The present invention highlights the identification of two new biomarkers for the diagnosis of pediatric B-cell acute lymphoblastic leukemia (B-ALL). In this sense, the analysis of the expression of the lncRNA and mRNA pair makes it possible to recognize and evaluate patients who develop the disease. Consequently, its use is support in therapeutic decision-making in patients with B-ALL.
Pediatric B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood malignancy that, characterized by its heterogeneity and aggressiveness, requires new targeted therapies. In recent years, this search has focused on the identification of non-coding RNA (ncRNA), crucial regulators of gene expression. Dysregulation of these long ncRNAs (lncRNAs) has been linked to numerous human diseases and is also associated with oncogenic or tumor suppressor phenotypes.
Given the absence of a clinically relevant lncRNA consensus signature for pediatric B-ALL, researchers at the University of Granada have studied the lncRNA profiles of pediatric patients with this lymphoma, thus identifying two new biomarkers for the diagnosis, prognosis, prevention, improvement or alleviation in the treatment of this.
This invention provides the use of lncRNA AL133346.1 and mRNA CCN2 as diagnostic biomarkers, whose method consists in the quantification of their expression levels from an isolated sample of the bone marrow of the individual. In this way, by comparing the amounts expressed of AL133346.1 and CCN2 in this sample with reference amounts, it is possible to obtain useful data for the diagnosis of pediatric B-ALL, facilitating therapeutic decision-making in these patients.
ADVANTAGES AND BENEFITS
Applications
Diagnosis of pediatric B-ALL
Prognosis, prevention, improvement or alleviation in the treatment of pediatric B-ALL.
Desired business relationship
Patent licensing
Granada University is one of the most important universities of Spain. The main goal is to transfer technology that our research groups, more than 500, are developing to the industries and companies which are able to take profit from them. It is a general University so Research and Development are offered in different fields like Health Science and Technology, Physics, Chemistry and Mathematics, Environment and Natural Resources, Biotechnology, Information and Communication Technologies, Social, Economic and Legal Sciences....
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