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University of Szeged posted this:
Endocytosis routing sequence peptide for cell delivery systemsA range of cell delivery systems are crafted for intracellular delivery such as cationic lipids, protein transduction agents or cell-penetrating peptides. Despite of the large number of techniques, transport of macromolecules are rare and only a small portion of these systems are capable of transporting proteins and only very few of them are delivering antibodies. Possible ways for macromolecular translocation is through endocytosis. In some existing applications there are cell-penetrating peptides with a residue number of about 20 amino acids and these molecules are triggering the clathrin-dependent endocytosis. In the recent patent a short WYKYW pentapeptide is applied to deliver relatively large cargo (antibodies, for example) inside the cell via lipid-raft/caveolin-dependent manner through binding to ganglioside GM1.
Universidad de Alcalá-OTRIUniversidad de Alcalá-OTRIUniversidad de Alcalá-OTRI posted this:
Endothelial microvesicles with microbicidal effect for the preparation of a medicament or for a direct useThe research group "Cell damage associated with senescence" of the University of Alcalá presents the microbicidal capacity of endothelial microvesicles. These vesicles destroy the main pathogens involved in sepsis and even strains derived from them resistant to multiple antibiotics. They have also been shown to be effective against the biofilms that form these microorganisms. The group seeks to reach licensing agreements, cooperation or commercial agreements with technical assistance, with pharmaceutical companies interested in the design of new medicines.
University of Porto posted this:
Energy harvesting and storage feedback cellThe present invention discloses a device that consists of a kinetic energy harvest and electrical energy storage feedback cell. The cell combines a 2-dimensional superconductor whose performance is induced by a ferroelectric-metal with a quantum Hall Effect placed within two conductor/semiconductor materials with different chemical potentials. In this invention, the alignment of the chemical potentials of material/ferroelectric/material happens by spontaneously forming Electrical Double Layer Capacitors (EDLCs). The feedback (which corresponds to external and internal conduction and tunnelling of the electrons in the cell) allows the electrical potential difference to increase during discharge of the cell with a load. The feedback cell harvests kinetic energy and heat. Besides it stores electrostatic and electrochemical energy whose supercurrent can be induced during several years in the feedback, at room temperature.
PhD Isabel Gavilanes-Perez (RTTP)Spanish National Research CouncilSpanish National Research Council posted this:
Energy harvesting from ambient vibrations for wireless sensors applicationResearchers from the Spanish National Research Council at the Barcelona Microelectronics Institute (IMB-CNM) have recently developed a mechanical energy harvesting device by using a low-cost microelectronic fabrication process. The device acts as an electrical generator and is driven by environmentally-available mechanical energy such as ambient vibrations. Due to its flexibility and small size, it is of easy integration as power generator permitting the provision of full power autonomy to any wireless sensor node during its lifecycle into a network infrastructure following the philosophy “install and forget”. Industrial partners are being sought to exploit the existing know-how through a patent license agreement.
Rui Manuel SilvaNOVA University LisbonRui Manuel Silva posted this:
Energy-free Liquid Crystal-based Bacterial InstrumentA portable, energy-free liquid crystal-based optical instrument that uses engineered proteins to detect bacteria at point of use. This technology refers to engineered recombinant proteins that bind to peptidoglycan (PG), a structure unique and ubiquitous to bacteria.
Innovation Manager at NOVA University Lisbon
Technoton EngineeringTechnoton Engineering
Georgetown UniversityGeorgetown UniversityGeorgetown University posted this:
Engineering Stem Cell-like Memory CD4+ T Cells for Enhanced ImmunotherapyThis invention introduces a novel method to generate stem cell-like memory T (TSCM) cells from CD4+ T cells using MEK1/2 inhibitors. These engineered TSCM cells exhibit enhanced properties including self-renewal, robust antigen-specific responses, and the ability to differentiate into various CD4+ subpopulations. This approach addresses the limitations of current T cell therapies by producing more durable and effective therapeutic cells for treating cancer, infections, and autoimmune disorders.BACKGROUND T cell therapy is a promising area in immunotherapy, but current methods face challenges such as T cell exhaustion and limited efficacy. This invention provides a solution by re-engineering CD4+ T cells into TSCM cells, offering a more robust and versatile approach to cellular immunotherapy. The technology has potential applications in various diseases, addressing the need for more effective and personalized treatments.
Hussein IbrahimJazan UniversityHussein IbrahimInventor,Business Developer Manager at Jazan University
Hussein Ibrahim posted this:
Enhance cooling in Evaporative Air condition and greenhouses for AgricultureThe internal area of the air conditioners frame contains two chambers : an upper chamber and lower chamber contains two basic elements: a fan and motor. The fan is installed horizontally whereby it sucks air upwards with the air passing through a holed partition which is also installed horizontally. The partition also contains a heat exchange medium, namely a cardboard which is also specially designed for air – conditioners. The cardboard is fixed horizontally a above the holed practitioner.
Inventor,Business Developer Manager at Jazan University
Hussein Ibrahim posted this:
Enhance Evaporative cooling for greenhouses for agricuture in hot drty areasIt is new patent submitted to WIPO international in Swiss and searched by E SA in enhances cooling for greenhouses the cooler system is devised to tow chamber separated by horizontal cooling pad there is a turbo fan lower to the horizontal cooling pad that pulling air in to penetrate through the horizontal cooling pat up to the upper chamber where the exhausted fans push in the cooler air into indoor also there are type of hybrid indirect cooling system the re pushing air resulted out of indirect heat exchange into inside the greenhouses
Agricultural and water expert at Agriculture
- Georgetown UniversityGeorgetown University
Georgetown University posted this:
Enhanced Conversational Search through Caching Historical EmbeddingsThis technology introduces a client-side document embedding cache designed to enhance the responsiveness of conversational search systems. By caching document embeddings relevant to a conversation's initial topic, it enables faster and more relevant responses to successive queries, leveraging dense retrieval models for semantic understanding. This innovation not only achieves a high hit rate but also maintains the integrity of search results. For example, when a user inquires about "weather patterns," and later asks about "rainfall in the forest," the system could quickly provides specific, relevant documents from the cache based on the semantic linkage established by the initial query, thus streamlining the search process within the conversational context.
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
Enhanced detection of ssRNA viruses by FokI-assisted digestionEnhanced detection of ssRNA viruses by FokI-assisted digestion CSIC has developed a signal amplification method for single-stranded nucleic acids detection through self-sustained loop cleavage of DNA:DNA duplexes or RNA:DNA hybrids by the Fokl enzyme. This combination of molecular beacon technology and enzymatic digestion has proved to be a highly specific, cost-effective and fast alternative for detecting virus as SARS-CoV-2 in complex samples. Industrial partners from the health industry are being sought to collaborate through a patent licence agreement. An offer for Patent Licensing
- Georgetown UniversityGeorgetown University
Georgetown University posted this:
Enhanced Mobile Device Information Security SystemThis invention introduces an advanced method for protecting sensitive information on mobile devices using asymmetric information processing. It generates unique identifiers and encryption keys from partial asymmetric input and salts, creating ciphered information associated with these identifiers. This approach enhances data security without requiring full key storage, making it ideal for mobile devices with limited secure storage capacity. For example, it can secure contact information, file names, or device IDs on smartphones without compromising performance or user experience.
University of WaterlooUniversity of WaterlooUniversity of Waterloo posted this:
Enhanced probiotic delivery in functional foodsBackground Probiotics effectively inhibit harmful bacteria by secreting antibacterial bacteriocin, lactic acid, intestinal settlement of harmful bacteria, which enhances our immune system. Probiotics must survive by withstanding the gastric acid secreted in the stomach, bile from the gallbladder, and various digestive enzymes from the small intestines. However, adding probiotic cells directly to foods results in a significant reduction in cell viability from production through to the time of consumption. Therefore, probiotics must be encapsulated with another protective material, where the encapsulation protects probiotic the cells from external environmental factors and promotes bacterial viability during processing, storage and digestion.
Jim Pantzos posted this:
Enhancing sustainability and reducing food waste at all points along the food value chainWe are an innovative group with disruptive technology focused on reducing food waste at all points along the Value Chain. We've developed multiple versions of a web-based platform that will instantly connect, in real time, B2B Buyers to the Suppliers of short-dated product. With enhanced features that include the opportunity to execute transactions in advance, potential food waste is reduced (upstream) at the planning stage thus contributing to a sustainable value chain.
Founder at Resetfoods
Unitat de Valorització de la URVFundació URVUnitat de Valorització de la URV posted this:
ENTREVISTO: Platform for selection of employees for the service sector."Entre-Visto" is an application that allows to develop a structured interview for the confirmation and contrast of the information offered by the traditional tests used in the selection process.
Licensing Manager at Fundació URV- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Environmental indices through LandSAT images The Spanish National Research Council (Consejo Superior de Investigaciones Científicas, CSIC) has developed the software GINASAT version 1.0 (Semi-Automatic Generation of Environmental Indices by Landsat), to automate the extraction of information from Landsat satellite images downloaded from USGS (US Geological Survey) server (http://earthexplorer.usgs.gov/). The program has been developed in version 1.0 and it runs integrated into ArcGIS©, for different versions from 10.
Universitat Politècnica de Catalunya - UPCUniversitat Politècnica de Catalunya - UPCUniversitat Politècnica de Catalunya - UPC posted this:
Environmental Quality Assessment of contaminated soilsEnvironmental quality of soils is determined using analytical chemistry methods, with expensive and sophisticated equipment. Toxicity assays provide a global response regarding the danger of contaminated soil to living organisms. However bioassays are based in lengthy experimental procedures (between 7 and 28 days) to provide reliable results. Normalized soil assays use different species of earthworms and collembola that must be grown and maintained in specialized facilities. Partners to further develop the technology and/or to establish commercial agreements along with technical cooperation are sought.
Universitat de València posted this:
Environmentally friendly colorimetric sensors for detecting hydrogen cyanide (HCN)The main advantages provided by the this colorimetric sensor are: - Detection Limits: The direct reaction between the sensor and the HCN leads to a marked color change with detection limits below 1 ppm. - Selectivity: in the presence of other gases such as CO, HCl, NH3, H2S, at concentrations up to 50 ppm - Environmentally friendly: no heavy metals used. - Reversibility: The reaction is reversible by irradiation with UV light so it can be reused in successive cycles - Minimizing false positives: Regeneration by UV radiation occurs only if the sensor reacted with HCN.Cardinaltech Company S.L. posted this:
Environmentally friendly graffiti removerGraffiti has become a hurdle for most cities, public transportation and private owners, to maintain their infrastructures clean with ease at reasonable costs. Our solution is looking to solve the need of a product that truly works in multiple surfaces, in a relatively short time, without specific safety equipment and training and without any human safety risks (e.g.: strong chemical solvents), while not damaging the original surface. A user-friendly product, that can be used both by professionals and individuals, and that’s also environmentally friendly. We believe it’s hard to find a solution that truly works while tackling all these needs. Link to a video to see its performance: https://youtu.be/bw025FbYmtQ
Universidad de AlicanteUniversidad de AlicanteUniversidad de Alicante posted this:
Environmentally friendly holographic recording materialOur research group has developed a new photopolymer which may be used as a holographic recording material. It is easy to prepare in layers of the desired thickness and has a lower potential toxicity than conventional materials. It is characterized by being environmentally friendly, since it does not contain any petroleum-derived solvents or other components classified as toxic, biotoxic, explosive, radioactive, oxidising, corrosive, inflammable or environmentally hazardous, and no such substances are used to prepare it. The only solvent used is water, thus minimizing any risk of contamination and, at the end of its useful life, it is easy to recycle in aqueous phase. It is possible to automatize all the stages of its preparation, and it enables holograms to be obtained in a single stage without the need for subsequent processing. We are looking for companies interested in acquiring this technology for its commercial exploitation. Innovative aspects: • Due to its characteristics and the fact that during the preparation process, its useful life and subsequent elimination, water is the only solvent used, the negative impact of this material on the environment is minimized. • It does not contain any components classified as toxic, biotoxic, explosive, radioactive, oxidising, corrosive, inflammable or hazardous for the environment. • Although the fabrication process is totally safe for workers, it is possible to automatize all the stages, thereby reducing the production costs. • Layers of different thicknesses may be easily obtained and they may be used at different wavelengths.
UNIVERSIDAD DE BURGOSUNIVERSIDAD DE BURGOSUNIVERSIDAD DE BURGOS posted this:
Environmentally friendly procedure for the synthesis of aldehydes and ketones from diols/ Procedure for the oxidative cleavage of 1,2-diols using dimethyl sulfoxide as oxidizing agentThe oxidative cleavage of vicinal diols to the corresponding aldehydes or ketones is a highly useful transformation in organic synthesis. Traditional methods for carrying out this transformation encompass the use of lead tetraacetate or periodates, that show obvious disadvantages such as the high toxicity of lead tetraacetate and its use in stoichiometric amounts, that implies the generation as byproduct of big amounts of lead diacetate, also toxic. On the other hand, the use of periodates shows limitations in the scope, as ditertiary diols cannot be used. Therefore, a new method has been developed that uses as oxidant dimethyl sulfoxide, easily accessible and environmentally friendly, for the efficient synthesis of aldehydes and ketones by oxidative cleavage of 1,2-diols.
UNIVERSIDAD DE BURGOS posted this:
Environmentally friendly procedure for the synthesis of aldehydes and ketones from diols/ Procedure for the oxidative cleavage of 1,2-diols using dimethyl sulfoxide as oxidizing agentThe oxidative cleavage of vicinal diols to the corresponding aldehydes or ketones is a highly useful transformation in organic synthesis. Traditional methods for carrying out this transformation encompass the use of lead tetraacetate or periodates, that show obvious disadvantages such as the high toxicity of lead tetraacetate and its use in stoichiometric amounts, that implies the generation as byproduct of big amounts of lead diacetate, also toxic. On the other hand, the use of periodates shows limitations in the scope, as ditertiary diols cannot be used. Therefore, a new method has been developed that uses as oxidant dimethyl sulfoxide, easily accessible and environmentally friendly, for the efficient synthesis of aldehydes and ketones by oxidative cleavage of 1,2-diols.
Fundació URV posted this:
Environmentally friendly processing of thermosets by two-stage sequential aza-Michael addition and free-radical polymerization of amine-acrylate mixturesEnvironmentally friendly preparation of thermosets for applications on thermosensitive substrates. A two-step curing process, which consists in an Aza-Michael addition at room temperature, followed by UV radical polymerization of acrylates or methacrylates amine formulations without the need of adding solvents. The presence of amines in the structure suppress the radical inhibition by oxygen, which is a typical drawback in radical polymerizations. The invention allows leading the curing in two separate stages with a stable intermediate material, being the process controlled by the amount of amine in the formulation.
Barry McGrawAirable Research Lab, business line of Ohio Soybean CouncilBarry McGraw posted this:
EnzoMeal™ - A Sustainable Food Source for Farm-Raised FishAn advanced soybean-based fish feed, EnzoMeal addresses a key impediment to the widespread expansion of aquaculture, the fastest-growing food production sector. Historically, fisheries have used fishmeal as fish feed, but the primary ingredients—wild fish and shrimp—are rapidly dwindling resources, making the feed expensive and unsustainable. Soybean meal presents an attractive alternative. It closely meets the dietary requirements of fish: it is rich in protein content, essential fatty acids, and unsaturated fats, and it has the most balanced amino acid composition of all agricultural-based meals. Yet conventional soybean meal contains carbohydrates that fish cannot easily digest. Airable Research Lab partnered with Battelle to develop a technology that removes nondigestible carbohydrates and increases crude proteins in the soybean meal, resolving the challenges that to date have limited soybean use as a substitute fish feed protein.
CEO at Airable Research Lab, business line of Ohio Soybean Council
- Universitat Politècnica de Catalunya - UPCUniversitat Politècnica de Catalunya - UPC
Universitat Politècnica de Catalunya - UPC posted this:
Enzymatic aqueous preparation for the surface functionalization of paper or cellulosic substratesA new biotechnological product for the chemical modification of the surface of cellulosic substrates has been patented. The bioproduct is obtained from an enzyme-mediator system, and several properties can be easily conferred to substrates applying very low concentrations of this enzymatic product in their surface. Partners to further develop the product and/or to establish commercial agreements along with technical cooperation are sought.
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
Enzymatic production of 2,5-furandicarboxylic acid from 5-methoxymethylfurfuraa a l l CSIC, University of Zaragoza and Technische Universität Dresden have developed an enzymatic composition and its use as an enzymatic cascade for the production of 2,5-furandicarboxylic acid (FDCA) from 5-methoxymethylfurfural (MMF). This cascade is self-sustained with the only consumption of atmospheric oxygen and the MMF itself. The method can be applied to the conversion of MMF into FDCA step in the bioplastic producing industry, switching from the current inorganic catalysts employed to the use of enzymes for the FDCA production. Industrial partners are being sought to develop and commercialize the enzymatic composition through a patent licence agreement. An offer for Patent Licensing
UNIVERSIDAD DE BURGOS posted this:
Enzymatic synthesis of structured lipids enriched in fatty acids. Study of its oxidative stability.It is intended to apply biotechnological procedures (lipases), alternative to chemical treatments of transesterification and hydrolysis, for the modification of fats and oils. Lipases allow carrying out enzymatic processes for the formulation of "structured" lipid nutritional products, formulated to measure for a specific nutritional or technological function. Additionally, the oxidative stability of the synthesized lipids will be evaluated.
- University of WaterlooUniversity of Waterloo
University of Waterloo posted this:
Enzyme degradable gelatin hydrogel for drug delivery in wound healingBackground Drug delivery systems, in general, help transport pharmaceutical compounds safely to the target site in the body as needed to achieve a desired therapeutic effect. The majority of drug delivery systems use a passive diffusion mechanism to slowly release their drug payload. However, such drug delivery systems are not truly controlled, as the quantity and timing of the drug release cannot be precisely controlled on demand. Gelatin-based hydrogels, such as Gelatin methacrylate (GelMA) hydrogels, are enzyme-degradable hydrogels derived from collagen. They have been studied extensively in tissue engineering applications, such as tissue scaffolding, but are not generally considered for drug delivery applications due to their poor mechanical strength and high porosity. For example, given their use as soft biocompatible gels for cell encapsulation, or as cell scaffolds, they are necessarily freely diffusive such that nutrients and large molecules can diffuse to and from the cells.
