Universidad de Alicante

Novel method to fabricate highly selective sensors for different substances of interest

Posted by Universidad de AlicanteResponsive · Patents for licensing · Spain

Summary of the technology

The research group "Electro catalysis and Electrochemistry of Polymers", Department of Physical Chemistry at the University of Alicante has developed a novel method that allows highly selective electrode manufacture biometrics to detect any biochemical substance of interest, food or environmental. The method is based on the electro assisted deposit of molecularly imprinted silica layers on different electrodes. This allows a fast and efficient detection of the molecule of interest, independently of the other interfering. In addition, allows the regeneration of the electrode in a very simple way and lets its usage almost indefinitely.

Innovative aspects

The biometrical electrode manufacturing method is based on a electro assisted method of molecularly imprinted silica layers on different electrodes. With this new procedure, we obtain uniform and consistent layers of silica that allow highly selective detection of any biochemical substance of interest, food or environmental when these electrodes are used as amperometric, voltammetric, impedimetric and potentiometric sensors.
Main advantatges of the technology

The main advantage of the electro assisted deposit respect to conventional methods of thin film deposition (spin-coating or dip-coating), lies in the control of consistency and porosity of the layers. Due to the prevention of uncontrolled pore formation, avoids the indiscriminate passage of species from the solution to the electrode surface, reducing the interference in the detection of the analyte of interest.

It has a high specificity and affinity for the molecule of interest.

High control on the deposition of silica when is done by electro assisted mode. The possibility of varying the thickness of the silica layer and layer morphology allows for a highly consistent and reproducible layer.

Electro assisted deposit method is capable of "self-healing", i.e. prevents the formation of holes in the assisted layer that interfere with the detection of the molecule of interest.

With continued use, the sensor loses its effectiveness by the collapse of the pores with the species to be determined. In this case, the regeneration process is very simple: just repeat the procedure for removing the template molecule to be performed after the gel layer (electrochemical extraction or cleaning solvents). Thus, the pores of the sensing phase are released for use again.

Description of the technology

Novel method that allows highly selective electrode manufacture biometrics to detect any biochemical substance of interest, food or environmental. The method is based on the electro assisted deposit of molecularly imprinted silica layers on different electrodes. This allows a fast and efficient detection of the molecule of interest, independently of the other interfering. In addition, allows the regeneration of the electrode in a very simple way and lets its usage almost indefinitely.

Specifications

Applications

  • Biomedical Sector: -Hormones (Melatonin, serotonin, adrenaline / epinephrine, noradrenaline / norepinephrine, angiotensin, vasopressin, calcitonin, erythropoietin, glucagon, insulin, growth hormone, oxytocin, histamine, cortisol, testosterone, progesterone), - Neurotransmitters (dopamine, acetylcholine, endorphin, taurine, gaba), - Sugars (glucose, galactose, fructose, sucrose, lactose, maltose) - Aminoácidos (glutamato, aspartato, glicina) - Proteins, -Enzymes, -Antigens, - Cholesterol, - Uric Acid
  • Environmental control and defense: - Pollutants, - Pathogens, - Explosive
  • Food control: - Resveratrol, - Cytotoxins, - Alkaloids, - Pesticides, - Vitamins
  • Others: In general, any organic molecule or biologically active metabolite can be analyzed by electrochemical methods
  • The biometric electrodes are used for highly selective detection of any substances of biochemical, nutritional or environmental interest, among others.

Related keywords

  • Biosensor
  • Environmental and Biometrics Sensors, Actuators
  • Sensor Technology related to measurements
  • Medical Technology / Biomedical Engineering
  • Food Microbiology / Toxicology / Quality Control
  • Genetic Engineering / Molecular Biology
  • Industrial Products
  • Communications
  • Medical Health related
  • Computer related
  • sensors

About Universidad de Alicante

Research & Technology Organization from Spain

As one of the largest universities of Spain, Universidad de Alicante has a rich history of innovation. Our main objective is to transfer the technology that our research teams are developing to the industries and companies which are able to take profit from them. R & D & Innovation results and know-how are offered in the domains of Chemistry, Materials, Environment, IT, Building and other applied subjects.

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