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RAMOT at Tel Aviv University Ltd.RAMOT at Tel Aviv University Ltd.RAMOT at Tel Aviv University Ltd. posted this:
A novel behavioral bioassay for preclinical testing and characterization of CNS agentsOur team, including zoologists, statisticians, and computer scientists have developed a new hi-res bioassay for preclinical testing and characterization of CNS agents, extracting key animal-centered parameters of behavior via computerized tracking and measurement of free exploration. The features that distinguish our system and method from other existing systems and methods are: elaborate data preparation for analysis and a methodology that secures replicability of results across laboratories, and exposes active management of kinematic variables. Our measured parameters are carefully designed, animal-centered building blocks of behavior. They are selected on the basis of an in-depth understanding of the mouse’s functional world. These quite unexpected and unusual parameters reflect the animal’s cognitive and emotional state and its information processing capacity; therefore they are most prone to be affected by drugs that act on respective CNS structures that mediate these states. Unlike all other existing systems we expose and quantify the rich and highly organized developmental dynamics of self regulated behavioral growth. The dynamics of this process before and after genetic manipulation and/or pharmacological treatment can now be readily measured by our system, articulating the effects of potential CNS drugs on behavioral growth and decay processes. Project ID : 2-2009-11
Yissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew UniversityTechnology Transfer Office
View ProfileYissum - Research Development Company of the Hebrew University posted this:
A Novel Blood Test to Diagnose Disease and its Origins through Identification of Cell Free DNACluster7 Cluster8 Liquid Biopsy A diagnostic two-pronged approach to interrogate epigenetic modifications in cfDNA The assay simultaneously measures cfDNA methylation and covalent histone modifications of circulating nucleosomes, and develop analysis methods for inferring the rate of cell death, physiological state, and transcriptionally active pathways in originating tissues Keywords: Diagnosis, cell free DNA diagnosis, circulating DNA, liquid biopsies, methylation patterns, histone modification pattern, tissue of origin detection, cancer diagnosis, drug monitoring Digital Health Project ID : 6-2017-4530- Yissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew University
Technology Transfer Office
View ProfileYissum - Research Development Company of the Hebrew University posted this:
A Novel Chip-set for Autonomous Positioning, Localization and MappingThis is targeted as a spinout but also could be an R&O. Project ID : 43-2018-4622
CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas posted this:
A novel high-performance graphene fabrication methodResearchers from the Spanish National Research Council (CSIC) and the Catalan Institute of Nanoscience and Nanotechnology (ICN2-BIST) have recently developed a novel electrochemical reactor and procedure to fabricate graphene. This method has been proved as prototype and shows high performance and fine tuning of the graphene oxidation. Graphene producers are being sought to collaborate and/or exploit the existing know-how through a patent license agreement. An offer for Patent Licensing
University of Vigo posted this:
A novel mild and efficient method to prepare ε-Caprolactam precursor of Nylon 6ε-Caprolactam, the main precursor of the synthetic fibber Nylon 6, is prepared from cyclohexanone oxime by treatment with a new salt as promoter. This procedure requires mild reaction conditions and affords excellent levels of conversion and selectivity to obtain pure ε-caprolactam. No reaction by-products are formed. The new promoter salt is cheap, no corrosive, and easy to prepare. All these characteristics makes the procedure suitable for undustrial purposes.
University of Vigo posted this:
A novel mild and efficient method to prepare ε-Caprolactam, the precursor of Nylon 6ε-caprolactam is the main precursor used for the synthesis Nylon 6; its global market have reached around 5 million metric tons per year. Synthetic polyamide Nylon 6 is of the highest importance for the textile industry and development of polymers and material science. The production of ε-caprolactam
Jagiellonian UniversityJagiellonian UniversityJagiellonian University posted this:
A novel route of the CMK-3 carbon replica synthesis, which may be a material useful in various catalytic and sorption processes as well as electrochemical applicationsThe major advantages of the proposed synthesis route are following: •minimizing of the number of synthesis steps, •elimination of toxic reagents and solvents, •simplification of the equipment required for the synthesis as well as reduction of time and energy consumption, •high reproducibility of obtained product, •a higher structural arrangement of the resultant replica in comparison to materials obtained by the methods previously reported in the literature, •higher content of surface oxygen-containing groups responsible for the high catalytic activity and sorption capacity.- Yissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew University
Technology Transfer Office
View ProfileYissum - Research Development Company of the Hebrew University posted this:
A novel spatial (non-topical) mosquito repellent using unique bio-friendly chemical compoundChemical compound (GRAS, DEET-free) to be used as spatial (non topical) mosquito repellent Known mechanism of action A novel spatial (non-topical) mosquito repellent, for long range based on unique chemical compound Project ID : 8-2018-4611
- Yissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew University
Technology Transfer Office
View ProfileYissum - Research Development Company of the Hebrew University posted this:
A Novel Target for Treatment of Rare Genetic Diseases Caused by Nonsense MutationsDuchenne Muscular Dystrophy (DMD) and Becker Dystrophy Molecules tested on patient-derived cells: 5-AzaC, Ataluren, Amlexanox, +8 new drugs Project ID : 6-2018-4579
Covid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by Innoget posted this:
A Novel Therapeutic Approach Targeting Coronavirus Replication-Essential RNAs by OligonucleotidesA Novel Therapeutic Approach Targeting Coronavirus Replication-Essential RNAs by Oligonucleotides. The research team plans to develop a drug to inhibit human SARS-CoV-2 replication. They will use comparative genomics to detect conserved regions within the coronavirus family, and within human CoV-19 population, in order to identify essential genes that can be targeted to inhibit the virus replication. Project ID : 47-2020-10912
- Yissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew University
Technology Transfer Office
View ProfileYissum - Research Development Company of the Hebrew University posted this:
A Novel Therapeutic Approach Targeting Coronavirus Replication-Essential RNAs by OligonucleotidesA Novel Therapeutic Approach Targeting Coronavirus Replication-Essential RNAs by Oligonucleotides Project ID : 47-2020-10912
Innovation APTA posted this:
A Pack of a Routing, Fault Tolerance and Sizing Method for Dynamic WDM Optical NetworksThe technology corresponds to a set of three technologies that incorporate a least-cost routing method, a fault-tolerance method, and a wavelength dimensioning method for dynamic WDM optical networks with wavelength continuity constraints. The first technology corresponds to a routing method for a dynamic WDM optical network that has wavelength continuity constraints, and that aims to determine the set of routes that allow transmitting to each user in the network. The method is more efficient than existing methods, in terms of the number of wavelengths, and due to the fixed routing strategy used, its implementation is simple, and its online operation is very fast. The second technology corresponds to a method for determining the set of additional routes, called secondary routes, which are used to keep each user connected in cases where any set of simultaneous link failures occur. In addition, the number of wavelengths available on each link in the network is calculated such that the probability of blocking each connection is less than a predetermined threshold (which is a network design parameter), despite the occurrence of any set of simultaneous links. The third technology corresponds to a method for implementing an optical WDM network with wavelength continuity constraint that is based on a definition of a policy for assigning wavelengths to each network connection and on a calculation of the number of wavelengths in dynamic optical WDM networks with wavelength continuity constraint.
Innovation Analist at Hub APTAYeda posted this:
A Platform for Boosting Efficiency of Therapeutic RNA EditingSingle-point mutations can give rise to a wide spectrum of genetic diseases. Recent therapeutic approaches aim at editing the mutated mRNA, providing a safe, reversible and tunable treatment. However, these methods are currently not efficient due to knowledge gaps in the understanding of the rules determining RNA editing. Here we provide a powerful method to enhance the efficiency of RNA editing for treating genetic diseases associated with single-point mutations.
IMIM Institut Recerca Hospital del MarIMIM Institut Recerca Hospital del MarIMIM Institut Recerca Hospital del Mar posted this:
A prognostic and predictive serum biomarker in Small Cell Lung CancerPeripheral blood and its components (serum, plasma, and circulating cells) is an easily accessible fluid. An ELISA-based system that exploit circulating protein biomarkers found in this medium is more convenient to the patient compared to a more invasive lung biopsy. The researchers have found that high levels of serum hepatocyte growth factor (sHGF) protein in patients with SCLC shows clearly predicted for shortened survival and an incremental risk for death. HGF is a natural ligand for the oncogenic epithelial transition factor (c-Met) transmembrane tyrosine kinase receptor and serum HGF could be predictive of individual responses to new anti-cancer drugs: the Met inhibitors. The Met inhibitors are targeted therapies against c-Met receptor that are currently in development for the treatment of other neoplasms and are planned to be evaluated in SCLC. Therefore, a biomarker of prediction of response to these new Met inhibitors would be crucial for correct selection of patients for the clinical trials. Incorrect selection through other biomarkers in NSCLC has leaded to lack of benefit from these drugs in already performed phase 3 clinical trials, stressing the relevance of correct patient selection- Yissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew University
Technology Transfer Office
View ProfileYissum - Research Development Company of the Hebrew University posted this:
A Promising Agent for Coronavirus SARS-CoV-2 Infection therapy: Orally Available - Highly Potent Integrin avb3/avb5 InhibitorA Promising Agent for Coronavirus SARS-CoV-2 Infection therapy: Orally Available - Highly Potent Integrin avb3/avb5 Inhibitor Project ID : 47-2020-10889 UNIVERSIDAD DE BURGOS posted this:
A promising organic compound for redox flow batteriesIn the search for organic compounds for redox flow batteries, researchers from the University of Burgos have developed a synthetic procedure that allows obtaining a viologen, 3,3'-([4,4'-bipyridin]-1,1'-diio-1,1'-diyl)bis(butane-1-sulfonate), in a simple, selective and multigram scale. The use of this molecule can replace metals such as vanadium, giving as a result more economical and ecological batteries, among other advantages. Moreover, compared to other viologens, batteries built with the compound developed at UBU have a superior stability.
Cracow University of TechnologyCracow University of TechnologyCracow University of Technology posted this:
A propulsion/drive system of aquatic vessels.Both proposed side fins drive systems have similar features which are realized by slightly different mechanisms dependant on the room inside vehicles hull. Those features are as follows: - multi-functionality, - ability to generate an extra driving force, - significant increase of swimming speed, - reduction of robot unwanted hull movements during swimming with side fins enabling proper work of onboard equipment and sensors etc. (for solutions in robots imitating fish); - increasing the dynamic of swimming depth changes; - wide range of change of direction of thrust force (also reverse thrust). - unlimited range of change of thrust around axis of rotation of side fins, - ability to dynamically stabilize heel movement of the hull - no change in the direction of rotation of the main engine transferred into oscillatory motion of lateral fins, - less energy consumption, - frequency of oscillation at a level of several Hz
Unismart - University of Padua FoundationUnismart - University of Padua FoundationUnismart - University of Padua Foundation posted this:
A resilient and user-friendly CAPTCHAThis patented image-based CAPTCHA relies on user interaction because it depends on the innate human ability to recognize shapes in a confused environment.
Universitat Politècnica de Catalunya - UPCUniversitat Politècnica de Catalunya - UPCUniversitat Politècnica de Catalunya - UPC posted this:
A sea wave detector for improved autopilot systemsA new method for processing the signal from a speed log meter enables rapid and cost-effective wave detection, which in turn improves autopilot performance and provides safer operation in rough seas. We are seeking partners to further develop the system and/or to establish commercial and technical cooperation agreements.
Robert DiSilvestro posted this:
A seminatural ingredient drug for triglcyeride loweringA drug combination of 3 USA Generally Regarded as Safe (GRAS), seminatural ingredients is proposed for lowering plasma triglyceride (TG) readings (US and international patents pending). The ingredients are diet components, but have laboratory generated aspects. Some human and animal data exists for TG lowering of each ingredient, but the combination has not been tested. Compared to existing drugs, the newly proposed formula is relatively safe, cost effective, with a low pill burden. The envisioned product could be used alone and added to existing therapies.
Emeritus Professor, LLC President
Universidad de Granada posted this:
A simultaneous detection system of chromosomal alterations by sequencing, cytometry and imagingNew in vitro method to evaluate the presence of chromosomal alterations, particularly in 17q25. That applies three techniques combined (magnetic capture, flow cytometry and microscopy techniques) using a single specific DNA-labeled probe. The probe's multifunctional character opens the door to a powerful diagnostic, prognostic or monitoring kit for different types of cancer and diseases of genetic origin where these alterations are present.
INESC TEC posted this:
a single-stage, bidirectional and high-frequency isolated power conversion systemACDC Cube is a single-stage, bidirectional and high-frequency isolated power conversion system. ACDC Cube also uses a novel control method to do the interface between the Alternate Current (AC) distribution networks and a battery pack, or other Direct Current (DC) sources/loads, delivering higher power quality in a compact design. ACDC Cube has lower total volume and weight, increased durability and equivalent reliability when compared with a standard solution such as the voltage source converter plus dual active bridge. Due to its innovative features, ACDC Cube is especially suitable for applications where the size of the power conversion system is critical.
- Unismart - University of Padua FoundationUnismart - University of Padua Foundation
Unismart - University of Padua Foundation posted this:
A small molecule inhibitor of OPA1 GTPase activity with anti-cancer propertiesThe invention belongs to the field of research to improve the treatment of disorders such as cancer and cancer-induced angiogenesis involving the upregulation of the levels of the said protein OPA1.
- Universitat Politècnica de Catalunya - UPCUniversitat Politècnica de Catalunya - UPC
Universitat Politècnica de Catalunya - UPC posted this:
A Software System for the Microbial Source Tracking ProblemA Software System for the Microbial Source Tracking Problem
- CSIC - Consejo Superior de Investigaciones CientíficasCSIC - Consejo Superior de Investigaciones Científicas
CSIC - Consejo Superior de Investigaciones Científicas posted this:
A Sustainable Procedure to Released Bioactive Compounds from BiomassCSIC has developed a procedure to extract bioactive compounds from wet biomass, in example microalgae or/and seaweeds, by using a sequential methodology. The procedure is quick, selective, give high yields, maintain bioactivity and minimize the impact to the environment. Industrial partners from the chemical or pharmaceutical or food industry are being sought to collaborate through a patent licence agreement. An offer for Patent Licensing
Universidad Andres BelloUniversidad Andres Bello- IMIM Institut Recerca Hospital del MarIMIM Institut Recerca Hospital del Mar
IMIM Institut Recerca Hospital del Mar posted this:
A TREATMENT FOR TRIPLE NEGATIVE BREAST CANCERTriple negative breast cancers are tipically associated with por prognosis, due to aggressive tumor phenotype(s), only partial response to chemoterapy and present lack of clinically established targeted therapies and respresent the focus of increasing interest at the clinical, biological and epidemiological level, as disclosed in Podo et al., Triple –negative breast cancer: Present challenges and new perspectives, Mol. Oncol., 2010, 4, 209-229. There is, thus, a particular need for new active agents suitable for breast cancer treatment, and in particular need for triple negative breast cancers. - Covid-19 Innovation Challenges by InnogetCovid-19 Innovation Challenges by Innoget
- Yissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew UniversityYissum - Research Development Company of the Hebrew University
Technology Transfer Office
View ProfileYissum - Research Development Company of the Hebrew University posted this:
A Unique Platform for Curing Coronavirus and Similar Lethal DiseasesA Unique Platform for Curing Coronavirus and Similar Lethal Diseases Project ID : 47-2020-10878
