Yissum - Research Development Company of the Hebrew University

A novel approach to suppression of reproductive performance of the Mediterranean Fruit Fly (Ceratitis capitata) and other major pests of agriculture

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

The Sterile Insect Technique (SIT) to control insect pests is based on their mass-production in dedicated facilities, separation and sterilization of males and their periodic release, in order to compete with wild-type males, and essentially impose female sterility. Their are several problems associated with this procedure:
(1) Females tend to soon overcome imposed monogamy, and remate again with males available at that time. Based on research funded by the ISF and the Chief Scientists Fund of the Ministry of Agriculture, we have devised a novel transgenic procedure to prevent or reduce subsequent re-mating of the females in the field, and suppress egg development, which is normally induced by mating. Such transgenic males produce a modified "Sex Peptide", as a component of their seminal fluid, which imposes long-term non-receptivity on females subsequent to initial mating.
(2) The second problem is that the current practice of irradiation-imposed sterilization of males is debilitating and reduces their field performance. It is also logistically time-consuming and costly. This situation requires the release of a large overabundance of males (in the case of the Medfly, twice-weekly throughout the year). We propose that irradiation be replaced by genetic sterility and have several suggestion of how this might be approached. The genetic sterility we propose would be incorporated with the persistent modified Sex Peptide, and combined, these two male-specific transgenes would significantly augment the SIT.

Project ID : 8-2006-1709

Description of the technology

Additional material on the technology can be supplied upon request

Project manager

Amichai Baron
VP, Head of Business Development, Agritech & Envir

Project researchers

Yael Heifetz
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences

Related keywords

  • Agro chemicals
  • Agriculture
  • Agricultural genetic engineering applications
  • Agricultural chemicals
  • Agriculture, Forestry, Fishing, Animal Husbandry and Related Products
  • agriculture
  • Plant Protection & Bio-Control

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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