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CNIC (TTO)Spanish National Center for Cardiovascular Research (CNIC)CNIC (TTO)Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)
View ProfileCNIC (TTO) posted this:
Antibodies for the diagnosis and/or treatment of atherosclerosisNovel atherosclerosis biomarkers are in need to improve the strategies for diagnosis and prognosis of cardiovascular disease. CNIC and DKFZ researchers have discovered 18 novel antibodies that show reactivity against the atherosclerotic plaque, which can thus be potentially used for the diagnosis of this disease. Moreover, the use of one such antibody, A12, delays the progression of atherosclerosis and reduces the level of free circulating cholesterol and LDL.
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
Antibodies to measure residual levels of mycotoxin ochratoxin A in foodCSIC and the University of Valencia have developed antibodies capable of determining ochratoxin A in food and ensure compliance with legislation on food products regarding the presence of this mycotoxin. Antibodies have been generated using novel functionalized derivatives of ochratoxin A. These immunoreagents have shown their efficacy in both direct and indirect competitive ELISA to detect concentrations close to parts per trillion. We are looking for companies interested in patent licensing for the development of fast, sensitive and portable kits for the analysis of ochratoxin A in foods and beverages based on these antibodies. The license of the patent is offered Effective, fast and accurate detection Ochratoxin A has a higher incidence in cereals, wine, juices and coffee One of the most harmful and frequent mycotoxins in food is ochratoxin A. Its presence is a real problem for human health due to its toxicity, and it causes significant economic losses to various productive sectors. The main fungi producing ochratoxin A belongs to the genera Penicillium and Aspergillus, and the products with the highest incidence are cereals, wine, juices and coffee. The small concentrations at which this potent toxin is usually found commonly require the use of sophisticated chromatographic methods. An alternative is the generation of antibodies against ochratoxin A with superior performance to the existing ones that allow this toxin being recognized with high affinity and specificity. These immunoreagents can be easily implemented in various analytical platforms, from the simplest, such as competitive ELISAs and immunochromatographic strips, to more complex, like chips or biosensors of different types, which allows us to simultaneously analyze a large number of samples in low-resource settings such as warehouses, cellars and even farmlands. Main applications and advantages Ochratoxin A derivatives functionalized at new positions have been synthesized that faithfully preserve the structure and characteristics of this potent mycotoxin. These new compounds have proven to be extremely efficient as haptens to generate antibodies capable of recognizing ochratoxin A with an affinity and selectivity not previously described. Immunoassays developed using these immunoreagents have been shown to be very sensitive, allowing analysis of ochratoxin A at levels close to 10 parts per trillion. These new methods are faster than instrumental procedures, especially when analyzing complex samples such as wine and coffee. The generated immunoreagents are easily adaptable to portable methods, such as ELISA kits or immunochromatographic strips. Patent status Prioriy patent application filed suitable for international extension For more information contact with: Mª Jesus Añón Marín Instituto de Agroquímica y Tecnología de Alimentos Consejo Superior de Investigaciones Científicas (CSIC) Tel.: +34 963900022 E-mail: mjanon@iata.csic.es
Yeda posted this:
Antibody Based Therapy to Treat Cancer and GI Related DiseasesA novel therapeutic antibody against MMP-7, with exceptional specificity, for the treatment of aggressive cancers. Although early programs targeting MMPs (matrix metalloproteins) were largely unsuccessful due to adverse side effects, they remain a viable and highly desirable therapeutic target. The main obstacle in the attempts to target MMPs is the ability to selectively target individual MMPs. The present invention provides highly selective targeted therapy against MMP-7, which is strongly associated with aspects of cancer development such as angiogenesis and metastasis. In a further development of their previous groundbreaking synthetic metal-protein mimicry molecules, researchers from Prof. Irit Sagi’s lab generated an antibody which exhibits exceptional degree of specificity towards MMP-7 over other MMPs. The present technology offers an opportunity to re-introduce improved MMP-targeting agents to the cancer therapeutics market, in particular aggressive cancers that face a major unmet medical need.
Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRIUniversidad de Alcalá-OTRI posted this:
Anticancer activity of Ru (II) Arene complexes with oxime ligands.Spanish research group from the department of Inorganic Chemistry the University of Alcala, together with a Moroccan research group from the University of Abdelmalek Essaadi, have developed a process to synthesize metal complexes with anticancer properties, which can be used for cancer treatment and prevention. The group is looking for companies working in the pharmaceutical and biomedical sector to achieve license, collaborative or commercial agreements with technical assistance.
Universidad Andres BelloUniversidad Andres BelloUniversidad Andres Bello posted this:
Antidepressant targeting AstrocytesA fast-acting antidepressant candidate whose pharmacological target is not a neuron receptor but an astrocyte channel. The technology is based on small molecules that modulate specific astrocyte channels showing antidepressive effects.
- Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRI
Universidad de Alcalá-OTRI posted this:
Antimicrobial electrospun fiber membrane with retention and controlled release capacity of active substancesResearchers from the Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering of the University of Alcalá in collaboration with researchers from the Department of Chemistry and Physics of the University of Almería, presents a procedure for the manufacture of active membranes based on submicron fibers combining an antimicrobial action with the ability to retain apolar contaminants in aqueous solution. The membranes are produced by an electrospinning process in aqueous solution from mixtures of water soluble polyacids and polyols, which are subsequently stabilized by a thermal curing process and post-functionalized by the incorporation of amino-terminated dendrimers by a grafting process using a coupling agent. The material can be applied to the treatment of drinking water, to the regeneration of waste water, to the treatment of process waters and also to the controlled release of active substances, such as drugs, food preservatives, etc. The group seeks companies from the pharmaceutical, food, material technology and environmental sectors to sign technical cooperation agreements, commercial agreement with technical assistance and patent licensing agreements.
Simona RatajUniversity of LjubljanaSimona Rataj posted this:
Antiviral and antibacterial textiles functionalized with natural biologically active dyeThe University of Ljubljana developed functionalized coloured textiles with antiviral and antibacterial properties based on emodin and its derivatives.
Alliance Manager at University of LjubljanaIker García posted this:
AONIR PLATFORM, for in line and real-time production characterization based on NIRS technology.AONIR is our system based on NIR spectroscopy, for inline monitoring of processes in the food and pharmaceutical industry. It allows real-time quality control of the entire production process, from the evaluation of raw materials to the final product. This monitoring, in addition to homogenising production and increasing the quality of the final product, achieves more efficient and sustainable production.
CEO at AOTECH
IBIMA-Plataforma BionandIBIMA-Plataforma BionandIBIMA-Plataforma Bionand posted this:
Aortic aneurysm treatment deviceA new improved device for the treatment of aortic aneurysm, which solves the surgical problems of current alternatives. -Universality, it can be used in any anatomy. -It has a lower learning curve, as the same system can be used for all patients. Ease of use. -Speed, it is not necessary to make a customized stent for each patient, thus reducing the waiting time for the surgery to be performed. -Thanks to the smaller diameter, the implantation procedure could be performed under local anesthesia and by arterial puncture, and used in the most unfavorable anatomies.
Germans Trias i Pujol Health Sciences Research InstituteGermans Trias i Pujol Health Sciences Research InstituteGermans Trias i Pujol Health Sciences Research Institute posted this:
Apotransferrin to treat strokeOur group has demonstrated that intravenous administration of apotransferrin strongly reduces the brain damage (up to 75%) in 3 different rat models including both transient and permanent ischemic stroke and improves the neurological impairment (neuroscore 60%) induced by stroke. Thus, this new approach may benefit not only stroke patients who can be treated with current treatment to induce recanalization (transient stroke) but also the 80% of patients who could not benefit from current therapies directed to induce recanalization of the artery (permanent strokes). Results in the preclinical area and some results obtained in serum of stroke patients lead us to think that apotransferrin is a good neuroprotector in the early stages of the ischemic event.
Korea Institute of Energy ResearchKorea Institute of Energy ResearchKorea Institute of Energy Research posted this:
Apparatus for producing silicon nanocrystals based on inductively coupled plasma.Researchers at the Korea Institute of Energy Research have developed a new apparatus for producing silicon nanocrystals based on inductively coupled plasma. Silicon nanocrystals have been widely investigated for several years because of their many interesting properties and potential use in several applications. Recently, silicon nanocrystals have been used in solar cells and light emitting device (LEDs). Silicon is an environmentally friendly material and is utilised for various applications in the field of electronic materials. The field of silicon nanocrystal production has grown enormously of late, in response to the observation of quantum confinement in porous silicon. Silicon is already widely used in the semiconductor industry, in large part because of its nontoxic properties and abundance, being the second most abundant element in the earth’s crust. Due to the high capacity of silicon paired with its relatively environmentally friendly properties it is an ideal material for use as a replacement to more commonly used environmentally costly materials. The common process of producing silicon nanocrystals can be classified into three distinct areas: solid-state reaction, liquid state reaction, and vapour state reaction. The solid-state reaction is the process whereby a thin film of SiO2, Si3N4 or the like containing excess Silicon (Si) is formed and subjected to heat treatment to enable the condensation of silicon and subsequent formation of silicon nanocrystals in a SiO2, Si3N4 or SiC matrix. In the liquid state reaction, silicon nanocrystals are prepared via a chemical reaction of silicon compounds, this is done through the application of variant methods, for example the high-temperature supercritical method. In the vapour state reaction, silicon nanocrystals are prepared by passing a silane compound gas through a high energy region such as laser or plasma. In the case of all three traditional silicon nanocrystals reaction methods (solid, liquid and gas) the process incurs significant cost due to the substantial need for heat energy and expensive deposition equipment. What’s more, in the liquid State reaction issues arise due to the severe difficulty in controlling particle size, which in turn leads to poor crystallinity quality. The vapour state reaction incurs further issues due to the extreme use of energy resulting in aggregated nanocrystals and the formation of secondary particles. To overcome the inherent issues of solid, liquid and vapour silicon nanocrystal reactions non-thermal plasma, such as inductively coupled plasma (IPC) has begun to be used. However, the conventional ICP-based apparatus has limitations and can result in issues pertaining to the management of the particle size of silicon nanocrystals, as well as extending reaction time and deteriorating silicon nanocrystal quality. To combat the aforementioned limitations in silicon nanocrystal production a new apparatus method has been designed, which can minimise plasma diffusion inside the reactor during production using ICP to improve the particle size characteristics and quality of the silicon nanocrystals.
Sandra MoczulskaTechnology Transfer Office (University of Warsaw)Sandra Moczulska posted this:
Application and method of producing cyclic compounds in olefin metathesis reactionThe olefin metathesis reaction has many advantages, the most important of which is the fact that it shortens the synthesis path by reducing the number of required steps and this lowers the cost of obtaining the target product. Unfortunately, the industrial application of the olefin metathesis reaction (especially in the production of macrocyclic rings in the RCM reaction) is currently experiencing difficulties such as: - lack of selectivity and product competition (a major problem with RCMs leading to large macrocyclic rings to minimize the problem of high dilution, but it clearly increases the cost of the process) - displacement of reaction equilibrium (RCM reaction is an equilibrium process, so to move the process towards the formation of products it is necessary to react under reduced pressure) - migration of double bond C = C (migration within the substrates as well as target product due to side reactions. This inconvenience can be eliminated by using, for example, quinones - unfortunately, this elimination is only partial.) - the need to use a homogeneous ruthenium catalyst (a large amount of catalyst is required to reach the reaction, reaching over 20 mol%). The present invention relates to a process for the production of cyclic compounds in the olefin metathesis reaction and the use of ruthenium catalysts for the production of cyclic olefins in olefin metathesis reactions. The solution through optimization, overcomes the current problems. The expected product is obtained with high efficiency and selectivity. The method can find extensive use in organic synthesis, requiring metathetic ring closure (RCM), among others in the fragrance industry. Advantages of the presented solution from UW: 1. high process efficiency 2. high selectivity 3. low cost of synthesis
Technology Broker at Technology Transfer Office (University of Warsaw)- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Application of ultrasound in clinical physiotherapyThe CSIC has developed a device to apply physiotherapeutic ultrasound. The device allows controlled and programmable focusing. Industrial partners from the field of physiotherapy are being sought to collaborate through a patent license agreement.
Yissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew UniversityTechnology Transfer Office
View ProfileYissum - Research Development Company of the Hebrew University posted this:
Applying Organically Doped Copper to Filters and Surfaces to Act as Antiviral AgentsThe Avnir and Hayouka labs have been working together over the past few years, with the aim of developing novel copper composites that are resistant to pathogenic bacteria and are based on a new family of materials that Avnir has termed “organically doped metals” (organics@metal). These hybrid materials combine two very different chemical families —metals and any organic molecules — which have a synergetic effect in various applications, including biological and medical ones. The general approach for the preparation of the metallic composites involves a room-temperature, one-pot, reduction of the metal cation (its positively charged ions) in the presence of the desired organic molecule while using carefully selected reducing agents. Using this approach, the team has developed novel antimicrobial-doped copper in which antimicrobial peptides or small antibacterial molecules are entrapped. It has demonstrated the new materials’ high efficacy both in vitro and as a novel crop protection agent in plants. Prof. Avnir and Dr. Hayouka will expand their current study to develop efficient copper-based antiviral agents. They will explore the entrapment of various active agents, which have been suggested as capable of tackling HCoV-19. The designed compounds will be tested on HCoV-19. The researchers are negotiating to conduct the tests in China. They are also exploring the potential of converting the compounds into a product with an Israeli start-up specializing in nanometric copper. Project ID : 47-2020-10885
Fabian BelinLuxembourg Institute of Science and Technology (LIST)Fabian BelinPartnerships Development & IP Valorization at Luxembourg Institute of Science and Technology (LIST)
Fabian Belin posted this:
APTAMER : Small single-stranded nucleic acid (DNA or RNA) for virus detectionAn aptamer is a small single-stranded nucleic acid (DNA or RNA) capable of adopting a three-dimensional structure that gives it the ability to bind to its target with remarkable specificity and affinity. Therefore, aptamers are a very promising technology for overcoming the drawbacks and limitations faced by antibodies and molecular assays in the framework of viral diagnostic test development. However, very few aptamers are described for virus detection. and no solutions integrating the technical and commercial benefits of aptamers is currently available on the virus detection market.
Partnerships Development & IP Valorization at Luxembourg Institute of Science and Technology (LIST)
IMDEA Water Institute posted this:
Aquatic ecotoxicology and ecological risk assessmentEcotoxicology is a multidisciplinary science which aims to assess how interaction between pollutants and the environment affects ecosystems, taking into account the susceptibility of individuals, populations and communities to be affected by and recover from any type of toxic stress. Assessing ecological risk from pollutants requires preliminary research into the emission and transport of contaminating substances in the environment and the exposure to which live organisms may be subjected. Likewise, laboratory and/or field experiments help evaluate the toxic effects caused by different pollutants and exposure patterns. Finally, the results of these studies are combined to calculate the likelihood of ecosystems being affected by the use of potentially toxic substances.
University of Luxembourg posted this:
Aquatic platform - Luxembourg Centre for Systems BiomedicineThe LCSB Aquatic Platform is centered around the use of zebrafish (Danio rerio), a vertebrate model with high genetic and physiologic similarity to humans. This versatile, reliable model organism is widely used for the in vivo study of developmental biology, gene function, drug discovery and pathophysiological aspects of various human diseases such as epilepsy, rare diseases, neurodegenerative disorders, among others.
Unitat de Valorització de la URVFundació URVUnitat de Valorització de la URV posted this:
ARCH·E10 is a small, fast and efficient solution for recording archaeological and palaeontological data during fieldworks.This program, jointly developed by the Rovira i Virgili University, Barcelona University and IPHES helps you to quickly computerize your field data, to use a total station efficiently and easily, to export and edit your data, print labels and make sections and planimetries. ARCH·e10 is a software that focuses on ● facilitating the registration of data ● facilitating the use of a total station offline ● facilitating the manipulation of data ● implement vector registration (3D3p model) ● proposing analytical tools for fieldwork As a data manager, has different modes of work aimed at the intensive use of the total station. Therefore, the main feature of ARCH·e10 is its ease for integrating data from a total station into field databases. In the field, you should apply the data link protocol between the total station and the Database. In the lab, download the data from the total station, upload it to ARCH·e10, and run the application to import, and cross the coordinates and data.
Licensing Manager at Fundació URV
Jorian Bos posted this:
ARMADILLO - Global RegTech Information and KYC Compliance DocsArmadillo provides original registry documents, corporate reports, PEPs and Sanctions checks, as well as ID verification for Know Your customer (KYC), Due Dilligence and Enhanced Due Diligence (EDD) via proprietary technological solutions which we have been perfecting since 1997.
Other at EIT Digital
- Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRI
Universidad de Alcalá-OTRI posted this:
ARP-Path Shortest Path Bridges (FastPath Ethernet Transparent Bridges)Fastpath UD is the first proposal using for Layer two Shortest Path Bridging and unicast/multicast source rooted tree construction, without need of an additional (control plane) routing protocol and the simplest one. Provides very simple and performant Ethernet Shortest Path bridging devices Zero configuration. The group is looking for big companies or SMEs manufacturers of routers, switches. They also look for Ethernet switch manufacturers and investors on patent portfolios.The tasks to be performed of the partner sought would be the support in financial collaboration for international patent protection and for advanced, pure hardware prototype construction and validation 
University of Granada (OTRI)University of Granada (OTRI)University of Granada (OTRI) posted this:
Artificial biomaterials for its use as stiffness membranes with controlled elasticityScientists from the University of Granada and the Andalusian Health Service have developed through tissue engineering a biomaterial, which can be used for fabricating artificial tissue and membranes which stiffness and elasticity can be controlled. One of its main advantages is that it can be used for substituting tissues or organs damaged because of infectious, inflammatory or degenerative processes, or physical or chemical damages.- Yissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew University
Technology Transfer Office
View ProfileYissum - Research Development Company of the Hebrew University posted this:
Artificial Intelligence (AI) Based Sentiment Analysis for News ItemsCluster3 Project ID : 37-2015-3187
Yeda posted this:
Artificial PancreasThe alarmingly sharp increase in type 1 diabetes mellitus incidence in recent years has been coupled with a marked rise in the development of closed-loop systems aimed at continuously monitoring blood glucose levels, predicting glucose behavior and delivering adjusted insulin doses. However, to date, these systems still fall short of ensuring tight glycemic control in many patients, particularly in patients with high glucose variability. The presented clinically optimized blood glucose prediction technology, developed at the Weizamnn Institute of Science, provides for improved prediction accuracy, regardless of patient age and disease severity, and outperforms standard models, particularly in high-risk patient populations. The technology can be easily integrated into existing artificial pancreas systems and bears the potential of enhancing disease management and patient quality of life, translating to the long-term clinical benefits of stable glycemia.
Universidad de AlicanteUniversidad de AlicanteUniversidad de Alicante posted this:
Artificial reefs for safe and sustainable marine habitat regenerationA multidisciplinary group of researchers from the University of Alicante has developed a new system for the formation of artificial marine reefs and underwater structures with porous calcareous coating using electric current. The system is characterised by the fact that it starts from a lightweight metal base of any geometric shape –with the possibility of assembly– and the final structure can be easily transported and placed, or fabricated in-situ. During the processing stage, substances are released into the environment that favour the development of phytoplankton and are harmless to the habitat, thus establishing a greater diversity of marine species on the structure itself. This device allows the restoration of marine ecosystems, the purification of marine waters in aquaculture farms, as well as the sustainable exploitation of marine leisure (recreational diving). Companies interested in acquiring this technology for commercial exploitation through licensing agreements are being sought.
Gunter Fischer posted this:
Artificial Swarm Intelligence software - Brainalyzed InsightBrainalyzed fills the gap for Enterprise AI in the financial and industry sector. It also allows managers without specific prior knowledge of machine learning to easily collate data from available sources and to create and roll out high-performing AIs for their key use cases. Thanks to the greatly simplified possibilities of data preparation and training, the time from the first idea to the finished AI can be significantly reduced. Customers using Brainalyzed Insight benefit from the following unique selling points: • Optimization of inputs, architecture and weightings (holistic hyper parameter optimization) • Domain specific AI optimization • Enhanced prediction stability due to AI Swarm • Best performance over time due to flexible AI Swarm adjustment • Empowers domain experts without ML knowledge
CEO at Brainalyzed Finance GmbH
- Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRI
Universidad de Alcalá-OTRI posted this:
Artificial vision system for the semaphoric control of the access to parking and garages, through the monitoring of pedestrians.The research group “Intelligent Vehicles and Traffic Technologies” of the Automation Department of the University of Alcalá has developed a procedure for the semaphoric control of the access roads to parkings and garages by monitoring pedestrians using artificial vision. It is a road safety system that ensures that the exit access of the vehicles from the parking is performed safely for pedestrians, by monitoring the different access points to the parking, using a stereoscopic vision system with infrared lighting. The images provided by the stereoscopic vision system are processed by a computer, obtaining information regarding the presence of pedestrians in the vicinity of the monitored access point. This information is used to act on a traffic light that controls the exit access of vehicles. The group looks for licensing agreements, technical cooperation agreements, manufacturing agreements or commercial agreements with technical assistance, with companies from the sector of transport infrastructure and traffic safety.
Yeda posted this:
Artificial Womb Device for Extended Mammalian EmbryogenesisMammalian embryos develop inside the uterine environment, making them inaccessible for direct monitoring and perturbations. Therefore, the full in-depth understanding of the developmental process that occurs post embryo implantation in the uterus remains limited. The lab of Prof. Jacob Hanna recently developed a culture system that enables growing mouse embryos from pre-gastrulation to advanced organogenesis stages, in a manner that faithfully recapitulates the normal in-uterus developmental process. This provides a powerful tool to characterize the effect of different perturbations on early mammalian development that can be combined with genetic modification, chemical screens, tissue manipulation, and microscopy methods. In the future, the system could also be used to study the development of additional mammalian species, and possibly provide a tool for the development of organ cultures for biomedical purposes.
