Yissum - Research Development Company of the Hebrew University

A Method for Improvement of Protein Production in Mammalian Cells

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

we aim to generate a new concept of vector design that incorporates a gene-specific enhanced translation elements and assess their performance in CHO cells.
Expression of Onco-Kit improves the production of proteins in mammalian cells
Project ID : 6-2017-4484

Description of the technology

Category

LifeSciences and BioTechnology

Keywords

Cell line productivity, Cell line engineering, Biosimilars

Current development stage

TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro models

Application

We suggest companies to engineer their cell line with a protein that endows cells with better growth and productivity.

Our Innovation

A new concept of vector design that incorporates a gene-specific enhanced translation elements and assess their performance in CHO cells

A single protein (oncoKIT) which improves growth and resilience to stress.

Technology

Generating stable expression of oncoKIT in production cell lines.

Opportunity

We offer companies that have their own propriety cells to use this for improvement. The proposed method to enhance protein expression has broad range of applications in R&D and biomanufacturing. The method helps to reduce the production costs and simplify the downstream processes of purification.

There is a growing demand in the field of biological drugs for improved protein expression platforms. Consequently there is a need for affordable manufacturing methods.

Project manager

Shani Bullock
VP, Business Development, Healthcare

Project researchers

Boaz Tirosh
HUJI, School of Medicine - IMRIC
School of Pharmacy- Institute for Drug Research

Related keywords

  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Toxicology Market
  • In vitro Testing, Trials Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Gene Expression, Proteom Research Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Diagnostic
  • Therapeutic
  • Other Medical/Health Related
  • Agro and Marine biotech
  • Anatomy, Pathology, Immunology, Physiology
  • Clinical Medicine
  • Life Science & Biotechnology
  • Antibodies

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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