Yonatan is a Phytopathology expert using microfluidics system to do high throughput screening of libraries to identify antimicrobial agents which can be either chemical or biological (proteins or bacteria). Yonatan is testing pathogens sensitivity against combinations of bacteria and chemical agents from the libraries using the high-throughput microfluidics system. When Potential Producer, Potential Inducer have a combined affect on a Pathogen target (killing) efficiency become of interest. This is because in nature a single bacteria species is susceptible to environmental stresses but when combined with helper bacteria they support each other synergistically.
Project ID : 47-2019-10825
Life Science and Biotechnology
Microfluidics, high throughput screening, synergism, Biocontrol
Current development stage
General list: TRL1 Basic Principles Observed
Sponsored Research with an option to License Research Results
Numerous bacteria harbor genes that encode for novel antimicrobials. A major barrier to characterizing and utilizing these novel antimicrobials is that bacteria typically do not produce them under standard laboratory conditions. Rather, they are produced only in response to the presence of specific competing bacterial species and/or chemical conditions. Therefore, a systematic way of exploring combinations of bacterial species under different environmental conditions may elicit the production of novel antimicrobials and may be of commercial value.
By using a specifically designed microfluidics system, the researcher is able to generate hundreds of thousands of combination of bacteria and chemical agents, and screen these combinations for ones that suppress a bacterial pathogen’s growth.
The researcher is offering his research capabilities to parties interested in identifying novel antimicrobials via Sponsored Research Projects.
VP, BD AGTECH, FOODTECH, VETERINARY & ENVIRONMENT
Jonathan / Yonatan Friedman
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
Plant Pathology and Microbiology