Technology Offers Page 4

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

Antibodies for the diagnosis and/or treatment of atherosclerosis Novel atherosclerosis biomarkers are in need to improve the strategies for diagnosis and prognosis of cardiovascular disease. CNIC and DKFZ researchers have discovered 18 novel antibodies that show reactivity against the atherosclerotic plaque, which can thus be potentially used for the diagnosis of this disease. Moreover, the use of one such antibody, A12, delays the progression of atherosclerosis and reduces the level of free circulating cholesterol and LDL.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

iSuRe-Cre as a new genetic tool to modify and understand gene function Most analysis of gene function in biomedical research relies on the use of Cre-lox technology. Since its introduction in 1994, this technology has revolutionized biomedical science because it allows scientists to eliminate or activate the function of any gene in any cell type in the mouse. Because the Cre-loxP recombination event is invisible, genetic and fluorescent reporters have been developed to track Cre activity, so that cells reaching a certain threshold of Cre activity are labeled. However, the main problem is that often the Cre activity level is insufficient to fully recombine and eliminate expression of the target gene, generating uncertainty about whether the desired genetic modification has been achieved. CNIC researchers have developed a method that increases the efficiency and reliability of the analysis of Cre-dependent gene function. Moreover, the use of this genetic tool permits the induction of multiple genetic deletions in the same cell, to allow the study of functional genetic interactions.

Unitat de Valorització de la URV posted this:
Licensing Manager at Fundació URV

New composition for prevention, amelioration or treatment of obesity and metabolic syndrome-related diseases The invention consists in the design and evaluation of a functional ingredient composed of several bioactive compounds for the treatment of obesity and other metabolic syndrome-related diseases. Functionality of this multi-ingredient has been tested in a cafeteria diet-induced obesity model. It has been shown that animals fed a cafeteria diet develop metabolic syndrome. The chronic administration of our multi-ingredient product reduces the effect produced by the consumption of cafeteria diet. Hence, a reduction of body weight, improvement of insulin and leptin resistance and endothelial function, a hypolipidemic, hypoglicemic and antihypertensive effect have been observed. Nowadays, there are some functional ingredients to treat or prevent some aspects of these pathologies but the novelty of this invention is that the designed multi-ingredient product is able to act in several targets at the same time.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

A new therapy for the treatment of myeloproliferative diseases Myelodysplastic/myeloproliferative neoplasms (MPN) are a group of diseases that affect normal blood cell production in the bone marrow. In this case the bone marrow causes an overproduction of one or more blood cell types (red cells, white cells or platelets). Complications arise over time due to the abnormally high number of blood cells that accumulate in the bone marrow and in the circulating blood. In many cases, these diseases develop slowly and get worse gradually. In some cases, MPN can progress to leukemia. Compounds capable of preventing and treating these types of diseases are urgently needed. CNIC researchers have identified new therapeutic targets based on alterations in the regulation of mesenchymal stem cells (MSC) in the hematopoietic niche by sympathetic nerves. They have also defined an in vitro method for prognosis/diagnosis of MPNs and/or to define the disease´s stage, and a method to screen for therapeutic compounds useful to treat MPNs.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

Use of selective Beta-3 adrenergic receptor agonists to treat pulmonary hypertension Pulmonary hypertension (PH), defined as the increase of mean pulmonary blood pressure above normal values, encompasses a series of disorders characterized by the increase of pulmonary vascular resistance and progressive deterioration of the right ventricle. The incidence of pulmonary hypertension in the population is high and it is associated with high morbidity and mortality. Approximately two thirds of patients with left ventricular dysfunction (systolic or isolated diastolic) develop pulmonary hypertension. Currently, there is a lack of treatments for pulmonary hypertension. CNIC and CLINIC researchers have described a novel effective treatment for pulmonary hypertension of different etiology, both chronic and acute. They have found that selective stimulation of beta-3 adrenergic receptors has a beneficial effect in pulmonary hypertension.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

New microRNAs for the diagnosis of cardiomyopathies Inflammation in the myocardium or myocarditis is a disease with heterogeneous aetiology, frequently caused by an infectious pathogen, toxins, drugs or by an autoimmune disorder. Its clinical variability and its nonspecific symptoms make the diagnosis of myocarditis a process that is not always easy. There is an urgent need for accurate, fast point-of-care tests that simultaneously provide diagnostic and prognostic information about a patient entering the hospital with symptoms of acute heart failure. CNIC researchers have identified the role of an specific miRNA in cardiomyopathies processes and have studied the differential expression in blood plasma of patients compared with healthy subjects. These miRNAs can be used as biomarker to improve the diagnosis of acute myocarditis.

CNIC (TTO) posted this:
Technology Transfer Office at Spanish National Center for Cardiovascular Research (CNIC)

SHIP-1 inhibitors for prophylactic treatment and/or prevention of infectious diseases Trained immunity can be defined as a defacto innate immune memory that induces enhanced inflammatory and antimicrobial properties in innate immune cells. Innate immune cells can be trained to exhibit an enhanced and lasting response to subsequent infections with microbial components. Importantly, this boosted response can be triggered against pathogens diverse from those that induce the training. However, improving the heterologous response of trained innate immune cells remains complicated. CNIC, Syracuse University and SUNY Upstate Medical University researchers have discovered that the use of SHIP-1 inhibitors, enhance the non-specific response of trained innate immune cells. This increased activity may offer an improved prophylactic treatment or prevention of subsequent infections.

Bara Prixova posted this:
Commercialization Specialist at Czech University of Life Sciences

Food Processor employing Pulsed Electric Field (PEF) Technology • Our device uses pulsed electric heating technology to process food at low temperatures (approx. 42⁰C). • High-voltage pulsation is a gentle way of preparing food, in which all healthy substances, especially vitamins, are preserved. • During processing, cell membranes in food cells are opened, which allows better absorption of vitamins and enzymes in the human body. • Food is sterilized by a pulsed electric field and is therefore suitable for direct consumption.

Unitat de Valorització de la URV posted this:
Licensing Manager at Fundació URV

New gas nanosensor that increases the sensitivity and durability of current sensors by 300%A new lead halide perovskite-graphene hybrid applied to gas sensing has been developed. Ultra-fast sensors able to work at room temperature have been developed and the role in the gas sensing mechanisms of different ions in perovskite nanocrystals decorating graphene elucidated. Our invention shows for first time that the anion and cation in the perovskite structure (ABX3) have a significant effect on gas sensing performance. In particular, gas sensors employing graphene decorated with different perovskite configurations were successfully employed to detect voc vapours at ppm levels.

Unitat de Valorització de la URV posted this:
Licensing Manager at Fundació URV

New Catalysts for olefin and polar monomer copolymerization and olefin polymerization The present invention deals with the development of new homogeneous catalytic systems for the synthesis of functionalized polyolefins featuring the polar vinyl monomer into the main polymer chain. Currently, the two technologies applied for the industrial production of functionalized polyolefins are: i. radical polymerization and ii. post-polymerization functionalization. Both technologies are based on radical processes that require high temperature (473 K) and pressure (3000 bar of ethylene), thus implying high energy consumption, low cost efficiency and poor control over the macromolecule structure. The new homogeneous catalytic system developed within this invention enables the production of functionalized polyolefins under very mild reaction conditions, temperature of 308 K and ethylene pressure of 2.5 bar, with a high control of the macromolecule architecture.

Jorian Bos posted this:
Other at EIT Digital

DC BRAIN - Optimise Your Networks in Real Time DCbrain is the Artificial Intelligence specialist applied to Energy and Logistics networks allowing industrial companies to optimize, forecast and make reliable flows to obtain operational recommendations in real time.

Jorian Bos posted this:
Other at EIT Digital

CERBAIR - Drone detection and neutralisation via radio frequency CerbAir develops its Anti-Drone and Drone Detection Solutions from start to finish. Rethink your airspace security and trust us to defend your sensitive site or event from any kind of drone intrusion.

Bara Prixova posted this:
Commercialization Specialist at Czech University of Life Sciences

Equipment for planting woody-seedlings in areas of precipitation deficiency TECHNOLOGY DESCRIPTION • The device applies a mixture of a hydrophilic polymer (hydrogel), water and optionally fertilizers and other substances at a specified dose to each seedling. • Hydrogels are strongly water-binding substances (up to 300 times their own weight), which can subsequently be used for growth and development. The water consumption of irrigated seedlings is reduced by half using hydrogel. Hydrogel also allows the growth of seedlings where it is due to lack of precipitation impossible (semi-desert, desert). Hydrogel is harmless, completely disintegrates after about five years (the time required for establishment of seedlings). • The device enables fast and efficient planting of eight thousand seedlings of forest trees, as well as agricultural crops such as coffee, banana and many others. • The device is ideal for use on large areas with low slope and well-paced terrain, such as plantations.

Jorian Bos posted this:
Other at EIT Digital

FLYNEX - Data mining platform for industrial BI using automated drones The FlyNex system enables automated flight operations with fast compliance for flight certification, leading to unique data-generation for security, research, predictive maintenance, rehabilitation, and construction.

Jorian Bos posted this:
Other at EIT Digital

VELCO - Urban Mobility made easy without reaching your phone Finally enjoy a simple and intuitive navigation system for your favorite means of transportation. Velco's offers a connected bike handlebar and flexible solutions for navigation and security services ideal for fleet managers and city mobility.

Technology Offers Page 4

Innovation Resources

Sitemaps

Support

Company

Top Posts Categories

Recognitions

Technology Offers Page 4

Recognitions

Follow us