Programable Release of 3D Printing of Drugs
Cluster9 Project ID : 6-2017-4487
Summary of the technology
Project ID : 6-2017-4487
Description of the technology
3D printing, drug delivery, Hydrogels, pH responsive, Swelling
Current development stage
TRL7System prototype demonstration
A novel approach for fabrication of a programmable oral dosage system in the form of responsive hydrogels, that can be swollen and then release a drug at specific conditions such as pH, by 3D Digital Light Processing (DLP) printing technology.
Oral dosage forms of pH responsive hydrogels were 3D printed using monomer (acrylic acid), cross-linker (PEGDA) and photoinitiator (TPO nanoparticles) that lead to biocompatible polymers.
The technology is based on photo-polymerization, enabled by DLP for curing photo-reactive compositions. The localized polymerization is performed within a bath filled with a polymerizable ink, usually by proper focusing UV light. DLP allows high resolution, complex structures, low printing cost and large build size.
The printed structures exhibited pH responsiveness and structure dependence of swelling and release.
Fig. 1:Images of the 3D printed hydrogel tablets using DLP technique. (A. Box; B. Hemisphere; C. 5X5; D. Hive). E-F are scanning electron microscopy images of D and C shapes respectively. Photo: 3D Print. Med. 219–229, 2017)
Fig.2: Left: Images of Sulforhodamine B loaded 3D printed tablets with different shapes, before and after 24h swelling in phosphate buffer (pH 7.4); A. Box; B. Hemisphere; C. 5X5; D. Hive.
Right: Correlation between the tablet expansion and drug release in different 3D printed shape. Measurement were taken at 0,1,2,4,8 and 24 hours. Photo: 3D Print. Med. 219–229, 2017