Yissum - Research Development Company of the Hebrew University

Treatment for Preventing Immunological Complications using Drug-Free Carriers

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Treatment with a placebo, drug-free carrier, prior to administration of particulate medicines to prevent allergic reactions to the medicines

Formulation
Project ID : 6-2008-2098

Description of the technology

Categories

Drug Allergy, Drug Delivery, Nano-pharmaceuticals

Development Stage

TRL4, Successfully tested in large animals

Patent Status

US and Europe patent

Opportunity

Intravenous injection of some liposomal drugs, diagnostic agents, micelles and other lipid-based nanoparticles cause hypersensitivity reactions in up to 45% of patients

Highlights

  • Intravenous infusion of certain drugs and diagnostic agents that contain particles in the range
    10-9-10-6m (particulate medicines PCM) produce pseudo-allergic reactions that appear to be similar to those caused by pollen or foods, but in fact differ from those reactions.
  • PCM reactions appear to be initiated by the complement system (C) of the immune system.
  • Liposomes, micelles, and other particulate drug carriers which do not carry C inhibitors on their surfaces activate these hypersensitive reactions.

Our Innovation

Treatment with a placebo, drug-free carrier, prior to administration of particulate medicines to prevent allergic reactions to the medicines

Key Features

  • Technology specifically inhibits PCM-triggered C3a/C5a receptor-mediated complement activation-related pseudoallergy (CARPA) reactions
  • Toxicology tests for this technology are very simple

The Opportunity

Opportunity to incorporate new technology with minimal regulatory process

Researcher Informationbiochemistry.huji.ac.il/faculty_barenholz.asp,research.ekmd.huji.ac.il/researchers.asp?id=166,nanoscience.huji.ac.il/researchers/barenholz.htm

Project manager

Shani Bullock
VP, Business Development, Healthcare

Project researchers

Yechezkel Barenholz
HUJI, School of Medicine - IMRIC
Biochemistry and Molecular Biology

Related keywords

  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Toxicology Market
  • In vitro Testing, Trials Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Gene Expression, Proteom Research Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Clinical Medicine
  • Anatomy, Pathology, Immunology, Physiology
  • Agro and Marine biotech
  • Other Medical/Health Related
  • Therapeutic
  • Diagnostic
  • Life Science & Biotechnology
  • immunology

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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