Portable device to detect, diagnose and monitoring of tyrosinemia

Summary of the technology

A Spanish research Group from Analytical Chemistry, Physical Chemistry and Chemical Engineering Departments at University of Alcala (Spain) has designed and developed a metabolic rare disease sensor to diagnose and monitoring tyrosinemia in different biological fluidics (blood, plasma and urine) using very few amounts of the sample without any pretreatment. This device uses a non-invasive approach for and in situ monitoring of the disease, even by the own patient at home.
The group is looking for companies to manufacturing a prototype, reaching licensing agreements or collaboration.

Universidad de Alcalá-OTRI

Details of the Technology Offer


The fast diagnosis and monitoring of tyrosinemia are essential to avoid the serious complications of this disease such as hepatic damage, mental retardation or even death in the first days of life without a diagnosis. Additionally, there is no and efficient treatment yet so patients have to control their disease during the whole life to avoid serious damages.  
This invention consists on a fully integrate and portable device for in situ and fast tyrosinemia sensing composed by: (i) disposable electrodes based on filtered nanomaterials and (ii) an electronic device what includes a miniaturized potentiostat for the electrochemical measurements coupled to a software to become the electrochemical current into a digital signal (number or lights) and a simple hardware for an easy interpretation by a non-specialized user. The hardware would be composed by a miniaturized potentiostat, on/off and start/stop buttons, a screen and lights for signal interpretation by the user and a hole to insert the disposable electrode; all integrated into a single portable device. 

Due to the grave effects of tyrosinemia and its associated problems, a fast diagnosis and strict control during the whole life has to be carried out. However, current control of tyrosinemia involves a tedious process in specialized laboratories as well as expensive and very timeconsuming methods which provoke a delay in diagnosis and monitoring, which is very dangerous for patient’s survival and to their quality of life later on. 

Thus, this invention is a portable and easy-to-use device, use very few amounts of sample (50 µl) and perform fast analysis (1 minute), which become it into a very valuable approach for tyrosinemia diagnosis and monitoring by the non-specialized user. So, the present invention is an ideal alternative for fast diagnosis and monitoring since there is not any commercial availability of portable devices for tyrosinemia yet, so it would be the first device commercially available to this aim. 


Diagnosis, monitoring, tyrosinemia, portable device, electrochemical detection, disposable electrodes, filtered carbon nanotubes as exclusive transducer, clinical samples.

- Possible use for other diseases related to tyrosinemia and uric acid as a biomarker. 
- Simple and fast technology (1-minute-long analysis and 50 µl of the sample) using one single device coupled with disposable electrodes that can be exploited commercially. 
- It does not need any sophisticated equipment for their use. 


The group seeks to achieve trade, manufacturing or license agreements with industries of Pharmaceuticals and Cosmetics, Industrial Engineer and Sensors Companies as well as Diagnosis Industry. The task to be performed by the partner would be to manufacturing the device for its commercial availability. 

Related Keywords

  • Electronics, IT and Telecomms
  • Applications for Health
  • Measurement devices
  • Medicine, Human Health
  • Clinical Research, Trials
  • Diagnostics, Diagnosis
  • Gene - DNA Therapy
  • Remote diagnostics
  • Measurements and Standards
  • Analyses / Test Facilities and Methods
  • Protecting Man and Environment
  • Diagnostic
  • Diagnostic services
  • Other ( Diagnostic related )
  • Computer-aided diagnosis and therapy
  • Clinical Medicine
  • Diagnostic equipment
  • electrodes
  • electrochemical detection
  • diagnosis, monitoring, tyrosinemia
  • portable device
  • metabollism
  • clinical smaples
  • rare disease

About Universidad de Alcalá-OTRI

The Technology Transfer Office at Alcalá University serves as a liaison between the University and its socioeconomic environment in terms of research and innovation. It encorages collaboration between research groups from universities and companies/institutions, with the objective to promote and commercialize research results and scientific capabilities.

Some of the services offered by this office are specified in the following list:

- Promotion of R & D and improvement of the relationships with companies.
- Promote the participation in R & D projects applicants to public calls (regional, national and European).
- Advising, processing and monitoring of patents and other forms of industrial protection.
- Support in the negotiation of contracts and agreements for R&D&i

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