High Throughput Screening of Antimicrobial Agents Using Microfluidics

Summary of the technology

Yonatan is a Phytopathology expert using microfluidics system to do high throughput screening of libraries to identify antimicrobial agents which can be either chemical or biological (proteins or bacteria). Yonatan is testing pathogens sensitivity against combinations of bacteria and chemical agents from the libraries using the high-throughput microfluidics system. When Potential Producer, Potential Inducer have a combined affect on a Pathogen target (killing) efficiency become of interest. This is because in nature a single bacteria species is susceptible to environmental stresses but when combined with helper bacteria they support each other synergistically.

Project ID : 47-2019-10825

Details of the Technology Offer


Life Science and Biotechnology


Microfluidics, high throughput screening, synergism, Biocontrol

Current development stage

General list: TRL1 Basic Principles Observed

Collaboration Opportunity

Sponsored Research with an option to License Research Results


Numerous bacteria harbor genes that encode for novel antimicrobials. A major barrier to characterizing and utilizing these novel antimicrobials is that bacteria typically do not produce them under standard laboratory conditions. Rather, they are produced only in response to the presence of specific competing bacterial species and/or chemical conditions. Therefore, a systematic way of exploring combinations of bacterial species under different environmental conditions may elicit the production of novel antimicrobials and may be of commercial value.

Our Innovation

By using a specifically designed microfluidics system, the researcher is able to generate hundreds of thousands of combination of bacteria and chemical agents, and screen these combinations for ones that suppress a bacterial pathogen’s growth.


The researcher is offering his research capabilities to parties interested in identifying novel antimicrobials via Sponsored Research Projects.

Project manager

Ilya Pittel

Project researchers

Jonathan / Yonatan Friedman
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
Plant Pathology and Microbiology

Related Keywords

  • Agro chemicals
  • Agriculture
  • Pharmaceutical Products / Drugs
  • Agricultural genetic engineering applications
  • Agricultural chemicals
  • Agriculture, Forestry, Fishing, Animal Husbandry and Related Products
  • agriculture
  • Plant Protection & Bio-Control

About Yissum - Research Development Company of the Hebrew University

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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