Yissum - Research Development Company of the Hebrew University

Simple, Cost-Effective Bio-Sensor for DNA Detection

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Provisional filed Nov. 2015.

Project ID : 9-2015-4246

Yissum - Research Development Company of the Hebrew University

Description of the technology

Self-assembled peptide-based conjugates provide highly sensitive biosensors


Nano-medicine / biotechnology, Diagnostics, Nanoprocesses, Diagnostics, Homeland Security, Research Tools

Development Stage

Proof of concept

Patent Status

Provisional patent filed


  • Self-assembled nanomaterials possess unique optical, electronic and catalytic properties which are particularly useful in the development of sensitive biosensors.
  • Novel sensitive and selective sensing platform can discriminate between one mismatch and can perform even in the presence of other interfering proteins.

Our Innovation

Self-assembled nanostructures generated by a a (modified) peptide-based compound provide a highly sensitive optical sensing platform for DNA detection.

DNA detection by a ligand peptide material conjugate (LM). Schematic representation of the experimental design for detecting target HIV DNA using LM as a sensing platform. In the first step, the fluorescein-labeled probe DNA interacts and adsorbs on the self-assembled aggregated spherical structures of LM; this triggers the florescence quenching. The presence of the target DNA induces fluorescence recovery owing to the conformational change of the dye-labeled SS DN) into a duplex form.

Key Features

  • Rapid, simple and cost-effective biosensors for proteins and nucleic acids.
  • Can detect diseases and pathogens
  • The system can selectively detect single stranded DNA fragments by fluorescent measurements as it can discriminate between even a single mismatch.
  • The system is stable and functions in the presence of polyanions such as polyacrylic acid.
  • Can perform even in the presence of other interfering proteins

Development Milestones

Perform in vitro studies using biological samples from infected animals and in vivo studies.

The Opportunity

  • May be used in lab-on-a-chip applications for molecular diagnostics, industrial and environmental monitoring and civil defence. The world biochip market was forecast to reach $14.4 billion by 2018.
  • Important for forensics. The DNA forensics industry provides DNA paternity testing, DNA forensic services, veterinary DNA testing, ancestry tracking and other services related to human genetics. DNA forensics is also used following world disasters such as tsunamis and terrorist attacks, which kill thousands of people, leaving many unidentified bodies. DNA testing is expected to increase at a compound annual growth rate (CAGR) of 11.6% to more than $2.3 billion by 2016.

Researcher Information


Project manager

Shani Bullock
VP, Business Development, Healthcare

Project researchers

Meital Reches
HUJI, Faculty of Science
The Institute of Chemistry

Related keywords

  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Chemistry
  • Materials Technology
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Toxicology Market
  • In vitro Testing, Trials Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Gene Expression, Proteom Research Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Clinical Medicine
  • Anatomy, Pathology, Immunology, Physiology
  • Agro and Marine biotech
  • Other Medical/Health Related
  • Therapeutic
  • Diagnostic
  • Chemicals and Materials
  • Life Science & Biotechnology
  • diagnostics

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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