Yissum - Research Development Company of the Hebrew University

A METHOD FOR THE DIAGNOSIS AND TREATMENT OF COLORECTAL CANCER

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

A METHOD FOR THE DIAGNOSIS AND TREATMENT OF COLORECTAL CANCER
Project ID : 6-2019-9743

Description of the technology

Category

LifeSciences and BioTechnology

Keywords

colorectal cancer, gut microbiota, personalized medicine

Current development stage

For Pharmaceutical development: TRL4 - POC & Safety of candidate drug formulation is demonstrated in defined animal model

Application

Identifying, preventing, and treating patients at high risk for developing colorectal cancer.

Our Innovation

The present invention is based on the surprising finding that gut microbiota, and in particular polyphenol producing microbiota, promotes colorectal cancer, and has a clear pro-tumorigenic effect on patients with a specific genetic background.

Our innovation suggests a method to prevent and treat cancer by exposing the patient to gradually reduced amounts of the discovered specific polyphenol.

Technology

Personalized monitoring of microbiota and the associated metabolites content for colorectal cancer patients or people bearing high risk for the disease. The technology will also be used to prevent the development of colorectal cancer in high risk patients as well as treat patients already afflicted by colorectal cancer through dietary measures, antibiotic treatment, or administration of small molecules that reduce the amount of the specific polyphenol .

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Yinon Ben-Neriah
HUJI, School of Medicine - IMRIC
Immunology and Cancer Research

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About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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