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Yeda posted this:
Anti-QSOX1 Antibody for Treating Cancer and MetastasisCancer, and especially cancer metastasis, is a leading cause of death worldwide. Research in recent years highlighted the importance of the extracellular matrix (ECM) surrounding the tumor in cancer progression metastasis formation. Therefore, many attempts currently address the unmet need to target enzymes that remodel the ECM to treat cancer. The current technology is a monoclonal antibody that specifically inhibits QSOX1, an enzyme that remodels the ECM and is up-regulated in several cancers. The antibody effectively inhibited tumor progression and metastasis formation in several mouse models, especially when combined with chemotherapies. The antibody potentially offers a generalized treatment for several cancer types as a single agent or in combination with standard of care chemotherapies.
Javier Montiel BonmatíUniversidad de AlicanteJavier Montiel Bonmatí posted this:
Antibacterial alternative to antibiotics, with high specificity against Escherichia coliThe "Molecular Microbiology" research group at the University of Alicante has modified several phage proteins (Poll-N and UK-C) that have high specificity against Escherichia coli (E. coli), but not against other Gram-negative (G-) bacteria. For these reasons, their use as a specific antimicrobial against E. coli is potentially interesting, especially in the case of contaminated food, cosmetics or water. It would also be useful in the treatment of diseases (infections) caused by E. coli. The presence of a histidine tail attached to the phage proteins not only facilitates their purification but also improves lysis efficiency without the need of cell permeabilization treatments. Companies interested in the commercial exploitation of the technology through license agreements and/or technical cooperation are sought.
Universidad de Alicante
Dirección de Transferencia Tecnológica (DIT) Contact: Martín Flores DonosoUniversidad Adolfo IbáñezDirección de Transferencia Tecnológica (DIT) Contact: Martín Flores DonosoAgente de Innovación at Universidad Adolfo Ibáñez
View ProfileDirección de Transferencia Tecnológica (DIT) Contact: Martín Flores Donoso posted this:
Antibacterial Nano-Spheres, wide range of applicationsThis innovative method synthesizes hollow titanium dioxide nano-spheres with high antimicrobial capacity and a broad spectrum of application, ranging from food to the disinfection of surgical instruments and hospital rooms. In contrast with other known methods such a electro-deposition, in-situ synthesis or freeze-unfreeze cycles, it is better at handling the residues from the synthesizes process, less complex and economic. It is a most effective method than antibiotics due to the rose of resistance in bacterias.
Agente de Innovación at Universidad Adolfo Ibáñez
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
Antibiotics to treat diseases caused by HelicobacterCSIC, the University of Zaragoza, Institute Pasteur, IISA and ARAID have developed chemical derivatives that act selectively against the bacterium Helicobacter pylori, managing to reduce the bacterial load and even eradicate gastric infections caused by it. Industrial partners from the pharmaceutical industry are being sought to collaborate through a patent licence agreement. An offer for Patent Licensing
CNIC (TTO)Spanish National Center for Cardiovascular Research (CNIC)CNIC (TTO)Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)
View ProfileCNIC (TTO) posted this:
Antibodies for the diagnosis and/or treatment of atherosclerosisNovel atherosclerosis biomarkers are in need to improve the strategies for diagnosis and prognosis of cardiovascular disease. CNIC and DKFZ researchers have discovered 18 novel antibodies that show reactivity against the atherosclerotic plaque, which can thus be potentially used for the diagnosis of this disease. Moreover, the use of one such antibody, A12, delays the progression of atherosclerosis and reduces the level of free circulating cholesterol and LDL.
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Antibodies to measure residual levels of mycotoxin ochratoxin A in foodCSIC and the University of Valencia have developed antibodies capable of determining ochratoxin A in food and ensure compliance with legislation on food products regarding the presence of this mycotoxin. Antibodies have been generated using novel functionalized derivatives of ochratoxin A. These immunoreagents have shown their efficacy in both direct and indirect competitive ELISA to detect concentrations close to parts per trillion. We are looking for companies interested in patent licensing for the development of fast, sensitive and portable kits for the analysis of ochratoxin A in foods and beverages based on these antibodies. The license of the patent is offered Effective, fast and accurate detection Ochratoxin A has a higher incidence in cereals, wine, juices and coffee One of the most harmful and frequent mycotoxins in food is ochratoxin A. Its presence is a real problem for human health due to its toxicity, and it causes significant economic losses to various productive sectors. The main fungi producing ochratoxin A belongs to the genera Penicillium and Aspergillus, and the products with the highest incidence are cereals, wine, juices and coffee. The small concentrations at which this potent toxin is usually found commonly require the use of sophisticated chromatographic methods. An alternative is the generation of antibodies against ochratoxin A with superior performance to the existing ones that allow this toxin being recognized with high affinity and specificity. These immunoreagents can be easily implemented in various analytical platforms, from the simplest, such as competitive ELISAs and immunochromatographic strips, to more complex, like chips or biosensors of different types, which allows us to simultaneously analyze a large number of samples in low-resource settings such as warehouses, cellars and even farmlands. Main applications and advantages Ochratoxin A derivatives functionalized at new positions have been synthesized that faithfully preserve the structure and characteristics of this potent mycotoxin. These new compounds have proven to be extremely efficient as haptens to generate antibodies capable of recognizing ochratoxin A with an affinity and selectivity not previously described. Immunoassays developed using these immunoreagents have been shown to be very sensitive, allowing analysis of ochratoxin A at levels close to 10 parts per trillion. These new methods are faster than instrumental procedures, especially when analyzing complex samples such as wine and coffee. The generated immunoreagents are easily adaptable to portable methods, such as ELISA kits or immunochromatographic strips. Patent status Prioriy patent application filed suitable for international extension For more information contact with: Mª Jesus Añón Marín Instituto de Agroquímica y Tecnología de Alimentos Consejo Superior de Investigaciones Científicas (CSIC) Tel.: +34 963900022 E-mail: mjanon@iata.csic.es
Yeda posted this:
Antibody Based Therapy to Treat Cancer and GI Related DiseasesA novel therapeutic antibody against MMP-7, with exceptional specificity, for the treatment of aggressive cancers. Although early programs targeting MMPs (matrix metalloproteins) were largely unsuccessful due to adverse side effects, they remain a viable and highly desirable therapeutic target. The main obstacle in the attempts to target MMPs is the ability to selectively target individual MMPs. The present invention provides highly selective targeted therapy against MMP-7, which is strongly associated with aspects of cancer development such as angiogenesis and metastasis. In a further development of their previous groundbreaking synthetic metal-protein mimicry molecules, researchers from Prof. Irit Sagi’s lab generated an antibody which exhibits exceptional degree of specificity towards MMP-7 over other MMPs. The present technology offers an opportunity to re-introduce improved MMP-targeting agents to the cancer therapeutics market, in particular aggressive cancers that face a major unmet medical need.
ALL Chemistry Inc. posted this:
Antibody Drug Conjugates (ADCs)At ALL Chemistry Inc. we are dedicated to providing our customers with the highest quality Antibody-drug Conjugates technology. From our passionate customer service staff to our cutting edge technology, we guarantee that no project is too great or too small. So if you're looking for an experienced and reliable provider of Antibody-drug Conjugates technology, we at ALL Chemistry Inc. are here to help!
Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRIUniversidad de Alcalá-OTRI posted this:
Anticancer activity of Ru (II) Arene complexes with oxime ligands.Spanish research group from the department of Inorganic Chemistry the University of Alcala, together with a Moroccan research group from the University of Abdelmalek Essaadi, have developed a process to synthesize metal complexes with anticancer properties, which can be used for cancer treatment and prevention. The group is looking for companies working in the pharmaceutical and biomedical sector to achieve license, collaborative or commercial agreements with technical assistance.
Universidad Andres BelloUniversidad Andres BelloUniversidad Andres Bello posted this:
Antidepressant targeting AstrocytesA fast-acting antidepressant candidate whose pharmacological target is not a neuron receptor but an astrocyte channel. The technology is based on small molecules that modulate specific astrocyte channels showing antidepressive effects.
Rui Manuel SilvaNOVA University LisbonRui Manuel Silva posted this:
Antimalarial Agent, Methods and Uses ThereofThe present disclosure relates to compounds and compositions for the treatment of malarian diseases. The compounds comprise a class of halogenated alkyl-aromatic secondary metabolites, including hierridic C, or pharmaceutically acceptable salts, esters, solvates or prodrugs thereof. The compounds comprise a halogen; C1-C6 alkyl, H, COCH3, COH, CO-alkyl, or CO-aryl; and a C3-C30 alkyl. In at least one embodiment, the compound is 3-chloro-4,6-dimethoxy-2-pentadecylphenol. The present disclosure also relates to methods of obtain the compounds from a solution comprising a cyanobacterium.
Innovation Manager at NOVA University Lisbon
University of Alberta, Technology Transfer ServicesUniversity of Alberta, Technology Transfer ServicesUniversity of Alberta, Technology Transfer Services posted this:
Antimicrobial Coating for Face Masks and Self-Sanitizing SurfacesUniversal virus/bacteria negation coating efficiently inactivates transmissible viral/bacterial aerosols/droplets. Potential to improve safety and reusability of current face masks.
- Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRI
Universidad de Alcalá-OTRI posted this:
Antimicrobial electrospun fiber membrane with retention and controlled release capacity of active substancesResearchers from the Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering of the University of Alcalá in collaboration with researchers from the Department of Chemistry and Physics of the University of Almería, presents a procedure for the manufacture of active membranes based on submicron fibers combining an antimicrobial action with the ability to retain apolar contaminants in aqueous solution. The membranes are produced by an electrospinning process in aqueous solution from mixtures of water soluble polyacids and polyols, which are subsequently stabilized by a thermal curing process and post-functionalized by the incorporation of amino-terminated dendrimers by a grafting process using a coupling agent. The material can be applied to the treatment of drinking water, to the regeneration of waste water, to the treatment of process waters and also to the controlled release of active substances, such as drugs, food preservatives, etc. The group seeks companies from the pharmaceutical, food, material technology and environmental sectors to sign technical cooperation agreements, commercial agreement with technical assistance and patent licensing agreements.
Simona RatajUniversity of LjubljanaSimona Rataj posted this:
Antiviral and antibacterial textiles functionalized with natural biologically active dyeThe University of Ljubljana developed functionalized coloured textiles with antiviral and antibacterial properties based on emodin and its derivatives.
Alliance Manager at University of LjubljanaIker García posted this:
AONIR PLATFORM, for in line and real-time production characterization based on NIRS technology.AONIR is our system based on NIR spectroscopy, for inline monitoring of processes in the food and pharmaceutical industry. It allows real-time quality control of the entire production process, from the evaluation of raw materials to the final product. This monitoring, in addition to homogenising production and increasing the quality of the final product, achieves more efficient and sustainable production.
CEO at AOTECH
IBIMA-Plataforma BionandIBIMA-Plataforma BionandIBIMA-Plataforma Bionand posted this:
Aortic aneurysm treatment deviceA new improved device for the treatment of aortic aneurysm, which solves the surgical problems of current alternatives. -Universality, it can be used in any anatomy. -It has a lower learning curve, as the same system can be used for all patients. Ease of use. -Speed, it is not necessary to make a customized stent for each patient, thus reducing the waiting time for the surgery to be performed. -Thanks to the smaller diameter, the implantation procedure could be performed under local anesthesia and by arterial puncture, and used in the most unfavorable anatomies.
Germans Trias i Pujol Health Sciences Research InstituteGermans Trias i Pujol Health Sciences Research InstituteGermans Trias i Pujol Health Sciences Research Institute posted this:
Apotransferrin to treat strokeOur group has demonstrated that intravenous administration of apotransferrin strongly reduces the brain damage (up to 75%) in 3 different rat models including both transient and permanent ischemic stroke and improves the neurological impairment (neuroscore 60%) induced by stroke. Thus, this new approach may benefit not only stroke patients who can be treated with current treatment to induce recanalization (transient stroke) but also the 80% of patients who could not benefit from current therapies directed to induce recanalization of the artery (permanent strokes). Results in the preclinical area and some results obtained in serum of stroke patients lead us to think that apotransferrin is a good neuroprotector in the early stages of the ischemic event.
Georgetown UniversityGeorgetown UniversityGeorgetown University posted this:
Apparatus and Method for Delivery of Antimicrobial During a Transdermal Sampling and Delivery Process- Minimally invasive transdermal device for delivering an antimicrobial to skin at access point of interstitial fluid sampling, medical monitoring, and/or transdermal drug delivery. - Mitigates risk of infection at surgical and other wound sites. - Can deliver multiple antimicrobials to the site at the same time. Antimicrobials can be delivered on-demand or through the use of a hand-held device, or as scheduled through patch design.
Korea Institute of Energy ResearchKorea Institute of Energy ResearchKorea Institute of Energy Research posted this:
Apparatus for producing silicon nanocrystals based on inductively coupled plasma.Researchers at the Korea Institute of Energy Research have developed a new apparatus for producing silicon nanocrystals based on inductively coupled plasma. Silicon nanocrystals have been widely investigated for several years because of their many interesting properties and potential use in several applications. Recently, silicon nanocrystals have been used in solar cells and light emitting device (LEDs). Silicon is an environmentally friendly material and is utilised for various applications in the field of electronic materials. The field of silicon nanocrystal production has grown enormously of late, in response to the observation of quantum confinement in porous silicon. Silicon is already widely used in the semiconductor industry, in large part because of its nontoxic properties and abundance, being the second most abundant element in the earth’s crust. Due to the high capacity of silicon paired with its relatively environmentally friendly properties it is an ideal material for use as a replacement to more commonly used environmentally costly materials. The common process of producing silicon nanocrystals can be classified into three distinct areas: solid-state reaction, liquid state reaction, and vapour state reaction. The solid-state reaction is the process whereby a thin film of SiO2, Si3N4 or the like containing excess Silicon (Si) is formed and subjected to heat treatment to enable the condensation of silicon and subsequent formation of silicon nanocrystals in a SiO2, Si3N4 or SiC matrix. In the liquid state reaction, silicon nanocrystals are prepared via a chemical reaction of silicon compounds, this is done through the application of variant methods, for example the high-temperature supercritical method. In the vapour state reaction, silicon nanocrystals are prepared by passing a silane compound gas through a high energy region such as laser or plasma. In the case of all three traditional silicon nanocrystals reaction methods (solid, liquid and gas) the process incurs significant cost due to the substantial need for heat energy and expensive deposition equipment. What’s more, in the liquid State reaction issues arise due to the severe difficulty in controlling particle size, which in turn leads to poor crystallinity quality. The vapour state reaction incurs further issues due to the extreme use of energy resulting in aggregated nanocrystals and the formation of secondary particles. To overcome the inherent issues of solid, liquid and vapour silicon nanocrystal reactions non-thermal plasma, such as inductively coupled plasma (IPC) has begun to be used. However, the conventional ICP-based apparatus has limitations and can result in issues pertaining to the management of the particle size of silicon nanocrystals, as well as extending reaction time and deteriorating silicon nanocrystal quality. To combat the aforementioned limitations in silicon nanocrystal production a new apparatus method has been designed, which can minimise plasma diffusion inside the reactor during production using ICP to improve the particle size characteristics and quality of the silicon nanocrystals.
Sandra MoczulskaTechnology Transfer Office (University of Warsaw)Sandra Moczulska posted this:
Application and method of producing cyclic compounds in olefin metathesis reactionThe olefin metathesis reaction has many advantages, the most important of which is the fact that it shortens the synthesis path by reducing the number of required steps and this lowers the cost of obtaining the target product. Unfortunately, the industrial application of the olefin metathesis reaction (especially in the production of macrocyclic rings in the RCM reaction) is currently experiencing difficulties such as: - lack of selectivity and product competition (a major problem with RCMs leading to large macrocyclic rings to minimize the problem of high dilution, but it clearly increases the cost of the process) - displacement of reaction equilibrium (RCM reaction is an equilibrium process, so to move the process towards the formation of products it is necessary to react under reduced pressure) - migration of double bond C = C (migration within the substrates as well as target product due to side reactions. This inconvenience can be eliminated by using, for example, quinones - unfortunately, this elimination is only partial.) - the need to use a homogeneous ruthenium catalyst (a large amount of catalyst is required to reach the reaction, reaching over 20 mol%). The present invention relates to a process for the production of cyclic compounds in the olefin metathesis reaction and the use of ruthenium catalysts for the production of cyclic olefins in olefin metathesis reactions. The solution through optimization, overcomes the current problems. The expected product is obtained with high efficiency and selectivity. The method can find extensive use in organic synthesis, requiring metathetic ring closure (RCM), among others in the fragrance industry. Advantages of the presented solution from UW: 1. high process efficiency 2. high selectivity 3. low cost of synthesis
Technology Broker at Technology Transfer Office (University of Warsaw)- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Application of ultrasound in clinical physiotherapyThe CSIC has developed a device to apply physiotherapeutic ultrasound. The device allows controlled and programmable focusing. Industrial partners from the field of physiotherapy are being sought to collaborate through a patent license agreement.
Fabian BelinLuxembourg Institute of Science and Technology (LIST)Fabian BelinPartnerships Development & IP Valorization at Luxembourg Institute of Science and Technology (LIST)
Fabian Belin posted this:
APTAMER : Small single-stranded nucleic acid (DNA or RNA) for virus detectionAn aptamer is a small single-stranded nucleic acid (DNA or RNA) capable of adopting a three-dimensional structure that gives it the ability to bind to its target with remarkable specificity and affinity. Therefore, aptamers are a very promising technology for overcoming the drawbacks and limitations faced by antibodies and molecular assays in the framework of viral diagnostic test development. However, very few aptamers are described for virus detection. and no solutions integrating the technical and commercial benefits of aptamers is currently available on the virus detection market.
Partnerships Development & IP Valorization at Luxembourg Institute of Science and Technology (LIST)
IMDEA Water Institute posted this:
Aquatic ecotoxicology and ecological risk assessmentEcotoxicology is a multidisciplinary science which aims to assess how interaction between pollutants and the environment affects ecosystems, taking into account the susceptibility of individuals, populations and communities to be affected by and recover from any type of toxic stress. Assessing ecological risk from pollutants requires preliminary research into the emission and transport of contaminating substances in the environment and the exposure to which live organisms may be subjected. Likewise, laboratory and/or field experiments help evaluate the toxic effects caused by different pollutants and exposure patterns. Finally, the results of these studies are combined to calculate the likelihood of ecosystems being affected by the use of potentially toxic substances.
University of Luxembourg posted this:
Aquatic platform - Luxembourg Centre for Systems BiomedicineThe LCSB Aquatic Platform is centered around the use of zebrafish (Danio rerio), a vertebrate model with high genetic and physiologic similarity to humans. This versatile, reliable model organism is widely used for the in vivo study of developmental biology, gene function, drug discovery and pathophysiological aspects of various human diseases such as epilepsy, rare diseases, neurodegenerative disorders, among others.
CINBIO posted this:
Aqueous antioxidant extracts of vegetable raw materials, procedure of obtaining and their use in the composition of a cosmetic and/or dermatological productAqueous antioxidant extracts of vegetable raw materials, procedure of obtaining and their use in the composition of a cosmetic and/or dermatological product. Extracts obtained from Cytisus scoparius flowers, Pleurotus ostreatus mushrooms, Brassica rapa leaves and Quercus robur acorns using microwave-assisted hydrodiffusion and combined with gravity (Microwave hydrodiffusion and gravity, MHG). These extracts were used in the formulation of moisturizing creams with sun protection made with different thermal waters, evaluating their chemical and bioactive stability, as well as their mechanical properties.
Unitat de Valorització de la URVFundació URVUnitat de Valorització de la URV posted this:
ARCH·E10 is a small, fast and efficient solution for recording archaeological and palaeontological data during fieldworks.This program, jointly developed by the Rovira i Virgili University, Barcelona University and IPHES helps you to quickly computerize your field data, to use a total station efficiently and easily, to export and edit your data, print labels and make sections and planimetries. ARCH·e10 is a software that focuses on ● facilitating the registration of data ● facilitating the use of a total station offline ● facilitating the manipulation of data ● implement vector registration (3D3p model) ● proposing analytical tools for fieldwork As a data manager, has different modes of work aimed at the intensive use of the total station. Therefore, the main feature of ARCH·e10 is its ease for integrating data from a total station into field databases. In the field, you should apply the data link protocol between the total station and the Database. In the lab, download the data from the total station, upload it to ARCH·e10, and run the application to import, and cross the coordinates and data. For further information, please click here: https://arche.iphes.cat
Licensing Manager at Fundació URV
