Pharmaceutics Technology Offers

Centre Technology Transfer CITTRU posted this:

A new method of the stereoselective synthesis of chosen medicines The subject of the offer is a new method of an asymmetric reduction of prochiral ketones and imines used in the synthesis of commonly used medicines, e.g. hormonal (eg. Cincalcet), pulmonary (eg. Salbutamol) and neurological ones (eg. Rasagiline).

Maria João Cardoso posted this:
Science and Technology Manager at UATEC - Unidade de Transferência de Tecnologia

Magnetic nanoparticles for selective enrichment of proteins in complex mixtures New method for preparing ion chelating magnetic nanoparticles, which allow selective protein enrichment, namely metalloproteases (MMPs) and His-tagged proteins, from complex mixtures.

Mahesh Kulkarni posted this:
Assistant Vice President-Business Development at Praj Industries Limited

Sodium Pyruvate an platform chemical for energy booster Sodium Pyruvate is biochemical used in nutrition and Healthcare industry. It is important intermediate for production of Perindopril and Levodopa. Novel Biotransformation process developed using yeast as biocatalyst. Fermentation and Downstream has been optimized from bench scale bioreactors upto10 liter pilot scale.

Maria João Cardoso posted this:
Science and Technology Manager at UATEC - Unidade de Transferência de Tecnologia

Innovative methodology for nanoencapsulation of montelukast in cyclodextrin Cyclodextrin is a nano-sized capsule that allows increasing the stability and aqueous solubility of active pharmaceutical ingredients such as montelukast. This technology comprehends an alternative method to obtain an amorphous solid composed by montelukast and cyclodextrin. In alternative to conventional methodologies, this method allows the encapsulation to occur without requiring the use of solvents and the formation of degradation products.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendrimers with terminal thiol groups on their surface. Their preparation and their uses.The research group in «Dendrimers for biomedical applications» of the University of Alcalá presents the procedure for obtaining and using carbosilane dendrimers with terminal thiol groups on their surface, as antioxidants and radical scavengers for their application in the food industry, cosmetic and pharmaceutical. The group seeks to reach licensing agreements, collaboration agreements or commercial agreements with technical assistance, with enterprises from the food industry, cosmetic, biotechnology, Biomedicine or pharmaceutical sector.

Universidad de Alicante posted this:

Holographic sensor for detection of adulterants in essential oils The research group of Holography and Optical Processing of the University of Alicante has developed a holographic technique for the detection of adulterants in essential oils. This technique is able to detect different types of adulterants qualitatively. In addition, a quantitative measurement of the degree of adulteration of an essential oil can also be performed by means of pre-calibration of the sensor for a particular adulterant. The sensor could be miniaturized and manufactured at a low cost compared to traditional methods of analysis such as gas chromatography and high performance liquid chromatography. The sensor can be used by unqualified personnel.

UATEC - Unidade de Transferência de Tecnologia posted this:

Ohmic heating reactor for chemical synthesis, the method and its applications In ohmic heating electrical energy is dissipated in heat with a very high efficiency (electrodes in contact with the reaction medium), resulting in fast and uniform heating and in the increase of charged species movement. As in the case of the heating with microwave radiation, electrical energy is transformed into thermal energy. However, on contrary of heating with microwave radiation (penetration depth of microwave radiation in absorbing media is limited) the penetration depth is virtually unlimited and the extent of heating is regulated only by the spatial uniformity of electrical conductivity throughout the reaction medium and the time spent in the ohmic reactor. Thus, the direct scaling of the ohmic heating for the pilot or industrial scale shouldn’t have the limitations presented by microwave radiation heating. It is also possible to reduce reaction times and increase the energy efficiency of chemical reactions

Cracow University of Technology posted this:

New preparation method of silver nanoparticles suspension and silver nanoparticles suspension for medical, cosmetic and pharmaceutical application.Subject of this offer is the preparation method of silver nanoparticles suspension by reduction of silver salt by using reducing agent of natural origin and in the presence of a stabilizer. In this method, the following reducing agents are used apiproduct or extract of amber. The obtained nanoparticles can be applied in various industries, but the largest future is in the medical area, and as ingredient in cosmetic compositions due to the presence of non-toxic ingredients.

Cracow University of Technology posted this:

Suspension containing gold or silver nanoparticles or a mixture thereof and a production method thereof The present invention relates to a process for the preparation of nanosilver and nanogold using an aqueous extract of dog rose, white grape and knotweed. Substances which were extracted from these plants act both as reducer of silver and gold ions and stabilizing agent of forming silver and gold nanodispersion, preventing them from agglomeration and inhibiting their growth, so that the resulting particle size does not exceed 100 nm.

University of Vigo posted this:

Pyridazin-3(2H)-one Derivatives as Selective Inhibitors of Monoamine Oxidase-B Isoform (MAO-B)The pyridazine ring is a privileged fragment found in compounds with very different pharmacological properties, such as antihypertensive, antiplatelet, anti-inflammatory, antinociceptive, antidepressant, hypoglycemic, antiinfective or anticancer agents, many of them being pyridazin-3(2H)-one derivatives. The pyridazine ring is also included in polycyclic compounds acting as MAO-B inhibitors. However, simple pyridazin-3(2H)-one derivatives have not been described so far as selective MAO-B inhibitors. The present invention provides novel pyridazin-3(2H)-one derivatives substituted at C4, C5 or C6 with several dithiocarbamate moieties that selectively inhibit the MAO-B activity and whose structure is unrelated to those currently available.

University of Vigo posted this:

Procedure for the extraction of biosurfactants contained in corn steep liquors Nowadays, most of the pharmaceutical and cosmetic products in the market contain chemically synthesized surfactants in its composition. In many cases, these surfactants are the same as those used in regular cleanup activities. In order to get more natural and biocompatible products, it would be interesting to include natural surfactants instead of chemical surfactants in the preparation of these pharmaceutical and cosmetic products. These biosurfactants are also present in the formulation of greener nanoparticles, replacing the chemical surfactants currently used in the preparation thereof. Most biosurfactants have antimicrobial activity, which would improve the properties of certain nanoparticles, as well as many pharmaceutical and cosmetic products. The main disadvantage of biosurfactants industrial production is related to the high cost compared to chemically synthesized surfactant production. The solution proposed by the Chemical Engineering research group at the University of Vigo, is the development of eco-friendly simple extraction of biosurfactant from a corn wet-milling industry byproduct, such as corn wash liquors, better known as "corn steep liquor (CSL)", which could compete in terms of cost production with its chemical counterparts.

Institute of Chemical Research of Catalonia posted this:

Valorization of HFC-23: trifluoromethylation reactions - clean production of trifluromethylcopper reagent - process works at room temperature and atmospheric pressure - inexpensive and abundant trifluoromethyl source - environmentally friendly process - low-cost reagents - valorization of fluoroform: a by-product of PTFE production - Versatile reagent allowing for a broad scope of reactivity

Institute of Chemical Research of Catalonia posted this:

Crysforma: services in pharmaceutical solid state development Crysforma provides complete scientific support for the discovery, analysis and scale-up of polymorphs, hydrates, amorphous phases, salts and co-crystals of active pharmaceutical ingredients or intermediates. Crysforma has developed its own crystallization screening methodology based on the combination of several crystallization procedures. We use high-throughput crystallization systems controlled by highly skilled scientists to maximize the information drawn from each experiment. Our projects are always carried out in close collaboration with the client, adapted to the customer's needs and under strict confidentiality conditions.

UATEC - Unidade de Transferência de Tecnologia posted this:

System for the collection , storage and exhaled alveolar air conditioning for clinical analysis A group of researchers from Portuguese university developed a device that allows the collection and storage of the exhaled alveolar air by humans. The invention aims simultaneously to overcome some of the technical difficulties in the current state of the art, such as i) little or no response in the selective collection of alveolar air fraction ii) the inability to couple systems that allow concentration/extraction of analytes of interest iii) the inexistence of systems to the storage of the collected biofluid under controlled conditions and iv) the inability to collect exhaled air in liquid or vapor state. The university is looking for companies interested in the industrial production of the equipment and its commercialization.

Universidad de Alcalá-OTRI posted this:

Carbosilane dendritic compounds homo and heterofunctionalized A Spanish research group from the Department of Organic and Inorganic Chemistry of Alcala University has developed a highly branched macromolecules called dendrimers or dendrons, with carbosilane structure and functionalized on its periphery with anionic or cationic groups, providing the macromolecule a net negative or positive charge respectively. The invention also concerns the dendrimers’ procurement process and their biomedical applications, particularly as carriers of drugs or nucleic acids (such ODN, siRNA, dsRNA or DNA), or as therapeutic agents with antiviral or antibacterial activity. The group is looking for companies in the biomedical sector to reach licensing agreements, collaboration and commercial agreements with technical assistance.

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