Organic Chemistry Technology Offers

Sandra Moczulska posted this:
Technology Broker at Technology Transfer Office (University of Warsaw)

The olefin metathesis reaction has many advantages, the most important of which is the fact that it shortens the synthesis path by reducing the number of required steps and this lowers the cost of obtaining the target product. Unfortunately, the industrial application of the olefin metathesis reaction (especially in the production of macrocyclic rings in the RCM reaction) is currently experiencing difficulties such as: - lack of selectivity and product competition (a major problem with RCMs leading to large macrocyclic rings to minimize the problem of high dilution, but it clearly increases the cost of the process) - displacement of reaction equilibrium (RCM reaction is an equilibrium process, so to move the process towards the formation of products it is necessary to react under reduced pressure) - migration of double bond C = C (migration within the substrates as well as target product due to side reactions. This inconvenience can be eliminated by using, for example, quinones - unfortunately, this elimination is only partial.) - the need to use a homogeneous ruthenium catalyst (a large amount of catalyst is required to reach the reaction, reaching over 20 mol%). The present invention relates to a process for the production of cyclic compounds in the olefin metathesis reaction and the use of ruthenium catalysts for the production of cyclic olefins in olefin metathesis reactions. The solution through optimization, overcomes the current problems. The expected product is obtained with high efficiency and selectivity. The method can find extensive use in organic synthesis, requiring metathetic ring closure (RCM), among others in the fragrance industry. Advantages of the presented solution from UW: 1. high process efficiency 2. high selectivity 3. low cost of synthesis