Summary of the technology
we aim to generate a new concept of vector design that incorporates a gene-specific enhanced translation elements and assess their performance in CHO cells.
Expression of Onco-Kit improves the production of proteins in mammalian cells
Project ID : 6-2017-4484
Description of the technology
LifeSciences and BioTechnology
Cell line productivity, Cell line engineering, Biosimilars
Current development stage
TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro models
We suggest companies to engineer their cell line with a protein that endows cells with better growth and productivity.
A new concept of vector design that incorporates a gene-specific enhanced translation elements and assess their performance in CHO cells
A single protein (oncoKIT) which improves growth and resilience to stress.
Generating stable expression of oncoKIT in production cell lines.
We offer companies that have their own propriety cells to use this for improvement. The proposed method to enhance protein expression has broad range of applications in R&D and biomanufacturing. The method helps to reduce the production costs and simplify the downstream processes of purification.
There is a growing demand in the field of biological drugs for improved protein expression platforms. Consequently there is a need for affordable manufacturing methods.