissible viral/bacterial aerosols/droplets. Potential to improve safety and reusability of current face masks.
- Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRI
Universidad de Alcalá-OTRI posted this:
Antimicrobial electrospun fiber membrane with retention and controlled release capacity of active substancesResearchers from the Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering of the University of Alcalá in collaboration with researchers from the Department of Chemistry and Physics of the University of Almería, presents a procedure for the manufacture of active membranes based on submicron fibers combining an antimicrobial action with the ability to retain apolar contaminants in aqueous solution. The membranes are produced by an electrospinning process in aqueous solution from mixtures of water soluble polyacids and polyols, which are subsequently stabilized by a thermal curing process and post-functionalized by the incorporation of amino-terminated dendrimers by a grafting process using a coupling agent. The material can be applied to the treatment of drinking water, to the regeneration of waste water, to the treatment of process waters and also to the controlled release of active substances, such as drugs, food preservatives, etc. The group seeks companies from the pharmaceutical, food, material technology and environmental sectors to sign technical cooperation agreements, commercial agreement with technical assistance and patent licensing agreements.
Simona RatajUniversity of LjubljanaSimona Rataj posted this:
Antiviral and antibacterial textiles functionalized with natural biologically active dyeThe University of Ljubljana developed functionalized coloured textiles with antiviral and antibacterial properties based on emodin and its derivatives.
Alliance Manager at University of LjubljanaIker García posted this:
AONIR PLATFORM, for in line and real-time production characterization based on NIRS technology.AONIR is our system based on NIR spectroscopy, for inline monitoring of processes in the food and pharmaceutical industry. It allows real-time quality control of the entire production process, from the evaluation of raw materials to the final product. This monitoring, in addition to homogenising production and increasing the quality of the final product, achieves more efficient and sustainable production.
CEO at AOTECH
IBIMA-Plataforma BionandIBIMA-Plataforma BionandIBIMA-Plataforma Bionand posted this:
Aortic aneurysm treatment deviceA new improved device for the treatment of aortic aneurysm, which solves the surgical problems of current alternatives. -Universality, it can be used in any anatomy. -It has a lower learning curve, as the same system can be used for all patients. Ease of use. -Speed, it is not necessary to make a customized stent for each patient, thus reducing the waiting time for the surgery to be performed. -Thanks to the smaller diameter, the implantation procedure could be performed under local anesthesia and by arterial puncture, and used in the most unfavorable anatomies.
Germans Trias i Pujol Health Sciences Research InstituteGermans Trias i Pujol Health Sciences Research InstituteGermans Trias i Pujol Health Sciences Research Institute posted this:
Apotransferrin to treat strokeOur group has demonstrated that intravenous administration of apotransferrin strongly reduces the brain damage (up to 75%) in 3 different rat models including both transient and permanent ischemic stroke and improves the neurological impairment (neuroscore 60%) induced by stroke. Thus, this new approach may benefit not only stroke patients who can be treated with current treatment to induce recanalization (transient stroke) but also the 80% of patients who could not benefit from current therapies directed to induce recanalization of the artery (permanent strokes). Results in the preclinical area and some results obtained in serum of stroke patients lead us to think that apotransferrin is a good neuroprotector in the early stages of the ischemic event.
- Rohan Joy MathewGeorgetown University
Rohan Joy Mathew posted this:
Apparatus and Method for Delivery of Antimicrobial During a Transdermal Sampling and Delivery Process- Minimally invasive transdermal device for delivering an antimicrobial to skin at access point of interstitial fluid sampling, medical monitoring, and/or transdermal drug delivery. - Mitigates risk of infection at surgical and other wound sites. - Can deliver multiple antimicrobials to the site at the same time. Antimicrobials can be delivered on-demand or through the use of a hand-held device, or as scheduled through patch design.
Program Specialist at Georgetown University
Georgetown UniversityGeorgetown UniversityGeorgetown University posted this:
Apparatus and Methods for PARCI Mass Spectrometry- PARCI-MS revolutionizes elemental quantitation, achieving 100 times better sensitivity for fluorine quantitation than current methods, ensuring unparalleled precision in measurements. - The innovation requires only one standard per element, streamlining workflows by eliminating the need for compound-specific calibrations and reducing experimentation time and costs. - PARCI-MS facilitates the simultaneous measurement of multiple elements, enabling rapid quantitation and identification of compounds in pharmaceuticals, environmental samples, food products, and forensic materials.
Korea Institute of Energy ResearchKorea Institute of Energy ResearchKorea Institute of Energy Research posted this:
Apparatus for producing silicon nanocrystals based on inductively coupled plasma.Researchers at the Korea Institute of Energy Research have developed a new apparatus for producing silicon nanocrystals based on inductively coupled plasma. Silicon nanocrystals have been widely investigated for several years because of their many interesting properties and potential use in several applications. Recently, silicon nanocrystals have been used in solar cells and light emitting device (LEDs). Silicon is an environmentally friendly material and is utilised for various applications in the field of electronic materials. The field of silicon nanocrystal production has grown enormously of late, in response to the observation of quantum confinement in porous silicon. Silicon is already widely used in the semiconductor industry, in large part because of its nontoxic properties and abundance, being the second most abundant element in the earth’s crust. Due to the high capacity of silicon paired with its relatively environmentally friendly properties it is an ideal material for use as a replacement to more commonly used environmentally costly materials. The common process of producing silicon nanocrystals can be classified into three distinct areas: solid-state reaction, liquid state reaction, and vapour state reaction. The solid-state reaction is the process whereby a thin film of SiO2, Si3N4 or the like containing excess Silicon (Si) is formed and subjected to heat treatment to enable the condensation of silicon and subsequent formation of silicon nanocrystals in a SiO2, Si3N4 or SiC matrix. In the liquid state reaction, silicon nanocrystals are prepared via a chemical reaction of silicon compounds, this is done through the application of variant methods, for example the high-temperature supercritical method. In the vapour state reaction, silicon nanocrystals are prepared by passing a silane compound gas through a high energy region such as laser or plasma. In the case of all three traditional silicon nanocrystals reaction methods (solid, liquid and gas) the process incurs significant cost due to the substantial need for heat energy and expensive deposition equipment. What’s more, in the liquid State reaction issues arise due to the severe difficulty in controlling particle size, which in turn leads to poor crystallinity quality. The vapour state reaction incurs further issues due to the extreme use of energy resulting in aggregated nanocrystals and the formation of secondary particles. To overcome the inherent issues of solid, liquid and vapour silicon nanocrystal reactions non-thermal plasma, such as inductively coupled plasma (IPC) has begun to be used. However, the conventional ICP-based apparatus has limitations and can result in issues pertaining to the management of the particle size of silicon nanocrystals, as well as extending reaction time and deteriorating silicon nanocrystal quality. To combat the aforementioned limitations in silicon nanocrystal production a new apparatus method has been designed, which can minimise plasma diffusion inside the reactor during production using ICP to improve the particle size characteristics and quality of the silicon nanocrystals.
